Prepare the results of a DCE to be analysed through choice models.'DCEmgmt reshapes DCE data from wide to long format considering the special characteristics of a DCE. DCEmgmt includes the function DCEestm which estimates choice models once the database has been reshaped with DCEmgmt'.

Robust distance-based methods applied to matrices and data frames, producing distance matrices that can be used as input for various visualization techniques such as graphs, heatmaps, or multidimensional scaling configurations. See Boj and Grané (2024) <doi:10.1016/j.seps.2024.101992>.

This package provides a unified framework to building Area Deprivation Index (ADI), Social Vulnerability Index (SVI), and Neighborhood Deprivation Index (NDI) deprivation measures and accessing related data from the U.S. Census Bureau such as Gini coefficient data. Tools are also available for calculating percentiles, quantiles, and for creating clear map breaks for data visualization.

This package provides a revision to the stats::ks.test() function and the associated ks.test.Rd help page. With one minor exception, it does not change the existing behavior of ks.test(), and it adds features necessary for doing one-sample tests with hypothesized discrete distributions. The package also contains cvm.test(), for doing one-sample Cramer-von Mises goodness-of-fit tests.

Inference by sequential Monte Carlo for dynamic tree regression and classification models with hooks provided for sequential design and optimization, fully online learning with drift, variable selection, and sensitivity analysis of inputs. Illustrative examples from the original dynamic trees paper (Gramacy, Taddy & Polson (2011); <doi:10.1198/jasa.2011.ap09769>) are facilitated by demos in the package; see demo(package="dynaTree").

Parses command line arguments and supplies values to scripts. Users can specify names to which parsed inputs are assigned, value types into which inputs are cast, long options or short options, input splitters and callbacks that define how options should be specified and how input values are supplied.

Estimation of a density from grouped (tabulated) summary statistics evaluated in each of the big bins (or classes) partitioning the support of the variable. These statistics include class frequencies and central moments of order one up to four. The log-density is modelled using a linear combination of penalised B-splines. The multinomial log-likelihood involving the frequencies adds up to a roughness penalty based on the differences in the coefficients of neighbouring B-splines and the log of a root-n approximation of the sampling density of the observed vector of central moments in each class. The so-obtained penalized log-likelihood is maximized using the EM algorithm to get an estimate of the spline parameters and, consequently, of the variable density and related quantities such as quantiles, see Lambert, P. (2021) <arXiv:2107.03883> for details.

Local linear hazard estimator and its multiplicatively bias correction, including three bandwidth selection methods: best one-sided cross-validation, double one-sided cross-validation, and standard cross-validation.

While it has been well established that drugs affect and help patients differently, personalized drug response predictions remain challenging. Solutions based on single omics measurements have been proposed, and networks provide means to incorporate molecular interactions into reasoning. However, how to integrate the wealth of information contained in multiple omics layers still poses a complex problem. We present a novel network analysis pipeline, DrDimont, Drug response prediction from Differential analysis of multi-omics networks. It allows for comparative conclusions between two conditions and translates them into differential drug response predictions. DrDimont focuses on molecular interactions. It establishes condition-specific networks from correlation within an omics layer that are then reduced and combined into heterogeneous, multi-omics molecular networks. A novel semi-local, path-based integration step ensures integrative conclusions. Differential predictions are derived from comparing the condition-specific integrated networks. DrDimont's predictions are explainable, i.e., molecular differences that are the source of high differential drug scores can be retrieved. Our proposed pipeline leverages multi-omics data for differential predictions, e.g. on drug response, and includes prior information on interactions. The case study presented in the vignette uses data published by Krug (2020) <doi:10.1016/j.cell.2020.10.036>. The package license applies only to the software and explicitly not to the included data.

Functionality for analyzing dose-volume histograms (DVH) in radiation oncology: Read DVH text files, calculate DVH metrics as well as generalized equivalent uniform dose (gEUD), biologically effective dose (BED), equivalent dose in 2 Gy fractions (EQD2), normal tissue complication probability (NTCP), and tumor control probability (TCP). Show DVH diagrams, check and visualize quality assurance constraints for the DVH. Includes web-based graphical user interface.

Estimation of incidence and case fatality for a chronic disease, given partial information, using a multi-state model. Given data on age-specific mortality and either incidence or prevalence, Bayesian inference is used to estimate the posterior distributions of incidence, case fatality, and functions of these such as prevalence. The methods are described in Jackson et al. (2023) <doi:10.1093/jrsssa/qnac015>.

This package provides a foreach parallel adapter for parabar backends. This package offers a minimal implementation of the %dopar% operator, enabling users to run foreach loops in parallel, leveraging the parallel and progress-tracking capabilities of the parabar package. Learn more about parabar and doParabar at <https://parabar.mihaiconstantin.com>.

Interface with the Dat p2p network protocol <https://datproject.org>. Clone archives from the network, share your own files, and install packages from the network.

This package provides methods to detect differential item functioning (DIF) in dichotomous, polytomous, and continuous items, using both classical and modern approaches. These include Mantel-Haenszel procedures, logistic regression (including ordinal models), and regularization-based methods such as LASSO. Uniform and non-uniform DIF effects can be detected, and some methods support multiple focal groups. The package also provides tools for anchor purification, rest score matching, effect size estimation, and DIF simulation. See Magis, Beland, Tuerlinckx, and De Boeck (2010, Behavior Research Methods, 42, 847â 862, <doi:10.3758/BRM.42.3.847>) for a general overview.

Functions, methods, and datasets for fitting dimension reduction regression, using slicing (methods SAVE and SIR), Principal Hessian Directions (phd, using residuals and the response), and an iterative IRE. Partial methods, that condition on categorical predictors are also available. A variety of tests, and stepwise deletion of predictors, is also included. Also included is code for computing permutation tests of dimension. Adding additional methods of estimating dimension is straightforward. For documentation, see the vignette in the package. With version 3.0.4, the arguments for dr.step have been modified.

This package implements maximum likelihood methods for evaluating the durability of vaccine efficacy in a randomized, placebo-controlled clinical trial with staggered enrollment of participants and potential crossover of placebo recipients before the end of the trial. Lin, D. Y., Zeng, D., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab226> and Lin, D. Y., Gu, Y., Zeng, D., Janes, H. E., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab630>.

Allows clinicians and researchers to compute daily dose (and subsequently days supply) for prescription refills using the following methods: Fixed window, fixed tablet, defined daily dose (DDD), and Random Effects Warfarin Days Supply (REWarDS). Daily dose is the computed dose that the patient takes every day. For medications with fixed dosing (e.g. direct oral anticoagulants) this is known and does not need to be estimated. For medications with varying dose such as warfarin, however, the daily dose should be assumed or estimated to allow measurement of drug exposure. Daysâ supply is the number of days that patientsâ supply of medication will last after each prescription fill. Estimating daysâ supply is necessary to calculate drug exposure. The package computes daysâ supply and daily dose at both the prescription and patient levels. Results at the prescription level are denoted with â -Rx-â and those at patient level are denoted with â -Pt-â .

This package provides a collection of widely used univariate data sets of various applied domains on applications of distribution theory. The functions allow researchers and practitioners to quickly, easily, and efficiently access and use these data sets. The data are related to different applied domains and as follows: Bio-medical, survival analysis, medicine, reliability analysis, hydrology, actuarial science, operational research, meteorology, extreme values, quality control, engineering, finance, sports and economics. The total 100 data sets are documented along with associated references for further details and uses.

Decompose a time series into seasonal, trend and irregular components using transformations to amplitude-frequency domain.

This package provides functions providing an easy and intuitive way for fitting and clusters data using the Mixture of Unigrams models by means the Expectation-Maximization algorithm (Nigam, K. et al. (2000). <doi:10.1023/A:1007692713085>), Mixture of Dirichlet-Multinomials estimated by Gradient Descent (Anderlucci, Viroli (2020) <doi:10.1007/s11634-020-00399-3>) and Deep Mixture of Multinomials whose estimates are obtained with Gibbs sampling scheme (Viroli, Anderlucci (2020) <doi:10.1007/s11222-020-09989-9>). There are also functions for graphical representation of clusters obtained.

Assists in finding the most suitable thread count for the various data.table routines that support parallel processing.

An open, multi-algorithmic pipeline for easy, fast and efficient analysis of cellular sub-populations and the molecular signatures that characterize them. The pipeline consists of four successive steps: data pre-processing, cellular clustering with pseudo-temporal ordering, defining differential expressed genes and biomarker identification. More details on Ghannoum et. al. (2021) <doi:10.3390/ijms22031399>. This package implements extensions of the work published by Ghannoum et. al. (2019) <doi:10.1101/700989>.

Graphical interface for loading datasets in RStudio from all installed (including unloaded) packages, also includes command line interfaces.

This package provides statistical tests and support functions for detecting irregular digit patterns in numerical data. The package includes tools for extracting digits at various locations in a number, tests for repeated values, and (Bayesian) tests of digit distributions.