This package provides a toolkit for working with Biological Observation Matrix (BIOM) files. Features include reading/writing all BIOM formats, rarefaction, alpha diversity, beta diversity (including UniFrac), summarizing counts by taxonomic level, and sample subsetting. Standalone functions for reading, writing, and subsetting phylogenetic trees are also provided.

This package provides functions for extracting feature contributions from a random forest model from package randomForest. Feature contributions provide detailed information about the relationship between data variables and the predicted value returned by random forest model.

This package tests the goodness of fit of a distribution of offspring to the Normal, Poisson, and Gamma distribution and estimates the proportional paternity of the second male (P2) based on the best fit distribution.

This is a package for the manipulation of genetic data (SNPs). Computation of genetic relationship matrix (GRM) and dominance matrix, linkage disequilibrium (LD), and heritability with efficient algorithms for linear mixed models (AIREML).

This package provides tools for making the descriptive "Table 1" used in medical articles, a transition plot for showing changes between categories (also known as a Sankey diagram), flow charts by extending the grid package, a method for variable selection based on the SVD, Bezier lines with arrows complementing the ones in the grid package, and more.

Designed for simplicity, a mirai evaluates an R expression asynchronously in a parallel process, locally or distributed over the network. The result is automatically available upon completion. Modern networking and concurrency, built on nanonext and NNG (Nanomsg Next Gen), ensures reliable and efficient scheduling over fast inter-process communications or TCP/IP secured by TLS. Distributed computing can launch remote resources via SSH or cluster managers. An inherently queued architecture handles many more tasks than available processes, and requires no storage on the file system. Innovative features include support for otherwise non-exportable reference objects, event-driven promises, and asynchronous parallel map.

This package provides a general framework for high-dimensional undirected graph estimation. It integrates data preprocessing, neighborhood screening, graph estimation, and model selection techniques into a pipeline.

This package provides a differential evolution (DE) stochastic algorithms for global optimization of problems with and without constraints. The aim is to curate a collection of its state-of-the-art variants that

1. do not sacrifice simplicity of design,

2. are essentially tuning-free, and

3. can be efficiently implemented directly in the R language.

This package contains some functions to help users (especially data explorers) to make more sense of their variables and take the most out of variables and hardware resources. Functions in this package are supposed to be efficient and easy to use.

This package provides a fast dimensionality reduction method scalable to large numbers of samples. Landmark Multi-Dimensional Scaling (LMDS) is an extension of classical Torgerson MDS, but rather than calculating a complete distance matrix between all pairs of samples, only the distances between a set of landmarks and the samples are calculated.

This package provides a collection of artificial and real-world machine learning benchmark problems, including, e.g., several data sets from the UCI repository.

This is a package for estimation and inference from generalized linear models based on various methods for bias reduction and maximum penalized likelihood with powers of the Jeffreys prior as penalty. The brglmFit fitting method can achieve reduction of estimation bias by solving either the mean bias-reducing adjusted score equations in Firth (1993) <doi:10.1093/biomet/80.1.27> and Kosmidis and Firth (2009) <doi:10.1093/biomet/asp055>, or the median bias-reduction adjusted score equations in Kenne et al. (2017) <doi:10.1093/biomet/asx046>, or through the direct subtraction of an estimate of the bias of the maximum likelihood estimator from the maximum likelihood estimates as in Cordeiro and McCullagh (1991) <https://www.jstor.org/stable/2345592>.

This package provides a simple interface for creating active bindings where the bound function accepts additional arguments.

spacetime provides classes and methods for spatio-temporal data, including space-time regular lattices, sparse lattices, irregular data, and trajectories; utility functions for plotting data as map sequences (lattice or animation) or multiple time series; methods for spatial and temporal matching or aggregation, retrieving coordinates, print, summary, etc.

This package provides an API for efficient .hic file data extraction with programmatic matrix access. It doesn't store the pointer data for all the matrices, only the one queried, and currently it only supports matrices.

This package wraps the AntiWord utility to extract text from Microsoft Word documents. The utility only supports the old doc format, not the new XML based docx format. Use the xml2 package to read the latter.

This package implements various estimators of entropy, such as the shrinkage estimator by Hausser and Strimmer, the maximum likelihood and the Millow-Madow estimator, various Bayesian estimators, and the Chao-Shen estimator. It also offers an R interface to the NSB estimator. Furthermore, it provides functions for estimating Kullback-Leibler divergence, chi-squared, mutual information, and chi-squared statistic of independence. In addition there are functions for discretizing continuous random variables.

This tool provides methods for aggregating ranked lists, especially lists of genes. It implements the Robust Rank Aggregation and other simple algorithms for the task. RRA method uses a probabilistic model for aggregation that is robust to noise and also facilitates the calculation of significance probabilities for all the elements in the final ranking.

This package implements various measures of information theory based on several entropy estimators.

This package provides a toolset for functional enrichment analysis and visualization, gene/protein/SNP identifier conversion and mapping orthologous genes across species via g:Profiler. The main tools are:

1. g:GOSt, functional enrichment analysis and visualization of gene lists;

2. g:Convert, gene/protein/transcript identifier conversion across various namespaces;

3. g:Orth, orthology search across species;

4. g:SNPense, mapping SNP rs identifiers to chromosome positions, genes and variant effects.

This package is an R interface corresponding to the 2019 update of g:Profiler and provides access to versions e94_eg41_p11 and higher.

This library lets you place an exclusive or shared lock on a file using the appropriate system call provided by the underlying operating system.

This package serves two purposes:

1. Provide a comfortable R interface to query the Google server for static maps, and

2. Use the map as a background image to overlay plots within R. This requires proper coordinate scaling.

This is a package for converting natural language text into tokens. It includes tokenizers for shingled n-grams, skip n-grams, words, word stems, sentences, paragraphs, characters, shingled characters, lines, tweets, Penn Treebank, regular expressions, as well as functions for counting characters, words, and sentences, and a function for splitting longer texts into separate documents, each with the same number of words. The tokenizers have a consistent interface, and the package is built on the stringi and Rcpp packages for fast yet correct tokenization in UTF-8 encoding.

This package provides tools to obtain estimated marginal means (EMMs) for many linear, generalized linear, and mixed models. It can be used to compute contrasts or linear functions of EMMs, trends, and comparisons of slopes.