Calculates the percentage coefficient of variation (CV) for mass spectrometry-based proteomic data. The CV can be calculated with the traditional formula for raw (non log transformed) intensity data, or log transformed data.

Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters. The workflow was first mentioned in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).

An htmlwidgets binding for the FINOS Perspective <https://perspective-dev.github.io/> library, a high-performance WebAssembly'-powered data visualization engine. Provides interactive pivot tables, cross-tabulations, and multiple chart types (bar, line, scatter, heatmap, and more) that run entirely in the browser. Supports self-service analytics with drag-and-drop column selection, group-by/split-by pivoting, filtering, sorting, aggregation, and computed expressions. Works in RStudio Viewer, R Markdown', Quarto', and Shiny with streaming data updates via proxy interface.

This package provides functions for generating variants of curves: restricted cubic spline, periodic restricted cubic spline, periodic cubic spline. Periodic splines can be used to model data that has periodic nature / seasonality.

Pooling, backward and forward selection of linear, logistic and Cox regression models in multiply imputed datasets. Backward and forward selection can be done from the pooled model using Rubin's Rules (RR), the D1, D2, D3, D4 and the median p-values method. This is also possible for Mixed models. The models can contain continuous, dichotomous, categorical and restricted cubic spline predictors and interaction terms between all these type of predictors. The stability of the models can be evaluated using (cluster) bootstrapping. The package further contains functions to pool model performance measures as ROC/AUC, Reclassification, R-squared, scaled Brier score, H&L test and calibration plots for logistic regression models. Internal validation can be done across multiply imputed datasets with cross-validation or bootstrapping. The adjusted intercept after shrinkage of pooled regression coefficients can be obtained. Backward and forward selection as part of internal validation is possible. A function to externally validate logistic prediction models in multiple imputed datasets is available and a function to compare models. For Cox models a strata variable can be included. Eekhout (2017) <doi:10.1186/s12874-017-0404-7>. Wiel (2009) <doi:10.1093/biostatistics/kxp011>. Marshall (2009) <doi:10.1186/1471-2288-9-57>.

Enables the manufacturing, analysis and display of pressure volume curves. From the progression of the curves, turgor loss point, osmotic potential and apoplastic fraction can be derived. Methods adapted from Bartlett, Scoffoni and Sack (2012) <doi:10.1111/j.1461-0248.2012.01751.x>.

Spatial Analysis for exploration of Pakistan Population Census 2017 (<https://www.pbs.gov.pk/content/population-census>). It uses data from R package PakPC2017'.

Search CRAN metadata about packages by keyword, popularity, recent activity, package name and more. Uses the R-hub search server, see <https://r-pkg.org> and the CRAN metadata database, that contains information about CRAN packages. Note that this is _not_ a CRAN project.

Includes functions to wrap most endpoints of the PaleobioDB API and to visualize and process the obtained fossil data. The API documentation for the Paleobiology Database can be found at <https://paleobiodb.org/data1.2/>.

Automate pharmacokinetic/pharmacodynamic bioanalytical procedures based on best practices and regulatory recommendations. The package impose regulatory constrains and sanity checking for common bioanalytical procedures. Additionally, PKbioanalysis provides a relational infrastructure for plate management and injection sequence.

Calculates multivariate analysis of variance based on permutations and some associated pictorial representations. The pictorial representation is based on the principal coordinates of the group means. There are some original results that will be published soon.

Robust penalized (adaptive) elastic net S and M estimators for linear regression. The adaptive methods are proposed in Kepplinger, D. (2023) <doi:10.1016/j.csda.2023.107730> and the non-adaptive methods in Cohen Freue, G. V., Kepplinger, D., Salibián-Barrera, M., and Smucler, E. (2019) <doi:10.1214/19-AOAS1269>. The package implements robust hyper-parameter selection with robust information sharing cross-validation according to Kepplinger & Wei (2025) <doi:10.1080/00401706.2025.2540970>.

This package provides data set and function for exploration of Multiple Indicator Cluster Survey (MICS) 2017-18 Household questionnaire data for Punjab, Pakistan. The results of the present survey are critically important for the purposes of Sustainable Development Goals (SDGs) monitoring, as the survey produces information on 32 global Sustainable Development Goals (SDGs) indicators. The data was collected from 53,840 households selected at the second stage with systematic random sampling out of a sample of 2,692 clusters selected using probability proportional to size sampling. Six questionnaires were used in the survey: (1) a household questionnaire to collect basic demographic information on all de jure household members (usual residents), the household, and the dwelling; (2) a water quality testing questionnaire administered in three households in each cluster of the sample; (3) a questionnaire for individual women administered in each household to all women age 15-49 years; (4) a questionnaire for individual men administered in every second household to all men age 15-49 years; (5) an under-5 questionnaire, administered to mothers (or caretakers) of all children under 5 living in the household; and (6) a questionnaire for children age 5-17 years, administered to the mother (or caretaker) of one randomly selected child age 5-17 years living in the household (<http://www.mics.unicef.org/surveys>).

Support functions, data sets, and vignettes for the psych package. Contains several of the biggest data sets for the psych package as well as four vignettes. A few helper functions for file manipulation are included as well. For more information, see the <https://personality-project.org/r/> web page.

This package provides a new metric named dependency heaviness is proposed that measures the number of additional dependency packages that a parent package brings to its child package and are unique to the dependency packages imported by all other parents. The dependency heaviness analysis is visualized by a customized heatmap. The package is described in <doi:10.1093/bioinformatics/btac449>. We have also performed the dependency heaviness analysis on the CRAN/Bioconductor package ecosystem, described in <doi:10.1016/j.jss.2023.111610>.

Includes functions for keyword search of pdf files. There is also a wrapper that includes searching of all files within a single directory.

This package provides a small, dependency-free way to generate random names. Methods provided include the adjective-surname approach of Docker containers ('<https://github.com/moby/moby/blob/master/pkg/namesgenerator/names-generator.go>'), and combinations of common English or Spanish words.

The aim of postpack is to provide the infrastructure for a standardized workflow for mcmc.list objects. These objects can be used to store output from models fitted with Bayesian inference using JAGS', WinBUGS', OpenBUGS', NIMBLE', Stan', or even custom MCMC algorithms. Although the coda R package provides some methods for these objects, it is somewhat limited in easily performing post-processing tasks for specific nodes. Models are ever increasing in their complexity and the number of tracked nodes, and oftentimes a user may wish to summarize/diagnose sampling behavior for only a small subset of nodes at a time for a particular question or figure. Thus, many postpack functions support performing tasks on a subset of nodes, where the subset is specified with regular expressions. The functions in postpack streamline the extraction, summarization, and diagnostics of specific monitored nodes after model fitting. Further, because there is rarely only ever one model under consideration, postpack scales efficiently to perform the same tasks on output from multiple models simultaneously, facilitating rapid assessment of model sensitivity to changes in assumptions.

Read depth data from genotyping-by-sequencing (GBS) or restriction site-associated DNA sequencing (RAD-seq) are imported and used to make Bayesian probability estimates of genotypes in polyploids or diploids. The genotype probabilities, posterior mean genotypes, or most probable genotypes can then be exported for downstream analysis. polyRAD is described by Clark et al. (2019) <doi:10.1534/g3.118.200913>, and the Hind/He statistic for marker filtering is described by Clark et al. (2022) <doi:10.1186/s12859-022-04635-9>. A variant calling pipeline for highly duplicated genomes is also included and is described by Clark et al. (2020, Version 1) <doi:10.1101/2020.01.11.902890>.

This package provides functions to create confidence intervals for ratios of Poisson rates under misclassification using double sampling. Implementations of the methods described in Kahle, D., P. Young, B. Greer, and D. Young (2016). "Confidence Intervals for the Ratio of Two Poisson Rates Under One-Way Differential Misclassification Using Double Sampling." Computational Statistics & Data Analysis, 95:122â 132.

Like similar profiling tools, the proffer package automatically detects sources of slowness in R code. The distinguishing feature of proffer is its utilization of pprof', which supplies interactive visualizations that are efficient and easy to interpret. Behind the scenes, the profile package converts native Rprof() data to a protocol buffer that pprof understands. For the documentation of proffer', visit <https://r-prof.github.io/proffer/>. To learn about the implementations and methodologies of pprof', profile', and protocol buffers, visit <https://github.com/google/pprof>. <https://protobuf.dev>, and <https://github.com/r-prof/profile>, respectively.

This package provides an implementation of particle swarm optimisation consistent with the standard PSO 2007/2011 by Maurice Clerc. Additionally a number of ancillary routines are provided for easy testing and graphics.

Miscellaneous printing of numeric or statistical results in R Markdown or Quarto documents according to guidelines of the "Publication Manual" of the American Psychological Association (2020, ISBN: 978-1-4338-3215-4). These guidelines are usually referred to as APA style (<https://apastyle.apa.org/>) and include specific rules on the formatting of numbers and statistical test results. APA style has to be implemented when submitting scientific reports in a wide range of research fields, especially in the social sciences. The default output of numbers in the R console or R Markdown and Quarto documents does not meet the APA style requirements, and reformatting results manually can be cumbersome and error-prone. This package covers the automatic conversion of R objects to textual representations that meet the APA style requirements, which can be included in R Markdown or Quarto documents. It covers some basic statistical tests (t-test, ANOVA, correlation, chi-squared test, Wilcoxon test) as well as some basic number printing manipulations (formatting p-values, removing leading zeros for numbers that cannot be greater than one, and others). Other packages exist for formatting numbers and tests according to the APA style guidelines, such as papaja (<https://cran.r-project.org/package=papaja>) and apa (<https://cran.r-project.org/package=apa>), but they do not offer all convenience functionality included in prmisc'. The vignette has an overview of most of the functions included in the package.

This package performs pathway enrichment analysis using a voting-based framework that integrates CpGâ gene regulatory information from expression quantitative trait methylation (eQTM) data. For a grid of top-ranked CpGs and filtering thresholds, gene sets are generated and refined using an entropy-based pruning strategy that balances information richness, stability, and probe bias correction. In particular, gene lists dominated by genes with disproportionately high numbers of CpG mappings are penalized to mitigate active probe biasâ a common artifact in methylation data analysis. Enrichment results across parameter combinations are then aggregated using a voting scheme, prioritizing pathways that are consistently recovered under diverse settings and robust to parameter perturbations.