It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) <doi: 10.1016/j.envres.2022.112890> and Feng et al. (2022) <doi: 10.7150/ijms.67815> for disease expression profiles; see Wishart et al. (2018) <doi: 10.1093/nar/gkx1037> and Gaulton et al. (2017) <doi: 10.1093/nar/gkw1074> for drug target information; see Kanehisa et al. (2021) <doi: 10.1093/nar/gkaa970> for the details of KEGG database.).

Several statistical methods for analyzing survival data under various forms of dependent censoring are implemented in the package. In addition to accounting for dependent censoring, it offers tools to adjust for unmeasured confounding factors. The implemented approaches allow users to estimate the dependency between survival time and dependent censoring time, based solely on observed survival data. For more details on the methods, refer to Deresa and Van Keilegom (2021) <doi:10.1093/biomet/asaa095>, Czado and Van Keilegom (2023) <doi:10.1093/biomet/asac067>, Crommen et al. (2024) <doi:10.1007/s11749-023-00903-9>, Deresa and Van Keilegom (2024) <doi:10.1080/01621459.2022.2161387>, Willems et al. (2025) <doi:10.48550/arXiv.2403.11860>, Ding and Van Keilegom (2025) and D'Haen et al. (2025) <doi:10.1007/s10985-025-09647-0>.

Dual Wavelet based Nonlinear Autoregressive Distributed Lag model has been developed for noisy time series analysis. This package is designed to capture both short-run and long-run relationships in time series data, while incorporating wavelet transformations. The methodology combines the NARDL model with wavelet decomposition to better capture the nonlinear dynamics of the series and exogenous variables. The package is useful for analyzing economic and financial time series data that exhibit both long-term trends and short-term fluctuations. This package has been developed using algorithm of Jammazi et al. <doi:10.1016/j.intfin.2014.11.011>.

Empirical Bayes methods for learning prior distributions from data. An unknown prior distribution (g) has yielded (unobservable) parameters, each of which produces a data point from a parametric exponential family (f). The goal is to estimate the unknown prior ("g-modeling") by deconvolution and Empirical Bayes methods. Details and examples are in the paper by Narasimhan and Efron (2020, <doi:10.18637/jss.v094.i11>).

This package contains functions that check for formatting of the Subject Phenotype data set and data dictionary as specified by the National Center for Biotechnology Information (NCBI) Database of Genotypes and Phenotypes (dbGaP) <https://www.ncbi.nlm.nih.gov/gap/docs/submissionguide/>.

We consider a multiple testing procedure used in many modern applications which is the q-value method proposed by Storey and Tibshirani (2003), <doi:10.1073/pnas.1530509100>. The q-value method is based on the false discovery rate (FDR), hence versions of the q-value method can be defined depending on which estimator of the proportion of true null hypotheses, p0, is plugged in the FDR estimator. We implement the q-value method based on two classical pi0 estimators, and furthermore, we propose and implement three versions of the q-value method for homogeneous discrete uniform P-values based on pi0 estimators which take into account the discrete distribution of the P-values.

Simulates and computes the (maximum) likelihood of a dynamical model of island biota assembly through speciation, immigration and extinction. See Valente et al. (2015) <doi:10.1111/ele.12461>.

Implement weighted higher-order initialization and angle-based iteration for multi-way spherical clustering under degree-corrected tensor block model. See reference Jiaxin Hu and Miaoyan Wang (2023) <doi:10.1109/TIT.2023.3239521>.

Differential exon usage test for RNA-Seq data via an empirical Bayes shrinkage method for the dispersion parameter the utilizes inclusion-exclusion data to analyze the propensity to skip an exon across groups. The input data consists of two matrices where each row represents an exon and the columns represent the biological samples. The first matrix is the count of the number of reads expressing the exon for each sample. The second matrix is the count of the number of reads that either express the exon or explicitly skip the exon across the samples, a.k.a. the total count matrix. Dividing the two matrices yields proportions representing the propensity to express the exon versus skipping the exon for each sample.

Test for no adverse shift in two-sample comparison when we have a training set, the reference distribution, and a test set. The approach is flexible and relies on a robust and powerful test statistic, the weighted AUC. Technical details are in Kamulete, V. M. (2021) <arXiv:1908.04000>. Modern notions of outlyingness such as trust scores and prediction uncertainty can be used as the underlying scores for example.

This package contains functions to help with generating tables with descriptive statistics. In addition, the package can display results of statistical tests for group comparisons. A wide range of test procedures is supported, and user-defined test functions can be incorporated.

This package provides a specific and comprehensive framework for the analyses of time-to-event data in agriculture. Fit non-parametric and parametric time-to-event models. Compare time-to-event curves for different experimental groups. Plots and other displays. It is particularly tailored to the analyses of data from germination and emergence assays. The methods are described in Onofri et al. (2022) "A unified framework for the analysis of germination, emergence, and other time-to-event data in weed science", Weed Science, 70, 259-271 <doi:10.1017/wsc.2022.8>.

Distribution (S4-)classes for elliptically contoured distributions (based on package distr').

With bivariate data, it is possible to calculate 2-dimensional kernel density estimates that return polygons at given levels of probability. densityarea returns these polygons for analysis, including for calculating their area.

This package provides the mathematical model described by "Serostatus Testing & Dengue Vaccine Cost-Benefit Thresholds" in <doi:10.1098/rsif.2019.0234>. Using the functions in the package, that analysis can be repeated using sample life histories, either synthesized from local seroprevalence data using other functions in this package (as in the manuscript) or from some other source. The package provides a vignette which walks through the analysis in the publication, as well as a function to generate a project skeleton for such an analysis.

This package performs differential network analysis to infer disease specific gene networks.

Access Datastream content through <https://product.datastream.com/dswsclient/Docs/Default.aspx>., our historical financial database with over 35 million individual instruments or indicators across all major asset classes, including over 19 million active economic indicators. It features 120 years of data, across 175 countries â the information you need to interpret market trends, economic cycles, and the impact of world events. Data spans bond indices, bonds, commodities, convertibles, credit default swaps, derivatives, economics, energy, equities, equity indices, ESG, estimates, exchange rates, fixed income, funds, fundamentals, interest rates, and investment trusts. Unique content includes I/B/E/S Estimates, Worldscope Fundamentals, point-in-time data, and Reuters Polls. Alongside the content, sit a set of powerful analytical tools for exploring relationships between different asset types, with a library of customizable analytical functions. In-house timeseries can also be uploaded using the package to comingle with Datastream maintained datasets, use with these analytical tools and displayed in Datastreamâ s flexible charting facilities in Microsoft Office.

Extends package distr by functionals, distances, and conditional distributions.

Explore neural networks in a layer oriented way, the framework is intended to give the user total control of the internals of a net without much effort. Use classes like PerceptronLayer to create a layer of Percetron neurons, and specify how many you want. The package does all the tricky stuff internally leaving you focused in what you want. I wrote this package during a neural networks course to help me with the problem set.

Mimics the demo functionality for Shiny apps in a package. Apps stored to the package subdirectory inst/shiny can be called by demoShiny(topic).

This package provides a big-data-friendly and memory-efficient difference-in-differences estimator for staggered (and non-staggered) treatment contexts.

This package provides a flexible container to transport and manipulate complex sets of data. These data may consist of multiple data files and associated meta data and ancillary files. Individual data objects have associated system level meta data, and data files are linked together using the OAI-ORE standard resource map which describes the relationships between the files. The OAI- ORE standard is described at <https://www.openarchives.org/ore/>. Data packages can be serialized and transported as structured files that have been created following the BagIt specification. The BagIt specification is described at <https://datatracker.ietf.org/doc/html/draft-kunze-bagit-08>.

Rare variant association test integrating variant position information. It aims to identify the presence of clusters of disease-risk variants in specific gene regions. For more details, please read the publication from Persyn et al. (2017) <doi:10.1371/journal.pone.0179364>.

This package provides friendly wrappers for creating duckdb'-backed connections to tabular datasets ('csv', parquet, etc) on local or remote file systems. This mimics the behaviour of "open_dataset" in the arrow package, but in addition to S3 file system also generalizes to any list of http URLs.