Linear and logistic regression models penalized with hierarchical shrinkage priors for selection of biomarkers (or more general variable selection), which can be fitted using Stan (Carpenter et al. (2017) <doi:10.18637/jss.v076.i01>). It implements the horseshoe and regularized horseshoe priors (Piironen and Vehtari (2017) <doi:10.1214/17-EJS1337SI>), as well as the projection predictive selection approach to recover a sparse set of predictive biomarkers (Piironen, Paasiniemi and Vehtari (2020) <doi:10.1214/20-EJS1711>).

This package provides a correlation-based batch process for fast, accurate imputation for high dimensional missing data problems via chained random forests. See Waggoner (2023) <doi:10.1007/s00180-023-01325-9> for more on hdImpute', Stekhoven and Bühlmann (2012) <doi:10.1093/bioinformatics/btr597> for more on missForest', and Mayer (2022) <https://github.com/mayer79/missRanger> for more on missRanger'.

This package contains the National Health and Nutrition Examination Survey 24-hour dietary recall data and Healthy Eating Index scoring standards used by the heiscore package.

This package provides functionality to download and cache files from Hugging Face Hub <https://huggingface.co/models>. Uses the same caching structure so files can be shared between different client libraries.

Computes the ACMIF test and Bonferroni-adjusted p-value of interaction in two-factor studies. Produces corresponding interaction plot and analysis of variance tables and p-values from several other tests of non-additivity.

Estimates the shape and volume of high-dimensional datasets and performs set operations: intersection / overlap, union, unique components, inclusion test, and hole detection. Uses stochastic geometry approach to high-dimensional kernel density estimation, support vector machine delineation, and convex hull generation. Applications include modeling trait and niche hypervolumes and species distribution modeling.

This package provides functions to estimate population genetics summary statistics from haplo-diploid systems, where one sex is haploid and the other diploid (e.g. Hymenoptera insects). It implements a theoretical model assuming equal sex ratio, random mating, no selection, no mutation, and no gene flow, deriving expected genotype frequencies for both sexes under these equilibrium conditions. The package includes windowed calculations (operating over genomic sliding windows from VCF input) for allele and genotype frequencies, the inbreeding coefficient (Fis), pairwise Fst, Nei's H (gene diversity), Watterson's Theta, and sex-specific reference allele frequencies. Most statistics are agnostic to ploidy, allowing the package to be applied to both strictly haplo-diploid and fully diploid systems.

Facilitates building topology preserving maps for data analysis.

This package provides a handy collection of utility functions designed to aid in package development, plotting and scientific research. Package development functionalities includes among others tools such as cross-referencing package imports with the description file, analysis of redundant package imports, editing of the description file and the creation of package badges for GitHub. Some of the other functionalities include automatic package installation and loading, plotting points without overlap, creating nice breaks for plots, overview tables and many more handy utility functions.

Develops algorithms for fitting, prediction, simulation and initialization of the following models (1)- hidden hybrid Markov/semi-Markov model, introduced by Guedon (2005) <doi:10.1016/j.csda.2004.05.033>, (2)- nonparametric mixture of B-splines emissions (Langrock et al., 2015 <doi:10.1111/biom.12282>), (3)- regime switching regression model (Kim et al., 2008 <doi:10.1016/j.jeconom.2007.10.002>) and auto-regressive hidden hybrid Markov/semi-Markov model, (4)- spline-based nonparametric estimation of additive state-switching models (Langrock et al., 2018 <doi:10.1111/stan.12133>) (5)- robust emission model proposed by Qin et al, 2024 <doi:10.1007/s10479-024-05989-4> (6)- several emission distributions, including mixture of multivariate normal (which can also handle missing data using EM algorithm) and multi-nomial emission (for modeling polymer or DNA sequences) (7)- tools for prediction of future state sequence, computing the score of a new sequence, splitting the samples and sequences to train and test sets, computing the information measures of the models, computing the residual useful lifetime (reliability) and many other useful tools ... (read for more description: Amini et al., 2022 <doi:10.1007/s00180-022-01248-x> and its arxiv version: <doi:10.48550/arXiv.2109.12489>).

Calculate expected relative risk and proportion protected assuming normally distributed log10 transformed antibody dose for a several component vaccine. Uses Hill models for each component which are combined under Bliss independence. See Saul and Fay, 2007 <DOI:10.1371/journal.pone.0000850>.

Simulates stochastic hybrid models for transmission of infectious diseases in dynamic networks. It is a metapopulation model in which each node in the network is a sub-population and disease spreads within nodes and among them, combining two approaches: stochastic simulation algorithm (<doi:10.1146/annurev.physchem.58.032806.104637>) and individual-based approach, respectively. Equations that models spread within nodes are customizable and there are two link types among nodes: migration and influence (commuting). More information in Fernando S. Marques, Jose H. H. Grisi-Filho, Marcos Amaku et al. (2020) <doi:10.18637/jss.v094.i06>.

Makes it easy to extract and combine variables from the HILDA (Household, Income and Labour Dynamics in Australia) survey maintained by the Melbourne Institute <https://melbourneinstitute.unimelb.edu.au/hilda>.

This package implements the method developed by Cao and Kosorok (2011) for the significance analysis of thousands of features in high-dimensional biological studies. It is an asymptotically valid data-driven procedure to find critical values for rejection regions controlling the k-familywise error rate, false discovery rate, and the tail probability of false discovery proportion.

Enables chat completion and text annotation with local and OpenAI <https://openai.com/> language models, supporting batch processing, multiple annotators, and consistent output formats.

Calculate an optimal embedding of a set of data points into low-dimensional hyperbolic space. This uses the strain-minimizing hyperbolic embedding of Keller-Ressel and Nargang (2019), see <arXiv:1903.08977>.

Automatically displays the order and spatial weighting matrix of the distance between locations. This concept was derived from the research of Mubarak, Aslanargun, and Siklar (2021) <doi:10.52403/ijrr.20211150> and Mubarak, Aslanargun, and Siklar (2022) <doi:10.17654/0972361722052>. Distance data between locations can be imported from Ms. Excel', maps package or created in R programming directly. This package also provides 5 simulations of distances between locations derived from fictitious data, the maps package, and from research by Mubarak, Aslanargun, and Siklar (2022) <doi:10.29244/ijsa.v6i1p90-100>.

Offers efficient algorithms for fitting regularization paths for lasso or elastic-net penalized regression models with Huber loss, quantile loss or squared loss. Reference: Congrui Yi and Jian Huang (2017) <doi:10.1080/10618600.2016.1256816>.

Used for predicting a genotypeâ s allelic state at a specific locus/QTL/gene. This is accomplished by using both a genotype matrix and a separate file which has categorizations about loci/QTL/genes of interest for the individuals in the genotypic matrix. A training population can be created from a panel of individuals who have been previously screened for specific loci/QTL/genes, and this previous screening could be summarized into a category. Using the categorization of individuals which have been genotyped using a genome wide marker platform, a model can be trained to predict what category (haplotype) an individual belongs in based on their genetic sequence in the region associated with the locus/QTL/gene. These trained models can then be used to predict the haplotype of a locus/QTL/gene for individuals which have been genotyped with a genome wide platform yet not genotyped for the specific locus/QTL/gene. This package is based off work done by Winn et al 2021. For more specific information on this method, refer to <doi:10.1007/s00122-022-04178-w>.

Can be used for paternity and maternity assignment and outperforms conventional methods where closely related individuals occur in the pool of possible parents. The method compares the genotypes of offspring with any combination of potentials parents and scores the number of mismatches of these individuals at bi-allelic genetic markers (e.g. Single Nucleotide Polymorphisms). It elaborates on a prior exclusion method based on the Homozygous Opposite Test (HOT; Huisman 2017 <doi:10.1111/1755-0998.12665>) by introducing the additional exclusion criterion HIPHOP (Homozygous Identical Parents, Heterozygous Offspring are Precluded; Cockburn et al., in revision). Potential parents are excluded if they have more mismatches than can be expected due to genotyping error and mutation, and thereby one can identify the true genetic parents and detect situations where one (or both) of the true parents is not sampled. Package hiphop can deal with (a) the case where there is contextual information about parentage of the mother (i.e. a female has been seen to be involved in reproductive tasks such as nest building), but paternity is unknown (e.g. due to promiscuity), (b) where both parents need to be assigned, because there is no contextual information on which female laid eggs and which male fertilized them (e.g. polygynandrous mating system where multiple females and males deposit young in a common nest, or organisms with external fertilisation that breed in aggregations). For details: Cockburn, A., Penalba, J.V.,Jaccoud, D.,Kilian, A., Brouwer, L., Double, M.C., Margraf, N., Osmond, H.L., van de Pol, M. and Kruuk, L.E.B. (in revision). HIPHOP: improved paternity assignment among close relatives using a simple exclusion method for bi-allelic markers. Molecular Ecology Resources, DOI to be added upon acceptance.

An important environmental impact on running water ecosystems is caused by hydropeaking - the discontinuous release of turbine water because of peaks of energy demand. An event-based algorithm is implemented to detect flow fluctuations referring to increase events (IC) and decrease events (DC). For each event, a set of parameters related to the fluctuation intensity is calculated. The framework is introduced in Greimel et al. (2016) "A method to detect and characterize sub-daily flow fluctuations" <doi:10.1002/hyp.10773> and can be used to identify different fluctuation types according to the potential source: e.g., sub-daily flow fluctuations caused by hydropeaking, rainfall, or snow and glacier melt. This is a companion to the package hydroroute', which is used to detect and follow hydropower plant-specific hydropeaking waves at the sub-catchment scale and to describe how hydropeaking flow parameters change along the longitudinal flow path as proposed and validated in Greimel et al. (2022).

Given a high-dimensional dataset that typically represents a cytometry dataset, and a subset of the datapoints, this algorithm outputs an hyperrectangle so that datapoints within the hyperrectangle best correspond to the specified subset. In essence, this allows the conversion of clustering algorithms outputs to gating strategies outputs.

HDF5 (Hierarchical Data Format 5) is a high-performance library and file format for storing and managing large, complex data. This package provides the static libraries and headers for the HDF5 C library (release 2.0.0). It is intended for R package developers to use in the LinkingTo field, which eliminates the need for users to install system-level HDF5 dependencies. This build is compiled with thread-safety enabled and supports dynamic loading of external compression filters. HDF5 is developed by The HDF Group <https://www.hdfgroup.org/>.

Hadoop InteractiVE facilitates distributed computing via the MapReduce paradigm through R and Hadoop. An easy to use interface to Hadoop, the Hadoop Distributed File System (HDFS), and Hadoop Streaming is provided.