Datasets for nlmixr2 and rxode2'. nlmixr2 is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

This package implements the Normal-Block model, a Gaussian graphical model with a latent clustering structure for the multivariate analysis of continuous data. The model clusters variables and, building on the graphical lasso, infers a network of statistical dependencies between clusters rather than between individual variables, for known or unknown clusterings, with an optional zero-inflation extension for data with an excess of exact zeros. A complementary family clusters variables by their regression response to covariates rather than by their covariance, sharing one profile per cluster. See Tous & Chiquet (2026) <doi:10.1016/j.csda.2026.108347> for the model itself and its variational expectation-maximization estimation procedure.

This package provides a nomogram can not be easily applied, because it is difficult to calculate the points or even the survival probability. The package, including a function of nomogramEx(), is to extract the polynomial equations to calculate the points of each variable, and the survival probability corresponding to the total points.

Indices, heuristics, simulations and strategies to help determine the number of factors/components to retain in exploratory factor analysis and principal component analysis.

Features tools for the network data analysis and community detection. Provides multiple methods for fitting, model selection and goodness-of-fit testing in degree-corrected stochastic blocks models. Most of the computations are fast and scalable for sparse networks, esp. for Poisson versions of the models. Implements the following: Amini, Chen, Bickel and Levina (2013) <doi:10.1214/13-AOS1138> Bickel and Sarkar (2015) <doi:10.1111/rssb.12117> Lei (2016) <doi:10.1214/15-AOS1370> Wang and Bickel (2017) <doi:10.1214/16-AOS1457> Zhang and Amini (2020) <arXiv:2012.15047> Le and Levina (2022) <doi:10.1214/21-EJS1971>.

For use in summary functions to omit missing values conditionally using specified checks.

Offers a programmatic interface to the NORMAN Network REST API, facilitating the systematic query, retrieval, and parsing of environmental chemistry data, emerging substance registries, and mass spectrometry workflows. All data structures are tailored to support downstream environmental data analysis and ecotoxicological modelling.

Utilities for unambiguous, neat and legible representation of data (date, time stamp, numbers, percentages and strings) for presentation of analysis , aiming for elegance and consistency. The purpose of this package is to format data, that is better for presentation and any automation jobs that reports numbers.

Neighbourhood functions are key components of local-search algorithms such as Simulated Annealing or Threshold Accepting. These functions take a solution and return a slightly-modified copy of it, i.e. a neighbour. The package provides a function neighbourfun() that constructs such neighbourhood functions, based on parameters such as admissible ranges for elements in a solution. Supported are numeric and logical solutions. The algorithms were originally created for portfolio-optimisation applications, but can be used for other models as well. Several recipes for neighbour computations are taken from "Numerical Methods and Optimization in Finance" by M. Gilli, D. Maringer and E. Schumann (2019, ISBN:978-0128150658).

Converts number spellings into their equivalent numbers. Supports numbers written in English, French, or Spanish.

Systematically creates and modifies NONMEM(R) control streams. Harvests NONMEM output, builds run logs, creates derivative data, generates diagnostics. NONMEM (ICON Development Solutions <https://www.iconplc.com/>) is software for nonlinear mixed effects modeling. See package?nonmemica'.

This permutation based hypothesis test, suited for several types of data supported by the estimateNetwork function of the bootnet package (Epskamp & Fried, 2018), assesses the difference between two networks based on several invariance measures (network structure invariance, global strength invariance, edge invariance, several centrality measures, etc.). Network structures are estimated with l1-regularization. The Network Comparison Test is suited for comparison of independent (e.g., two different groups) and dependent samples (e.g., one group that is measured twice). See van Borkulo et al. (2021), available from <doi:10.1037/met0000476>.

Estimation, inference, bandwidth selection, and graphical procedures for kernel density and local polynomial regression methods, including robust bias-corrected confidence intervals as described in Calonico, Cattaneo and Farrell (2018, <doi:10.1080/01621459.2017.1285776>). The package includes lprobust() for local polynomial point estimation and robust bias-corrected inference, lpbwselect() for local polynomial bandwidth selection, kdrobust() for kernel density point estimation and robust bias-corrected inference, kdbwselect() for kernel density bandwidth selection, and nprobust.plot() for plotting results. The main methodological and numerical features are described in Calonico, Cattaneo and Farrell (2019, <doi:10.18637/jss.v091.i08>).

Optimizing regular numeric problems in optically stimulated luminescence dating, such as: equivalent dose calculation, dose rate determination, growth curve fitting, decay curve decomposition, statistical age model optimization, and statistical plot visualization.

Implement and enhance the performance of spatial fuzzy clustering using Fuzzy Geographically Weighted Clustering with various optimization algorithms, mainly from Xin She Yang (2014) <ISBN:9780124167438> with book entitled Nature-Inspired Optimization Algorithms. The optimization algorithm is useful to tackle the disadvantages of clustering inconsistency when using the traditional approach. The distance measurements option is also provided in order to increase the quality of clustering results. The Fuzzy Geographically Weighted Clustering with nature inspired optimisation algorithm was firstly developed by Arie Wahyu Wijayanto and Ayu Purwarianti (2014) <doi:10.1109/CITSM.2014.7042178> using Artificial Bee Colony algorithm.

This package implements several nonparametric regression approaches for the inclusion of covariate information on the receiver operating characteristic (ROC) framework.

Segregation is a network-level property such that edges between predefined groups of vertices are relatively less likely. Network homophily is a individual-level tendency to form relations with people who are similar on some attribute (e.g. gender, music taste, social status, etc.). In general homophily leads to segregation, but segregation might arise without homophily. This package implements descriptive indices measuring homophily/segregation. It is a computational companion to Bojanowski & Corten (2014) <doi:10.1016/j.socnet.2014.04.001>.

Optimization for nonlinear objective and constraint functions. Linear or nonlinear equality and inequality constraints are allowed. It accepts the input parameters as a constrained matrix.

This package performs variable selection in sparse negative binomial GLARMA (Generalised Linear Autoregressive Moving Average) models. For further details we refer the reader to the paper Gomtsyan (2023), <arXiv:2307.00929>.

This package provides a comprehensive toolkit for statistical and machine learning-based analysis of long-term Natural Resource Management (NRM) datasets. Integrates formula-driven approaches, statistical inference, and machine learning (ML) models for advanced analytics. Modules cover trend and structural analysis (Mann-Kendall test, slope estimation, Chow test, structural break detection), multivariate system modelling (Partial Least Squares (PLS), Structural Equation Modelling (SEM)), response curve optimisation, time-series forecasting (Autoregressive Integrated Moving Average (ARIMA), hybrid models), panel data and treatment effects (Difference-in-Differences (DiD), causal machine learning), uncertainty and sensitivity analysis (bootstrap, Monte Carlo, Bayesian), and automated model selection and performance comparison. Designed for long-term datasets covering soil, water, crop, and climate domains. Key references: Mann and Kendall (1945) <doi:10.2307/1907187>; Sen (1968) <doi:10.1080/01621459.1968.10480934>; Bai and Perron (2003) <doi:10.1002/jae.659>; Rosseel (2012) <doi:10.18637/jss.v048.i02>; Croissant and Millo (2008) <doi:10.18637/jss.v027.i02>.

This package performs exhaustive or groupwise (backward elimination) variable selection for binary outcome prediction models using cross-validated Net Benefit as the optimization criterion. It supports predictor costs, restricted cubic splines, interaction terms, permutation importance, and parallel computation. It includes visualizations for model comparison and variable importance. References include Vickers AJ & Elkin EB (2006) <doi:10.1177/0272989X06295361>, Van Calster B et al. (2018) <doi:10.1016/j.eururo.2018.08.038>, Vickers AJ et al. (2019) <doi:10.1186/s41512-019-0064-7>, and Baker SG et al. (2012) <doi:10.1515/1557-4679.1395>.

This package provides neutrosophic analysis of variance (NANOVA) and analysis of covariance (NANCOVA) for Completely Randomized Designs (CRD) and Randomized Complete Block Designs (RCBD) using interval-valued observations. Computes interval sums of squares, mean squares, F-statistics, significance tests, and interval-based least significant difference (LSD) comparisons. When lower and upper observations are identical (crisp data), the methods reduce to the corresponding classical ANOVA and ANCOVA.

This package implements some risk measures for (financial) networks, such as DebtRank, Impact Susceptibility, Impact Diffusion and Impact Fluidity.

This package creates quasi-proportional Venn diagrams with an arbitrary number of sets. It is related to the old nVennR package, but the algorithm and use have been reworked.