The predictive value of a statistical model can often be improved by applying shrinkage methods. This can be achieved, e.g., by regularized regression or empirical Bayes approaches. Various types of shrinkage factors can also be estimated after a maximum likelihood. While global shrinkage modifies all regression coefficients by the same factor, parameterwise shrinkage factors differ between regression coefficients. With variables which are either highly correlated or associated with regard to contents, such as several columns of a design matrix describing a nonlinear effect, parameterwise shrinkage factors are not interpretable and a compromise between global and parameterwise shrinkage, termed joint shrinkage', is a useful extension. A computational shortcut to resampling-based shrinkage factor estimation based on DFBETA residuals can be applied. Global, parameterwise and joint shrinkage for models fitted by lm(), glm(), coxph(), or mfp() is available.

Suns-Voc (or Isc-Voc) curves can provide the current-voltage (I-V) characteristics of the diode of photovoltaic cells without the effect of series resistance. Here, Suns-Voc curves can be constructed with outdoor time-series I-V curves [1,2,3] of full-size photovoltaic (PV) modules instead of having to be measured in the lab. Time series of four different power loss modes can be calculated based on obtained Isc-Voc curves. This material is based upon work supported by the U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy (EERE) under Solar Energy Technologies Office (SETO) Agreement Number DE-EE0008172. Jennifer L. Braid is supported by the U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy administered by the Oak Ridge Institute for Science and Education (ORISE) for the DOE. ORISE is managed by Oak Ridge Associated Universities (ORAU) under DOE contract number DE-SC0014664. [1] Wang, M. et al, 2018. <doi:10.1109/PVSC.2018.8547772>. [2] Walters et al, 2018 <doi:10.1109/PVSC.2018.8548187>. [3] Guo, S. et al, 2016. <doi:10.1117/12.2236939>.

Fitting a smooth path to a given set of noisy spherical data observed at known time points. It implements a piecewise geodesic curve fitting method on the unit sphere based on a velocity-based penalization scheme. The proposed approach is implemented using the Riemannian block coordinate descent algorithm. To understand the method and algorithm, one can refer to Bak, K. Y., Shin, J. K., & Koo, J. Y. (2023) <doi:10.1080/02664763.2022.2054962> for the case of order 1. Additionally, this package includes various functions necessary for handling spherical data.

This package provides the density, distribution, quantile and generation functions of some obscure probability distributions, including the doubly non-central t, F, Beta, and Eta distributions; the lambda-prime and K-prime; the upsilon distribution; the (weighted) sum of non-central chi-squares to a power; the (weighted) sum of log non-central chi-squares; the product of non-central chi-squares to powers; the product of doubly non-central F variables; the product of independent normals.

This package provides an implementation of simplicial complexes for Topological Data Analysis (TDA). The package includes functions to compute faces, boundary operators, Betti numbers, Euler characteristic, and to construct simplicial complexes. It also implements persistent homology, from building filtrations to computing persistence diagrams, with the aim of helping readers understand the core concepts of computational topology. Methods are based on standard references in persistent homology such as Zomorodian and Carlsson (2005) <doi:10.1007/s00454-004-1146-y> and Chazal and Michel (2021) <doi:10.3389/frai.2021.667963>.

This package provides a set of function that implements for seasonal multivariate time series analysis based on Seasonal Generalized Space Time Autoregressive with Seemingly Unrelated Regression (S-GSTAR-SUR) Model by Setiawan(2016)<https://www.researchgate.net/publication/316517889_S-GSTAR-SUR_model_for_seasonal_spatio_temporal_data_forecasting>.

This package provides a computing tool is developed to automated identify somatic mutation-driven immune cells. The operation modes including: i) inferring the relative abundance matrix of tumor-infiltrating immune cells and integrating it with a particular gene mutation status, ii) detecting differential immune cells with respect to the gene mutation status and converting the abundance matrix of significant differential immune cell into two binary matrices (one for up-regulated and one for down-regulated), iii) identifying somatic mutation-driven immune cells by comparing the gene mutation status with each immune cell in the binary matrices across all samples, and iv) visualization of immune cell abundance of samples in different mutation status..

Propose an area-level, non-parametric regression estimator based on Nadaraya-Watson kernel on small area mean. Adopt a two-stage estimation approach proposed by Prasad and Rao (1990). Mean Squared Error (MSE) estimators are not readily available, so resampling method that called bootstrap is applied. This package are based on the model proposed in Two stage non-parametric approach for small area estimation by Pushpal Mukhopadhyay and Tapabrata Maiti(2004) <http://www.asasrms.org/Proceedings/y2004/files/Jsm2004-000737.pdf>.

Genomic alterations including single nucleotide substitution, copy number alteration, etc. are the major force for cancer initialization and development. Due to the specificity of molecular lesions caused by genomic alterations, we can generate characteristic alteration spectra, called signature (Wang, Shixiang, et al. (2021) <DOI:10.1371/journal.pgen.1009557> & Alexandrov, Ludmil B., et al. (2020) <DOI:10.1038/s41586-020-1943-3> & Steele Christopher D., et al. (2022) <DOI:10.1038/s41586-022-04738-6>). This package helps users to extract, analyze and visualize signatures from genomic alteration records, thus providing new insight into cancer study.

This package provides a mechanism for easily generating and organizing a collection of seeds from a single seed, which may be subsequently used to ensure reproducibility in processes/pipelines that utilize multiple random components (e.g., trial simulation).

This package creates a contextual menu that can be triggered with keyboard shortcuts or programmatically. This can replace traditional sidebars or navigation bars, thereby enhancing the user experience with lighter user interfaces.

Customise Shiny disconnected screens as well as sanitize error messages to make them clearer and friendlier to the user.

This package provides a graphical user interface for cross-sectional network modeling with the statnet software suite <https://github.com/statnet>.

This package provides an imputation pipeline for single-cell RNA sequencing data. The scISR method uses a hypothesis-testing technique to identify zero-valued entries that are most likely affected by dropout events and estimates the dropout values using a subspace regression model (Tran et.al. (2022) <DOI:10.1038/s41598-022-06500-4>).

This data package contains four datasets of quantitative PCR (qPCR) amplification curves that were used as supplementary data in the research article by Sisti et al. (2010), <doi:10.1186/1471-2105-11-186>. The primary dataset comprises a ten-fold dilution series spanning copy numbers from 3.14 Ã 10^7 to 3.14 Ã 10^2, with twelve replicates per concentration. These samples are based on a pGEM-T Promega plasmid containing a 104 bp fragment of the mitochondrial gene NADH dehydrogenase 1 (MT-ND1), amplified using the ND1/ND2 primer pair. The remaining three datasets contain qPCR results in the presence of specific PCR inhibitors: tannic acid, immunoglobulin G (IgG), and quercetin, respectively, to assess their effects on the amplification process. These datasets are useful for researchers interested in PCR kinetics. The original raw data file is available as Additional File 1: <https://static-content.springer.com/esm/art%3A10.1186%2F1471-2105-11-186/MediaObjects/12859_2009_3643_MOESM1_ESM.XLS>.

Generate simulated datasets from an initial underlying distribution and apply transformations to obtain realistic data. Implements the NORTA (Normal-to-anything) approach from Cario and Nelson (1997) and other data generating mechanisms. Simple network visualization tools are provided to facilitate communicating the simulation setup.

The Stratified-Petersen Analysis System (SPAS) is designed to estimate abundance in two-sample capture-recapture experiments where the capture and recaptures are stratified. This is a generalization of the simple Lincoln-Petersen estimator. Strata may be defined in time or in space or both, and the s strata in which marking takes place may differ from the t strata in which recoveries take place. When s=t, SPAS reduces to the method described by Darroch (1961) <doi:10.2307/2332748>. When s<t, SPAS implements the methods described in Plante, Rivest, and Tremblay (1988) <doi:10.2307/2533994>. Schwarz and Taylor (1998) <doi:10.1139/f97-238> describe the use of SPAS in estimating return of salmon stratified by time and geography. A related package, BTSPAS, deals with temporal stratification where a spline is used to model the distribution of the population over time as it passes the second capture location. This is the R-version of the (now obsolete) standalone Windows program of the same name.

Application of theoretical results which ensure that the summation of an infinite discrete series is within an arbitrary margin of error of its true value. The C code under the hood is shared through header files to allow users to sum their own low level functions as well. Based on the paper by Braden (1992) <doi: 10.2307/2324995>.

Pathway Analysis is statistically linking observations on the molecular level to biological processes or pathways on the systems(i.e., organism, organ, tissue, cell) level. Traditionally, pathway analysis methods regard pathways as collections of single genes and treat all genes in a pathway as equally informative. However, this can lead to identifying spurious pathways as statistically significant since components are often shared amongst pathways. SIGORA seeks to avoid this pitfall by focusing on genes or gene pairs that are (as a combination) specific to a single pathway. In relying on such pathway gene-pair signatures (Pathway-GPS), SIGORA inherently uses the status of other genes in the experimental context to identify the most relevant pathways. The current version allows for pathway analysis of human and mouse datasets. In addition, it contains pre-computed Pathway-GPS data for pathways in the KEGG and Reactome pathway repositories and mechanisms for extracting GPS for user-supplied repositories.

Create mixed models with repeated measures using natural cubic splines applied to an observed continuous time variable, as described by Donohue et al. (2023) <doi:10.1002/pst.2285>. Iterate through multiple covariance structure types until one converges. Categorize observed time according to scheduled visits. Perform subgroup analyses.

This package provides a pipeline for estimating the stellar age, mass, and radius given observational effective temperature, [Fe/H], and astroseismic parameters. The results are obtained adopting a maximum likelihood technique over a grid of pre-computed stellar models, as described in Valle et al. (2014) <doi:10.1051/0004-6361/201322210>.

An introduction to several novel predictive variable selection methods for random forest. They are based on various variable importance methods (i.e., averaged variable importance (AVI), and knowledge informed AVI (i.e., KIAVI, and KIAVI2)) and predictive accuracy in stepwise algorithms. For details of the variable selection methods, please see: Li, J., Siwabessy, J., Huang, Z. and Nichol, S. (2019) <doi:10.3390/geosciences9040180>. Li, J., Alvarez, B., Siwabessy, J., Tran, M., Huang, Z., Przeslawski, R., Radke, L., Howard, F., Nichol, S. (2017). <DOI: 10.13140/RG.2.2.27686.22085>.

Constructs cell-typeâ specific gene regulatory networks from single-cell RNA-sequencing data. The method implements the SCORPION algorithm, which first aggregates individual cells into supercells and then applies PANDA (Passing Attributes between Networks for Data Assimilation) to infer transcription factorâ target regulatory relationships. It also provides statistical methods for differential edge analysis.

Interactively play a game of sokoban ,which has nine game levels.Sokoban is a type of transport puzzle, in which the player pushes boxes or crates around in a warehouse, trying to get them to storage locations.