This package contains the function mice.impute.midastouch(). Technically this function is to be run from within the mice package (van Buuren et al. 2011), type ??mice. It substitutes the method pmm within mice by midastouch'. The authors have shown that midastouch is superior to default pmm'. Many ideas are based on Siddique / Belin 2008's MIDAS.

Companion package of Carrion-i-Silvestre & Sansó (2023): "Generalized Extreme Value Approximation to the CUMSUMQ Test for Constant Unconditional Variance in Heavy-Tailed Time Series". It implements the Modified Iterative Cumulative Sum of Squares Algorithm, which is an extension of the Iterative Cumulative Sum of Squares (ICSS) Algorithm of Inclan and Tiao (1994), and it checks for changes in the unconditional variance of a time series controlling for the tail index of the underlying distribution. The fourth order moment is estimated non-parametrically to avoid the size problems when the innovations are non-Gaussian (see, Sansó et al., 2004). Critical values and p-values are generated using a Generalized Extreme Value distribution approach. References Carrion-i-Silvestre J.J & Sansó A (2023) <https://www.ub.edu/irea/working_papers/2023/202309.pdf>. Inclan C & Tiao G.C (1994) <doi:10.1080/01621459.1994.10476824>, Sansó A & Aragó V & Carrion-i-Silvestre J.L (2004) <https://dspace.uib.es/xmlui/bitstream/handle/11201/152078/524035.pdf>.

The maybe type represents the possibility of some value or nothing. It is often used instead of throwing an error or returning `NULL`. The advantage of using a maybe type over `NULL` is that it is both composable and requires the developer to explicitly acknowledge the potential absence of a value, helping to avoid the existence of unexpected behaviour.

Calculate dissolved gas concentrations from raw MIMS (Membrane Inlet Mass Spectrometer) signal data. Use mimsy() on a formatted CSV file to return dissolved gas concentrations (mg and microMole) of N2, O2, Ar based on gas solubility at temperature, pressure, and salinity. See references Benson and Krause (1984), Garcia and Gordon (1992), Stull (1947), and Hamme and Emerson (2004) for more information. Easily save the output to a nicely-formatted multi-tab Excel workbook with mimsy.save(). Supports dual-temperature standard calibration for dual-bath MIMS setups.

Similarity plots based on correlation and median absolute deviation (MAD); adjusting colors for heatmaps; aggregate technical replicates; calculate pairwise fold-changes and log fold-changes; compute one- and two-way ANOVA; simplified interface to package limma (Ritchie et al. (2015), <doi:10.1093/nar/gkv007> ) for moderated t-test and one-way ANOVA; Hamming and Levenshtein (edit) distance of strings as well as optimal alignment scores for global (Needleman-Wunsch) and local (Smith-Waterman) alignments with constant gap penalties (Merkl and Waack (2009), ISBN:978-3-527-32594-8).

This package provides functions to calculate Unique Trait Combinations (UTC) and scaled Unique Trait Combinations (sUTC) as measures of multivariate richness. The package can also calculate beta-diversity for trait richness and can partition this into nestedness-related and turnover components. The code will also calculate several measures of overlap. See Keyel and Wiegand (2016) <doi:10.1111/2041-210X.12558> for more details.

This package provides functions for carrying out nonparametric hypothesis tests of the MCAR hypothesis based on the theory of Frechet classes and compatibility. Also gives functions for computing halfspace representations of the marginal polytope and related geometric objects.

This package provides a macro language for R programs, which provides a macro facility similar to SAS®'. This package contains basic macro capabilities like defining macro variables, executing conditional logic, and defining macro functions.

Computes the posterior model probabilities for standard meta-analysis models (null model vs. alternative model assuming either fixed- or random-effects, respectively). These posterior probabilities are used to estimate the overall mean effect size as the weighted average of the mean effect size estimates of the random- and fixed-effect model as proposed by Gronau, Van Erp, Heck, Cesario, Jonas, & Wagenmakers (2017, <doi:10.1080/23743603.2017.1326760>). The user can define a wide range of non-informative or informative priors for the mean effect size and the heterogeneity coefficient. Moreover, using pre-compiled Stan models, meta-analysis with continuous and discrete moderators with Jeffreys-Zellner-Siow (JZS) priors can be fitted and tested. This allows to compute Bayes factors and perform Bayesian model averaging across random- and fixed-effects meta-analysis with and without moderators. For a primer on Bayesian model-averaged meta-analysis, see Gronau, Heck, Berkhout, Haaf, & Wagenmakers (2021, <doi:10.1177/25152459211031256>).

This package provides a minimal library specifically designed to make the estimation of Machine Learning (ML) techniques as easy and accessible as possible, particularly within the framework of the Knowledge Discovery in Databases (KDD) process in data mining. The package provides essential tools to structure and execute each stage of a predictive or classification modeling workflow, aligning closely with the fundamental steps of the KDD methodology, from data selection and preparation, through model building and tuning, to the interpretation and evaluation of results using Sensitivity Analysis. The MLwrap workflow is organized into four core steps; preprocessing(), build_model(), fine_tuning(), and sensitivity_analysis(). It also includes global and pairwise interaction analysis based on Friedmanâ s H-statistic to support a more detailed interpretation of complex feature relationships.These steps correspond, respectively, to data preparation and transformation, model construction, hyperparameter optimization, and sensitivity analysis. The user can access comprehensive model evaluation results including fit assessment metrics, plots, predictions, and performance diagnostics for ML models implemented through Neural Networks', Random Forest', XGBoost (Extreme Gradient Boosting), and Support Vector Machines (SVM) algorithms. By streamlining these phases, MLwrap aims to simplify the implementation of ML techniques, allowing analysts and data scientists to focus on extracting actionable insights and meaningful patterns from large datasets, in line with the objectives of the KDD process.

Metadynamics is a state of the art biomolecular simulation technique. Plumed Tribello, G.A. et al. (2014) <doi:10.1016/j.cpc.2013.09.018> program makes it possible to perform metadynamics using various simulation codes. The results of metadynamics done in Plumed can be analyzed by metadynminer'. The package metadynminer reads 1D and 2D metadynamics hills files from Plumed package. It uses a fast algorithm by Hosek, P. and Spiwok, V. (2016) <doi:10.1016/j.cpc.2015.08.037> to calculate a free energy surface from hills. Minima can be located and plotted on the free energy surface. Transition states can be analyzed by Nudged Elastic Band method by Henkelman, G. and Jonsson, H. (2000) <doi:10.1063/1.1323224>. Free energy surfaces, minima and transition paths can be plotted to produce publication quality images.

Several functions can be used to analyze multiblock multivariable data. If the input is a single matrix, then principal components analysis (PCA) is implemented. If the input is a list of matrices, then multiblock PCA is implemented. If the input is two matrices, for exploratory and objective variables, then partial least squares (PLS) analysis is implemented. If the input is two lists of matrices, for exploratory and objective variables, then multiblock PLS analysis is implemented. Additionally, if an extra outcome variable is specified, then a supervised version of the methods above is implemented. For each method, sparse modeling is also incorporated. Functions for selecting the number of components and regularized parameters are also provided.

Tool for exploring DNA and amino acid variation and inferring the presence of target lineages from microbial high-throughput genomic DNA samples that potentially contain mixtures of variants/lineages. MixviR was originally created to help analyze environmental SARS-CoV-2/Covid-19 samples from environmental sources such as wastewater or dust, but can be applied to any microbial group. Inputs include reference genome information in commonly-used file formats (fasta, bed) and one or more variant call format (VCF) files, which can be generated with programs such as Illumina's DRAGEN, the Genome Analysis Toolkit, or bcftools. See DePristo et al (2011) <doi:10.1038/ng.806> and Danecek et al (2021) <doi:10.1093/gigascience/giab008> for these tools, respectively. Available outputs include a table of mutations observed in the sample(s), estimates of proportions of target lineages in the sample(s), and an R Shiny dashboard to interactively explore the data.

Routines to perform estimation and inference under the multivariate t-distribution <doi:10.1007/s10182-022-00468-2>. Currently, the following methodologies are implemented: multivariate mean and covariance estimation, hypothesis testing about equicorrelation and homogeneity of variances, the Wilson-Hilferty transformation, QQ-plots with envelopes and random variate generation.

It is designed to work with text written in Bahasa Malaysia. We provide functions and data sets that will make working with Bahasa Malaysia text much easier. For word stemming in particular, we will look up the Malay words in a dictionary and then proceed to remove "extra suffix" as explained in Khan, Rehman Ullah, Fitri Suraya Mohamad, Muh Inam UlHaq, Shahren Ahmad Zadi Adruce, Philip Nuli Anding, Sajjad Nawaz Khan, and Abdulrazak Yahya Saleh Al-Hababi (2017) <https://ijrest.net/vol-4-issue-12.html> . This package includes a dictionary of Malay words that may be used to perform word stemming, a dataset of Malay stop words, a dataset of sentiment words and a dataset of normalized words.

This package implements order selection for Vector Autoregressive (VAR) models using the Mean Square Information Criterion (MIC). Unlike standard methods such as AIC and BIC, MIC is likelihood-free. This method consistently estimates VAR order and has robust performance under model misspecification. For more details, see Hellstern and Shojaie (2025) <doi:10.48550/arXiv.2511.19761>.

Estimate diagnostic classification models (also called cognitive diagnostic models) with Stan'. Diagnostic classification models are confirmatory latent class models, as described by Rupp et al. (2010, ISBN: 978-1-60623-527-0). Automatically generate Stan code for the general loglinear cognitive diagnostic diagnostic model proposed by Henson et al. (2009) <doi:10.1007/s11336-008-9089-5> and other subtypes that introduce additional model constraints. Using the generated Stan code, estimate the model evaluate the model's performance using model fit indices, information criteria, and reliability metrics.

This package implements an interface to the legacy Fortran code from O'Connell and Dobson (1984) <DOI:10.2307/2531148>. Implements Fortran 77 code for the methods developed by Schouten (1982) <DOI:10.1111/j.1467-9574.1982.tb00774.x>. Includes estimates of average agreement for each observer and average agreement for each subject.

Implementing a multiple imputation algorithm for multivariate data with missing and censored values under a coarsening at random assumption (Heitjan and Rubin, 1991<doi:10.1214/aos/1176348396>). The multiple imputation algorithm is based on the data augmentation algorithm proposed by Tanner and Wong (1987)<doi:10.1080/01621459.1987.10478458>. The Gibbs sampling algorithm is adopted to to update the model parameters and draw imputations of the coarse data.

Multivariate Information-based Inductive Causation, better known by its acronym MIIC, is a causal discovery method, based on information theory principles, which learns a large class of causal or non-causal graphical models from purely observational data, while including the effects of unobserved latent variables. Starting from a complete graph, the method iteratively removes dispensable edges, by uncovering significant information contributions from indirect paths, and assesses edge-specific confidences from randomization of available data. The remaining edges are then oriented based on the signature of causality in observational data. The recent more interpretable MIIC extension (iMIIC) further distinguishes genuine causes from putative and latent causal effects, while scaling to very large datasets (hundreds of thousands of samples). Since the version 2.0, MIIC also includes a temporal mode (tMIIC) to learn temporal causal graphs from stationary time series data. MIIC has been applied to a wide range of biological and biomedical data, such as single cell gene expression data, genomic alterations in tumors, live-cell time-lapse imaging data (CausalXtract), as well as medical records of patients. MIIC brings unique insights based on causal interpretation and could be used in a broad range of other data science domains (technology, climatology, economy, ...). For more information, you can refer to: Simon et al., eLife 2024, <doi:10.1101/2024.02.06.579177>, Ribeiro-Dantas et al., iScience 2024, <doi:10.1016/j.isci.2024.109736>, Cabeli et al., NeurIPS 2021, <https://why21.causalai.net/papers/WHY21_24.pdf>, Cabeli et al., Comput. Biol. 2020, <doi:10.1371/journal.pcbi.1007866>, Li et al., NeurIPS 2019, <https://papers.nips.cc/paper/9573-constraint-based-causal-structure-learning-with-consistent-separating-sets>, Verny et al., PLoS Comput. Biol. 2017, <doi:10.1371/journal.pcbi.1005662>, Affeldt et al., UAI 2015, <https://auai.org/uai2015/proceedings/papers/293.pdf>. Changes from the previous 1.5.3 release on CRAN are available at <https://github.com/miicTeam/miic_R_package/blob/master/NEWS.md>.

Tokenize text into morphemes. The morphemepiece algorithm uses a lookup table to determine the morpheme breakdown of words, and falls back on a modified wordpiece tokenization algorithm for words not found in the lookup table.

Create legends for maps and other graphics. Thematic maps need to be accompanied by legible legends to be fully comprehensible. This package offers a wide range of legends useful for cartography, some of which may also be useful for other types of graphics.

This package provides methods for fitting mixture distributions to univariate data using expectation maximization, HWHM and other methods. Supports Gaussian, Cauchy, Student's t and von Mises mixtures. For more details see Merkys (2018) <https://www.lvb.lt/permalink/370LABT_NETWORK/1m6ui06/alma9910036312108451>.

Advanced methods for a valuable quantitative environmental risk assessment using Bayesian inference of survival Data with toxicokinetics toxicodynamics (TKTD) models. Among others, it facilitates Bayesian inference of the general unified threshold model of survival (GUTS). See models description in Jager et al. (2011) <doi:10.1021/es103092a> and implementation using Bayesian inference in Baudrot and Charles (2019) <doi:10.1038/s41598-019-47698-0>.