Offers the Generalized Berk-Jones (GBJ) test for set-based inference in genetic association studies. The GBJ is designed as an alternative to tests such as Berk-Jones (BJ), Higher Criticism (HC), Generalized Higher Criticism (GHC), Minimum p-value (minP), and Sequence Kernel Association Test (SKAT). All of these other methods (except for SKAT) are also implemented in this package, and we additionally provide an omnibus test (OMNI) which integrates information from each of the tests. The GBJ has been shown to outperform other tests in genetic association studies when signals are correlated and moderately sparse. Please see the vignette for a quickstart guide or Sun and Lin (2017) <arXiv:1710.02469> for more details.

The Gaussian Interval Plot (GIplot) is a pictorial representation of the mean and the standard deviation of a quantitative variable. It also flags potential outliers (together with their frequencies) that are c standard deviations away from the mean.

Graph clustering using an agglomerative algorithm to maximize the integrated classification likelihood criterion and a mixture of stochastic block models. The method is described in the article "Model-based clustering of multiple networks with a hierarchical algorithm" by T. Rebafka (2022) <arXiv:2211.02314>.

Create R functions that interact with OAuth2 Google APIs <https://developers.google.com/apis-explorer/> easily, with auto-refresh and Shiny compatibility.

Multivariate time series analysis based on Generalized Space-Time Autoregressive Model by Ruchjana et al.(2012) <doi:10.1063/1.4724118>.

This package provides a collection of fast k-means clustering algorithms under a single, uniform interface. The core method is Geometric-k-means, a bound-free algorithm of Sharma et al. (2026) <doi:10.1007/s10994-025-06891-1> that uses geometry to restrict computation to the data points able to change clusters, substantially reducing distance computations and runtime while returning the same result as standard k-means. Also included are Lloyd's algorithm, Elkan, Hamerly, Annulus, Exponion, and Ball k-means. All algorithms are implemented in C++ via Rcpp and RcppEigen and return the final centroids, optional per-point cluster assignments, and computational statistics.

Model and estimate the model parameters for the spatial model of individual-level infectious disease transmission in Susceptible-Infected-Recovered (SIR) framework.

Calculate different glucose variability measures, including average measures of glycemia, measures of glycemic variability and measures of glycemic risk, from continuous glucose monitoring data. Boris P. Kovatchev, Erik Otto, Daniel Cox, Linda Gonder-Frederick, and William Clarke (2006) <doi:10.2337/dc06-1085>. Jean-Pierre Le Floch, Philippe Escuyer, Eric Baudin, Dominique Baudon, and Leon Perlemuter (1990) <doi:10.2337/diacare.13.2.172>. C.M. McDonnell, S.M. Donath, S.I. Vidmar, G.A. Werther, and F.J. Cameron (2005) <doi:10.1089/dia.2005.7.253>. Everitt, Brian (1998) <doi:10.1111/j.1751-5823.2011.00149_2.x>. Becker, R. A., Chambers, J. M. and Wilks, A. R. (1988) <doi:10.2307/2234167>. Dougherty, R. L., Edelman, A. and Hyman, J. M. (1989) <doi:10.1090/S0025-5718-1989-0962209-1>. Tukey, J. W. (1977) <doi:10.1016/0377-2217(86)90209-2>. F. John Service (2013) <doi:10.2337/db12-1396>. Edmond A. Ryan, Tami Shandro, Kristy Green, Breay W. Paty, Peter A. Senior, David Bigam, A.M. James Shapiro, and Marie-Christine Vantyghem (2004) <doi:10.2337/diabetes.53.4.955>. F. John Service, George D. Molnar, John W. Rosevear, Eugene Ackerman, Leal C. Gatewood, William F. Taylor (1970) <doi:10.2337/diab.19.9.644>. Sarah E. Siegelaar, Frits Holleman, Joost B. L. Hoekstra, and J. Hans DeVries (2010) <doi:10.1210/er.2009-0021>. Gabor Marics, Zsofia Lendvai, Csaba Lodi, Levente Koncz, David Zakarias, Gyorgy Schuster, Borbala Mikos, Csaba Hermann, Attila J. Szabo, and Peter Toth-Heyn (2015) <doi:10.1186/s12938-015-0035-3>. Thomas Danne, Revital Nimri, Tadej Battelino, Richard M. Bergenstal, Kelly L. Close, J. Hans DeVries, SatishGarg, Lutz Heinemann, Irl Hirsch, Stephanie A. Amiel, Roy Beck, Emanuele Bosi, Bruce Buckingham, ClaudioCobelli, Eyal Dassau, Francis J. Doyle, Simon Heller, Roman Hovorka, Weiping Jia, Tim Jones, Olga Kordonouri,Boris Kovatchev, Aaron Kowalski, Lori Laffel, David Maahs, Helen R. Murphy, Kirsten Nørgaard, Christopher G.Parkin, Eric Renard, Banshi Saboo, Mauro Scharf, William V. Tamborlane, Stuart A. Weinzimer, and Moshe Phillip.International consensus on use of continuous glucose monitoring.Diabetes Care, 2017 <doi:10.2337/dc17-1600>.

Compute bivariate dependence measures and perform bivariate competing risks analysis under the generalized Farlie-Gumbel-Morgenstern (FGM) copula. See Shih and Emura (2018) <doi:10.1007/s00180-018-0804-0> and Shih and Emura (2019) <doi:10.1007/s00362-016-0865-5> for details.

Uses jackknife and bootstrap methods to quantify the sampling uncertainty in goodness-of-fit statistics. Full details are in Clark et al. (2021), "The abuse of popular performance metrics in hydrologic modeling", Water Resources Research, <doi:10.1029/2020WR029001>.

Basic functions for plotting 2D and 3D views of a sphere, by default the Earth with its major coastline, and additional lines and points.

Fits high dimensional penalized generalized linear mixed models using the Monte Carlo Expectation Conditional Minimization (MCECM) algorithm. The purpose of the package is to perform variable selection on both the fixed and random effects simultaneously for generalized linear mixed models. The package supports fitting of Binomial, Gaussian, and Poisson data with canonical links, and supports penalization using the MCP, SCAD, or LASSO penalties. The MCECM algorithm is described in Rashid et al. (2020) <doi:10.1080/01621459.2019.1671197>. The techniques used in the minimization portion of the procedure (the M-step) are derived from the procedures of the ncvreg package (Breheny and Huang (2011) <doi:10.1214/10-AOAS388>) and grpreg package (Breheny and Huang (2015) <doi:10.1007/s11222-013-9424-2>), with appropriate modifications to account for the estimation and penalization of the random effects. The ncvreg and grpreg packages also describe the MCP, SCAD, and LASSO penalties.

This package provides functions are provided for quantifying evolution and selection on complex traits. The package implements effective handling and analysis algorithms scaled for genome-wide data and calculates a composite statistic, denoted Ghat, which is used to test for selection on a trait. The package provides a number of simple examples for handling and analysing the genome data and visualising the output and results. Beissinger et al., (2018) <doi:10.1534/genetics.118.300857>.

Readable, complete and pretty graphs for correspondence analysis made with FactoMineR'. They can be rendered as interactive HTML plots, showing useful informations at mouse hover. The interest is not mainly visual but statistical: it helps the reader to keep in mind the data contained in the cross-table or Burt table while reading the correspondence analysis, thus preventing over-interpretation. Most graphs are made with ggplot2', which means that you can use the + syntax to manually add as many graphical pieces you want, or change theme elements. 3D graphs are made with plotly'.

Streamlines exploratory data analysis by providing a turnkey approach to visualising n-dimensional data which graphically reveals correlative or associative relationships between 2 or more features. Represents all dataset features as distinct, vertically aligned bar or tile plots, with plot types auto-selected based on whether variables are categorical or numeric.

An intuitive interface to simulate superimposed (marked) point patterns with vectorized parameterization of random point pattern and distribution of marks. The author has retired from academic research. Accordingly, this package should not be considered a validated tool for use in peer-reviewed publications or as the basis for grant applications.

Plot glycans following the Symbol Nomenclature for Glycans (SNFG) using ggplot2'. SNFG provides a standardized visual representation of glycan structures.

Functionalities for modelling functional data with multidimensional inputs, multivariate functional data, and non-separable and/or non-stationary covariance structure of function-valued processes. In addition, there are functionalities for functional regression models where the mean function depends on scalar and/or functional covariates and the covariance structure depends on functional covariates. The development version of the package can be found on <https://github.com/gpfda/GPFDA-dev>.

The philosophy in the package is described in Stasny (1988) <doi:10.2307/1391558> and Guti?rrez, A., Trujillo, L. & Silva, N. (2014), <ISSN:1492-0921> to estimate the gross flows under complex surveys using a Markov chain approach with non response.

This package implements a variant of the Self-Organizing Map (SOM) algorithm designed for mixed-attribute datasets. Similarity between observations is computed using the Gower distance, and categorical prototypes are updated via heuristic strategies (weighted mode and multinomial sampling). Provides functions for model fitting, mapping, visualization (U-Matrix and component planes), and evaluation, making SOM applicable to heterogeneous real-world data. For methodological details see Sáez and Salas (2026) <doi:10.1007/s41060-025-00941-6>.

For plant physiologists, converts conductance (e.g. stomatal conductance) to different units: m/s, mol/m^2/s, and umol/m^2/s/Pa.

This package provides a genomic simulation approach for creating biologically informed individual genotypes from empirical data that 1) samples alleles from populations without replacement, 2) segregates alleles based on species-specific recombination rates. gscramble is a flexible simulation approach that allows users to create pedigrees of varying complexity in order to simulate admixed genotypes. Furthermore, it allows users to track haplotype blocks from the source populations through the pedigrees.

This package provides a group-specific recommendation system to use dependency information from users and items which share similar characteristics under the singular value decomposition framework. Refer to paper A Group-Specific Recommender System <doi:10.1080/01621459.2016.1219261> for the details.

It implements a hybrid spatial model for improved spatial prediction by combining the variable selection capability of LASSO (Least Absolute Shrinkage and Selection Operator) with the Geographically Weighted Regression (GWR) model that captures the spatially varying relationship efficiently. For method details see, Wheeler, D.C.(2009).<DOI:10.1068/a40256>. The developed hybrid model efficiently selects the relevant variables by using LASSO as the first step; these selected variables are then incorporated into the GWR framework, allowing the estimation of spatially varying regression coefficients at unknown locations and finally predicting the values of the response variable at unknown test locations while taking into account the spatial heterogeneity of the data. Integrating the LASSO and GWR models enhances prediction accuracy by considering spatial heterogeneity and capturing the local relationships between the predictors and the response variable. The developed hybrid spatial model can be useful for spatial modeling, especially in scenarios involving complex spatial patterns and large datasets with multiple predictor variables.