In computer experiments space-filling designs are having great impact. Most popularly used space-filling designs are Uniform designs (UDs), Latin hypercube designs (LHDs) etc. For further references one can see Mckay (1979) <DOI:10.1080/00401706.1979.10489755> and Fang (1980) <https://cir.nii.ac.jp/crid/1570291225616774784>. In this package, we have provided algorithms for generate efficient LHDs and UDs. Here, generated LHDs are efficient as they possess lower value of Maxpro measure, Phi_p value and Maximum Absolute Correlation (MAC) value based on the weightage given to each criterion. On the other hand, the produced UDs are having good space-filling property as they always attain the lower bound of Discrete Discrepancy measure. Further, some useful functions added in this package for adding more value to this package.

Clustering multi-subject resting state functional Magnetic Resonance Imaging data. This methods enables the clustering of subjects based on multi-subject resting state functional Magnetic Resonance Imaging data. Objects are clustered based on similarities and differences in cluster-specific estimated components obtained by Independent Component Analysis.

The developed function is a comprehensive tool for the analysis of India Meteorological Department (IMD) NetCDF rainfall data. Specifically designed to process high-resolution daily gridded rainfall datasets. It provides four key functions to process IMD NetCDF rainfall data and create rasters for various temporal scales, including annual, seasonal, monthly, and weekly rainfall. For method details see, Malik, A. (2019).<DOI:10.1007/s12517-019-4454-5>. It supports different aggregation methods, such as sum, min, max, mean, and standard deviation. These functions are designed for spatio-temporal analysis of rainfall patterns, trend analysis,geostatistical modeling of rainfall variability, identifying rainfall anomalies and extreme events and can be an input for hydrological and agricultural models.

CLUster Evaluation (CLUE) is a computational method for identifying optimal number of clusters in a given time-course dataset clustered by cmeans or kmeans algorithms and subsequently identify key kinases or pathways from each cluster. Its implementation in R is called ClueR. See README on <https://github.com/PYangLab/ClueR> for more details. P Yang et al. (2015) <doi:10.1371/journal.pcbi.1004403>.

Utilities that support the usage of pyDarwin (<https://certara.github.io/pyDarwin/>) for ease of setup and execution of a machine learning based pharmacometric model search with Certara's Non-Linear Mixed Effects (NLME) modeling engine.

Analyzes data from a Conconi et al. (1996) <doi:10.1055/s-2007-972887> treadmill fitness test where speed is augmented by a constant amount every set number of seconds to estimate the anaerobic (lactate) threshold speed and heart rate. It reads a TCX file, allows optional removal observations from before and after the actual test, fits a change-point linear model where the change-point is the estimate of the lactate threshold, and plots the data points and fit model. Details of administering the fitness test are provided in the package vignette. Functions work by default for Garmin Connect TCX exports but may require additional data preparation for heart rate, time, and speed data from other sources.

Fits a pseudo Cox proprotional hazards model when survival times are missing for control groups.

Datasets for the book entitled "Modelling Survival Data in Medical Research" by Collett (2023) <doi:10.1201/9781003282525>. The datasets provide extensive examples of time-to-event data.

This package provides a comprehensive API for colour conversion between popular colour spaces ('RGB', HSL', OKLab', OKLch', hex', and named colours) along with clean, modern CSS Color Level 4 syntax output. Integrates seamlessly into Shiny and Quarto workflows. Includes nearest colour name lookup powered by a curated database of over 30,000 colour names. OKLab'/'OKLCh colour spaces are described in Ottosson (2020) <https://bottosson.github.io/posts/oklab/>. CSS Color Level 4 syntax follows the W3C specification <https://www.w3.org/TR/css-color-4/>.

This package provides a set of radiative transfer models to quantitatively describe the absorption, reflectance and transmission of solar energy in vegetation, and model remotely sensed spectral signatures of vegetation at distinct spatial scales (leaf,canopy and stand). The main principle behind ccrtm is that many radiative transfer models can form a coupled chain, basically models that feed into each other in a linked chain (from leaf, to canopy, to stand, to atmosphere). It allows the simulation of spectral datasets in the solar spectrum (400-2500nm) using leaf models as PROSPECT5, 5b, and D which can be coupled with canopy models as FLIM', SAIL and SAIL2'. Currently, only a simple atmospheric model ('skyl') is implemented. Jacquemoud et al 2008 provide the most comprehensive overview of these models <doi:10.1016/j.rse.2008.01.026>.

Filtering, also known as gating, of flow cytometry samples using the curvHDR method, which is described in Naumann, U., Luta, G. and Wand, M.P. (2010) <DOI:10.1186/1471-2105-11-44>.

Significance test of Spearman's Rho or Kendall's Tau between short-range dependent random variables.

An implementation of several functions for feature extraction in categorical time series datasets. Specifically, some features related to marginal distributions and serial dependence patterns can be computed. These features can be used to feed clustering and classification algorithms for categorical time series, among others. The package also includes some interesting datasets containing biological sequences. Practitioners from a broad variety of fields could benefit from the general framework provided by ctsfeatures'.

This package provides a large number of measurements generate count data. This is a statistical data type that only assumes non-negative integer values and is generated by counting. Typically, counting data can be found in biomedical applications, such as the analysis of DNA double-strand breaks. The number of DNA double-strand breaks can be counted in individual cells using various bioanalytical methods. For diagnostic applications, it is relevant to record the distribution of the number data in order to determine their biomedical significance (Roediger, S. et al., 2018. Journal of Laboratory and Precision Medicine. <doi:10.21037/jlpm.2018.04.10>). The software offers functions for a comprehensive automated evaluation of distribution models of count data. In addition to programmatic interaction, a graphical user interface (web server) is included, which enables fast and interactive data-scientific analyses. The user is supported in selecting the most suitable counting distribution for his own data set.

Estimates a lasso penalized precision matrix via the blockwise coordinate descent (BCD). This package is a simple wrapper around the popular glasso package that extends and enhances its capabilities. These enhancements include built-in cross validation and visualizations. See Friedman et al (2008) <doi:10.1093/biostatistics/kxm045> for details regarding the estimation method.

Provide functions for overlaps clustering, fuzzy clustering and interval-valued data manipulation. The package implement the following algorithms: OKM (Overlapping Kmeans) from Cleuziou, G. (2007) <doi:10.1109/icpr.2008.4761079> ; NEOKM (Non-exhaustive overlapping Kmeans) from Whang, J. J., Dhillon, I. S., and Gleich, D. F. (2015) <doi:10.1137/1.9781611974010.105> ; Fuzzy Cmeans from Bezdek, J. C. (1981) <doi:10.1007/978-1-4757-0450-1> ; Fuzzy I-Cmeans from de A.T. De Carvalho, F. (2005) <doi:10.1016/j.patrec.2006.08.014>.

Provided R functions for working with the Conditional Negative Binomial distribution.

Bindings to Google's C++ library Compact Language Detector 2 (see <https://github.com/cld2owners/cld2#readme> for more information). Probabilistically detects over 80 languages in plain text or HTML. For mixed-language input it returns the top three detected languages and their approximate proportion of the total classified text bytes (e.g. 80% English and 20% French out of 1000 bytes). There is also a cld3 package on CRAN which uses a neural network model instead.

Helps users standardise data to the Darwin Core Standard, a global data standard to store, document, and share biodiversity data like species occurrence records. The package provides tools to manipulate data to conform with, and check validity against, the Darwin Core Standard. Using corella allows users to verify that their data can be used to build Darwin Core Archives using the galaxias package.

Collection of routines for efficient scientific computations in physics and astrophysics. These routines include utility functions, numerical computation tools, as well as visualisation tools. They can be used, for example, for generating random numbers from spherical and custom distributions, information and entropy analysis, special Fourier transforms, two-point correlation estimation (e.g. as in Landy & Szalay (1993) <doi:10.1086/172900>), binning & gridding of point sets, 2D interpolation, Monte Carlo integration, vector arithmetic and coordinate transformations. Also included is a non-exhaustive list of important constants and cosmological conversion functions. The graphics routines can be used to produce and export publication-ready scientific plots and movies, e.g. as used in Obreschkow et al. (2020, MNRAS Vol 493, Issue 3, Pages 4551â 4569). These routines include special color scales, projection functions, and bitmap handling routines.

Estimation of counterfactual outcomes for multiple values of continuous interventions at different time points, and plotting of causal dose-response curves. Details are given in Schomaker, McIlleron, Denti, Diaz (2024) <doi:10.48550/arXiv.2305.06645>.

Utility functions that help with common base-R problems relating to lists. Lists in base-R are very flexible. This package provides functions to quickly and easily characterize types of lists. That is, to identify if all elements in a list are null, data.frames, lists, or fully named lists. Other functionality is provided for the handling of lists, such as the easy splitting of lists into equally sized groups, and the unnesting of data.frames within fully named lists.

This package provides tools for the combination of individual study results in meta-analyses using p-value functions. Implements various combination methods including those by Fisher, Stouffer, Tippett, Edgington along with weighted generalizations. Contains functionality for the visualization and calculation of confidence curves and drapery plots to summarize evidence across studies.

This package provides a set of tools that can be used across data.frame and imputationList objects.