This package provides an extensive and curated collection of datasets related to the digestive system, stomach, intestines, liver, pancreas, and associated diseases. This package includes clinical trials, observational studies, experimental datasets, cohort data, and case series involving gastrointestinal disorders such as gastritis, ulcers, pancreatitis, liver cirrhosis, colon cancer, colorectal conditions, Helicobacter pylori infection, irritable bowel syndrome, intestinal infections, and post-surgical outcomes. The datasets support educational, clinical, and research applications in gastroenterology, public health, epidemiology, and biomedical sciences. Designed for researchers, clinicians, data scientists, students, and educators interested in digestive diseases, the package facilitates reproducible analysis, modeling, and hypothesis testing using real-world and historical data.

This package provides statistical tools for analyzing net and relative survival, with a key feature of relaxing the assumption of independent censoring and incorporating the effect of dependent competing risks. It employs a copula-based methodology, specifically the Archimedean copula, to simulate data, conduct survival analysis, and offer comparisons with other methods. This approach is detailed in the work of Adatorwovor et al. (2022) <doi:10.1515/ijb-2021-0016>.

This package provides a simple way of fitting detection functions to distance sampling data for both line and point transects. Adjustment term selection, left and right truncation as well as monotonicity constraints and binning are supported. Abundance and density estimates can also be calculated (via a Horvitz-Thompson-like estimator) if survey area information is provided. See Miller et al. (2019) <doi:10.18637/jss.v089.i01> for more information on methods and <https://distancesampling.org/resources/vignettes.html> for example analyses.

This package implements an algorithm to effortlessly split a column in an R data frame filled with multiple values separated by delimiters. This automates the process of creating separate columns for each unique value, transforming them into binary outcomes.

Functionalities for analyzing high-dimensional and longitudinal biomarker data to facilitate precision medicine, using a joint model of Bayesian sparse factor analysis and dependent Gaussian processes. This paper illustrates the method in detail: J Cai, RJB Goudie, C Starr, BDM Tom (2023) <doi:10.48550/arXiv.2307.02781>.

This package provides tools to simulate genetic distance matrices, align and compare them via multidimensional scaling (MDS) and Procrustes, and evaluate imputation with the Bootstrapping Evaluation for Structural Missingness Imputation (BESMI) framework. Methods align with Zhu et al. (2025) <doi:10.3389/fpls.2025.1543956> and the associated software resource Zhu (2025) <doi:10.26188/28602953>.

Supports the process of applying a cut to Standard Data Tabulation Model (SDTM), as part of the analysis of specific points in time of the data, normally as part of investigation into clinical trials. The functions support different approaches of cutting to the different domains of SDTM normally observed.

Various utilities for the Davies distribution.

This package provides a comprehensive approach for identifying and estimating change points in multivariate time series through various statistical methods. Implements the multiple change point detection methodology from Ryan & Killick (2023) <doi:10.1080/00401706.2023.2183261> and a novel estimation methodology from Fotopoulos et al. (2023) <doi:10.1007/s00362-023-01495-0> generalized to fit the detection methodologies. Performs both detection and estimation of change points, providing visualization and summary information of the estimation process for each detected change point.

This package provides a system for analyzing descriptive representation, especially for comparing the composition of a political body to the population it represents. Users can compute the expected degree of representation for a body under a random sampling model, the expected degree of representation variability, as well as representation scores from observed political bodies. The package is based on Gerring, Jerzak, and Oncel (2024) <doi:10.1017/S0003055423000680>.

Detects and filters damaged cells in single-cell RNA sequencing (scRNA-seq) data using a novel approach inspired by DoubletFinder'. Damage is detected by measuring the extent to which cells deviate from artificially damaged profiles of themselves, simulated through the probabilistic escape of cytoplasmic RNA. As output, a damage score ranging from 0 to 1 is given for each cell providing an intuitive scale for filtering that is standardised across cell types, samples, and experiments.

This package provides a set of control charts for batch processes based on the VAR model. The package contains the implementation of T2.var and W.var control charts based on VAR model coefficients using the couple vectors theory. In each time-instant the VAR coefficients are estimated from a historical in-control dataset and a decision rule is made for online classifying of a new batch data. Those charts allow efficient online monitoring since the very first time-instant. The offline version is available too. In order to evaluate the chart's performance, this package contains functions to generate batch data for offline and online monitoring.See in Danilo Marcondes Filho and Marcio Valk (2020) <doi:10.1016/j.ejor.2019.12.038>.

Read Word documents containing bibliographic references, search for corresponding DOIs using the Crossref API, and append the retrieved DOIs directly to the references. Supports parallel processing for faster retrieval and produces a new Word document with numbered references including DOIs.

Generates an RMarkdown data report with two components: a summary of an input dataset and a diff of the dataset relative to an old version.

Analysis and visualization of dropout between conditions in surveys and (online) experiments. Features include computation of dropout statistics, comparing dropout between conditions (e.g. Chi square), analyzing survival (e.g. Kaplan-Meier estimation), comparing conditions with the most different rates of dropout (Kolmogorov-Smirnov) and visualizing the result of each in designated plotting functions. Sources: Andrea Frick, Marie-Terese Baechtiger & Ulf-Dietrich Reips (2001) <https://www.researchgate.net/publication/223956222_Financial_incentives_personal_information_and_drop-out_in_online_studies>; Ulf-Dietrich Reips (2002) "Standards for Internet-Based Experimenting" <doi:10.1027//1618-3169.49.4.243>.

Compares the fit of alternative models of continuous trait differentiation between sister species and other paired lineages. Differences in trait means between two lineages arise as they diverge from a common ancestor, and alternative processes of evolutionary divergence are expected to leave unique signatures in the distribution of trait differentiation in datasets comprised of many lineage pairs. Models include approximations of divergent selection, drift, and stabilizing selection. A variety of model extensions facilitate the testing of process-to-pattern hypotheses. Users supply trait data and divergence times for each lineage pair. The fit of alternative models is compared in a likelihood framework.

This package provides select, insert, update, upsert, and delete database operations. Supports PostgreSQL', MySQL', SQLite', and more, and plays nicely with the DBI package.

Cancer genomes contain large numbers of somatic alterations but few genes drive tumor development. Identifying cancer driver genes is critical for precision oncology. Most of current approaches either identify driver genes based on mutational recurrence or using estimated scores predicting the functional consequences of mutations. driveR is a tool for personalized or batch analysis of genomic data for driver gene prioritization by combining genomic information and prior biological knowledge. As features, driveR uses coding impact metaprediction scores, non-coding impact scores, somatic copy number alteration scores, hotspot gene/double-hit gene condition, phenolyzer gene scores and memberships to cancer-related KEGG pathways. It uses these features to estimate cancer-type-specific probability for each gene of being a cancer driver using the related task of a multi-task learning classification model. The method is described in detail in Ulgen E, Sezerman OU. 2021. driveR: driveR: a novel method for prioritizing cancer driver genes using somatic genomics data. BMC Bioinformatics <doi:10.1186/s12859-021-04203-7>.

This package provides a comprehensive visualization toolkit built with coders of all skill levels and color-vision impaired audiences in mind. It allows creation of finely-tuned, publication-quality figures from single function calls. Visualizations include scatter plots, compositional bar plots, violin, box, and ridge plots, and more. Customization ranges from size and title adjustments to discrete-group circling and labeling, hidden data overlay upon cursor hovering via ggplotly() conversion, and many more, all with simple, discrete inputs. Color blindness friendliness is powered by legend adjustments (enlarged keys), and by allowing the use of shapes or letter-overlay in addition to the carefully selected dittoColors().

Base DataSHIELD functions for the client side. DataSHIELD is a software package which allows you to do non-disclosive federated analysis on sensitive data. DataSHIELD analytic functions have been designed to only share non disclosive summary statistics, with built in automated output checking based on statistical disclosure control. With data sites setting the threshold values for the automated output checks. For more details, see citation('dsBaseClient').

This package contains data sets, examples and software from the Second Edition of "Design of Observational Studies"; see Rosenbaum, P.R. (2010) <doi:10.1007/978-1-4419-1213-8>.

This package implements the locally efficient doubly robust difference-in-differences (DiD) estimators for the average treatment effect proposed by Sant'Anna and Zhao (2020) <doi:10.1016/j.jeconom.2020.06.003>. The estimator combines inverse probability weighting and outcome regression estimators (also implemented in the package) to form estimators with more attractive statistical properties. Two different estimation methods can be used to estimate the nuisance functions.

Robust distance-based methods applied to matrices and data frames, producing distance matrices that can be used as input for various visualization techniques such as graphs, heatmaps, or multidimensional scaling configurations. See Boj and Grané (2024) <doi:10.1016/j.seps.2024.101992>.

Diversification is one of the most important concepts in portfolio management. This framework offers scholars, practitioners and policymakers a useful toolbox to measure diversification. Specifically, this framework provides recent diversification measures from the recent literature. These diversification measures are based on the works of Rudin and Morgan (2006) <doi:10.3905/jpm.2006.611807>, Choueifaty and Coignard (2008) <doi:10.3905/JPM.2008.35.1.40>, Vermorken et al. (2012) <doi:10.3905/jpm.2012.39.1.067>, Flores et al. (2017) <doi:10.3905/jpm.2017.43.4.112>, Calvet et al. (2007) <doi:10.1086/524204>, and Candelon, Fuerst and Hasse (2020).