Obtaining relevant set of trait specific genes from gene expression data is important for clinical diagnosis of disease and discovery of disease mechanisms in plants and animals. This process involves identification of relevant genes and removal of redundant genes as much as possible from a whole gene set. This package returns the trait specific gene set from the high dimensional RNA-seq count data by applying combination of two conventional machine learning algorithms, support vector machine (SVM) and genetic algorithm (GA). GA is used to control and optimize the subset of genes sent to the SVM for classification and evaluation. Genetic algorithm uses repeated learning steps and cross validation over number of possible solution and selects the best. The algorithm selects the set of genes based on a fitness function that is obtained via support vector machines. Using SVM as the classifier performance and the genetic algorithm for feature selection, a set of trait specific gene set is obtained.

This package provides tools for decomposing differences in rate metrics between two groups into contributions from individual subgroups and visualizing them as a "Theseus Plot". Inspired by the story of the Ship of Theseus, the method replaces subgroup data from one group with that of another step by step, recalculating the overall metric at each stage to quantify subgroup contributions. A Theseus Plot combines the stepwise progression of a waterfall plot with the comparative bars of a bar chart, offering an intuitive way to understand subgroup-level effects.

This package provides a set of functions to estimate rank and factor loadings of time series tensor factor models. A tensor is a multidimensional array. To analyze high-dimensional tensor time series, factor model is a major dimension reduction tool. TensorPreAve provides functions to estimate the rank of core tensors and factor loading spaces of tensor time series. More specifically, a pre-averaging method that accumulates information from tensor fibres is used to estimate the factor loading spaces. The estimated directions corresponding to the strongest factors are then used for projecting the data for a potentially improved re-estimation of the factor loading spaces themselves. A new rank estimation method is also implemented to utilizes correlation information from the projected data. See Chen and Lam (2023) <arXiv:2208.04012> for more details.

This package provides functions that can be used to calculate time-dependent state and parameter sensitivities for both continuous- and discrete-time deterministic models. See Ng et al. (2023) <doi:10.1086/726143> for more information about time-dependent sensitivity analysis.

This package provides tools for computing various vector summaries of persistence diagrams studied in Topological Data Analysis. For improved computational efficiency, all code for the vector summaries is written in C++ using the Rcpp and RcppArmadillo packages.

The aim of the R package treebalance is to provide functions for the computation of a large variety of (im)balance indices for rooted trees. The package accompanies the book Tree Balance Indices - A Comprehensive Survey by M. Fischer, L. Herbst, S. Kersting, L. Kuehn and K. Wicke (2023) <doi:10.1007/978-3-031-39800-1>, which gives a precise definition for the terms balance index and imbalance index (Chapter 4) and provides an overview of the terminology in this manual (Chapter 2). For further information on (im)balance indices, see also Fischer et al. (2021) <https://treebalance.wordpress.com>. Considering both established and new (im)balance indices, treebalance provides (among others) functions for calculating the following 18 established indices and index families: the average leaf depth, the B1 and B2 index, the Colijn-Plazzotta rank, the normal, corrected, quadratic and equal weights Colless index, the family of Colless-like indices, the family of I-based indices, the Rogers J index, the Furnas rank, the rooted quartet index, the s-shape statistic, the Sackin index, the symmetry nodes index, the total cophenetic index and the variance of leaf depths. Additionally, we include 6 tree shape statistics that satisfy the definition of an (im)balance index but have not been thoroughly analyzed in terms of tree balance in the literature yet. These are: the maximum width, the modified maximum difference in widths, the maximum depth, the maximum width over maximum depth, the stairs1 and the stairs2 index. As input, most functions of treebalance require a rooted (phylogenetic) tree in phylo format (as introduced in ape 1.9 in November 2006). phylo is used to store (phylogenetic) trees with no vertices of out-degree one. For further information on the format we kindly refer the reader to E. Paradis (2012) <https://emmanuelparadis.github.io/misc/FormatTreeR_24Oct2012.pdf>.

This package provides a lightweight toolkit that provides functions for printing tables from input data in the R console or terminal with customizable formatting. Supported outputs include American Psychological Association (APA)-style tables (American Psychological Association, 2020, ISBN:9781433832178), correlation matrices, contingency tables, and two-column summary tables.

This package provides functions for multivariate analysis with compositional data. Includes a function for doing compositional canonical correlation analysis. This analysis requires two data matrices of compositions, which can be adequately transformed and used as entries in a specialized program for canonical correlation analysis, that is able to deal with singular covariance matrices. The methodology is described in Graffelman et al. (2017) <doi:10.1101/144584>. Functions for log-ratio principal component analysis with condition number computations and log-ratio discriminant analysis have been added to the package.

The modern database TileDB introduces a powerful on-disk format for storing and accessing any complex data based on multi-dimensional arrays. It supports dense and sparse arrays, dataframes and key-values stores, cloud storage ('S3', GCS', Azure'), chunked arrays, multiple compression, encryption and checksum filters, uses a fully multi-threaded implementation, supports parallel I/O, data versioning ('time travel'), metadata and groups. It is implemented as an embeddable cross-platform C++ library with APIs from several languages, and integrations. This package provides the R support.

Identifies clusters of individual longitudinal trajectories. In the spirit of Leffondre et al. (2004), the procedure involves identifying each trajectory to a point in the space of measures. In this context, a measure is a quantity meant to capture a certain characteristic feature of the trajectory. The points in the space of measures are then clustered using a version of the Spectral Clustering algorithm.

Tri-hierarchical incomplete block design is defined as an arrangement of v treatments each replicated r times in a three system of blocks if, each block of the first system contains m_1 blocks of second system and each block of the second system contains m_2 blocks of the third system. Ignoring the first and second system of blocks, it leaves an incomplete block design with b_3 blocks of size k_3i units; ignoring first and third system of blocks, it leaves an incomplete block design with b_2 blocks each of size k_2i units and ignoring the second and third system of blocks, it leaves an incomplete block design with b_1 blocks each of size k_1 units. For dealing with experimental circumstances where there are three nested sources of variation, a tri-hierarchical incomplete block design can be adopted. Tri - hierarchical incomplete block designs can find application potential in obtaining mating-environmental designs for breeding trials. To know more about nested block designs one can refer Preece (1967) <doi:10.1093/biomet/54.3-4.479>. This package includes series1(), series2(), series3() and series4() functions. This package generates tri-hierarchical designs with six component designs under certain parameter restrictions.

This package provides a transparent, rule-based framework for detecting changes between successive data cuts of clinical trial datasets, classifying those changes into clinically meaningful categories, tracing user-defined data lineage, and assessing which downstream analyses and outputs may be affected. The package is designed to complement existing low-level data frame comparison tools by adding clinical-trial-specific classification, lineage and impact-assessment layers on top of deterministic comparison. The rule-based classification is similar in spirit to the data validation infrastructure of van der Loo and de Jonge (2021) <doi:10.18637/jss.v097.i10>.

This package provides a screening process utilizing training and testing samples to filter out uninformative DNA methylation sites. Surrogate variables (SVs) of DNA methylation are included in the filtering process to explain unknown factor effects. This package also provides two screening functions for screening high-dimensional predictors when the events are rare. The firth method is called Rare-Screening which employs a repeated random sampling with replacement and using linear modeling with Bayes adjustment. The Second method is called Firth-ttScreening which uses ttScreening method with additional Firth correction term in the maximum likelihood for the logistic regression model. These methods handle the high-dimensionality and low event rates.

Themes for ggplot2 are a convenient way to style plots. The hrbrthemes package contains a particularly nice one, but brings along a significant tail of dependencies. So this (currently experimental) package brings along just the theme_ipsum_rc theme using the Roboto Condensed font. Should the font not be installed on your system, see the help in the package hrbrthemes on how to install Roboto Condensed'. Note that hrbrthemes is now archived at CRAN.

Automates translating the instructions of iatgen generated qsf (Qualtrics survey files) to other languages using either officially supported or user-supplied translations (for tutorial see Santos et al., 2023 <doi:10.17504/protocols.io.kxygx34jdg8j/v1>).

Implementation of ZENIT-POLAR substitution cipher method of encryption using by default the TENIS-POLAR cipher. This last cipher of encryption became famous through the collection of Brazilian books "Os Karas" by the author Pedro Bandeira. For more details, see "A Cryptographic Dictionary" (GC&CS, 1944).

Download TIGER/Line shapefiles from the United States Census Bureau (<https://www.census.gov/geographies/mapping-files/time-series/geo/tiger-line-file.html>) and load into R as sf objects.

Implementation of Time-course Gene Set Analysis (TcGSA), a method for analyzing longitudinal gene-expression data at the gene set level. Method is detailed in: Hejblum, Skinner & Thiebaut (2015) <doi: 10.1371/journal.pcbi.1004310>.

Compute and visualize the Tissot Indicatrix for map projections. The indicatrix characterizes projection distortion by computing scale factors, angular deformation, areal distortion, and convergence at arbitrary points. Based on the calculations shared by Bill Huber on <https://gis.stackexchange.com/a/5075/482>. Uses PROJ for coordinate transformation and distortion factor computation. Developed using the method published in Snyder, JP (1987) <doi:10.3133/pp1395>.

The â TADâ package compiled an analytical framework based on an analysis of the shape of the trait abundance distributions to better understand community assembly processes, and predict community dynamics under environmental changes. This framework mobilized a study of the relationship between the moments describing the shape of the distributions: the skewness and the kurtosis (SKR). The SKR allows the identification of commonalities in the shape of trait distributions across contrasting communities. Derived from the SKR, we developed mathematical parameters that summarise the complex pattern of distributions by assessing (i) the R², (ii) the Y-intercept, (iii) the slope, (iv) the functional stability of community (TADstab), and, (v) the distance from specific distribution families (i.e., the distance from the skew-uniform family a limit to the highest degree of evenness: TADeve).

This package provides a traceability focused tool created to simplify the data manipulation necessary to create clinical summaries.

This package provides the "r, q, p, and d" distribution functions for the triangle distribution. Also includes maximum likelihood estimation of parameters.

This package provides a tm Source to create corpora from articles exported from the Dow Jones Factiva content provider as XML or HTML files. It is able to read both text content and meta-data information (including source, date, title, author, subject, geographical coverage, company, industry, and various provider-specific fields).

This package provides a version of the Titanic survival data tailored for people analytics demonstrations and practice. While another package, titanic', reproduces the Kaggle competition files with minimal preprocessing, tidytitanic combines the train and test datasets into the single dataset, passengers', for exploration and summary across all passengers. It also extracts personal identifiersâ such as first names, last names, and titles from the raw name field, enabling demographic analysis. The passengers data does not cover the crew, but this package also provides the more bare-bones, crew-containing datasets tidy_titanic and flat_titanic based on the Titanic data set from datasets for further exploration. This human-centered data package is designed to support exploratory data analysis, feature engineering, and pedagogical use cases.