This package provides a wrapper for optim for nonlinear regression problems; see Nocedal J and Write S (2006, ISBN: 978-0387-30303-1). Performs ordinary least squares (OLS), iterative re-weighted least squares (IRWLS), and maximum likelihood (MLE). Also includes the robust outlier detection (ROUT) algorithm; see Motulsky, H and Brown, R (2006) <doi:10.1186/1471-2105-7-123>.

Incorporates functions for image preprocessing, filtering and image recognition. The package takes advantage of RcppArmadillo to speed up computationally intensive functions. The histogram of oriented gradients descriptor is a modification of the findHOGFeatures function of the SimpleCV computer vision platform, the average_hash(), dhash() and phash() functions are based on the ImageHash python library. The Gabor Feature Extraction functions are based on Matlab code of the paper, "CloudID: Trustworthy cloud-based and cross-enterprise biometric identification" by M. Haghighat, S. Zonouz, M. Abdel-Mottaleb, Expert Systems with Applications, vol. 42, no. 21, pp. 7905-7916, 2015, <doi:10.1016/j.eswa.2015.06.025>. The SLIC and SLICO superpixel algorithms were explained in detail in (i) "SLIC Superpixels Compared to State-of-the-art Superpixel Methods", Radhakrishna Achanta, Appu Shaji, Kevin Smith, Aurelien Lucchi, Pascal Fua, and Sabine Suesstrunk, IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 34, num. 11, p. 2274-2282, May 2012, <doi:10.1109/TPAMI.2012.120> and (ii) "SLIC Superpixels", Radhakrishna Achanta, Appu Shaji, Kevin Smith, Aurelien Lucchi, Pascal Fua, and Sabine Suesstrunk, EPFL Technical Report no. 149300, June 2010.

The online principal component method can process the online data set. The philosophy of the package is described in Guo G. (2018) <doi:10.1080/10485252.2018.1531130>.

Provide functions for users or machines to quickly and easily retrieve datasets from the mindat.org API (<https://api.mindat.org/schema/redoc/>).

This package provides a wrapper for the OpenTripPlanner <http://www.opentripplanner.org/> REST API. Queries are submitted to the relevant OpenTripPlanner API resource, the response is parsed and useful R objects are returned.

This package provides a regression framework for response variables which are continuous self-rating scales such as the Visual Analog Scale (VAS) used in pain assessment, or the Linear Analog Self-Assessment (LASA) scales in quality of life studies. These scales measure subjects perception of an intangible quantity, and cannot be handled as ratio variables because of their inherent non-linearity. We treat them as ordinal variables, measured on a continuous scale. A function (the g function) connects the scale with an underlying continuous latent variable. The link function is the inverse of the CDF of the assumed underlying distribution of the latent variable. A variety of link functions are currently implemented. Such models are described in Manuguerra et al (2020) <doi:10.18637/jss.v096.i08>.

Two-stage design for single-arm phase II trials with time-to-event endpoints (e.g., clinical trials on immunotherapies among cancer patients) can be calculated using this package. Two notable advantages of the package: 1) It provides flexible choices from three design methods (optimal, minmax, and admissible), and 2) the power of the design is more accurately calculated using the exact variance in the one-sample log-rank test. The package can be used for 1) planning the sample sizes and other design parameters, and 2) conducting the interim and final analyses for the Go/No-go decisions. More details about the design method can be found in: Wu, J, Chen L, Wei J, Weiss H, Chauhan A. (2020). <doi:10.1002/pst.1983>.

The client streamlines access to the services provided by <https://api.openrouteservice.org>. It allows you to painlessly query for directions, isochrones, time-distance matrices, geocoding, elevation, points of interest, and more.

Defines thresholds for breaking data into a number of discrete levels, minimizing the (mean) squared error within all bins.

The separate p-values of SNPs, RNA expressions and DNA methylations are calculated by KM regression. The correlation between different omics data are taken into account. This method can be applied to either samples with all three types of omics data or samples with two types.

This package implements a tree-based method specifically designed for personalized medicine applications. By using genomic and mutational data, ODT efficiently identifies optimal drug recommendations tailored to individual patient profiles. The ODT algorithm constructs decision trees that bifurcate at each node, selecting the most relevant markers (discrete or continuous) and corresponding treatments, thus ensuring that recommendations are both personalized and statistically robust. This iterative approach enhances therapeutic decision-making by refining treatment suggestions until a predefined group size is achieved. Moreover, the simplicity and interpretability of the resulting trees make the method accessible to healthcare professionals. Includes functions for training the decision tree, making predictions on new samples or patients, and visualizing the resulting tree. For detailed insights into the methodology, please refer to Gimeno et al. (2023) <doi:10.1093/bib/bbad200>.

This package provides a collection of functions to facilitate analysis of proteomic data from Olink, primarily NPX data that has been exported from Olink Software. The functions also work on QUANT data from Olink by log- transforming the QUANT data. The functions are focused on reading data, facilitating data wrangling and quality control analysis, performing statistical analysis and generating figures to visualize the results of the statistical analysis. The goal of this package is to help users extract biological insights from proteomic data run on the Olink platform.

Predictive scores must be updated with care, because actions taken on the basis of existing risk scores causes bias in risk estimates from the updated score. A holdout set is a straightforward way to manage this problem: a proportion of the population is held-out from computation of the previous risk score. This package provides tools to estimate a size for this holdout set and associated errors. Comprehensive vignettes are included. Please see: Haidar-Wehbe S, Emerson SR, Aslett LJM, Liley J (2022) <doi:10.48550/arXiv.2202.06374> (to appear in Annals of Applied Statistics) for details of methods.

Ensemble functions for outlier/anomaly detection. There is a new ensemble method proposed using Item Response Theory. Existing outlier ensemble methods from Schubert et al (2012) <doi:10.1137/1.9781611972825.90>, Chiang et al (2017) <doi:10.1016/j.jal.2016.12.002> and Aggarwal and Sathe (2015) <doi:10.1145/2830544.2830549> are also included.

We proposes a framework that provides real time support for early detection of anomalous series within a large collection of streaming time series data. By definition, anomalies are rare in comparison to a system's typical behaviour. We define an anomaly as an observation that is very unlikely given the forecast distribution. The algorithm first forecasts a boundary for the system's typical behaviour using a representative sample of the typical behaviour of the system. An approach based on extreme value theory is used for this boundary prediction process. Then a sliding window is used to test for anomalous series within the newly arrived collection of series. Feature based representation of time series is used as the input to the model. To cope with concept drift, the forecast boundary for the system's typical behaviour is updated periodically. More details regarding the algorithm can be found in Talagala, P. D., Hyndman, R. J., Smith-Miles, K., et al. (2019) <doi:10.1080/10618600.2019.1617160>.

This package provides tools to build and work with an ontology of linked (open) data in a tidy workflow. It is inspired by the Food and Agrilculture Organizations (FAO) caliper platform <https://www.fao.org/statistics/caliper/web/> and makes use of the Simple Knowledge Organisation System (SKOS).

Estimates optimal number of biomarkers for two-group classification based on microarray data.

Setup and connect to OpenTripPlanner (OTP) <http://www.opentripplanner.org/>. OTP is an open source platform for multi-modal and multi-agency journey planning written in Java'. The package allows you to manage a local version or connect to remote OTP server to find walking, cycling, driving, or transit routes. This package has been peer-reviewed by rOpenSci (v. 0.2.0.0).

Additive proportional odds model for ordinal data using Laplace P-splines. The combination of Laplace approximations and P-splines enable fast and flexible inference in a Bayesian framework. Specific approximations are proposed to account for the asymmetry in the marginal posterior distributions of non-penalized parameters. For more details, see Lambert and Gressani (2023) <doi:10.1177/1471082X231181173> ; Preprint: <arXiv:2210.01668>).

This package provides a user-friendly R-based software package for gene clustering. Clusters are given by genes matched to prespecified profiles across various ordered treatment groups. It is particularly useful for analyzing data obtained from short time-course or dose-response microarray experiments.

This package implements the orthogonal reparameterization approach recommended by Lancaster (2002) to estimate dynamic panel models with fixed effects (and optionally: panel specific intercepts). The approach uses a likelihood-based estimator and produces estimates that are asymptotically unbiased as N goes to infinity, with a T as low as 2.

This package provides tools for processing and analyzing data from the O-GlcNAcAtlas database <https://oglcnac.org/>, as described in Ma (2021) <doi:10.1093/glycob/cwab003>. It integrates UniProt <https://www.uniprot.org/> API calls to retrieve additional information. It is specifically designed for research workflows involving O-GlcNAcAtlas data, providing a flexible and user-friendly interface for customizing and downloading processed results. Interactive elements allow users to easily adjust parameters and handle various biological datasets.

Use optimization to estimate weights that balance covariates for binary, multi-category, continuous, and multivariate treatments in the spirit of Zubizarreta (2015) <doi:10.1080/01621459.2015.1023805>. The degree of balance can be specified for each covariate. In addition, sampling weights can be estimated that allow a sample to generalize to a population specified with given target moments of covariates.

Inspired by S-PLUS function objects.summary(), provides a function with the same name that returns data class, storage mode, mode, type, dimension, and size information for R objects in the specified environment. Various filtering and sorting options are also proposed.