This package provides functions to design and apply tests that are anytime valid. The functions can be used to design hypothesis tests in the prospective/randomised control trial setting or in the observational/retrospective setting. The resulting tests remain valid under both optional stopping and optional continuation. The current version includes safe t-tests and safe tests of two proportions. For details on the theory of safe tests, see Grunwald, de Heide and Koolen (2019) "Safe Testing" <arXiv:1906.07801>, for details on safe logrank tests see ter Schure, Perez-Ortiz, Ly and Grunwald (2020) "The Safe Logrank Test: Error Control under Continuous Monitoring with Unlimited Horizon" <arXiv:2011.06931v3> and Turner, Ly and Grunwald (2021) "Safe Tests and Always-Valid Confidence Intervals for contingency tables and beyond" <arXiv:2106.02693> for details on safe contingency table tests.

Spatio-temporal change of support (STCOS) methods are designed for statistical inference on geographic and time domains which differ from those on which the data were observed. In particular, a parsimonious class of STCOS models supporting Gaussian outcomes was introduced by Bradley, Wikle, and Holan <doi:10.1002/sta4.94>. The stcos package contains tools which facilitate use of STCOS models.

This package provides a function sfc() to compute the substance flow with the input files --- "data" and "model". If sample.size is set more than 1, uncertainty analysis will be executed while the distributions and parameters are supplied in the file "data".

This package provides a pilot matching design to automatically stratify and match large datasets. The manual_stratify() function allows users to manually stratify a dataset based on categorical variables of interest, while the auto_stratify() function does automatically by allocating a held-aside (pilot) data set, fitting a prognostic score (see Hansen (2008) <doi:10.1093/biomet/asn004>) on the pilot set, and stratifying the data set based on prognostic score quantiles. The strata_match() function then does optimal matching of the data set in parallel within strata.

This package provides tools for optimizing sequencing resource allocation and estimating pathogen lineage prevalence under real-world genomic surveillance conditions. Implements constrained allocation optimization for limited sequencing capacity across multiple regions and sample sources. Includes Horvitz-Thompson and post-stratified estimators that account for unequal sequencing rates, delay-adjusted nowcasting for right-censored reporting data, and combined design-weighted delay-corrected inference with uncertainty propagation.

Computes multivariate normal (MVN) densities, and samples from MVN distributions, when the covariance or precision matrix is sparse.

This package implements the Changes-in-Changes (CIC) estimator of Athey and Imbens (2006) <doi:10.1111/j.1468-0262.2006.00668.x> combined with synthetic control methods. Provides both the continuous CIC estimator (Theorem 3.1) and the discrete CIC estimator (Theorem 4.1) for integer-valued outcomes, with analytic and bootstrap inference. Also provides nonparametric estimation of the entire counterfactual distribution of outcomes for a treated group, allowing evaluation of average, quantile, and distributional treatment effects. Synthetic control weights are constructed via elastic net regularization to handle settings with many potential control units.

This package provides a novel spatial topic model to integrate both cell type and spatial information to identify the complex spatial tissue architecture on multiplexed tissue images without human intervention. The Package implements a collapsed Gibbs sampling algorithm for inference. The method is highly scalable to large-scale image datasets without extracting neighborhood information for every single cell. The package supports spatially resolved cell-level data analysis, topic inference, visualization, and downstream biological interpretation of tissue microenvironments.

Allow to identify motifs in spatial-time series. A motif is a previously unknown subsequence of a (spatial) time series with relevant number of occurrences. For this purpose, the Combined Series Approach (CSA) is used.

Data practitioners regularly use the R and Python programming languages to prepare data for analyses. Thus, they encode important data preprocessing decisions in R and Python code. The smallsets package subsequently decodes these decisions into a Smallset Timeline, a static, compact visualisation of data preprocessing decisions (Lucchesi et al. (2022) <doi:10.1145/3531146.3533175>). The visualisation consists of small data snapshots of different preprocessing steps. The smallsets package builds this visualisation from a user's dataset and preprocessing code located in an R', R Markdown', Python', or Jupyter Notebook file. Users simply add structured comments with snapshot instructions to the preprocessing code. One optional feature in smallsets requires installation of the Gurobi optimisation software and gurobi R package, available from <https://www.gurobi.com>. More information regarding the optional feature and gurobi installation can be found in the smallsets vignette.

Algorithms to create prognostic biomarkers using biological genesets or networks.

Synthesize numeric, categorical, mixed and time series data. Data circumstances including mixed (or zero-inflated) distributions and missing data patterns are reproduced in the synthetic data. A single parameter allows balancing between high-quality synthetic data that represents correlations of the original data and lower quality but more privacy safe synthetic data without correlations. Tuning can be done per variable or for the whole dataset.

This package implements sparse generalized factor models (sparseGFM) for dimension reduction and variable selection in high-dimensional data with automatic adaptation to weak factor scenarios. The package supports multiple data types (continuous, count, binary) through generalized linear model frameworks and handles missing values automatically. It provides 12 different penalty functions including Least Absolute Shrinkage and Selection Operator (Lasso), adaptive Lasso, Smoothly Clipped Absolute Deviation (SCAD), Minimax Concave Penalty (MCP), group Lasso, and their adaptive versions for inducing row-wise sparsity in factor loadings. Key features include cross-validation for regularization parameter selection using Sparsity Information Criterion (SIC), automatic determination of the number of factors via multiple information criteria, and specialized algorithms for row-sparse loading structures. The methodology employs alternating minimization with Singular Value Decomposition (SVD)-based identifiability constraints and is particularly effective for high-dimensional applications in genomics, economics, and social sciences where interpretable sparse dimension reduction is crucial. For penalty functions, see Tibshirani (1996) <doi:10.1111/j.2517-6161.1996.tb02080.x>, Fan and Li (2001) <doi:10.1198/016214501753382273>, and Zhang (2010) <doi:10.1214/09-AOS729>.

This package contains space filling based tools for machine learning and data mining. Some functions offer several computational techniques and deal with the out of memory for large big data by using the ff package.

Sparse-group boosting to be used in conjunction with the mboost for modeling grouped data. Applicable to all sparse-group lasso type problems where within-group and between-group sparsity is desired. Interprets and visualizes individual variables and groups.

This is a compendium of C++ routines useful for Bayesian statistics. We steal other people's C++ code, repurpose it, and export it so developers of R packages can use it in their C++ code. We actually don't steal anything, or claim that Thomas Bayes did, but copy code that is compatible with our GPL 3 licence, fully acknowledging the authorship of the original code.

Access to the datasets and many of the functions used in "Statistics Using R: An Integrative Approach". These datasets include a subset of the National Education Longitudinal Study, the Framingham Heart Study, as well as several simulated datasets used in the examples throughout the textbook. The functions included in the package reproduce some of the functionality of Stata that is not directly available in R'. The package also contains a tutorial on basic data frame management, including how to handle missing data.

This package provides tools for sample survey planning, including sample size calculation, estimation of expected precision for the estimates of totals, and calculation of optimal sample size allocation.

When working across multiple machines and, similarly for reproducible research, it can be time consuming to ensure that you have all of the needed packages installed and loaded and that the correct working directory is set. simpleSetup provides simple functions for making these tasks more straightforward.

Sensitivity analysis for multiple outcomes in observational studies. For instance, all linear combinations of several outcomes may be explored using Scheffe projections in the comparison() function; see Rosenbaum (2016, Annals of Applied Statistics) <doi:10.1214/16-AOAS942>. Alternatively, attention may focus on a few principal components in the principal() function. The package includes parallel methods for individual outcomes, including tests in the senm() function and confidence intervals in the senmCI() function.

This package provides a scalable Gibbs sampling implementation for high dimensional Bayesian regression with the continuous spike-and-slab prior. Niloy Biswas, Lester Mackey and Xiao-Li Meng, "Scalable Spike-and-Slab" (2022) <arXiv:2204.01668>.

This package provides a fast and flexible set of tools for large scale estimation. It features many stochastic gradient methods, built-in models, visualization tools, automated hyperparameter tuning, model checking, interval estimation, and convergence diagnostics.

Taxonomic dictionaries, formative element lists, and functions related to the maintenance, development and application of U.S. Soil Taxonomy. Data and functionality are based on official U.S. Department of Agriculture sources including the latest edition of the Keys to Soil Taxonomy. Descriptions and metadata are obtained from the National Soil Information System or Soil Survey Geographic databases. Other sources are referenced in the data documentation. Provides tools for understanding and interacting with concepts in the U.S. Soil Taxonomic System. Most of the current utilities are for working with taxonomic concepts at the "higher" taxonomic levels: Order, Suborder, Great Group, and Subgroup.

This package provides functions for fitting discrete distribution models to count data. Included are the Poisson, the negative binomial, the Poisson-inverse gaussian and, most importantly, a new implementation of the Poisson-beta distribution (density, distribution and quantile functions, and random number generator) together with a needed new implementation of Kummer's function (also: confluent hypergeometric function of the first kind). Three different implementations of the Gillespie algorithm allow data simulation based on the basic, switching or bursting mRNA generating processes. Moreover, likelihood functions for four variants of each of the three aforementioned distributions are also available. The variants include one population and two population mixtures, both with and without zero-inflation. The package depends on the MPFR libraries (<https://www.mpfr.org/>) which need to be installed separately (see description at <https://github.com/fuchslab/scModels>). This package is supplement to the paper "A mechanistic model for the negative binomial distribution of single-cell mRNA counts" by Lisa Amrhein, Kumar Harsha and Christiane Fuchs (2019) <doi:10.1101/657619> available on bioRxiv.