Fast, wavelet-based Empirical Bayes shrinkage methods for signal denoising, including smoothing Poisson-distributed data and Gaussian-distributed data with possibly heteroskedastic error. The algorithms implement the methods described Z. Xing, P. Carbonetto & M. Stephens (2021) <https://jmlr.org/papers/v22/19-042.html>.

This package provides tools for analyzing spatial cell-cell interactions based on ligand-receptor pairs, including functions for local, regional, and global analysis using spatial transcriptomics data. Integrates with databases like CellChat <https://github.com/jinworks/CellChat>, CellPhoneDB <https://www.cellphonedb.org/>, Cellinker <https://www.rna-society.org/cellinker/>, ICELLNET <https://github.com/soumelis-lab/ICELLNET>, and ConnectomeDB <https://humanconnectome.org/software/connectomedb/> to identify ligand-receptor pairs, visualize interactions through heatmaps, chord diagrams, and infer interactions on different spatial scales.

Implementation of Sequential BATTing (bootstrapping and aggregating of thresholds from trees) for developing threshold-based multivariate (prognostic/predictive) biomarker signatures. Variable selection is automatically built-in. Final signatures are returned with interaction plots for predictive signatures. Cross-validation performance evaluation and testing dataset results are also output. Detail algorithms are described in Huang et al (2017) <doi:10.1002/sim.7236>.

Plots a QQ-Norm Plot with several Gaussian simulations.

Please see the shinytest to shinytest2 migration guide at <https://rstudio.github.io/shinytest2/articles/z-migration.html>.

This package contains methods to generate and evaluate semi-artificial data sets. Based on a given data set different methods learn data properties using machine learning algorithms and generate new data with the same properties. The package currently includes the following data generators: i) a RBF network based generator using rbfDDA() from package RSNNS', ii) a Random Forest based generator for both classification and regression problems iii) a density forest based generator for unsupervised data Data evaluation support tools include: a) single attribute based statistical evaluation: mean, median, standard deviation, skewness, kurtosis, medcouple, L/RMC, KS test, Hellinger distance b) evaluation based on clustering using Adjusted Rand Index (ARI) and FM c) evaluation based on classification performance with various learning models, e.g., random forests.

Evaluating the biasing impact of geographic features such as airports, cities, roads, rivers in datasets of coordinates based biological collection datasets, by Bayesian estimation of the parameters of a Poisson process. Enables also spatial visualization of sampling bias and includes a set of convenience functions for publication level plotting. Also available as shiny app. The reference for the methodology is: Zizka et al. (2020) <doi:10.1111/ecog.05102>.

This package provides a spatio-dynamic modelling package that focuses on three characteristic wetland plant communities in a semiarid Mediterranean wetland in response to hydrological pressures from the catchment. The package includes the data on watershed hydrological pressure and the initial raster maps of plant communities but also allows for random initial distribution of plant communities. For more detailed info see: Martinez-Lopez et al. (2015) <doi:10.1016/j.ecolmodel.2014.11.024>.

Estimate the size of a networked population based on respondent-driven sampling data. The package is part of the "RDS Analyst" suite of packages for the analysis of respondent-driven sampling data. See Handcock, Gile and Mar (2014) <doi:10.1214/14-EJS923>, Handcock, Gile and Mar (2015) <doi:10.1111/biom.12255>, Kim and Handcock (2021) <doi:10.1093/jssam/smz055>, and McLaughlin, et. al. (2023) <doi:10.1214/23-AOAS1807>.

This tool is designed to analyze up to 5 Fraud Detection Questions integrated into a survey, focusing on potential fraudulent participants to clean the survey dataset from potential fraud. Fraud Detection Questions and further information available at <https://surveydefense.org>.

Computes confidence intervals for variance using the Chi-Square distribution, without requiring raw data. Wikipedia (2025) <https://en.wikipedia.org/wiki/Chi-squared_distribution>. All-in-One Chi Distribution CI provides functions to calculate confidence intervals for the population variance based on a chi-squared distribution, utilizing a sample variance and sample size. It offers only a simple all-in-one method for quick calculations to find the CI for Chi Distribution.

The Semi Parametric Piecewise Distribution blends the Generalized Pareto Distribution for the tails with a kernel based interior.

This package provides helper functions to compute linear predictors, time-dependent ROC curves, and Harrell's concordance index for Cox proportional hazards models as described in Therneau (2024) <https://CRAN.R-project.org/package=survival>, Therneau and Grambsch (2000, ISBN:0-387-98784-3), Hung and Chiang (2010) <doi:10.1002/cjs.10046>, Uno et al. (2007) <doi:10.1198/016214507000000149>, Blanche, Dartigues, and Jacqmin-Gadda (2013) <doi:10.1002/sim.5958>, Blanche, Latouche, and Viallon (2013) <doi:10.1007/978-1-4614-8981-8_11>, Harrell et al. (1982) <doi:10.1001/jama.1982.03320430047030>, Peto and Peto (1972) <doi:10.2307/2344317>, Schemper (1992) <doi:10.2307/2349009>, and Uno et al. (2011) <doi:10.1002/sim.4154>.

An input controller for R Shiny: a matrix with radio buttons, where only one option per row can be selected.

This package provides functions to generate K-fold cross validation (CV) folds and CV test error estimates that take into account how a survey dataset's sampling design was constructed (SRS, clustering, stratification, and/or unequal sampling weights). You can input linear and logistic regression models, along with data and a type of survey design in order to get an output that can help you determine which model best fits the data using K-fold cross validation. Our paper on "K-Fold Cross-Validation for Complex Sample Surveys" by Wieczorek, Guerin, and McMahon (2022) <doi:10.1002/sta4.454> explains why differing how we take folds based on survey design is useful.

An extension of animate.css that allows user to easily add animations to any UI element in shiny app using the elements id.

Fetch data on targeted public investments from Plataforma +Brasil (SICONV) <http://plataformamaisbrasil.gov.br/>, the responsible system for requests, execution, and monitoring of federal discretionary transfers in Brazil.

Kataegis is a localized hypermutation occurring when a region is enriched in somatic SNVs. Kataegis can result from multiple cytosine deaminations catalyzed by the AID/APOBEC family of proteins. This package contains functions to detect kataegis from SNVs in BED format. This package reports two scores per kataegic event, a hypermutation score and an APOBEC mediated kataegic score. Yousif, F. et al.; The Origins and Consequences of Localized and Global Somatic Hypermutation; Biorxiv 2018 <doi:10.1101/287839>.

Set of tools to fit a linear multiple or semi-parametric regression models with the possibility of non-informative random right or left censoring. Under this setup, the localization parameter of the response variable distribution is modeled by using linear multiple regression or semi-parametric functions, whose non-parametric components may be approximated by natural cubic spline or P-splines. The supported distribution for the model error is a generalized log-gamma distribution which includes the generalized extreme value and standard normal distributions as important special cases. Inference is based on likelihood, penalized likelihood and bootstrap methods. Lastly, some numerical and graphical devices for diagnostic of the fitted models are offered.

Statistical analysis of spatio-temporal point processes on linear networks. This packages provides tools to visualise and analyse spatio-temporal point patterns on linear networks using first, second, and higher-order summary statistics.

Develop spatial interaction models (SIMs). SIMs predict the amount of interaction, for example number of trips per day, between geographic entities representing trip origins and destinations. Contains functions for creating origin-destination datasets from geographic input datasets and calculating movement between origin-destination pairs with constrained, production-constrained, and attraction-constrained models (Wilson 1979) <doi:10.1068/a030001>.

Projection pursuit is used to find interesting low-dimensional projections of high-dimensional data by optimizing an index over all possible projections. The spinebil package contains methods to evaluate the performance of projection pursuit index functions using tour methods. A paper describing the methods can be found at <doi:10.1007/s00180-020-00954-8>.

This is an all-encompassing suite to facilitate the simulation of so-called quantities of interest by way of a multivariate normal distribution of the regression model's coefficients and variance-covariance matrix.

The Sparse Marginal Epistasis Test is a computationally efficient genetics method which detects statistical epistasis in complex traits; see Stamp et al. (2025, <doi:10.1101/2025.01.11.632557>) for details.