Access data sets for demonstrating or testing diagnostic classification models. Simulated data sets can be used to compare estimated model output to true data-generating values. Real data sets can be used to demonstrate real-world applications of diagnostic models.

This package implements maximum likelihood methods for evaluating the durability of vaccine efficacy in a randomized, placebo-controlled clinical trial with staggered enrollment of participants and potential crossover of placebo recipients before the end of the trial. Lin, D. Y., Zeng, D., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab226> and Lin, D. Y., Gu, Y., Zeng, D., Janes, H. E., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab630>.

Detection and attribution of climate change using methods including optimal fingerprinting via generalized total least squares or an estimating equation approach (Li et al., 2025, <doi:10.1175/JCLI-D-24-0193.1>; Ma et al., 2023, <doi:10.1175/JCLI-D-22-0681.1>). Provides shrinkage estimators for the covariance matrix following Ledoit and Wolf (2004, <doi:10.1016/S0047-259X(03)00096-4>) and Ledoit and Wolf (2017, <doi:10.2139/ssrn.2383361>).

This package provides robustness checks to align estimands with the identification that they require. Given a dagitty object and a model specification, DAGassist classifies variables by causal roles, recovers a target estimand, and generates a report comparing the original model with DAG-derived adjustment sets. Exports publication-grade reports in LaTeX', Word', Excel', dotwhisker', or plain text/'markdown'. DAGassist is built on dagitty', an R package that uses the DAGitty web tool (<https://dagitty.net/>) for creating and analyzing DAGs. Methods draw on Pearl (2009) <doi:10.1017/CBO9780511803161> and Textor et al. (2016) <doi:10.1093/ije/dyw341>.

An implementation of the differentiable lasso (dlasso) and SCAD (dSCAD) using iterative ridge algorithm. This package allows selecting the tuning parameter by AIC, BIC, GIC and GIC.

This package provides functionality that assists in tabular description and statistical comparison of data.

Implement some deep learning architectures and neural network algorithms, including BP,RBM,DBN,Deep autoencoder and so on.

Ingredient specific diagnostics for drug exposure records in the Observational Medical Outcomes Partnership (OMOP) common data model.

This package provides the ability to display something analogous to Python's docstrings within R. By allowing the user to document their functions as comments at the beginning of their function without requiring putting the function into a package we allow more users to easily provide documentation for their functions. The documentation can be viewed just like any other help files for functions provided by packages as well.

Calculates Days Alive and Out of Hospital (DAOH) from administrative admission/discharge/mortality data using three algorithms (nights, days, exact) and three death-handling approaches (midday, midnight, zero). Includes tools for comparing methods (Bland-Altman, ICC, reclassification), and plotting.

This package provides a systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

This package provides fast, in-memory reading of DATASUS DBC files using native C code, along with a catalog of public health data sources, FTP file discovery, caching downloads, and a high-level datasus_fetch() function that lists, downloads, and reads files in a single call. Bundles the blast decompressor from zlib contrib/blast to decode PKWare DCL compressed DBC files and parses DBF records directly for efficient import into tibbles. See the DATASUS file transfer site <https://datasus.saude.gov.br> and Adler (2003) <https://github.com/madler/zlib/tree/master/contrib/blast> for details on the underlying data and compression format.

This package provides a collection of functions which aim to assist common computational workflow for analysis of matabolomic data..

We provide an R implementation of Deep Significance Clustering (DICE), a self-supervised learning framework designed to identify clinically meaningful and risk-stratified patient subgroups from electronic health record (EHR) data. DICE jointly optimizes deep representation learning, clustering, and outcome prediction while enforcing statistical significance between predicted outcomes and cluster membership. This integrated optimization produces subgroups that are both clinically coherent and predictive, addressing a gap where traditional unsupervised clustering methods and supervised risk prediction models alone may fail to generate actionable clinical groupings. See Huang et al. (2021) <doi:10.1093/jamia/ocab203>.

As a distributed imputation strategy, the Distributed full information Multiple Imputation method is developed to impute missing response variables in distributed linear regression. The philosophy of the package is described in Guo (2025) <doi:10.1038/s41598-025-93333-6>.

This package provides a robust identification of differential binding sites method for analyzing ChIP-seq (Chromatin Immunoprecipitation Sequencing) comparing two samples that considers an ensemble of finite mixture models combined with a local false discovery rate (fdr) allowing for flexible modeling of data. Methods for Differential Identification using Mixture Ensemble (DIME) is described in: Taslim et al., (2011) <doi:10.1093/bioinformatics/btr165>.

Useful functions for various DDI (Data Documentation Initiative) related inputs and outputs. Converts data files to and from DDI, SPSS, Stata, SAS, R and Excel, including user declared missing values.

This package provides a system for extracting news from Chilean media, specifically through Web Scapping from Chilean media. The package allows for news searches using search phrases and date filters, and returns the results in a structured format, ready for analysis. Additionally, it includes functions to clean the extracted data, visualize it, and store it in databases. All of this can be done automatically, facilitating the collection and analysis of relevant information from Chilean media.

This package implements discrete curvature estimation for ordered planar point sequences using circumcenter geometry on consecutive triplets, exposed through compiled C plus plus (C++) code via Rcpp for speed and numerical robustness. The package is useful for objective elbow detection in multivariate workflows, especially principal component analysis (PCA), where selecting the number of retained components can be subjective. It provides a shiny interface that supports upload of raw datasets or explained-variance tables, computes Kaiser-Meyer-Olkin (KMO) sampling-adequacy diagnostics, evaluates individual and cumulative variance curves, and reports curvature- based decision rules (m* and m**) with visual summaries for reproducible component-selection decisions. References: Arney et al. (2001); Axler (2024) <doi:10.1007/978-3-031-41026-0>; Bjorklund (2019) <doi:10.1111/evo.13835>; Burden and Faires (2015); Chang et al. (2023) <https://CRAN.R-project.org/package=shiny>; Christensen (2019); Cui (2020) <doi:10.18637/jss.v040.i08>; Eddelbuettel and Sanderson (2014) <doi:10.1016/j.csda.2013.02.005>; Engelke et al. (2023) <doi:10.1016/j.jseint.2023.04.010>; Gniazdowski (2021) <doi:10.26348/znwwsi.24.35>; Haynes et al. (2017); Jameel and Al-Salami (2023) <doi:10.24086/cuejhss.v7n1y2023.pp121-125>; Jolliffe (2002); Jolliffe and Cadima (2016) <doi:10.1098/rsta.2015.0202>; Kaiser (1974); Lehnert et al. (2019) <doi:10.18637/jss.v089.i12>; Ma and Dai (2011) <doi:10.1093/bib/bbq090>; Milligan (1995); Onumanyi et al. (2022) <doi:10.3390/app12157515>; Park (2010); Revelle (2024) <https://CRAN.R-project.org/package=psych>; Rodionova et al. (2021) <doi:10.1016/j.chemolab.2021.104304>; Sen and Cohen (2025) <doi:10.1177/01466216251344288>; Serneels and Verdonck (2008) <doi:10.1016/j.csda.2007.05.024>; Shi et al. (2021) <doi:10.1186/s13638-021-01910-w>; Shaukat et al. (2016) <doi:10.1515/eko-2016-0014>; Syakur et al. (2018) <doi:10.1088/1757-899X/336/1/012017>; Wickham and Bryan (2023) <https://CRAN.R-project.org/package=readxl>; Wu et al. (2017) <doi:10.1088/1755-1315/61/1/012054>; Youssef et al. (2023) <doi:10.21303/2461-4262.2023.002582>.

This package provides a grammar of data manipulation with data.table', providing a consistent a series of utility functions that help you solve the most common data manipulation challenges.

This package provides a systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. DrugSim2DR first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.

Hash an expression with its dependencies and store its value, reloading it from a file as long as both the expression and its dependencies stay the same.

Direction analysis is a set of tools designed to identify combinatorial effects of multiple treatments/conditions on pathways and kinases profiled by microarray, RNA-seq, proteomics, or phosphoproteomics data. See Yang P et al (2014) <doi:10.1093/bioinformatics/btt616>; and Yang P et al. (2016) <doi:10.1002/pmic.201600068>.

Allows users to quickly and easily detect data containing Personally Identifiable Information (PII) through convenience functions.