Temporally autocorrelated populations are correlated in their vital rates (growth, death, etc.) from year to year. It is very common for populations, whether they be bacteria, plants, or humans, to be temporally autocorrelated. This poses a challenge for stochastic population modeling, because a temporally correlated population will behave differently from an uncorrelated one. This package provides tools for simulating populations with white noise (no temporal autocorrelation), red noise (positive temporal autocorrelation), and blue noise (negative temporal autocorrelation). The algebraic formulation for autocorrelated noise comes from Ruokolainen et al. (2009) <doi:10.1016/j.tree.2009.04.009>. Models for unstructured populations and for structured populations (matrix models) are available.

This package performs least squares constrained optimization on a linear objective function. It contains a number of algorithms to choose from and offers a formula syntax similar to lm().

Filter CpGs based on Intra-class Correlation Coefficients (ICCs) when replicates are available. ICCs are calculated by fitting linear mixed effects models to all samples including the un-replicated samples. Including the large number of un-replicated samples improves ICC estimates dramatically. The method accommodates any replicate design.

Classical cryptography methods for words and brief phrases. Substitution, transposition and concealment (null) ciphers are available, like Caesar, Vigenère, Atbash, affine, simple substitution, Playfair, rail fence, Scytale, single column, bifid, trifid, and Polybius ciphers.

The number of bird or bat fatalities from collisions with buildings, towers or wind energy turbines can be estimated based on carcass searches and experimentally assessed carcass persistence times and searcher efficiency. Functions for estimating the probability that a bird or bat that died is found by a searcher are provided. Further functions calculate the posterior distribution of the number of fatalities based on the number of carcasses found and the estimated detection probability.

It computes full conformal, split conformal and multi-split conformal prediction regions when the response variable is multivariate (i.e. dimension is greater than one). Moreover, the package also contains plot functions to visualize the output of the full and split conformal functions. To guarantee consistency, the package structure mimics the univariate package conformalInference by Ryan Tibshirani. See Lei, Gâ sell, Rinaldo, Tibshirani, & Wasserman (2018) <doi:10.1080/01621459.2017.1307116> for full and split conformal prediction in regression, and Barber, Candès, Ramdas, & Tibshirani (2023) <doi:10.1214/23-AOS2276> for extensions beyond exchangeability.

Simulates parameterized single- and double-directional stem deformations in tree point clouds derived from terrestrial or mobile laser scanning, enabling the generation of realistic synthetic datasets for training and validating machine learning models in wood defect detection, quality assessment, and precision forestry. For more details see Pires (2025) <doi:10.54612/a.7hln0kr0ta>.

Interface to the Google Cloud Machine Learning Platform <https://cloud.google.com/vertex-ai>, which provides cloud tools for training machine learning models.

Bayesian and ML Emax model fitting, graphics and simulation for clinical dose response. The summary data from the dose response meta-analyses in Thomas, Sweeney, and Somayaji (2014) <doi:10.1080/19466315.2014.924876> and Thomas and Roy (2016) <doi:10.1080/19466315.2016.1256229> Wu, Banerjee, Jin, Menon, Martin, and Heatherington(2017) <doi:10.1177/0962280216684528> are included in the package. The prior distributions for the Bayesian analyses default to the posterior predictive distributions derived from these references.

ClickHouse (<https://clickhouse.com/>) is an open-source, high performance columnar OLAP (online analytical processing of queries) database management system for real-time analytics using SQL. This DBI backend relies on the ClickHouse HTTP interface and support HTTPS protocol.

The primary motivation of this package is to take the things that are great about the R packages flextable <https://davidgohel.github.io/flextable/> and officer <https://davidgohel.github.io/officer/>, take the standard and complex pieces of formatting clinical tables for regulatory use, and simplify the tedious pieces.

Method for visualizing proportions between objects of different sizes. The proportions are drawn as circles with different diameters, which makes them ideal for visualizing proportions between planets.

This package implements bound constrained optimal sample size allocation (BCOSSA) framework described in Bulus & Dong (2021) <doi:10.1080/00220973.2019.1636197> for power analysis of multilevel regression discontinuity designs (MRDDs) and multilevel randomized trials (MRTs) with continuous outcomes. Minimum detectable effect size (MDES) and power computations for MRDDs allow polynomial functional form specification for the score variable (with or without interaction with the treatment indicator). See Bulus (2021) <doi:10.1080/19345747.2021.1947425>.

Canonical correlation analysis (CCA) via reduced-rank regression with support for regularization and cross-validation. Several methods for estimating CCA in high-dimensional settings are implemented. The first set of methods, cca_rrr() (and variants: cca_group_rrr() and cca_graph_rrr()), assumes that one dataset is high-dimensional and the other is low-dimensional, while the second, ecca() (for Efficient CCA) assumes that both datasets are high-dimensional. For both methods, standard l1 regularization as well as group-lasso regularization are available. cca_graph_rrr further supports total variation regularization when there is a known graph structure among the variables of the high-dimensional dataset. In this case, the loadings of the canonical directions of the high-dimensional dataset are assumed to be smooth on the graph. For more details see Donnat and Tuzhilina (2024) <doi:10.48550/arXiv.2405.19539> and Wu, Tuzhilina and Donnat (2025) <doi:10.48550/arXiv.2507.11160>.

This package provides tools to interface with Cytobank's API via R, organized by endpoints that represent various areas of Cytobank functionality. Learn more about Cytobank at <https://www.beckman.com/flow-cytometry/software>.

The developed function is a comprehensive tool for the analysis of India Meteorological Department (IMD) NetCDF rainfall data. Specifically designed to process high-resolution daily gridded rainfall datasets. It provides four key functions to process IMD NetCDF rainfall data and create rasters for various temporal scales, including annual, seasonal, monthly, and weekly rainfall. For method details see, Malik, A. (2019).<DOI:10.1007/s12517-019-4454-5>. It supports different aggregation methods, such as sum, min, max, mean, and standard deviation. These functions are designed for spatio-temporal analysis of rainfall patterns, trend analysis,geostatistical modeling of rainfall variability, identifying rainfall anomalies and extreme events and can be an input for hydrological and agricultural models.

Hardware-based support for CRC32C cyclic redundancy checksum function is made available for x86_64 systems with SSE2 support as well as for arm64', and detected at build-time via cmake with a software-based fallback. This functionality is exported at the C'-language level for use by other packages. CRC32C is described in RFC 3270 at <https://datatracker.ietf.org/doc/html/rfc3720> and is based on Castagnoli et al <doi:10.1109/26.231911>.

This package provides a likelihood-based hypothesis testing approach is implemented for assessing causal mediation. Described in Millstein, Chen, and Breton (2016), <DOI:10.1093/bioinformatics/btw135>, it could be used to test for mediation of a known causal association between a DNA variant, the instrumental variable', and a clinical outcome or phenotype by gene expression or DNA methylation, the potential mediator. Another example would be testing mediation of the effect of a drug on a clinical outcome by the molecular target. The hypothesis test generates a p-value or permutation-based FDR value with confidence intervals to quantify uncertainty in the causal inference. The outcome can be represented by either a continuous or binary variable, the potential mediator is continuous, and the instrumental variable can be continuous or binary and is not limited to a single variable but may be a design matrix representing multiple variables.

Easily cache and retrieve computation results. The package works seamlessly across interactive R sessions, R scripts and Rmarkdown documents.

This package implements the multiple changepoint algorithm PELT with a nonparametric cost function based on the empirical distribution of the data. This package extends the changepoint package (see Killick, R and Eckley, I (2014) <doi:10.18637/jss.v058.i03> ).

Nonparametric two-sample procedure for comparing survival quantiles.

Finds a low-dimensional embedding of high-dimensional data, conditioning on available manifold information. The current version supports conditional MDS (based on either conditional SMACOF in Bui (2021) <arXiv:2111.13646> or closed-form solution in Bui (2022) <doi:10.1016/j.patrec.2022.11.007>) and conditional ISOMAP in Bui (2021) <arXiv:2111.13646>.

Graphically display the (causal) effect of a continuous variable on a time-to-event outcome using multiple different types of plots based on g-computation. Those functions include, among others, survival area plots, survival contour plots, survival quantile plots and 3D surface plots. Due to the use of g-computation, all plot allow confounder-adjustment naturally. For details, see Robin Denz, Nina Timmesfeld (2023) <doi:10.1097/EDE.0000000000001630>.

Method for fitting a cellwise robust linear M-regression model (CRM, Filzmoser et al. (2020) <DOI:10.1016/j.csda.2020.106944>) that yields both a map of cellwise outliers consistent with the linear model, and a vector of regression coefficients that is robust against vertical outliers and leverage points. As a by-product, the method yields an imputed data set that contains estimates of what the values in cellwise outliers would need to amount to if they had fit the model. The package also provides diagnostic tools for analyzing casewise and cellwise outliers using sparse directions of maximal outlyingness (SPADIMO, Debruyne et al. (2019) <DOI:10.1007/s11222-018-9831-5>).