Extension to xpose to support nlmixr2'. Provides functions to import nlmixr2 fit data into an xpose data object, allowing the use of xpose for nlmixr2 model diagnostics.

Reading and writing sheets of a single Excel file into and from a list of data frames. Eases I/O of tabular data in bioinformatics while keeping them in a human readable format.

This package provides tools for reading, parsing and visualizing simulation data stored in xvg'/'xpm file formats (commonly generated by GROMACS molecular dynamics software). Streamlines post-processing and analysis of molecular dynamics ('MD') simulation outputs, enabling efficient exploration of molecular stability and conformational changes. Supports import of trajectory metrics ('RMSD', energy, temperature) and creation of publication-ready visualizations through integration with ggplot2'.

We consider the problem where we observe k vectors (possibly of different lengths), each representing an independent multinomial random vector. For a given function that takes in the concatenated vector of multinomial probabilities and outputs a real number, this is a Monte Carlo estimation procedure of an exact p-value and confidence interval. The resulting inference is valid even in small samples, when the parameter is on the boundary, and when the function is not differentiable at the parameter value, all situations where asymptotic methods and the bootstrap would fail. For more details see Sachs, Fay, and Gabriel (2025) <doi:10.48550/arXiv.2406.19141>.

This package implements the Durbin-Hausman panel cointegration tests of Westerlund (2008) <doi:10.1002/jae.963>. The tests are robust to cross-sectional dependence through common factor extraction using principal components. Provides both group-mean (DHg) and panel (DHp) test statistics with automatic factor number selection via information criteria.

Grammatical evolution (see O'Neil, M. and Ryan, C. (2003,ISBN:1-4020-7444-1)) uses decoders to convert linear (binary or integer genes) into programs. In addition, automatic determination of codon precision with a limited rule choice bias is provided. For a recent survey of grammatical evolution, see Ryan, C., O'Neill, M., and Collins, J. J. (2018) <doi:10.1007/978-3-319-78717-6>.

An R interface to the OpenPyXL Python library to create native Excel charts and work with Microsoft Excel files.

This package provides a few functions which provide a quick way of subsetting genomic admixture data and generating customizable stacked barplots.

The circadian period of a time series data is predicted and the statistical significance of the periodicity are calculated using the chi-square periodogram.

This package provides a consistent interface for common feature importance methods as described in Ewald et al. (2024) <doi:10.1007/978-3-031-63797-1_22>, including permutation feature importance (PFI), conditional and relative feature importance (CFI, RFI), leave one covariate out (LOCO), and Shapley additive global importance (SAGE), as well as feature sampling mechanisms to support conditional importance methods.

Compute surrogate explanation groves for predictive machine learning models and analyze complexity vs. explanatory power of an explanation according to Szepannek, G. and von Holt, B. (2023) <doi:10.1007/s41237-023-00205-2>.

Create beautifully color-coordinated and customized themes for your xaringan slides, without writing any CSS. Complete your slide theme with ggplot2 themes that match the font and colors used in your slides. Customized styles can be created directly in your slides R Markdown source file or in a separate external script.

Fits relative survival regression models with or without proportional excess hazards and with the additional possibility to correct for background mortality by one or more parameter(s). These models are relevant when the observed mortality in the studied group is not comparable to that of the general population or in population-based studies where the available life tables used for net survival estimation are insufficiently stratified. In the latter case, the proposed model by Touraine et al. (2020) <doi:10.1177/0962280218823234> can be used. The user can also fit a model that relaxes the proportional expected hazards assumption considered in the Touraine et al. excess hazard model. This extension was proposed by Mba et al. (2020) <doi:10.1186/s12874-020-01139-z> to allow non-proportional effects of the additional variable on the general population mortality. In non-population-based studies, researchers can identify non-comparability source of bias in terms of expected mortality of selected individuals. An excess hazard model correcting this selection bias is presented in Goungounga et al. (2019) <doi:10.1186/s12874-019-0747-3>. This class of model with a random effect at the cluster level on excess hazard is presented in Goungounga et al. (2023) <doi:10.1002/bimj.202100210>.

This package provides tools for interactive data exploration built using shiny'. Includes apps for descriptive statistics, visualizing probability distributions, inferential statistics, linear regression, logistic regression and RFM analysis.

Supports a structured approach for exploring PKPD data <https://opensource.nibr.com/xgx/>. It also contains helper functions for enabling the modeler to follow best R practices (by appending the program name, figure name location, and draft status to each plot). In addition, it enables the modeler to follow best graphical practices (by providing a theme that reduces chart ink, and by providing time-scale, log-scale, and reverse-log-transform-scale functions for more readable axes). Finally, it provides some data checking and summarizing functions for rapidly exploring pharmacokinetics and pharmacodynamics (PKPD) datasets.

The XML-RPC is a remote procedure call protocol based on XML'. The xmlrpc2 package is inspired by the XMLRPC package but uses the curl and xml2 packages instead RCurl and XML'.

High-level functions to render LaTeX fragments in plots, including as labels and data symbols in ggplot2 plots, plus low-level functions to author LaTeX fragments (to produce LaTeX documents), typeset LaTeX documents (to produce DVI files), read DVI files (to produce "DVI" objects), and render "DVI" objects.

Analysis of crossover interference in experimental crosses, particularly regarding the gamma model. See, for example, Broman and Weber (2000) <doi:10.1086/302923>.

This package provides a set of functions devoted to multivariate exploratory statistics on textual data. Classical methods such as correspondence analysis and agglomerative hierarchical clustering are available. Chronologically constrained agglomerative hierarchical clustering enriched with labelled-by-words trees is offered. Given a division of the corpus into parts, their characteristic words and documents are identified. Further, accessing to FactoMineR functions is very easy. Two of them are relevant in textual domain. MFA() addresses multiple lexical table allowing applications such as dealing with multilingual corpora as well as simultaneously analyzing both open-ended and closed questions in surveys. See <http://xplortext.unileon.es> for examples.

Extras and extensions for xaringan slides. Navigate your slides with tile view. Make your slides editable, live! Announce slide changes with subtle tones. Animate slide transitions with animate.css'. Add tabbed panels to slides with panelset'. Use the Tachyons CSS utility toolkit for rapid slide development. Scribble on your slides. Add a copy button to your code chunks with clipboard'. Add a logo or top or bottom banner to every slide. Broadcast slides to stay in sync with remote viewers. Include yourself in your slides with webcam'. Plus a whole lot more!

This package provides tools to analyze sex differences in omics data for complex diseases. It includes functions for differential expression analysis using the limma method <doi:10.1093/nar/gkv007>, interaction testing between sex and disease, pathway enrichment with clusterProfiler <doi:10.1089/omi.2011.0118>, and gene regulatory network (GRN) construction and analysis using igraph'. The package enables a reproducible workflow from raw data processing to biological interpretation.

This package provides a fast and elegant interface for generating XML fragments and documents. It can be used in companion with R packages XML or xml2 to generate XML documents. The fast XML generation is implemented using the Rcpp package.

This package implements the recursively detrended panel unit root tests proposed by Westerlund (2015) <doi:10.1016/j.jeconom.2014.09.013>. Two variants are provided: the basic t-REC test assuming iid errors, and the robust t-RREC test that accounts for serial correlation, cross-sectional dependence, and heteroskedasticity via defactoring and BIC-selected lag augmentation. Both tests have a standard normal null distribution requiring no mean or variance correction. The panel must be strongly balanced.

An implementation of representation-dependent gene level operations for genetic algorithms with genes representing permutations: Initialization of genes, mutation, and crossover. The crossover operation provided is position-based crossover (Syswerda, G., Chap. 21 in Davis, L. (1991, ISBN:0-442-00173-8). For mutation, several variants are included: Order-based mutation (Syswerda, G., Chap. 21 in Davis, L. (1991, ISBN:0-442-00173-8), randomized Lin-Kernighan heuristics (Croes, G. A. (1958) <doi:10.1287/opre.6.6.791> and Lin, S. and Kernighan. B. W. (1973) <doi:10.1287/opre.21.2.498>), and randomized greedy operators. A random mix operator for mutation selects a mutation variant randomly.