It aims to find significant pathways through network topology information. It has several advantages compared with current pathway enrichment tools. First, pathway node instead of single gene is taken as the basic unit when analysing networks to meet the fact that genes must be constructed into complexes to hold normal functions. Second, multiple network centrality measures are applied simultaneously to measure importance of nodes from different aspects to make a full view on the biological system. CePa extends standard pathway enrichment methods, which include both over-representation analysis procedure and gene-set analysis procedure. <doi:10.1093/bioinformatics/btt008>.

Estimation, testing and regression modeling of subdistribution functions in competing risks using quantile regressions, as described in Peng and Fine (2009) <DOI:10.1198/jasa.2009.tm08228>.

This package provides functions to calculate the relative crystallinity of starch by X-ray Diffraction (XRD) and Infrared Spectroscopy (FTIR). Starch is biosynthesized by plants in the form of granules semicrystalline. For XRD, the relative crystallinity is obtained by separating the crystalline peaks from the amorphous scattering region. For FTIR, the relative crystallinity is achieved by setting of a Gaussian holocrystalline-peak in the 800-1300 cm-1 region of FTIR spectrum of starch which is divided into amorphous region and crystalline region. The relative crystallinity of native starch granules varies from 14 of 45 percent. This package was supported by FONDECYT 3150630 and CIPA Conicyt-Regional R08C1002 is gratefully acknowledged.

Allows users to identify similar cases for qualitative case studies using statistical matching methods.

Computes genomic breeding values using external information on the markers. The package fits a linear mixed model with heteroscedastic random effects, where the random effect variance is fitted using a linear predictor and a log link. The method is described in Mouresan, Selle and Ronnegard (2019) <doi:10.1101/636746>.

This package provides a publication-ready toolkit for modern survival and competing risks analysis with a minimal, formula-based interface. Both nonparametric estimation and direct polytomous regression of cumulative incidence functions (CIFs) are supported. The main functions cifcurve()', cifplot()', and cifpanel() estimate survival and CIF curves and produce high-quality graphics with risk tables, censoring and competing-risk marks, and multi-panel or inset layouts built on ggplot2 and ggsurvfit'. The modeling function polyreg() performs direct polytomous regression for coherent joint modeling of all cause-specific CIFs to estimate risk ratios, odds ratios, or subdistribution hazard ratios at user-specified time points. All core functions adopt a formula-and-data syntax and return tidy and extensible outputs that integrate smoothly with modelsummary', broom', and the broader tidyverse ecosystem. Key numerical routines are implemented in C++ via Rcpp'.

Compare double-precision floating point vectors using relative differences. All equality operations are calculated using cpp11'.

Helpful functions for the cleaning and manipulation of surveillance data, especially with regards to the creation and validation of panel data from individual level surveillance data.

This package provides functions for efficient computation of non-linear spatial predictions with local change of support (Hofer, C. and Papritz, A. (2011) "constrainedKriging: An R-package for customary, constrained and covariance-matching constrained point or block kriging" <doi:10.1016/j.cageo.2011.02.009>). This package supplies functions for two-dimensional spatial interpolation by constrained (Cressie, N. (1993) "Aggregation in geostatistical problems" <doi:10.1007/978-94-011-1739-5_3>), covariance-matching constrained (Aldworth, J. and Cressie, N. (2003) "Prediction of nonlinear spatial functionals" <doi:10.1016/S0378-3758(02)00321-X>) and universal (external drift) Kriging for points or blocks of any shape from data with a non-stationary mean function and an isotropic weakly stationary covariance function. The linear spatial interpolation methods, constrained and covariance-matching constrained Kriging, provide approximately unbiased prediction for non-linear target values under change of support. This package extends the range of tools for spatial predictions available in R and provides an alternative to conditional simulation for non-linear spatial prediction problems with local change of support.

Perform likelihood estimation and corresponding analysis under the copula-based Markov chain model for serially dependent event times with a dependent terminal event. Available are statistical methods in Huang, Wang and Emura (2020, JJSD accepted).

Java JAR files for the Apache Commons Mathematics Library for use by users and other packages.

This package provides a dynamic programming algorithm for optimal clustering multidimensional data with sequential constraint. The algorithm minimizes the sum of squares of within-cluster distances. The sequential constraint allows only subsequent items of the input data to form a cluster. The sequential constraint is typically required in clustering data streams or items with time stamps such as video frames, GPS signals of a vehicle, movement data of a person, e-pen data, etc. The algorithm represents an extension of Ckmeans.1d.dp to multiple dimensional spaces. Similarly to the one-dimensional case, the algorithm guarantees optimality and repeatability of clustering. Method clustering.sc.dp() can find the optimal clustering if the number of clusters is known. Otherwise, methods findwithinss.sc.dp() and backtracking.sc.dp() can be used. See Szkaliczki, T. (2016) "clustering.sc.dp: Optimal Clustering with Sequential Constraint by Using Dynamic Programming" <doi: 10.32614/RJ-2016-022> for more information.

The Concordance Test is a non-parametric method for testing whether two o more samples originate from the same distribution. It extends the Kendall Tau correlation coefficient when there are only two groups. For details, see Alcaraz J., Anton-Sanchez L., Monge J.F. (2022) The Concordance Test, an Alternative to Kruskal-Wallis Based on the Kendall-tau Distance: An R Package. The R Journal 14, 26â 53 <doi:10.32614/RJ-2022-039>.

Eases the use of ecotoxicological effect models. Can simulate common toxicokinetic-toxicodynamic (TK/TD) models such as General Unified Threshold models of Survival (GUTS) and Lemna. It can derive effects and effect profiles (EPx) from scenarios. It supports the use of tidyr workflows employing the pipe symbol. Time-consuming tasks can be parallelized.

This package provides functions for cobin and micobin regression models, a new family of generalized linear models for continuous proportional data (Y in the closed unit interval [0, 1]). It also includes an exact, efficient sampler for the Kolmogorov-Gamma random variable. For details, see Lee et al. (2025+) <doi:10.48550/arXiv.2504.15269>.

This package provides tools for measuring the compositionality of signalling systems (in particular the information-theoretic measure due to Spike (2016) <http://hdl.handle.net/1842/25930> and the Mantel test for distance matrix correlation (after Dietz 1983) <doi:10.1093/sysbio/32.1.21>), functions for computing string and meaning distance matrices as well as an implementation of the Page test for monotonicity of ranks (Page 1963) <doi:10.1080/01621459.1963.10500843> with exact p-values up to k = 22.

This package provides a collection of cardiovascular research datasets and analytical tools, including methods for cardiovascular procedural data, such as electrocardiography, echocardiography, and catheterization data. Additional methods exist for analysis of procedural billing codes.

Estimate bivariate common mean vector under copula models with known correlation. In the current version, available copulas are the Clayton, Gumbel, Frank, Farlie-Gumbel-Morgenstern (FGM), and normal copulas. See Shih et al. (2019) <doi:10.1080/02331888.2019.1581782> and Shih et al. (2021) <under review> for details under the FGM and general copulas, respectively.

Method for identifying the instar of Curculionid larvae from the observed distribution of the headcapsule size of mature larvae.

Model-free selection of covariates under unconfoundedness for situations where the parameter of interest is an average causal effect. This package is based on model-free backward elimination algorithms proposed in de Luna, Waernbaum and Richardson (2011). Marginal co-ordinate hypothesis testing is used in situations where all covariates are continuous while kernel-based smoothing appropriate for mixed data is used otherwise.

This package provides a convenient interface for making requests directly to the Civis Platform API <https://www.civisanalytics.com/platform>. Full documentation available here <https://civisanalytics.github.io/civis-r/>.

This package provides a class of methods that combine dimension reduction and clustering of continuous, categorical or mixed-type data (Markos, Iodice D'Enza and van de Velden 2019; <DOI:10.18637/jss.v091.i10>). For continuous data, the package contains implementations of factorial K-means (Vichi and Kiers 2001; <DOI:10.1016/S0167-9473(00)00064-5>) and reduced K-means (De Soete and Carroll 1994; <DOI:10.1007/978-3-642-51175-2_24>); both methods that combine principal component analysis with K-means clustering. For categorical data, the package provides MCA K-means (Hwang, Dillon and Takane 2006; <DOI:10.1007/s11336-004-1173-x>), i-FCB (Iodice D'Enza and Palumbo 2013, <DOI:10.1007/s00180-012-0329-x>) and Cluster Correspondence Analysis (van de Velden, Iodice D'Enza and Palumbo 2017; <DOI:10.1007/s11336-016-9514-0>), which combine multiple correspondence analysis with K-means. For mixed-type data, it provides mixed Reduced K-means and mixed Factorial K-means (van de Velden, Iodice D'Enza and Markos 2019; <DOI:10.1002/wics.1456>), which combine PCA for mixed-type data with K-means.

Constrained ordinary least squares is performed. One constraint is that all beta coefficients (including the constant) cannot be negative. They can be either 0 or strictly positive. Another constraint is that the sum of the beta coefficients equals a constant. References: Hansen, B. E. (2022). Econometrics, Princeton University Press. <ISBN:9780691235899>.

This package provides analytical methods for analyzing CRISPR screen data at different levels of gene expression. Multi-component normal mixture models and EM algorithms are used for modeling.