This package implements the conditionally symmetric multidimensional Gaussian mixture model (csmGmm) for large-scale testing of composite null hypotheses in genetic association applications such as mediation analysis, pleiotropy analysis, and replication analysis. In such analyses, we typically have J sets of K test statistics where K is a small number (e.g. 2 or 3) and J is large (e.g. 1 million). For each one of the J sets, we want to know if we can reject all K individual nulls. Please see the vignette for a quickstart guide. The paper describing these methods is "Testing a Large Number of Composite Null Hypotheses Using Conditionally Symmetric Multidimensional Gaussian Mixtures in Genome-Wide Studies" by Sun R, McCaw Z, & Lin X (Journal of the American Statistical Association 2025, <doi:10.1080/01621459.2024.2422124>).

This package provides a new method for identification of clusters of genomic regions within chromosomes. Primarily, it is used for calling clusters of cis-regulatory elements (COREs). CREAM uses genome-wide maps of genomic regions in the tissue or cell type of interest, such as those generated from chromatin-based assays including DNaseI, ATAC or ChIP-Seq. CREAM considers proximity of the elements within chromosomes of a given sample to identify COREs in the following steps: 1) It identifies window size or the maximum allowed distance between the elements within each CORE, 2) It identifies number of elements which should be clustered as a CORE, 3) It calls COREs, 4) It filters the COREs with lowest order which does not pass the threshold considered in the approach.

Impute the survival times for censored observations based on their conditional survival distributions derived from the Kaplan-Meier estimator. CondiS can replace the censored observations with the best approximations from the statistical model, allowing for direct application of machine learning-based methods. When covariates are available, CondiS is extended by incorporating the covariate information through machine learning-based regression modeling ('CondiS_X'), which can further improve the imputed survival time.

Simulating bivariate survival data from copula models. Estimation of the association parameter in copula models. Two different ways to estimate the association parameter in copula models are implemented. A goodness-of-fit test for a given copula model is implemented. See Emura, Lin and Wang (2010) <doi:10.1016/j.csda.2010.03.013> for details.

Joint distribution of number of crossings and the longest run in a series of independent Bernoulli trials. The computations uses an iterative procedure where computations are based on results from shorter series. The procedure conditions on the start value and partitions by further conditioning on the position of the first crossing (or none).

Predict Scope 1, 2 and 3 carbon emissions for UK Small and Medium-sized Enterprises (SMEs), using Standard Industrial Classification (SIC) codes and annual turnover data, as well as Scope 1 carbon emissions for UK farms. The carbonpredict package provides single and batch prediction, plotting, and workflow tools for carbon accounting and reporting. The package utilises pre-trained models, leveraging rich classified transaction data to accurately predict Scope 1, 2 and 3 carbon emissions for UK SMEs as well as identifying emissions hotspots. It also provides Scope 1 carbon emissions predictions for UK farms of types: Cereals ex. rice, Dairy, Mixed farming, Sheep and goats, Cattle & buffaloes, Poultry, Animal production and Support for crop production. The methodology used to produce the estimates in this package is fully detailed in the following peer-reviewed publication in the Journal of Industrial Ecology: Phillpotts, A., Owen. A., Norman, J., Trendl, A., Gathergood, J., Jobst, Norbert., Leake, D. (2025) <doi:10.1111/jiec.70106> "Bridging the SME Reporting Gap: A New Model for Predicting Scope 1 and 2 Emissions".

Compute the certainty equivalents and premium risks as tools for risk-efficiency analysis. For more technical information, please refer to: Hardaker, Richardson, Lien, & Schumann (2004) <doi:10.1111/j.1467-8489.2004.00239.x>, and Richardson, & Outlaw (2008) <doi:10.2495/RISK080231>.

An R implementation of the Critical Path Method (CPM). CPM is a method used to estimate the minimum project duration and determine the amount of scheduling flexibility on the logical network paths within the schedule model. The flexibility is in terms of early start, early finish, late start, late finish, total float and free float. Beside, it permits to quantify the complexity of network diagram through the analysis of topological indicators. Finally, it permits to change the activities duration to perform what-if scenario analysis. The package was built based on following references: To make topological sorting and other graph operation, we use Csardi, G. & Nepusz, T. (2005) <https://www.researchgate.net/publication/221995787_The_Igraph_Software_Package_for_Complex_Network_Research>; For schedule concept, the reference was Project Management Institute (2017) <https://www.pmi.org/pmbok-guide-standards/foundational/pmbok>; For standards terms, we use Project Management Institute (2017) <https://www.pmi.org/pmbok-guide-standards/lexicon>; For algorithms on Critical Path Method development, we use Vanhoucke, M. (2013) <doi:10.1007/978-3-642-40438-2> and Vanhoucke, M. (2014) <doi:10.1007/978-3-319-04331-9>; And, finally, for topological definitions, we use Vanhoucke, M. (2009) <doi:10.1007/978-1-4419-1014-1>.

This package implements the JSON, INI, YAML and TOML parser for R setting and writing of configuration file. The functionality of this package is similar to that of package config'.

This package contains most of the popular internal and external cluster validation methods ready to use for the most of the outputs produced by functions coming from package "cluster". Package contains also functions and examples of usage for cluster stability approach that might be applied to algorithms implemented in "cluster" package as well as user defined clustering algorithms.

Extends the functionality of base R lists and provides specialized data structures deque', set', dict', and dict.table', the latter to extend the data.table package.

Calculate some statistics aiming to help analyzing the clustering tendency of given data. In the first version, Hopkins statistic is implemented. See Hopkins and Skellam (1954) <doi:10.1093/oxfordjournals.aob.a083391>.

Implementation of a probabilistic method for biclustering adapted to overdispersed count data. It is a Gamma-Poisson Latent Block Model. It also implements two selection criteria in order to select the number of biclusters.

Interface to easily access Cropland Data Layer (CDL) data for any area of interest via the CropScape <https://nassgeodata.gmu.edu/CropScape/> web service.

Estimates sugar beet canopy closure with remotely sensed leaf area index and estimates when action might be needed to protect the crop from a Leaf Spot epidemic with a negative prognosis model based on published models.

This package provides a flexible interface for interacting with Large Language Model ('LLM') providers including OpenAI', Groq', Anthropic', DeepSeek', DashScope', Gemini', Grok and GitHub Models'. Supports both synchronous and asynchronous chat-completion APIs, with features such as retry logic, dynamic model selection, customizable parameters, and multi-message conversation handling. Designed to streamline integration with state-of-the-art LLM services across multiple platforms.

This package provides a series of wrapper functions to implement the 10 maximum likelihood models of animal orientation described by Schnute and Groot (1992) <DOI:10.1016/S0003-3472(05)80068-5>. The functions also include the ability to use different optimizer methods and calculate various model selection metrics (i.e., AIC, AICc, BIC). The ability to perform variants of the Hermans-Rasson test and Pycke test is also included as described in Landler et al. (2019) <DOI:10.1186/s12898-019-0246-8>. The latest version also includes a new method to calculate circular-circular and circular-linear distance correlations.

This package provides a framework that facilitates spatio-temporal analysis of climate dynamics through exploring and measuring different dimensions of climate change in space and time.

Easy way to draw chronological charts from tables, aiming to include an intuitive environment for anyone new to R. Includes ggplot2 geoms and theme for chronological charts.

Computes 138 standard climate indices at monthly, seasonal and annual resolution. These indices were selected, based on their direct and significant impacts on target sectors, after a thorough review of the literature in the field of extreme weather events and natural hazards. Overall, the selected indices characterize different aspects of the frequency, intensity and duration of extreme events, and are derived from a broad set of climatic variables, including surface air temperature, precipitation, relative humidity, wind speed, cloudiness, solar radiation, and snow cover. The 138 indices have been classified as follow: Temperature based indices (42), Precipitation based indices (22), Bioclimatic indices (21), Wind-based indices (5), Aridity/ continentality indices (10), Snow-based indices (13), Cloud/radiation based indices (6), Drought indices (8), Fire indices (5), Tourism indices (5).

An implementation of the statistical methods commonly used for advanced composite materials in aerospace applications. This package focuses on calculating basis values (lower tolerance bounds) for material strength properties, as well as performing the associated diagnostic tests. This package provides functions for calculating basis values assuming several different distributions, as well as providing functions for non-parametric methods of computing basis values. Functions are also provided for testing the hypothesis that there is no difference between strength and modulus data from an alternate sample and that from a "qualification" or "baseline" sample. For a discussion of these statistical methods and their use, see the Composite Materials Handbook, Volume 1 (2012, ISBN: 978-0-7680-7811-4). Additional details about this package are available in the paper by Kloppenborg (2020, <doi:10.21105/joss.02265>).

Generate balance tables and plots for covariates of groups preprocessed through matching, weighting or subclassification, for example, using propensity scores. Includes integration with MatchIt', WeightIt', MatchThem', twang', Matching', optmatch', CBPS', ebal', cem', sbw', and designmatch for assessing balance on the output of their preprocessing functions. Users can also specify data for balance assessment not generated through the above packages. Also included are methods for assessing balance in clustered or multiply imputed data sets or data sets with multi-category, continuous, or longitudinal treatments.

This package implements the iterated RMCD method of Cerioli (2010) for multivariate outlier detection via robust Mahalanobis distances. Also provides the finite-sample RMCD method discussed in the paper, as well as the methods provided in Hardin and Rocke (2005) <doi:10.1198/106186005X77685> and Green and Martin (2017) <https://christopherggreen.github.io/papers/hr05_extension.pdf>. See also Chapter 2 of Green (2017) <https://digital.lib.washington.edu/researchworks/handle/1773/40304>.

Calculate various cardiovascular disease risk scores from the Framingham Heart Study (FHS), the American College of Cardiology (ACC), and the American Heart Association (AHA) as described in Dâ agostino, et al (2008) <doi:10.1161/circulationaha.107.699579>, Goff, et al (2013) <doi:10.1161/01.cir.0000437741.48606.98>, and Mclelland, et al (2015) <doi:10.1016/j.jacc.2015.08.035>, and Khan, et al (2024) <doi:10.1161/CIRCULATIONAHA.123.067626>.