Data from multi environment agronomic trials, which are often carried out by plant breeders, can be analyzed with the tools offered by this package such as the Additive Main effects and Multiplicative Interaction model or AMMI ('Gauch 1992, ISBN:9780444892409) and the Site Regression model or SREG ('Cornelius 1996, <doi:10.1201/9780367802226>). Since these methods present a poor performance under the presence of outliers and missing values, this package includes robust versions of the AMMI model ('Rodrigues 2016, <doi:10.1093/bioinformatics/btv533>), and also imputation techniques specifically developed for this kind of data ('Arciniegas-Alarcón 2014, <doi:10.2478/bile-2014-0006>).

Builds a LASSO, Ridge, or Elastic Net model with glmnet or cv.glmnet with bootstrap inference statistics (SE, CI, and p-value) for selected coefficients with no shrinkage applied for them. Model performance can be evaluated on test data and an automated alpha selection is implemented for Elastic Net. Parallelized computation is used to speed up the process. The methods are described in Friedman et al. (2010) <doi:10.18637/jss.v033.i01> and Simon et al. (2011) <doi:10.18637/jss.v039.i05>.

Implement group response-adaptive randomization procedures, which also integrates standard non-group response-adaptive randomization methods as specialized instances. It is also uniquely capable of managing complex scenarios, including those with delayed and missing responses, thereby expanding its utility in real-world applications. This package offers 16 functions for simulating a variety of response adaptive randomization procedures. These functions are essential for guiding the selection of statistical methods in clinical trials, providing a flexible and effective approach to trial design. Some of the detailed methodologies and algorithms used in this package, please refer to the following references: LJ Wei (1979) <doi:10.1214/aos/1176344614> L. J. WEI and S. DURHAM (1978) <doi:10.1080/01621459.1978.10480109> Durham, S. D., FlournoY, N. AND LI, W. (1998) <doi:10.2307/3315771> Ivanova, A., Rosenberger, W. F., Durham, S. D. and Flournoy, N. (2000) <https://www.jstor.org/stable/25053121> Bai Z D, Hu F, Shen L. (2002) <doi:10.1006/jmva.2001.1987> Ivanova, A. (2003) <doi:10.1007/s001840200220> Hu, F., & Zhang, L. X. (2004) <doi:10.1214/aos/1079120137> Hu, F., & Rosenberger, W. F. (2006, ISBN:978-0-471-65396-7). Zhang, L. X., Chan, W. S., Cheung, S. H., & Hu, F. (2007) <https://www.jstor.org/stable/26432528> Zhang, L., & Rosenberger, W. F. (2006) <doi:10.1111/j.1541-0420.2005.00496.x> Hu, F., Zhang, L. X., Cheung, S. H., & Chan, W. S. (2008) <doi:10.1002/cjs.5550360404>.

This package provides functions to apply spatial fuzzy unsupervised classification, visualize and interpret results. This method is well suited when the user wants to analyze data with a fuzzy clustering algorithm and to account for the spatial dimension of the dataset. In addition, indexes for estimating the spatial consistency and classification quality are proposed. The methods were originally proposed in the field of brain imagery (seed Cai and al. 2007 <doi:10.1016/j.patcog.2006.07.011> and Zaho and al. 2013 <doi:10.1016/j.dsp.2012.09.016>) and recently applied in geography (see Gelb and Apparicio <doi:10.4000/cybergeo.36414>).

Several yield stability analyses are mentioned in this package: variation and regression based yield stability analyses. Resampling techniques are integrated with these stability analyses. The function stab.mean() provides the genotypic means and ranks including their corresponding confidence intervals. The function stab.var() provides the genotypic variances over environments including their corresponding confidence intervals. The function stab.fw() is an extended method from the Finlay-Wilkinson method (1963). This method can include several other factors that might impact yield stability. Resampling technique is integrated into this method. A few missing data points or unbalanced data are allowed too. The function stab.fw.check() is an extended method from the Finlay-Wilkinson method (1963). The yield stability is evaluated via common check line(s). Resampling technique is integrated.

This package contains five functions performing the calculation of unconditional and conditional Granger-causality spectra, bootstrap inference on both, and inference on the difference between them via the bootstrap approach of Farne and Montanari, 2018 <arXiv:1803.00374>.

This package provides classes and methods for handling networks or graphs whose nodes are geographical (i.e. locations in the globe). The functionality includes the creation of objects of class geonetwork as a graph with node coordinates, the computation of network measures, the support of spatial operations (projection to different Coordinate Reference Systems, handling of bounding boxes, etc.) and the plotting of the geonetwork object combined with supplementary cartography for spatial representation.

This package provides functions that make it easy to reveal ggplot2 graphs incrementally. The functions take a plot produced with ggplot2 and return a list of plots showing data incrementally by panels, layers, groups, the values in an axis or any arbitrary aesthetic.

Toolbox for various enrichment analysis methods and quantification of uncertainty of gene sets, Schmid et al. (2016) <doi:10.1093/bioinformatics/btw030>.

This package contains the implementation of a binary large margin classifier based on Gabriel Graph. References for this method can be found in L.C.B. Torres et al. (2015) <doi:10.1049/el.2015.1644>.

Generalized Turnbull's estimator proposed by Dehghan and Duchesne (2011).

Works with ggplot2 to add a Van Gogh color palette to the userâ s repertoire. It also has a function that work alongside ggplot2 to create more interesting data visualizations and add contextual information to the userâ s plots.

This package provides functions to assess the calibration of logistic regression models with the GiViTI (Gruppo Italiano per la Valutazione degli interventi in Terapia Intensiva, Italian Group for the Evaluation of the Interventions in Intensive Care Units - see <http://www.giviti.marionegri.it/>) approach. The approach consists in a graphical tool, namely the GiViTI calibration belt, and in the associated statistical test. These tools can be used both to evaluate the internal calibration (i.e. the goodness of fit) and to assess the validity of an externally developed model.

This package provides functions for survey data including svydesign objects from the survey package that call ggplot2 to make bar charts, histograms, boxplots, and hexplots of survey data.

Calculate, plot and animate the configuration of Jupiter's four largest satellites (known as Galilean satellites) for a given date and time (UTC - Coordinated Universal Time). The galsat() function returns numerical values of the satellitesâ positions. x â the apparent rectangular coordinate of the satellite with respect to the center of Jupiterâ s disk in the equatorial plane in the units of Jupiterâ s equatorial radius; X is positive toward the west, y â the apparent rectangular coordinate of the satellite with respect to the center of Jupiterâ s disk from the equatorial plane in the units of Jupiterâ s equatorial radius; Y is positive toward the north. For more details see Meeus (1988, ISBN 0-943396-22-0) "Astronomical Formulae for Calculators". The galsat_animate() function creates an animation of the Galilean satellites positions. You provide the starting time, duration, the time step between frames, and the pause between frames. The function delta_t() returns the value of delta-T in units of seconds.

This package provides functions for fitting and doing predictions with Gaussian process models using Vecchia's (1988) approximation. Package also includes functions for reordering input locations, finding ordered nearest neighbors (with help from FNN package), grouping operations, and conditional simulations. Covariance functions for spatial and spatial-temporal data on Euclidean domains and spheres are provided. The original approximation is due to Vecchia (1988) <http://www.jstor.org/stable/2345768>, and the reordering and grouping methods are from Guinness (2018) <doi:10.1080/00401706.2018.1437476>. Model fitting employs a Fisher scoring algorithm described in Guinness (2019) <doi:10.48550/arXiv.1905.08374>.

This package provides a variety of functions to fit linear and nonlinear regression with a large selection of distributions.

This package provides a minimal set of routines to calculate the Grantham distance <doi:10.1126/science.185.4154.862>. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.

Performing goodness-of-fit tests for stochastic block models used to fit network data. Among the three variants discussed in Karwa et al. (2023) <doi:10.1093/jrsssb/qkad084>, goodness-of-fit test has been performed for the Erdos-Renyi (ER) and Beta versions.

Accurate and computationally efficient p-value calculation methods for a general family of Fisher type statistics (GFisher). The GFisher covers Fisher's combination, Good's statistic, Lancaster's statistic, weighted Z-score combination, etc. It allows a flexible weighting scheme, as well as an omnibus procedure that automatically adapts proper weights and degrees of freedom to a given data. The new p-value calculation methods are based on novel ideas of moment-ratio matching and joint-distribution approximation. The technical details can be found in Hong Zhang and Zheyang Wu (2020) <arXiv:2003.01286>.

This package provides a procedure that uses target-decoy competition (or knockoffs) to reject multiple hypotheses in the presence of group structure. The procedure controls the false discovery rate (FDR) at a user-specified threshold.

This package provides tools for working with Gustavo Niemeyer's geohash coordinate system, including API for interacting with other common R GIS libraries.

An interface for fitting generalized additive models (GAMs) and generalized additive mixed models (GAMMs) using the lme4 package as the computational engine, as described in Helwig (2024) <doi:10.3390/stats7010003>. Supports default and formula methods for model specification, additive and tensor product splines for capturing nonlinear effects, and automatic determination of spline type based on the class of each predictor. Includes an S3 plot method for visualizing the (nonlinear) model terms, an S3 predict method for forming predictions from a fit model, and an S3 summary method for conducting significance testing using the Bayesian interpretation of a smoothing spline.

It provides functions to generate operating characteristics and to calculate Sequential Conditional Probability Ratio Tests(SCPRT) efficacy and futility boundary values along with sample/event size of Multi-Arm Multi-Stage(MAMS) trials for different outcomes. The package is based on Jianrong Wu, Yimei Li, Liang Zhu (2023) <doi:10.1002/sim.9682>, Jianrong Wu, Yimei Li (2023) "Group Sequential Multi-Arm Multi-Stage Survival Trial Design with Treatment Selection"(Manuscript accepted for publication) and Jianrong Wu, Yimei Li, Shengping Yang (2023) "Group Sequential Multi-Arm Multi-Stage Trial Design with Ordinal Endpoints"(In preparation).