Mainly for maximum likelihood estimation of nonparametric and semiparametric mixture models, but can also be used for fitting finite mixtures. The algorithms are developed in Wang (2007) <doi:10.1111/j.1467-9868.2007.00583.x> and Wang (2010) <doi:10.1007/s11222-009-9117-z>.

Fits regularization paths for linear regression, GLM, and Cox regression models using lasso or nonconvex penalties, in particular the minimax concave penalty (MCP) and smoothly clipped absolute deviation (SCAD) penalty, with options for additional L2 penalties (the "elastic net" idea). Utilities for carrying out cross-validation as well as post-fitting visualization, summarization, inference, and prediction are also provided. For more information, see Breheny and Huang (2011) <doi:10.1214/10-AOAS388> or visit the ncvreg homepage <https://pbreheny.github.io/ncvreg/>.

Renders dynamic network data from networkDynamic objects as movies, interactive animations, or other representations of changing relational structures and attributes.

This package implements univariate continuous probability distributions and associated model diagnostics based on the Lindley, Logistic, Half-Cauchy, Half-Logistic, and Poisson families. Provides functions for probability density, cumulative distribution, quantile, and hazard evaluation, random variate generation, and diagnostic procedures including Q-Q and P-P plots, goodness-of-fit tests, and model selection criteria.

This package provides tools to create time series and geometry NetCDF files.

This package implements methods introduced in Chen, Christensen, and Kankanala (2024) <doi:10.1093/restud/rdae025> for estimating and constructing uniform confidence bands for nonparametric structural functions using instrumental variables, including data-driven choice of tuning parameters. All methods in this package apply to nonparametric regression as a special case.

Neural decoding is method of analyzing neural data that uses a pattern classifiers to predict experimental conditions based on neural activity. NeuroDecodeR is a system of objects that makes it easy to run neural decoding analyses. For more information on neural decoding see Meyers & Kreiman (2011) <doi:10.7551/mitpress/8404.003.0024>.

Free United Kingdom National Health Service (NHS) and other healthcare, or population health-related data for education and training purposes. This package contains synthetic data based on real healthcare datasets, or cuts of open-licenced official data. This package exists to support skills development in the NHS-R community: <https://nhsrcommunity.com/>.

Classification, regression, and clustering with k nearest neighbors algorithm. Implements several distance and similarity measures, covering continuous and logical features. Outputs ranked neighbors. Most features of this package are directly based on the PMML specification for KNN.

This package implements the Network meta-Analytic Predictive (NAP) prior framework to accommodate changes in the standard of care (SoC) during ongoing randomized controlled trials (RCTs). The method synthesizes pre- and post-change in-trial data by leveraging external evidence, particularly head-to-head trials comparing the original and new standards of care, to bridge the two evidence periods and enable principled borrowing. The package provides utilities to construct NAP-based priors and perform Bayesian inference for time-to-event endpoints using summarized trial evidence.

NEON data packages can be accessed through the NEON Data Portal <https://www.neonscience.org> or through the NEON Data API (see <https://data.neonscience.org/data-api> for documentation). Data delivered from the Data Portal are provided as monthly zip files packaged within a parent zip file, while individual files can be accessed from the API. This package provides tools that aid in discovering, downloading, and reformatting data prior to use in analyses. This includes downloading data via the API, merging data tables by type, and converting formats. For more information, see the readme file at <https://github.com/NEONScience/NEON-utilities>.

The noweb system for source code, implemented in R.

Cross-Entropy optimisation of unconstrained deterministic and noisy functions illustrated in Rubinstein and Kroese (2004, ISBN: 978-1-4419-1940-3) through a highly flexible and customisable function which allows user to define custom variable domains, sampling distributions, updating and smoothing rules, and stopping criteria. Several built-in methods and settings make the package very easy-to-use under standard optimisation problems.

Computes and plots the boundary between night and day.

This package provides functions for classifying sparseness in 2 x 2 categorical data where one or more cells have zero counts. The classification uses three widely applied summary measures: Risk Difference (RD), Relative Risk (RR), and Odds Ratio (OR). Helps in selecting suitable continuity corrections for zero cells in multi-centre or meta-analysis studies. Also supports sensitivity analysis and can detect phenomena such as Simpson's paradox. The methodology is based on Subbiah and Srinivasan (2008) <doi:10.1016/j.spl.2008.06.023>.

Two implementations of canonical correlation analysis (CCA) that are based on iterated regression. By choosing the appropriate regression algorithm for each data domain, it is possible to enforce sparsity, non-negativity or other kinds of constraints on the projection vectors. Multiple canonical variables are computed sequentially using a generalized deflation scheme, where the additional correlation not explained by previous variables is maximized. nscancor() is used to analyze paired data from two domains, and has the same interface as cancor() from the stats package (plus some extra parameters). mcancor() is appropriate for analyzing data from three or more domains. See <https://sigg-iten.ch/learningbits/2014/01/20/canonical-correlation-analysis-under-constraints/> and Sigg et al. (2007) <doi:10.1109/MLSP.2007.4414315> for more details.

Network meta-analysis tools based on contrast-based approach using the multivariate meta-analysis and meta-regression models (Noma et al. (2025) <doi:10.1101/2025.09.15.25335823>). Comprehensive analysis tools for network meta-analysis and meta-regression (e.g., synthesis analysis, ranking analysis, and creating league table) are available through simple commands. For inconsistency assessment, the local and global inconsistency tests based on the Higgins design-by-treatment interaction model are available. In addition, the side-splitting methods and Jackson's random inconsistency model can be applied. Standard graphical tools for network meta-analysis, including network plots, ranked forest plots, and transitivity analyses, are also provided. For the synthesis analyses, the Noma-Hamura's improved REML (restricted maximum likelihood)-based methods (Noma et al. (2023) <doi:10.1002/jrsm.1652> <doi:10.1002/jrsm.1651>) are adopted as the default methods.

This package provides a set of functions providing several outlier (i.e., studies with extreme findings) and influential detection measures and methodologies in network meta-analysis : - simple outlier and influential detection measures - outlier and influential detection measures by considering study deletion (shift the mean) - plots for outlier and influential detection measures - Q-Q plot for network meta-analysis - Forward Search algorithm in network meta-analysis. - forward plots to monitor statistics in each step of the forward search algorithm - forward plots for summary estimates and their confidence intervals in each step of forward search algorithm.

Linear regression model and generalized linear models with nonparametric network effects on network-linked observations. The model is originally proposed by Le and Li (2022) <doi:10.48550/arXiv.2007.00803> and is assumed on observations that are connected by a network or similar relational data structure. A more recent work by Wang, Le and Li (2024) <doi:10.48550/arXiv.2410.01163> further extends the framework to generalized linear models. All these models are implemented in the current package. The model does not assume that the relational data or network structure to be precisely observed; thus, the method is provably robust to a certain level of perturbation of the network structure. The package contains the estimation and inference function for the model.

Segmentation of short text sequences - like hashtags - into the separated words sequence, done with the use of dictionary, which may be built on custom corpus of texts. Unigram dictionary is used to find most probable sequence, and n-grams approach is used to determine possible segmentation given the text corpus.

This package performs a Necessary Condition Analysis (NCA). (Dul, J. 2016. Necessary Condition Analysis (NCA). Logic and Methodology of Necessary but not Sufficient causality." Organizational Research Methods 19(1), 10-52) <doi:10.1177/1094428115584005>. NCA identifies necessary (but not sufficient) conditions in datasets, where x causes (e.g. precedes) y. Instead of drawing a regression line through the middle of the data in an xy-plot, NCA draws the ceiling line. The ceiling line y = f(x) separates the area with observations from the area without observations. (Nearly) all observations are below the ceiling line: y <= f(x). The empty zone is in the upper left hand corner of the xy-plot (with the convention that the x-axis is horizontal and the y-axis is vertical and that values increase upwards and to the right''). The ceiling line is a (piecewise) linear non-decreasing line: a linear step function or a straight line. It indicates which level of x (e.g. an effort or input) is necessary but not sufficient for a (desired) level of y (e.g. good performance or output). A quick start guide for using this package can be found here: <https://repub.eur.nl/pub/78323/> or <https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2624981>.

Do algebraic operations on neural networks. We seek here to implement in R, operations on neural networks and their resulting approximations. Our operations derive their descriptions mainly from Rafi S., Padgett, J.L., and Nakarmi, U. (2024), "Towards an Algebraic Framework For Approximating Functions Using Neural Network Polynomials", <doi:10.48550/arXiv.2402.01058>, Grohs P., Hornung, F., Jentzen, A. et al. (2023), "Space-time error estimates for deep neural network approximations for differential equations", <doi:10.1007/s10444-022-09970-2>, Jentzen A., Kuckuck B., von Wurstemberger, P. (2023), "Mathematical Introduction to Deep Learning Methods, Implementations, and Theory" <doi:10.48550/arXiv.2310.20360>. Our implementation is meant mainly as a pedagogical tool, and proof of concept. Faster implementations with deeper vectorizations may be made in future versions.

Creation and selection of N-way Partial Least Squares (NPLS) models. Selection of the optimal number of components can be done using ncrossreg(). NPLS was originally described by Rasmus Bro, see <doi:10.1002/%28SICI%291099-128X%28199601%2910%3A1%3C47%3A%3AAID-CEM400%3E3.0.CO%3B2-C>.

NONMEM has been a tool for running nonlinear mixed effects models since the 80s and is still used today (Bauer 2019 <doi:10.1002/psp4.12404>). This tool allows you to convert NONMEM models to rxode2 (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and with simple models nlmixr2 syntax (Fidler et al (2019) <doi:10.1002/psp4.12445>). The nlmixr2 syntax requires the residual specification to be included and it is not always translated. If available, the rxode2 model will read in the NONMEM data and compare the simulation for the population model ('PRED') individual model ('IPRED') and residual model ('IWRES') to immediately show how well the translation is performing. This saves the model development time for people who are creating an rxode2 model manually. Additionally, this package reads in all the information to allow simulation with uncertainty (that is the number of observations, the number of subjects, and the covariance matrix) with a rxode2 model. This is complementary to the babelmixr2 package that translates nlmixr2 models to NONMEM and can convert the objects converted from nonmem2rx to a full nlmixr2 fit.