Computes a confidence interval for a specified linear combination of the regression parameters in a linear regression model with iid normal errors with known variance when there is uncertain prior information that a distinct specified linear combination of the regression parameters takes a given value. This confidence interval, found by numerical nonlinear constrained optimization, has the required minimum coverage and utilizes this uncertain prior information through desirable expected length properties. This confidence interval has the following three practical applications. Firstly, if the error variance has been accurately estimated from previous data then it may be treated as being effectively known. Secondly, for sufficiently large (dimension of the response vector) minus (dimension of regression parameter vector), greater than or equal to 30 (say), if we replace the assumed known value of the error variance by its usual estimator in the formula for the confidence interval then the resulting interval has, to a very good approximation, the same coverage probability and expected length properties as when the error variance is known. Thirdly, some more complicated models can be approximated by the linear regression model with error variance known when certain unknown parameters are replaced by estimates. This confidence interval is described in Mainzer, R. and Kabaila, P. (2019) <doi:10.32614/RJ-2019-026>, and is a member of the family of confidence intervals proposed by Kabaila, P. and Giri, K. (2009) <doi:10.1016/j.jspi.2009.03.018>.

This package provides a spatially-aware cell clustering algorithm is provided with cluster significance assessment. It comprises four key modules: spatially-aware cell-gene co-embedding, cell clustering, signature gene identification, and cluster significant assessment. More details can be referred to Peng Xie, et al. (2025) <doi:10.1016/j.cell.2025.05.035>.

Simulates time-to-event data with type I right censoring using two methods: the inverse CDF method and our proposed memoryless method. The latter method takes advantage of the memoryless property of survival and simulates a separate distribution between change-points. We include two parametric distributions: exponential and Weibull. Inverse CDF method draws on the work of Rainer Walke (2010), <https://www.demogr.mpg.de/papers/technicalreports/tr-2010-003.pdf>.

Univariate and multivariate temporal and spatial diversity indices, rank abundance curves, and community stability measures. The functions implement measures that are either explicitly temporal and include the option to calculate them over multiple replicates, or spatial and include the option to calculate them over multiple time points. Functions fall into five categories: static diversity indices, temporal diversity indices, spatial diversity indices, rank abundance curves, and community stability measures. The diversity indices are temporal and spatial analogs to traditional diversity indices. Specifically, the package includes functions to calculate community richness, evenness and diversity at a given point in space and time. In addition, it contains functions to calculate species turnover, mean rank shifts, and lags in community similarity between two time points. Details of the methods are available in Hallett et al. (2016) <doi:10.1111/2041-210X.12569> and Avolio et al. (2019) <doi:10.1002/ecs2.2881>.

This package implements the general template for collaborative targeted maximum likelihood estimation. It also provides several commonly used C-TMLE instantiation, like the vanilla/scalable variable-selection C-TMLE (Ju et al. (2017) <doi:10.1177/0962280217729845>) and the glmnet-C-TMLE algorithm (Ju et al. (2017) <arXiv:1706.10029>).

Evaluates the probability density function (PDF), cumulative distribution function (CDF), quantile function (QF), random numbers and maximum likelihood estimates (MLEs) of well-known complementary binomial-G, complementary negative binomial-G and complementary geometric-G families of distributions taking baseline models such as exponential, extended exponential, Weibull, extended Weibull, Fisk, Lomax, Burr-XII and Burr-X. The functions also allow computing the goodness-of-fit measures namely the Akaike-information-criterion (AIC), the Bayesian-information-criterion (BIC), the minimum value of the negative log-likelihood (-2L) function, Anderson-Darling (A) test, Cramer-Von-Mises (W) test, Kolmogorov-Smirnov test, P-value and convergence status. Moreover, some commonly used data sets from the fields of actuarial, reliability, and medical science are also provided. Related works include: a) Tahir, M. H., & Cordeiro, G. M. (2016). Compounding of distributions: a survey and new generalized classes. Journal of Statistical Distributions and Applications, 3, 1-35. <doi:10.1186/s40488-016-0052-1>.

Calculating the fractal dimension of a coastline using the boxes and dividers methods.

This package provides tools for performing consensus clustering on multiple imputed datasets. The package supports a range of clustering algorithms across imputations, including hierarchical methods (e.g., Ward, single, complete, average) and partition-based approaches such as k-means, k-medoids (PAM), fuzzy clustering, model-based clustering ('mclust'), and methods for mixed or categorical data (k-modes and k-prototypes). A co-assignment matrix is constructed to quantify agreement between partitions, and consensus solutions are derived via hierarchical clustering applied to the resulting dissimilarity matrix. Additional functions are provided for validation and visualization of clustering results, facilitating robust analysis in the presence of missing data. Consensus clustering framework is based on Monti et al. (2003) <doi:10.1023/A:1023949509487>, rank aggregation methods follow Pihur et al. (2007) <doi:10.1093/bioinformatics/btm158>, and the PAC (Proportion of Ambiguous Clustering) metric is based on Senbabaoglu et al. (2014) <doi:10.1038/srep06207>.

Bayesian fit of a Dirichlet Process Mixture with hierarchical multivariate skew normal kernels and coarsened posteriors. For more information, see Gorsky, Chan and Ma (2024) <doi:10.1214/22-BA1356>.

This package provides a basic implementation of the change in mean detection method outlined in: Taylor, Wayne A. (2000) <https://variation.com/wp-content/uploads/change-point-analyzer/change-point-analysis-a-powerful-new-tool-for-detecting-changes.pdf>. The package recursively uses the mean-squared error change point calculation to identify candidate change points. The candidate change points are then re-estimated and Taylor's backwards elimination process is then employed to come up with a final set of change points. Many of the underlying functions are written in C++ for improved performance.

Facilitates the creation of xpose data objects from Nonlinear Mixed Effects (NLME) model outputs produced by Certara.RsNLME or Phoenix NLME. This integration enables users to utilize all ggplot2'-based plotting functions available in xpose for thorough model diagnostics and data visualization. Additionally, the package introduces specialized plotting functions tailored for covariate model evaluation, extending the analytical capabilities beyond those offered by xpose alone.

This package provides a series of wrapper functions to implement the 10 maximum likelihood models of animal orientation described by Schnute and Groot (1992) <DOI:10.1016/S0003-3472(05)80068-5>. The functions also include the ability to use different optimizer methods and calculate various model selection metrics (i.e., AIC, AICc, BIC). The ability to perform variants of the Hermans-Rasson test and Pycke test is also included as described in Landler et al. (2019) <DOI:10.1186/s12898-019-0246-8>. The latest version also includes a new method to calculate circular-circular and circular-linear distance correlations.

Curates biological sequences massively, quickly, without errors and without internet connection. Biological sequences curing is performed by aligning the forward and / or revers primers or ends of cloning vectors with the sequences to be cleaned. After the alignment, new subsequences are generated without biological fragment not desired by the user. Pozzi et al (2020) <doi:10.1007/s00438-020-01671-z>.

Can be useful for finding associations among different positions in a position-wise aligned sequence dataset. The approach adopted for finding associations among positions is based on the latent multivariate normal distribution.

Design and use of control charts for detecting mean changes based on a delayed updating of the in-control parameter estimates. See Capizzi and Masarotto (2019) <doi:10.1080/00224065.2019.1640096> for the description of the method.

Gain access to the Spark Catalog API making use of the sparklyr API. Catalog <https://spark.apache.org/docs/2.4.3/api/java/org/apache/spark/sql/catalog/Catalog.html> is the interface for managing a metastore (aka metadata catalog) of relational entities (e.g. database(s), tables, functions, table columns and temporary views).

The estimation of static and dynamic connectedness measures is created in a modular and user-friendly way. Besides, the time domain connectedness approaches, this package further allows to estimate the frequency connectedness approach, the joint spillover index and the extended joint connectedness approach. In addition, all connectedness frameworks can be based upon orthogonalized and generalized VAR, QVAR, LASSO VAR, Ridge VAR, Elastic Net VAR and TVP-VAR models. Furthermore, the package includes the conditional, decomposed and partial connectedness measures as well as the pairwise connectedness index, influence index and corrected total connectedness index. Finally, a battery of datasets are available allowing to replicate a variety of connectedness papers.

Generates continuous test norms in psychometrics and biometrics, and analyzes model fit. The package offers distribution-free modeling using Taylor polynomials, as well as parametric modeling using the beta-binomial distribution (for bounded accuracy tests), the Conway-Maxwell-Poisson distribution (for speeded tests and count data with over-, equi-, or under-dispersion), and the Sinh-Arcsinh (SHASH) distribution. Originally developed for psychological and educational assessment, it is applicable to a wide range of mental, physical, or other test scores dependent on continuous or discrete explanatory variables. The package minimizes deviations from representativeness in subsamples, interpolates between discrete levels of explanatory variables, and significantly reduces the required sample size compared to conventional norming per age group. cNORM enables graphical and analytical evaluation of model fit, accommodates a wide range of scales including those with negative and descending values, and supports conventional norming. It generates norm tables including confidence intervals and provides methods for addressing representativeness issues through Iterative Proportional Fitting. Based on Lenhard et al. (2016) <doi:10.1177/1073191116656437>, Lenhard et al. (2019) <doi:10.1371/journal.pone.0222279>, Lenhard and Lenhard (2021) <doi:10.1177/0013164420928457>, and Gary et al. (2023) <doi:10.1007/s00181-023-02456-0>.

Client for CKAN API (<https://ckan.org/>). Includes interface to CKAN APIs for search, list, show for packages, organizations, and resources. In addition, provides an interface to the datastore API.

This package provides an interface to the ClinicalOmicsDB API, allowing for easy data downloading and importing. ClinicalOmicsDB is a database of clinical and omics data from cancer patients. The database is accessible at <http://trials.linkedomics.org>.

Interactive shiny application for running classical test theory (item analysis).

Estimation of Markov generator matrices from discrete-time observations. The implemented approaches comprise diagonal and weighted adjustment of matrix logarithm based candidate solutions as in Israel (2001) <doi:10.1111/1467-9965.00114> as well as a quasi-optimization approach. Moreover, the expectation-maximization algorithm and the Gibbs sampling approach of Bladt and Sorensen (2005) <doi:10.1111/j.1467-9868.2005.00508.x> are included.

Use frequentist and Bayesian methods to estimate parameters from a binary outcome misclassification model. These methods correct for the problem of "label switching" by assuming that the sum of outcome sensitivity and specificity is at least 1. A description of the analysis methods is available in Hochstedler and Wells (2023) <doi:10.48550/arXiv.2303.10215>.

Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002.