Interactive adverse event (AE) volcano plot for monitoring clinical trial safety. This tool allows users to view the overall distribution of AEs in a clinical trial using standard (e.g. MedDRA preferred term) or custom (e.g. Gender) categories using a volcano plot similar to proposal by Zink et al. (2013) <doi:10.1177/1740774513485311>. This tool provides a stand-along shiny application and flexible shiny modules allowing this tool to be used as a part of more robust safety monitoring framework like the Shiny app from the safetyGraphics R package.

Implementation of shiny app to visualize adverse events based on the Common Terminology Criteria for Adverse Events (CTCAE) using stacked correspondence analysis as described in Diniz et. al (2021)<doi:10.1186/s12874-021-01368-w>.

This package provides methods for fitting semi-parametric mean and variance models, with normal or censored data. Extended to allow a regression in the location, scale and shape parameters, and further for multiple regression in each.

An implementation of methods related to sparse clustering and variable importance in clustering. The package currently allows to perform sparse k-means clustering with a group penalty, so that it automatically selects groups of numerical features. It also allows to perform sparse clustering and variable selection on mixed data (categorical and numerical features), by preprocessing each categorical feature as a group of numerical features. Several methods for visualizing and exploring the results are also provided. M. Chavent, J. Lacaille, A. Mourer and M. Olteanu (2020)<https://www.esann.org/sites/default/files/proceedings/2020/ES2020-103.pdf>.

The biomarker data set by Vermeulen et al. (2009) <doi:10.1016/S1470-2045(09)70154-8> is provided. The data source, however, is by Ruijter et al. (2013) <doi:10.1016/j.ymeth.2012.08.011>. The original data set may be downloaded from <https://medischebiologie.nl/wp-content/uploads/2019/02/qpcrdatamethods.zip>. This data set is for a real-time quantitative polymerase chain reaction (PCR) experiment that comprises the raw fluorescence data of 24,576 amplification curves. This data set comprises 59 genes of interest and 5 reference genes. Each gene was assessed on 366 neuroblastoma complementary DNA (cDNA) samples and on 18 standard dilution series samples (10-fold 5-point dilution series x 3 replicates + no template controls (NTC) x 3 replicates).

Interactive variogram diagnostics.

Generating functions for both optimal and ordinary difference sequences, and the difference-based estimation functions.

Estimates the type of variables in non-quality controlled data. The prediction is based on a random forest model, trained on over 5000 medical variables with accuracy of 99%. The accuracy can hardy depend on type and coding style of data.

Provide a collection of miscellaneous R functions related to the Vasicek distribution with the intent to make the lives of risk modelers easier.

Simulates and evaluates stochastic scenarios of death and lapse events in life reinsurance contracts with profit commissions. The methodology builds on materials published by the Institute of Actuaries of Japan <https://www.actuaries.jp/examin/textbook/pdf/modeling.pdf>. A paper describing the detailed algorithms will be published by the author within a few months after the initial release of this package.

This package provides a set of functions to: (1) perform fuzzy clustering of vegetation data (De Caceres et al, 2010) <doi:10.1111/j.1654-1103.2010.01211.x>; (2) to assess ecological community similarity on the basis of structure and composition (De Caceres et al, 2013) <doi:10.1111/2041-210X.12116>.

This package provides pedagogical tools for visualization and numerical computation in vector calculus. Includes functions for parametric curves, scalar and vector fields, gradients, divergences, curls, line and surface integrals, and dynamic 2D/3D graphical analysis to support teaching and learning. The implemented methods follow standard treatments in vector calculus and multivariable analysis as presented in Marsden and Tromba (2011) <ISBN:9781429215084>, Stewart (2015) <ISBN:9781285741550>, Thomas, Weir and Hass (2018) <ISBN:9780134438986>, Larson and Edwards (2016) <ISBN:9781285255869>, Apostol (1969) <ISBN:9780471000051>, Spivak (1971) <ISBN:9780805390216>, Schey (2005) <ISBN:9780071369080>, Colley (2019) <ISBN:9780321982384>, Lizarazo Osorio (2020) <ISBN:9789585450103>, Sievert (2020) <ISBN:9780367180165>, and Borowko (2013) <ISBN:9781439870791>.

Penalized weighted least-squares estimate for variable selection on correlated multiply imputed data and penalized estimating equations for generalized linear models with multiple imputation. Reference: Li, Y., Yang, H., Yu, H., Huang, H., Shen, Y*. (2023) "Penalized estimating equations for generalized linear models with multiple imputation", <doi:10.1214/22-AOAS1721>. Li, Y., Yang, H., Yu, H., Huang, H., Shen, Y*. (2023) "Penalized weighted least-squares estimate for variable selection on correlated multiply imputed data", <doi:10.1093/jrsssc/qlad028>.

The Vega-Lite JavaScript framework provides a higher-level grammar for visual analysis, akin to ggplot or Tableau', that generates complete Vega specifications. Functions exist which enable building a valid spec from scratch or importing a previously created spec file. Functions also exist to export spec files and to generate code which will enable plots to be embedded in properly configured web pages. The default behavior is to generate an htmlwidget'.

ANOVA and REML estimation of linear mixed models is implemented, once following Searle et al. (1991, ANOVA for unbalanced data), once making use of the lme4 package. The primary objective of this package is to perform a variance component analysis (VCA) according to CLSI EP05-A3 guideline "Evaluation of Precision of Quantitative Measurement Procedures" (2014). There are plotting methods for visualization of an experimental design, plotting random effects and residuals. For ANOVA type estimation two methods for computing ANOVA mean squares are implemented (SWEEP and quadratic forms). The covariance matrix of variance components can be derived, which is used in estimating confidence intervals. Linear hypotheses of fixed effects and LS means can be computed. LS means can be computed at specific values of covariables and with custom weighting schemes for factor variables. See ?VCA for a more comprehensive description of the features.

Automatically generates HTML variable documentation including variable names, labels, classes, value labels (if applicable), value ranges, and summary statistics. See the vignette "vtable" for a package overview.

Turn R analysis outputs into full sentences, by writing vectors into in-sentence lists, pluralising words conditionally, spelling out numbers if they are at the start of sentences, writing out dates in full following US or UK style, and managing capitalisations in tidy data.

The spectral characteristics of a bivariate series (Marginal Spectra, Coherency- and Phase-Spectrum) determine whether there is a strong presence of short-, medium-, or long-term fluctuations (components of certain frequencies in the spectral representation of the series) in each one of them. These are induced by strong peaks of the marginal spectra of each series at the corresponding frequencies. The spectral characteristics also determine how strongly these short-, medium-, or long-term fluctuations of the two series are correlated between the two series. Information on this is provided by the Coherency spectrum at the corresponding frequencies. Finally, certain fluctuations of the two series may be lagged to each other. Information on this is provided by the Phase spectrum at the corresponding frequencies. The idea in this package is to define a VAR (Vector autoregression) model with desired spectral characteristics by specifying a number of polynomials, required to define the VAR. See Ioannidis(2007) <doi:10.1016/j.jspi.2005.12.013>. These are specified via their roots, instead of via their coefficients. This is an idea borrowed from the Time Series Library of R. Dahlhaus, where it is used for defining ARMA models for univariate time series. This way, one may e.g. specify a VAR inducing a strong presence of long-term fluctuations in series 1 and in series 2, which are weakly correlated, but lagged by a number of time units to each other, while short-term fluctuations in series 1 and in series 2, are strongly present only in one of the two series, while they are strongly correlated to each other between the two series. Simulation from such models allows studying the behavior of data-analysis tools, such as estimation of the spectra, under different circumstances, as e.g. peaks in the spectra, generating bias, induced by leakage.

This package provides a lightweight package for sorting version codes in various forms. No strong dependencies guaranteed.

Bayesian variable selection using shrinkage priors to identify significant variables in high-dimensional datasets. The package includes methods for determining the number of significant variables through innovative clustering techniques of posterior distributions, specifically utilizing the 2-Means and Sequential 2-Means (S2M) approaches. The package aims to simplify the variable selection process with minimal tuning required in statistical analysis.

This package provides variable selection for linear models and generalized linear models using Bayesian information criterion (BIC) and model posterior probability (MPP). Given a set of candidate predictors, it evaluates candidate models and returns model-level summaries (BIC and MPP) and predictor-level posterior inclusion probabilities (PIP). For more details see Xu, S., Ferreira, M. A., & Tegge, A. N. (2025) <doi:10.48550/arXiv.2510.02628>.

Functionality for creating phase portraits of functions in the complex number plane. Works with R base graphics, whose full functionality is available. Parallel processing is used for optimum performance.

This package provides a programmatic interface in R for the US Department of Transportation (DOT) National Highway Transportation Safety Administration (NHTSA) vehicle identification number (VIN) API, located at <https://vpic.nhtsa.dot.gov/api/>. The API can decode up to 50 vehicle identification numbers in one call, and provides manufacturer information about the vehicles, including make, model, model year, and gross vehicle weight rating (GVWR).

This package implements the Vector Matching algorithm to match multiple treatment groups based on previously estimated generalized propensity scores. The package includes tools for visualizing initial confounder imbalances, estimating treatment assignment probabilities using various methods, defining the common support region, performing matching across multiple groups, and evaluating matching quality. For more details, see Lopez and Gutman (2017) <doi:10.1214/17-STS612>.