This package implements the TWO-Component Single Cell Model-Based Association Method (TWO-SIGMA) for gene-level differential expression (DE) analysis and DE-based gene set testing of single-cell RNA-sequencing datasets. See Van Buren et al. (2020) <doi:10.1002/gepi.22361> and Van Buren et al. (2021) <doi:10.1101/2021.01.24.427979>.

Analysis and visualization of data from temporal sensory methods, including for temporal check-all-that-apply (TCATA) and temporal dominance of sensations (TDS). Methods are mainly from manuscripts by Castura, J.C., Antúnez, L., Giménez, A., and Ares, G. (2016) <doi:10.1016/j.foodqual.2015.06.017>, Castura, Baker, and Ross (2016) <doi:10.1016/j.foodqual.2016.06.011>, and Pineau et al. (2009) <doi:10.1016/j.foodqual.2009.04.005>.

Obtaining relevant set of trait specific genes from gene expression data is important for clinical diagnosis of disease and discovery of disease mechanisms in plants and animals. This process involves identification of relevant genes and removal of redundant genes as much as possible from a whole gene set. This package returns the trait specific gene set from the high dimensional RNA-seq count data by applying combination of two conventional machine learning algorithms, support vector machine (SVM) and genetic algorithm (GA). GA is used to control and optimize the subset of genes sent to the SVM for classification and evaluation. Genetic algorithm uses repeated learning steps and cross validation over number of possible solution and selects the best. The algorithm selects the set of genes based on a fitness function that is obtained via support vector machines. Using SVM as the classifier performance and the genetic algorithm for feature selection, a set of trait specific gene set is obtained.

This package provides functions to get personal Google Scholar profile data from web API and show it in table or figure format.

This package provides a tidy workflow for generating, estimating, reporting, and plotting structural equation models using lavaan', OpenMx', or Mplus'. Throughout this workflow, elements of syntax, results, and graphs are represented as tidy data, making them easy to customize. Includes functionality to estimate latent class analyses, and to plot dagitty and igraph objects.

Calculate optimal Zhong's two-/three-stage Phase II designs (see Zhong (2012) <doi:10.1016/j.cct.2012.07.006>). Generate Target Toxicity decision table for Phase I dose-finding (two-/three-stage). This package also allows users to run dose-finding simulations based on customized decision table.

Estimators for semi-parametric linear regression models with truncated response variables (fixed truncation point). The estimators implemented are the Symmetrically Trimmed Least Squares (STLS) estimator introduced by Powell (1986) <doi:10.2307/1914308>, the Quadratic Mode (QME) estimator introduced by Lee (1993) <doi:10.1016/0304-4076(93)90056-B>, and the Left Truncated (LT) estimator introduced by Karlsson (2006) <doi:10.1007/s00184-005-0023-x>.

This package provides a pipeline of tools for analysing circadian time-series data using functional data analysis (FDA). The package supports smoothing of rhythmic time series, functional principle component analysis (FPCA), and extraction of group-level traits from functional representations. Analyses can incorporate multiple curve derivatives and optional temporal segmentation, enabling comparative analysis of circadian dynamics across experimental groups and time windows.

Transforms long data into a matrix form to allow for ease of input into modelling packages for regression, principal components, imputation or machine learning. It does this by pivoting on user defined columns, generating a key-value table for variable names to ensure one-to-one mappings are preserved. It is particularly useful when the indicator names in the columns are long descriptive strings, for example "Energy imports, net (% of energy use)". High level analysis wrapper functions for correlation and principal components analysis are provided.

This package provides tidyverse methods for wrangling and analyzing Earth Engine <https://earthengine.google.com/> data. These methods help the user with filtering, joining and summarising Earth Engine image collections.

Forecasting of long memory time series in presence of structural break by using TSF algorithm by Papailias and Dias (2015) <doi:10.1016/j.ijforecast.2015.01.006>.

Feasible Multivariate Generalized Autoregressive Conditional Heteroscedasticity (GARCH) models including Dynamic Conditional Correlation (DCC), Copula GARCH and Generalized Orthogonal GARCH with Generalized Hyperbolic distribution. A review of some of these models can be found in Boudt, Galanos, Payseur and Zivot (2019) <doi:10.1016/bs.host.2019.01.001>.

Variant determination and genotyping from high throughput sequences from multilocus amplicon libraries, typically sequenced in Illumina MiSeq or similar. It provides a set of core functions for the central steps: demultiplex by locus, truncate reads, variant calling, and genotype calling. Additionally, it provides a set of functions for diagnosis and estimation of best running parameters and multiple extensions for genotype/variants manipulation and reformatting. Output variants and genotypes are output in tidy format, thus facilitating reformatting, manipulation and potential connection to other R packages.

This package provides tools for estimating and inferring two-way partial area under receiver operating characteristic curves (two-way pAUC), partial area under receiver operating characteristic curves (pAUC), and partial area under ordinal dominance curves (pODC). Methods includes Mann-Whitney statistic and Jackknife, etc.

Visualisation, analysis and quality control of conversational data. Rapid and visual insights into the nature, timing and quality of time-aligned annotations in conversational corpora. For more details, see Dingemanse et al., (2022) <doi:10.18653/v1/2022.acl-long.385>.

Builds tables with customizable rows. Users can specify the type of data to use for each row, as well as how to handle missing data and the types of comparison tests to run on the table columns.

Bayesian trophic position models using stan by leveraging brms for stable isotope data. Trophic position models are derived by using equations from Post (2002) <doi:10.1890/0012-9658(2002)083[0703:USITET]2.0.CO;2>, Vander Zanden and Vadeboncoeur (2002) <doi:10.1890/0012-9658(2002)083[2152:FAIOBA]2.0.CO;2>, and Heuvel et al. (2024) <doi:10.1139/cjfas-2024-0028>.

This package provides a unified tidyverse-compatible interface to R's machine learning packages. Wraps established implementations from glmnet', randomForest', xgboost', e1071', rpart', gbm', nnet', cluster', dbscan', and others - providing consistent function signatures, tidy tibble output, and unified ggplot2'-based visualization. The underlying algorithms are unchanged; tidylearn simply makes them easier to use together. Access raw model objects via the $fit slot for package-specific functionality. Methods include random forests Breiman (2001) <doi:10.1023/A:1010933404324>, LASSO regression Tibshirani (1996) <doi:10.1111/j.2517-6161.1996.tb02080.x>, elastic net Zou and Hastie (2005) <doi:10.1111/j.1467-9868.2005.00503.x>, support vector machines Cortes and Vapnik (1995) <doi:10.1007/BF00994018>, and gradient boosting Friedman (2001) <doi:10.1214/aos/1013203451>.

This package provides functions for compounding and discounting calculations included here serve as a complete reference for various scenarios of time value of money. Raymond M. Brooks (â Financial Management,â 2018, ISBN: 9780134730417). Sheridan Titman, Arthur J. Keown, John D. Martin (â Financial Management: Principles and Applications,â 2017, ISBN: 9780134417219). Jonathan Berk, Peter DeMarzo, David Stangeland, Andras Marosi (â Fundamentals of Corporate Finance,â 2019, ISBN: 9780134735313). S. A. Hummelbrunner, Kelly Halliday, Ali R. Hassanlou (â Contemporary Business Mathematics with Canadian Applications,â 2020, ISBN: 9780135285015).

Articles in the R Journal were first authored in LaTeX', which performs admirably for PDF files but is less than ideal for modern online interfaces. The texor package does all the transitional chores and conversions necessary to move to the online versions.

It creates an invisible layer that allow to see the Seurat object as tibble and interact seamlessly with the tidyverse.

The analysis of microarray time series promises a deeper insight into the dynamics of the cellular response following stimulation. A common observation in this type of data is that some genes respond with quick, transient dynamics, while other genes change their expression slowly over time. The existing methods for detecting significant expression dynamics often fail when the expression dynamics show a large heterogeneity. Moreover, these methods often cannot cope with irregular and sparse measurements. The method proposed here is specifically designed for the analysis of perturbation responses. It combines different scores to capture fast and transient dynamics as well as slow expression changes, and performs well in the presence of low replicate numbers and irregular sampling times. The results are given in the form of tables including links to figures showing the expression dynamics of the respective transcript. These allow to quickly recognise the relevance of detection, to identify possible false positives and to discriminate early and late changes in gene expression. An extension of the method allows the analysis of the expression dynamics of functional groups of genes, providing a quick overview of the cellular response. The performance of this package was tested on microarray data derived from lung cancer cells stimulated with epidermal growth factor (EGF). Paper: Albrecht, Marco, et al. (2017)<DOI:10.1186/s12859-016-1440-8>.

Visualize your Tidyverse data analysis pipelines via the Tidy Data Tutor'(<https://tidydatatutor.com/>) web application.

Include the Twitter status widgets in HTML pages created using R markdown. The package uses the Twitter javascript APIs to embed in your document Twitter cards associated to specific statuses. The main targets are regular HTML pages or dashboards.