This package provides a likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) <doi:10.1002/pst.1661>.

Some very simple infrastructure for basis functions.

This project aims to enable the method of Path Analysis to infer causalities from data. For this we propose a hybrid approach, which uses Bayesian network structure learning algorithms from data to create the input file for creation of a PA model. The process is performed in a semi-automatic way by our intermediate algorithm, allowing novice researchers to create and evaluate their own PA models from a data set. The references used for this project are: Koller, D., & Friedman, N. (2009). Probabilistic graphical models: principles and techniques. MIT press. <doi:10.1017/S0269888910000275>. Nagarajan, R., Scutari, M., & Lèbre, S. (2013). Bayesian networks in r. Springer, 122, 125-127. Scutari, M., & Denis, J. B. <doi:10.1007/978-1-4614-6446-4>. Scutari M (2010). Bayesian networks: with examples in R. Chapman and Hall/CRC. <doi:10.1201/b17065>. Rosseel, Y. (2012). lavaan: An R Package for Structural Equation Modeling. Journal of Statistical Software, 48(2), 1 - 36. <doi:10.18637/jss.v048.i02>.

Fits smoothing spline regression models using scalable algorithms designed for large samples. Seven marginal spline types are supported: linear, cubic, different cubic, cubic periodic, cubic thin-plate, ordinal, and nominal. Random effects and parametric effects are also supported. Response can be Gaussian or non-Gaussian: Binomial, Poisson, Gamma, Inverse Gaussian, or Negative Binomial.

BAYesian inference for MEDical designs in R. Functions for the computation of Bayes factors for common biomedical research designs. Implemented are functions to test the equivalence (equiv_bf), non-inferiority (infer_bf), and superiority (super_bf) of an experimental group compared to a control group on a continuous outcome measure. Bayes factors for these three tests can be computed based on raw data (x, y) or summary statistics (n_x, n_y, mean_x, mean_y, sd_x, sd_y [or ci_margin and ci_level]).

Data sets for book "Basic Statistics and Data Analysis" by Larry J. Kitchens.

This package provides a framework for data manipulation and visualization using a web-based point and click user interface where analysis pipelines are decomposed into re-usable and parameterizable blocks.

Implementation of the Generalized Pairwise Comparisons (GPC) as defined in Buyse (2010) <doi:10.1002/sim.3923> for complete observations, and extended in Peron (2018) <doi:10.1177/0962280216658320> to deal with right-censoring. GPC compare two groups of observations (intervention vs. control group) regarding several prioritized endpoints to estimate the probability that a random observation drawn from one group performs better/worse/equivalently than a random observation drawn from the other group. Summary statistics such as the net treatment benefit, win ratio, or win odds are then deduced from these probabilities. Confidence intervals and p-values are obtained based on asymptotic results (Ozenne 2021 <doi:10.1177/09622802211037067>), non-parametric bootstrap, or permutations. The software enables the use of thresholds of minimal importance difference, stratification, non-prioritized endpoints (O Brien test), and can handle right-censoring and competing-risks.

BabyTime is an application for tracking infant and toddler care activities like sleeping, eating, etc. This package will take the outputted .zip files and parse it into a usable list object with cleaned data. It handles malformed and incomplete data gracefully and is designed to parse one directory at a time.

This package performs estimation of marginal treatment effects for binary outcomes when using logistic regression working models with covariate adjustment (see discussions in Magirr et al (2024) <https://osf.io/9mp58/>). Implements the variance estimators of Ge et al (2011) <doi:10.1177/009286151104500409> and Ye et al (2023) <doi:10.1080/24754269.2023.2205802>.

We provide a framework for testing the probability of ruin in the classical (compound Poisson) risk process. It also includes some procedures for assessing and comparing the performance between the bootstrap test and the test using asymptotic normality.

This package implements the Bayesian Synthetic Control method for causal inference in comparative case studies. This package provides tools for estimating treatment effects in settings with a single treated unit and multiple control units, allowing for uncertainty quantification and flexible modeling of time-varying effects. The methodology is based on the paper by Vives and Martinez (2022) <doi:10.48550/arXiv.2206.01779>.

Nuclear magnetic resonance (NMR) is a highly versatile analytical technique for studying molecular configuration, conformation, and dynamics, especially those of biomacromolecules such as proteins. Biological Magnetic Resonance Data Bank ('BMRB') is a repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules. Currently, BMRB offers an R package RBMRB to fetch data, however, it doesn't easily offer individual data file downloading and storing in a local directory. When using RBMRB', the data will stored as an R object, which fundamentally hinders the NMR researches to access the rich information from raw data, for example, the metadata. Here, BMRBr File Downloader ('BMRBr') offers a more fundamental, low level downloader, which will download original deposited .str format file. This type of file contains information such as entry title, authors, citation, protein sequences, and so on. Many factors affect NMR experiment outputs, such as temperature, resonance sensitivity and etc., approximately 40% of the entries in the BMRB have chemical shift accuracy problems [1,2] Unfortunately, current reference correction methods are heavily dependent on the availability of assigned protein chemical shifts or protein structure. This is my current research project is going to solve, which will be included in the future release of the package. The current version of the package is sufficient and robust enough for downloading individual BMRB data file from the BMRB database <http://www.bmrb.wisc.edu>. The functionalities of this package includes but not limited: * To simplifies NMR researches by combine data downloading and results analysis together. * To allows NMR data reaches a broader audience that could utilize more than just chemical shifts but also metadata. * To offer reference corrected data for entries without assignment or structure information (future release). Reference: [1] E.L. Ulrich, H. Akutsu, J.F. Doreleijers, Y. Harano, Y.E. Ioannidis, J. Lin, et al., BioMagResBank, Nucl. Acids Res. 36 (2008) D402â 8. <doi:10.1093/nar/gkm957>. [2] L. Wang, H.R. Eghbalnia, A. Bahrami, J.L. Markley, Linear analysis of carbon-13 chemical shift differences and its application to the detection and correction of errors in referencing and spin system identifications, J. Biomol. NMR. 32 (2005) 13â 22. <doi:10.1007/s10858-005-1717-0>.

This package provides a set of functions to select the optimal block-length for a dependent bootstrap (block-bootstrap). Includes the Hall, Horowitz, and Jing (1995) <doi:10.1093/biomet/82.3.561> subsampling-based cross-validation method, the Politis and White (2004) <doi:10.1081/ETC-120028836> Spectral Density Plug-in method, including the Patton, Politis, and White (2009) <doi:10.1080/07474930802459016> correction, and the Lahiri, Furukawa, and Lee (2007) <doi:10.1016/j.stamet.2006.08.002> nonparametric plug-in method, with a corresponding set of S3 plot methods.

Computations for Bessel function for complex, real and partly mpfr (arbitrary precision) numbers; notably interfacing TOMS 644; approximations for large arguments, experiments, etc.

Subgroup analyses are routinely performed in clinical trial analyses. From a methodological perspective, two key issues of subgroup analyses are multiplicity (even if only predefined subgroups are investigated) and the low sample sizes of subgroups which lead to highly variable estimates, see e.g. Yusuf et al (1991) <doi:10.1001/jama.1991.03470010097038>. This package implements subgroup estimates based on Bayesian shrinkage priors, see Carvalho et al (2019) <https://proceedings.mlr.press/v5/carvalho09a.html>. In addition, estimates based on penalized likelihood inference are available, based on Simon et al (2011) <doi:10.18637/jss.v039.i05>. The corresponding shrinkage based forest plots address the aforementioned issues and can complement standard forest plots in practical clinical trial analyses.

Prognostic Enrichment is a clinical trial strategy of evaluating an intervention in a patient population with a higher rate of the unwanted event than the broader patient population (R. Temple (2010) <DOI:10.1038/clpt.2010.233>). A higher event rate translates to a lower sample size for the clinical trial, which can have both practical and ethical advantages. This package is a tool to help evaluate biomarkers for prognostic enrichment of clinical trials.

This package implements the Block-wise Rank in Similarity Graph Edge-count test (BRISE), a rank-based two-sample test designed for block-wise missing data. The method constructs (pattern) pair-wise similarity graphs and derives quadratic test statistics with asymptotic chi-square distribution or permutation-based p-values. It provides both vectorized and congregated versions for flexible inference. The methodology is described in Zhang, Liang, Maile, and Zhou (2025) <doi:10.48550/arXiv.2508.17411>.

Fully Bayesian Classification with a subset of high-dimensional features, such as expression levels of genes. The data are modeled with a hierarchical Bayesian models using heavy-tailed t distributions as priors. When a large number of features are available, one may like to select only a subset of features to use, typically those features strongly correlated with the response in training cases. Such a feature selection procedure is however invalid since the relationship between the response and the features has be exaggerated by feature selection. This package provides a way to avoid this bias and yield better-calibrated predictions for future cases when one uses F-statistic to select features.

This package implements the distance measure for mixed-scale variables proposed by Buttler and Fickel (1995), based on normalized mean pairwise distances (Gini mean difference), and an R2 statistic to assess clustering quality.

This package provides a tool to perform all different statistical tests and calculations needed by Biological dosimetry Laboratories. Detailed documentation is available in <https://biodosetools-team.github.io/documentation/>.

This package provides a collection of functions for downloading and processing automatic weather station (AWS) data from INMET (Brazilâ s National Institute of Meteorology), designed to support the estimation of reference evapotranspiration (ETo). The package facilitates streamlined access to meteorological data and aims to simplify analyses in agricultural and environmental contexts.

Fast Bayesian estimation and forecasting of age-specific rates, probabilities, and means, based on Template Model Builder'.

Several tools for analyzing diagnostic tests and 2x2 contingency tables are provided. In particular, positive and negative predictive values for a diagnostic tests can be calculated from prevalence, sensitivity and specificity values. For contingency tables, relative risk and odds ratio measures are estimated. Furthermore, confidence intervals are provided.