This package provides an interface to the NoSQL database CouchDB (<http://couchdb.apache.org>). Methods are provided for managing databases within CouchDB', including creating/deleting/updating/transferring, and managing documents within databases. One can connect with a local CouchDB instance, or a remote CouchDB databases such as Cloudant'. Documents can be inserted directly from vectors, lists, data.frames, and JSON'. Targeted at CouchDB v2 or greater.

This package provides functions connecting to the Salesforce Platform APIs (REST, SOAP, Bulk 1.0, Bulk 2.0, Metadata, Reports and Dashboards) <https://trailhead.salesforce.com/content/learn/modules/api_basics/api_basics_overview>. "API" is an acronym for "application programming interface". Most all calls from these APIs are supported as they use CSV, XML or JSON data that can be parsed into R data structures. For more details please see the Salesforce API documentation and this package's website <https://stevenmmortimer.github.io/salesforcer/> for more information, documentation, and examples.

This package provides functions to manipulate PDF files: fill out PDF forms; merge multiple PDF files into one; remove selected pages from a file; rename multiple files in a directory; rotate entire pdf document; rotate selected pages of a pdf file; Select pages from a file; splits single input PDF document into individual pages; splits single input PDF document into parts from given points.

This package provides a simple HTTP server allows to connect GUI clients to R.

This package provides the spatial sign correlation and the two-stage spatial sign correlation as well as a one-sample test for the correlation coefficient.

This package provides a collection of functions for sensitivity analysis of model outputs (factor screening, global sensitivity analysis and robustness analysis), for variable importance measures of data, as well as for interpretability of machine learning models. Most of the functions have to be applied on scalar output, but several functions support multi-dimensional outputs.

Hyvärinen's score matching (Hyvärinen, 2005) <https://jmlr.org/papers/v6/hyvarinen05a.html> is a useful estimation technique when the normalising constant for a probability distribution is difficult to compute. This package implements score matching estimators using automatic differentiation in the CppAD library <https://github.com/coin-or/CppAD> and is designed for quickly implementing score matching estimators for new models. Also available is general robustification (Windham, 1995) <https://www.jstor.org/stable/2346159>. Already in the package are estimators for directional distributions (Mardia, Kent and Laha, 2016) <doi:10.48550/arXiv.1604.08470> and the flexible Polynomially-Tilted Pairwise Interaction model for compositional data. The latter estimators perform well when there are zeros in the compositions (Scealy and Wood, 2023) <doi:10.1080/01621459.2021.2016422>, even many zeros (Scealy, Hingee, Kent, and Wood, 2024) <doi:10.1007/s11222-024-10412-w>. A partial interface to CppAD's ADFun objects is also available.

This package provides a step-down procedure for controlling the False Discovery Proportion (FDP) in a competition-based setup, implementing Dong et al. (2020) <arXiv:2011.11939>. Such setups include target-decoy competition (TDC) in computational mass spectrometry and the knockoff construction in linear regression.

Add shiny inputs with one or more inline buttons that grow and shrink with inputs. Also add tool tips to input buttons and styling and messages for input validation.

Analysis of species count data in ecology often requires normalization to an identical sample size. Rarefying (random subsampling without replacement), which is a popular method for normalization, has been widely criticized for its poor reproducibility and potential distortion of the community structure. In the context of microbiome count data, researchers explicitly advised against the use of rarefying. An alternative to rarefying is scaling with ranked subsampling (SRS). SRS consists of two steps. In the first step, the total counts for all OTUs (operational taxonomic units) or species in each sample are divided by a scaling factor chosen in such a way that the sum of the scaled counts Cscaled equals Cmin. In the second step, the non-integer Cscaled values are converted into integers by an algorithm that we dub ranked subsampling. The Cscaled value for each OTU or species is split into the integer part Cint (Cint = floor(Cscaled)) and the fractional part Cfrac (Cfrac = Cscaled - Cints). Since the sum of Cint is smaller or equal to Cmin, additional delta C = Cmin - the sum of Cint counts have to be added to the library to reach the total count of Cmin. This is achieved as follows. OTUs are ranked in the descending order of their Cfrac values. Beginning with the OTU of the highest rank, single count per OTU is added to the normalized library until the total number of added counts reaches delta C and the sum of all counts in the normalized library equals Cmin. When the lowest Cfrag involved in picking delta C counts is shared by several OTUs, the OTUs used for adding a single count to the library are selected in the order of their Cint values. This selection minimizes the effect of normalization on the relative frequencies of OTUs. OTUs with identical Cfrag as well as Cint are sampled randomly without replacement. See Beule & Karlovsky (2020) <doi:10.7717/peerj.9593> for details.

Stores objects (e.g. neural networks) that are needed for using Sojourn accelerometer methods. For more information, see Lyden K, Keadle S, Staudenmayer J, & Freedson P (2014) <doi:10.1249/MSS.0b013e3182a42a2d>, Ellingson LD, Schwabacher IJ, Kim Y, Welk GJ, & Cook DB (2016) <doi:10.1249/MSS.0000000000000915>, and Hibbing PR, Ellingson LD, Dixon PM, & Welk GJ (2018) <doi:10.1249/MSS.0000000000001486>.

This package provides tools to simulate and analyze survival data with interval-, left-, right-, and uncensored observations under common parametric distributions, including "Weibull", "Exponential", "Log-Normal", "Log-Logistic", "Gamma", "Gompertz", "Normal", "Logistic", and "EMV". The package supports both direct maximum likelihood estimation and imputation-based methods, making it suitable for methodological research, simulation benchmarking, and teaching. A web-based companion app is also available for demonstration purposes.

This package provides functions for the stratigraphic analysis of phylogenetic trees.

This package provides functions and methods for estimating phenological dates (green up, start of a season, maturity, senescence, end of a season and dormancy) from (nearly) periodic Earth Observation time series. These dates are critical points of some derivatives of an idealized curve which, in turn, is obtained through a functional principal component analysis-based regression model. Some of the methods implemented here are based on T. Krivobokova, P. Serra and F. Rosales (2022) <https://www.sciencedirect.com/science/article/pii/S0167947322000998>. Methods for handling and plotting Earth observation time series are also provided.

Multiple imputation of missing data in a dataset using MICT or MICT-timing methods. The core idea of the algorithms is to fill gaps of missing data, which is the typical form of missing data in a longitudinal setting, recursively from their edges. Prediction is based on either a multinomial or random forest regression model. Covariates and time-dependent covariates can be included in the model.

This is a compilation of my preferred themes and related theme elements for ggplot2'. I believe these themes and theme elements are aesthetically pleasing, both for pedagogical instruction and for the presentation of applied statistical research to a wide audience. These themes imply routine use of easily obtained/free fonts, simple forms of which are included in this package.

Allows users to easily build custom docker images <https://docs.docker.com/> from Amazon Web Service Sagemaker <https://aws.amazon.com/sagemaker/> using Amazon Web Service CodeBuild <https://aws.amazon.com/codebuild/>.

One key exploratory analysis step in single-cell genomics data analysis is the prediction of features with different activity levels. For example, we want to predict differentially expressed genes (DEGs) in single-cell RNA-seq data, spatial DEGs in spatial transcriptomics data, or differentially accessible regions (DARs) in single-cell ATAC-seq data. singleCellHaystack predicts differentially active features in single cell omics datasets without relying on the clustering of cells into arbitrary clusters. singleCellHaystack uses Kullback-Leibler divergence to find features (e.g., genes, genomic regions, etc) that are active in subsets of cells that are non-randomly positioned inside an input space (such as 1D trajectories, 2D tissue sections, multi-dimensional embeddings, etc). For the theoretical background of singleCellHaystack we refer to our original paper Vandenbon and Diez (Nature Communications, 2020) <doi:10.1038/s41467-020-17900-3> and our update Vandenbon and Diez (Scientific Reports, 2023) <doi:10.1038/s41598-023-38965-2>.

Cluster-independent method based on topology structure of gene co-expression network for identifying feature gene sets, extracting cellular subpopulations, and elucidating intrinsic relationships among these subpopulations. Without prior cell clustering, SifiNet circumvents potential inaccuracies in clustering that may influence subsequent analyses. This method is introduced in Qi Gao, Zhicheng Ji, Liuyang Wang, Kouros Owzar, Qi-Jing Li, Cliburn Chan, Jichun Xie "SifiNet: a robust and accurate method to identify feature gene sets and annotate cells" (2024) <doi:10.1093/nar/gkae307>.

This package provides some basic routines for simulating a clinical trial. The primary intent is to provide some tools to generate trial simulations for trials with time to event outcomes. Piecewise exponential failure rates and piecewise constant enrollment rates are the underlying mechanism used to simulate a broad range of scenarios such as those presented in Lin et al. (2020) <doi:10.1080/19466315.2019.1697738>. However, the basic generation of data is done using pipes to allow maximum flexibility for users to meet different needs.

Generate continuous (normal or non-normal), binary, ordinal, and count (Poisson or Negative Binomial) variables with a specified correlation matrix. It can also produce a single continuous variable. This package can be used to simulate data sets that mimic real-world situations (i.e. clinical or genetic data sets, plasmodes). All variables are generated from standard normal variables with an imposed intermediate correlation matrix. Continuous variables are simulated by specifying mean, variance, skewness, standardized kurtosis, and fifth and sixth standardized cumulants using either Fleishman's third-order (<DOI:10.1007/BF02293811>) or Headrick's fifth-order (<DOI:10.1016/S0167-9473(02)00072-5>) polynomial transformation. Binary and ordinal variables are simulated using a modification of the ordsample() function from GenOrd'. Count variables are simulated using the inverse cdf method. There are two simulation pathways which differ primarily according to the calculation of the intermediate correlation matrix. In Correlation Method 1, the intercorrelations involving count variables are determined using a simulation based, logarithmic correlation correction (adapting Yahav and Shmueli's 2012 method, <DOI:10.1002/asmb.901>). In Correlation Method 2, the count variables are treated as ordinal (adapting Barbiero and Ferrari's 2015 modification of GenOrd, <DOI:10.1002/asmb.2072>). There is an optional error loop that corrects the final correlation matrix to be within a user-specified precision value of the target matrix. The package also includes functions to calculate standardized cumulants for theoretical distributions or from real data sets, check if a target correlation matrix is within the possible correlation bounds (given the distributions of the simulated variables), summarize results (numerically or graphically), to verify valid power method pdfs, and to calculate lower standardized kurtosis bounds.

Allows users to produce diagnostic procedures and graphic tools for the evaluation of Small Area estimators.

Extends the classical SSIM method proposed by Wang', Bovik', Sheikh', and Simoncelli'(2004) <doi:10.1109/TIP.2003.819861>. for irregular lattice-based maps and raster images. The geographical SSIM method incorporates well-developed geographically weighted summary statistics'('Brunsdon', Fotheringham and Charlton 2002) <doi:10.1016/S0198-9715(01)00009-6> with an adaptive bandwidth kernel function for irregular lattice-based maps.

It is often useful to produce short, quasi-unique identifiers (SQUIDs) without the benefit of a central authority to prevent duplication. Although Universally Unique Identifiers (UUIDs) provide for this, these are also unwieldy; for example, the most used UUID, version 4, is 36 characters long. SQUIDs are short (8 characters) at the expense of having more collisions, which can be mitigated by combining them with human-produced suffixes, yielding relatively brief, half human-readable, almost-unique identifiers (see for example the identifiers used for Decentralized Construct Taxonomies; Peters & Crutzen, 2024 <doi:10.15626/MP.2022.3638>). SQUIDs are the number of centiseconds elapsed since the beginning of 1970 converted to a base 30 system. This package contains functions to produce SQUIDs as well as convert them back into dates and times.