This package performs Bayesian nonparametric density estimation using Martingale posterior distributions including the Copula Resampling (CopRe) algorithm. Also included are a Gibbs sampler for the marginal Gibbs-type mixture model and an extension to include full uncertainty quantification via a predictive sequence resampling (SeqRe) algorithm. The CopRe and SeqRe samplers generate random nonparametric distributions as output, leading to complete nonparametric inference on posterior summaries. Routines for calculating arbitrary functionals from the sampled distributions are included as well as an important algorithm for finding the number and location of modes, which can then be used to estimate the clusters in the data using, for example, k-means. Implements work developed in Moya B., Walker S. G. (2022). <doi:10.48550/arxiv.2206.08418>, Fong, E., Holmes, C., Walker, S. G. (2021) <doi:10.48550/arxiv.2103.15671>, and Escobar M. D., West, M. (1995) <doi:10.1080/01621459.1995.10476550>.

Mines contiguous sequential patterns in text.

Client for CKAN API (<https://ckan.org/>). Includes interface to CKAN APIs for search, list, show for packages, organizations, and resources. In addition, provides an interface to the datastore API.

To optimize clinical trial designs and data analysis methods consistently through trial simulation, we need to simulate multivariate mixed-type virtual patient data independent of designs and analysis methods under evaluation. To make the outcome of optimization more realistic, relevant empirical patient level data should be utilized when itâ s available. However, a few problems arise in simulating trials based on small empirical data, where the underlying marginal distributions and their dependence structure cannot be understood or verified thoroughly due to the limited sample size. To resolve this issue, we use the copula invariance property, which can generate the joint distribution without making a strong parametric assumption. The function copula.sim can generate virtual patient data with optional data validation methods that are based on energy distance and ball divergence measurement. The function compare.copula.sim can conduct comparison of marginal mean and covariance of simulated data. To simulate patient-level data from a hypothetical treatment arm that would perform differently from the observed data, the function new.arm.copula.sim can be used to generate new multivariate data with the same dependence structure of the original data but with a shifted mean vector.

Design and evaluate choice-based conjoint survey experiments. Generate a variety of survey designs, including random designs, frequency-based designs, and D-optimal designs, as well as "labeled" designs (also known as "alternative-specific designs"), designs with "no choice" options, and designs with dominant alternatives removed. Conveniently inspect and compare designs using a variety of metrics, including design balance, overlap, and D-error, and simulate choice data for a survey design either randomly or according to a utility model defined by user-provided prior parameters. Conduct a power analysis for a given survey design by estimating the same model on different subsets of the data to simulate different sample sizes. Bayesian D-efficient designs using the cea and modfed methods are obtained using the idefix package by Traets et al (2020) <doi:10.18637/jss.v096.i03>. Choice simulation and model estimation in power analyses are handled using the logitr package by Helveston (2023) <doi:10.18637/jss.v105.i10>.

This package provides a minimum set of functions to perform compositional data analysis using the log-ratio approach introduced by John Aitchison (1982). Main functions have been implemented in c++ for better performance.

Modeling the correlation transitions under specified distributional assumptions within the realm of discretization in the context of the latency and threshold concepts. The details of the method are explained in Demirtas, H. and Vardar-Acar, C. (2017) <DOI:10.1007/978-981-10-3307-0_4>.

Explore calcium (Ca) and phosphate (Pi) homeostasis with two novel Shiny apps, building upon on a previously published mathematical model written in C, to ensure efficient computations. The underlying model is accessible here <https://pubmed.ncbi.nlm.nih.gov/28747359/)>. The first application explores the fundamentals of Ca-Pi homeostasis, while the second provides interactive case studies for in-depth exploration of the topic, thereby seeking to foster student engagement and an integrative understanding of Ca-Pi regulation.

The maximum likelihood estimation (MLE) of the count data models along with standard error of the estimates and Akaike information model section criterion are provided. The functions allow to compute the MLE for the following distributions such as the Bell distribution, the Borel distribution, the Poisson distribution, zero inflated Bell distribution, zero inflated Bell Touchard distribution, zero inflated Poisson distribution, zero one inflated Bell distribution and zero one inflated Poisson distribution. Moreover, the probability mass function (PMF), distribution function (CDF), quantile function (QF) and random numbers generation of the Bell Touchard and zero inflated Bell Touchard distribution are also provided.

Composite likelihood approach is implemented to estimating statistical models for spatial ordinal and proportional data based on Feng et al. (2014) <doi:10.1002/env.2306>. Parameter estimates are identified by maximizing composite log-likelihood functions using the limited memory BFGS optimization algorithm with bounding constraints, while standard errors are obtained by estimating the Godambe information matrix.

This package provides a set of functions to manage CRAN'-like repositories efficiently.

This package implements the chain binomial model for analysis of infectious disease data. Contains functions for calculating probabilities of the final size of infectious disease outbreaks using the method from D. Ludwig (1975) <doi:10.1016/0025-5564(75)90119-4> and for outbreaks that are not concluded, from Lindstrøm et al. (2024) <doi:10.48550/arXiv.2403.03948>. The package also contains methods for estimation and regression analysis of secondary attack rates.

This package provides tools for fitting, assessing, and comparing logistic and conditional logistic regression models. Includes residual diagnostics and goodness of fit measures for model development and evaluation in matched case control studies.

Correcting area under ROC (AUC) for measurement error based on probit-shift model.

An investigative tool designed to help users visualize correlations between variables in their datasets. This package aims to provide an easy and effective way to explore and visualize these correlations, making it easier to interpret and communicate results.

Accelerate the process from clinical data to medical publication, including clinical data cleaning, significant result screening, and the generation of publish-ready tables and figures.

Provided data containing an outcome variable, compositional variables and additional covariates (optional); linearly regress the outcome variable on an isometric log ratio (ilr) transformation of the linearly dependent compositional variables. The package provides predictions (with confidence intervals) in the change (delta) in the outcome/response variable based on the multiple linear regression model and evenly spaced reallocations of the compositional values. The compositional data analysis approach implemented is outlined in Dumuid et al. (2017a) <doi:10.1177/0962280217710835> and Dumuid et al. (2017b) <doi:10.1177/0962280217737805>.

Use machine learning algorithms and advanced geographic information system tools to build Species Distribution Modeling in a extensible and modern fashion.

This package provides a comprehensive set of functions designed for multivariate mean monitoring using the Critical-to-X Control Chart. These functions enable the determination of optimal control limits based on a specified in-control Average Run Length (ARL), the calculation of out-of-control ARL for a given control limit, and post-signal analysis to identify the specific variable responsible for a detected shift in the mean. This suite of tools provides robust support for precise and effective process monitoring and analysis.

This package provides a tool for causal meta-analysis. This package implements the aggregation formulas and inference methods proposed in Berenfeld et al. (2025) <doi:10.48550/arXiv.2505.20168>. Users can input aggregated data across multiple studies and compute causally meaningful aggregated effects of their choice (risk difference, risk ratio, odds ratio, etc) under user-specified population weighting. The built-in function camea() allows to obtain precise variance estimates for these effects and to compare the latter to a classical meta-analysis aggregate, the random effect model, as implemented in the metafor package <https://CRAN.R-project.org/package=metafor>.

Systematically Run R checks against multiple packages. Checks are run in parallel with strategies to minimize dependency installation. Provides out of the box interface for running reverse dependency check.

Execute Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. Specify engine parameters and select from different run options, including simple estimation, stepwise covariate search, bootstrapping, simulation, visual predictive check, and more. Models are executed using the Certara.RsNLME package.

This package provides functions and a workflow to easily and powerfully calculating specificity, sensitivity and ROC curves of biomarkers combinations. Allows to rank and select multi-markers signatures as well as to find the best performing sub-signatures, now also from single-cell RNA-seq datasets. The method used was first published as a Shiny app and described in Mazzara et al. (2017) <doi:10.1038/srep45477> and further described in Bombaci & Rossi (2019) <doi:10.1007/978-1-4939-9164-8_16>, and widely expanded as a package as presented in the bioRxiv pre print Ferrari et al. <doi:10.1101/2022.01.17.476603>.

Estimation of population size of migratory caribou herds based on large scale aggregations monitored by radio telemetry. It implements the methodology found in the article by Rivest et al. (1998) about caribou abundance estimation. It also includes a function based on the Lincoln-Petersen Index as applied to radio telemetry data by White and Garrott (1990).