Fits a pseudo Cox proprotional hazards model when survival times are missing for control groups.

This package provides a standardized and reproducible framework for characterizing and classifying discrete color classes from digital images of biological organisms. The package automatically determines the presence or absence of 10 human-visible color categories (black, blue, brown, green, grey, orange, purple, red, white, yellow) using a biologically-inspired Color Look-Up Table (CLUT) that partitions HSV color space. Supports both fully automated and semi-automated (interactive) workflows with complete provenance tracking for reproducibility. Pre-processes images using the recolorize package (Weller et al. 2024 <doi:10.1111/ele.14378>) for spatial-color binning, and integrates with pavo (Maia et al. 2019 <doi:10.1111/2041-210X.13174>) for color pattern geometry statistics. Designed for high-throughput analysis and seamless integration with downstream evolutionary analyses.

This package implements computationally-efficient construction of confidence intervals from permutation or randomization tests for simple differences in means, based on Nguyen (2009) <doi:10.15760/etd.7798>.

Execute Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. Specify engine parameters and select from different run options, including simple estimation, stepwise covariate search, bootstrapping, simulation, visual predictive check, and more. Models are executed using the Certara.RsNLME package.

This package provides a tool for exploring correlations. It makes it possible to easily perform routine tasks when exploring correlation matrices such as ignoring the diagonal, focusing on the correlations of certain variables against others, or rearranging and visualizing the matrix in terms of the strength of the correlations.

Quick and easy access to datasets that let you replicate the empirical examples in Cameron and Trivedi (2005) "Microeconometrics: Methods and Applications" (ISBN: 9780521848053).The data are available as soon as you install and load the package (lazy-loading) as data frames. The documentation includes reference to chapter sections and page numbers where the datasets are used.

Cluster analysis of a set of variables. Variables can be quantitative, qualitative or a mixture of both.

This package provides functions for computing the one-sided p-values of the Cochran-Armitage trend test statistic for the asymptotic and the exact conditional test. The computation of the p-value for the exact test is performed using an algorithm following an idea by Mehta, et al. (1992) <doi:10.2307/1390598>.

Uses the CMS application programming interface <https://dnav.cms.gov/api/healthdata> to provide users databases containing yearly Medicare reimbursement rates in the United States. Data can be acquired for the entire United States or only for specific localities. Currently, support is only provided for the Medicare Physician Fee Schedule, but support will be expanded for other CMS databases in future versions.

This package implements the adaptive designs for integrated phase I/II trials of drug combinations via continual reassessment method (CRM) to evaluate toxicity and efficacy simultaneously for each enrolled patient cohort based on Bayesian inference. It supports patients assignment guidance in a single trial using current enrolled data, as well as conducting extensive simulation studies to evaluate operating characteristics before the trial starts. It includes various link functions such as empiric, one-parameter logistic, two-parameter logistic, and hyperbolic tangent, as well as considering multiple prior distributions of the parameters like normal distribution, gamma distribution and exponential distribution to accommodate diverse clinical scenarios. Method using Bayesian framework with empiric link function is described in: Wages and Conaway (2014) <doi:10.1002/sim.6097>.

An R implementation of the Critical Path Method (CPM). CPM is a method used to estimate the minimum project duration and determine the amount of scheduling flexibility on the logical network paths within the schedule model. The flexibility is in terms of early start, early finish, late start, late finish, total float and free float. Beside, it permits to quantify the complexity of network diagram through the analysis of topological indicators. Finally, it permits to change the activities duration to perform what-if scenario analysis. The package was built based on following references: To make topological sorting and other graph operation, we use Csardi, G. & Nepusz, T. (2005) <https://www.researchgate.net/publication/221995787_The_Igraph_Software_Package_for_Complex_Network_Research>; For schedule concept, the reference was Project Management Institute (2017) <https://www.pmi.org/pmbok-guide-standards/foundational/pmbok>; For standards terms, we use Project Management Institute (2017) <https://www.pmi.org/pmbok-guide-standards/lexicon>; For algorithms on Critical Path Method development, we use Vanhoucke, M. (2013) <doi:10.1007/978-3-642-40438-2> and Vanhoucke, M. (2014) <doi:10.1007/978-3-319-04331-9>; And, finally, for topological definitions, we use Vanhoucke, M. (2009) <doi:10.1007/978-1-4419-1014-1>.

This package implements Monte Carlo conditional inference for the parameters of a linear nonnormal regression model.

API Client for the Climate Hazards Center CHIRPS and CHIRTS'. The CHIRPS data is a quasi-global (50°S â 50°N) high-resolution (0.05 arc-degrees) rainfall data set, which incorporates satellite imagery and in-situ station data to create gridded rainfall time series for trend analysis and seasonal drought monitoring. CHIRTS is a quasi-global (60°S â 70°N), high-resolution data set of daily maximum and minimum temperatures. For more details on CHIRPS and CHIRTS data please visit its official home page <https://www.chc.ucsb.edu/data>.

Fits predictive and symmetric co-correspondence analysis (CoCA) models to relate one data matrix to another data matrix. More specifically, CoCA maximises the weighted covariance between the weighted averaged species scores of one community and the weighted averaged species scores of another community. CoCA attempts to find patterns that are common to both communities.

Create interactive charts with the C3.js <http://c3js.org/> charting library. All plot types in C3.js are available and include line, bar, scatter, and mixed geometry plots. Plot annotations, labels and axis are highly adjustable. Interactive web based charts can be embedded in R Markdown documents or Shiny web applications.

Model soil gas fluxes with the Flux-Gradient Method. It includes functions for data handling, a forward and an inverse model for flux modeling and methods for calibration and uncertainty estimation. For more details see Gartiser et al. (2025a) <doi:10.21105/joss.08094> and Gartiser et al. (2025b) <doi:10.1111/ejss.70126>.

We provide a computationally efficient and robust implementation of the recently proposed C-JAMP (Copula-based Joint Analysis of Multiple Phenotypes) method (Konigorski et al., 2019, submitted). C-JAMP allows estimating and testing the association of one or multiple predictors on multiple outcomes in a joint model, and is implemented here with a focus on large-scale genome-wide association studies with two phenotypes. The use of copula functions allows modeling a wide range of multivariate dependencies between the phenotypes, and previous results are supporting that C-JAMP can increase the power of association studies to identify associated genetic variants in comparison to existing methods (Konigorski, Yilmaz, Pischon, 2016, <DOI:10.1186/s12919-016-0045-6>; Konigorski, Yilmaz, Bull, 2014, <DOI:10.1186/1753-6561-8-S1-S72>). In addition to the C-JAMP functions, functions are available to generate genetic and phenotypic data, to compute the minor allele frequency (MAF) of genetic markers, and to estimate the phenotypic variance explained by genetic markers.

This package implements convex regression with interpretable sharp partitions (CRISP), which considers the problem of predicting an outcome variable on the basis of two covariates, using an interpretable yet non-additive model. CRISP partitions the covariate space into blocks in a data-adaptive way, and fits a mean model within each block. Unlike other partitioning methods, CRISP is fit using a non-greedy approach by solving a convex optimization problem, resulting in low-variance fits. More details are provided in Petersen, A., Simon, N., and Witten, D. (2016). Convex Regression with Interpretable Sharp Partitions. Journal of Machine Learning Research, 17(94): 1-31 <http://jmlr.org/papers/volume17/15-344/15-344.pdf>.

Easily cache and retrieve computation results. The package works seamlessly across interactive R sessions, R scripts and Rmarkdown documents.

Inference with control function methods for nonlinear outcome models when the model is known ('Guo and Small (2016) <arXiv:1602.01051>) and when unknown but semiparametric ('Li and Guo (2021) <arXiv:2010.09922>).

Accelerate Bayesian analytics workflows in R through interactive modelling, visualization, and inference. Define probabilistic graphical models using directed acyclic graphs (DAGs) as a unifying language for business stakeholders, statisticians, and programmers. This package relies on interfacing with the numpyro python package.

The cyclotomic numbers are complex numbers that can be thought of as the rational numbers extended with the roots of unity. They are represented exactly, enabling exact computations. They contain the Gaussian rationals (complex numbers with rational real and imaginary parts) as well as the square roots of all rational numbers. They also contain the sine and cosine of all rational multiples of pi. The algorithms implemented in this package are taken from the Haskell package cyclotomic', whose algorithms are adapted from code by Martin Schoenert and Thomas Breuer in the GAP project (<https://www.gap-system.org/>). Cyclotomic numbers have applications in number theory, algebraic geometry, algebraic number theory, coding theory, and in the theory of graphs and combinatorics. They have connections to the theory of modular functions and modular curves.

Constrained randomization by Raab and Butcher (2001) <doi:10.1002/1097-0258(20010215)20:3%3C351::AID-SIM797%3E3.0.CO;2-C> is suitable for cluster randomized trials (CRTs) with a small number of clusters (e.g., 20 or fewer). The procedure of constrained randomization is based on the baseline values of some cluster-level covariates specified. The intervention effect on the individual outcome can then be analyzed through clustered permutation test introduced by Gail, et al. (1996) <doi:10.1002/(SICI)1097-0258(19960615)15:11%3C1069::AID-SIM220%3E3.0.CO;2-Q>. Motivated from Li, et al. (2016) <doi:10.1002/sim.7410>, the package performs constrained randomization on the baseline values of cluster-level covariates and clustered permutation test on the individual-level outcomes for cluster randomized trials.

This package implements the JSON, INI, YAML and TOML parser for R setting and writing of configuration file. The functionality of this package is similar to that of package config'.