Estimate model parameters to determine whether two compounds have synergy, antagonism, or Loewe's Additivity.

This package implements non-parametric tests from Higgins (2004, ISBN:0534387756), including tests for one sample, two samples, k samples, paired comparisons, blocked designs, trends and association. Built with Rcpp for efficiency and R6 for flexible, object-oriented design, the package provides a unified framework for performing or creating custom permutation tests.

Solves quadratic programming problems where the Hessian is represented as the product of two matrices. Thanks to Greg Hunt for helping getting this version back on CRAN. The methods in this package are described in: Ormerod, Wand and Koch (2008) "Penalised spline support vector classifiers: computational issues" <doi:10.1007/s00180-007-0102-8>.

Estimation of Latent Order Logistic (LOLOG) Models for Networks. LOLOGs are a flexible and fully general class of statistical graph models. This package provides functions for performing MOM, GMM and variational inference. Visual diagnostics and goodness of fit metrics are provided. See Fellows (2018) <doi:10.48550/arXiv.1804.04583> for a detailed description of the methods.

Conducts various numerical analyses and simulations in population genetics and evolutionary theory, primarily for the purpose of teaching (and learning about) key concepts in population & quantitative genetics, and evolutionary theory.

This package provides a complete framework for frequency analysis is provided by LMoFit'. It has functions related to the determination of sample L-moments as in Hosking, J.R.M. (1990) <doi:10.1111/j.2517-6161.1990.tb01775.x>, the fitting of various distributions as in Zaghloul et al. (2020) <doi:10.1016/j.advwatres.2020.103720> and Hosking, J.R.M. (2019) <https://CRAN.R-project.org/package=lmom>, besides plotting and manipulating L-space diagrams as in Papalexiou, S.M. & Koutsoyiannis, D. (2016) <doi:10.1016/j.advwatres.2016.05.005> for two-shape parametric distributions on the L-moment ratio diagram. Additionally, the quantile, probability density, and cumulative probability functions of various distributions are provided in a user-friendly manner.

This package provides tools for creating and using lenses to simplify data manipulation. Lenses are composable getter/setter pairs for working with data in a purely functional way. Inspired by the Haskell library lens (Kmett, 2012) <https://hackage.haskell.org/package/lens>. For a fairly comprehensive (and highly technical) history of lenses please see the lens wiki <https://github.com/ekmett/lens/wiki/History-of-Lenses>.

Obtain least-squares means for linear, generalized linear, and mixed models. Compute contrasts or linear functions of least-squares means, and comparisons of slopes. Plots and compact letter displays. Least-squares means were proposed in Harvey, W (1960) "Least-squares analysis of data with unequal subclass numbers", Tech Report ARS-20-8, USDA National Agricultural Library, and discussed further in Searle, Speed, and Milliken (1980) "Population marginal means in the linear model: An alternative to least squares means", The American Statistician 34(4), 216-221 <doi:10.1080/00031305.1980.10483031>. NOTE: lsmeans now relies primarily on code in the emmeans package. lsmeans will be archived in the near future.

The goal of LCMSQA is to make it easy to check the quality of liquid chromatograph/mass spectrometry (LC/MS) experiments using a shiny application. This package provides interactive data visualizations for quality control (QC) samples, including total ion current chromatogram (TIC), base peak chromatogram (BPC), mass spectrum, extracted ion chromatogram (XIC), and feature detection results from internal standards or known metabolites.

Analysis, imputation, and multiple imputation of count data using covariates. LORI uses a log-linear Poisson model where main row and column effects, as well as effects of known covariates and interaction terms can be fitted. The estimation procedure is based on the convex optimization of the Poisson loss penalized by a Lasso type penalty and a nuclear norm. LORI returns estimates of main effects, covariate effects and interactions, as well as an imputed count table. The package also contains a multiple imputation procedure. The methods are described in Robin, Josse, Moulines and Sardy (2019) <doi:10.1016/j.jmva.2019.04.004>.

Principal component analysis (PCA) is one of the most widely used data analysis techniques. This package provides a series of vignettes explaining PCA starting from basic concepts. The primary purpose is to serve as a self-study resource for anyone wishing to understand PCA better. A few convenience functions are provided as well.

Imports a data frame containing a single time resolved laser ablation mass spectrometry analysis of a foraminifera (or other carbonate shell), then detects when the laser has burnt through the foraminifera test as a function of change in signal over time.

Estimates a lognormal-Pareto mixture by means of the Expectation-Conditional-Maximization-Either algorithm and by maximizing the profile likelihood function. A likelihood ratio test for discriminating between lognormal and Pareto tail is also implemented. See Bee, M. (2022) <doi:10.1007/s11634-022-00497-4>.

Kernel regression smoothing with adaptive local or global plug-in bandwidth selection.

This package provides functions to simulate data from large-scale educational assessments, including background questionnaire data and cognitive item responses that adhere to a multiple-matrix sampled design. The theoretical foundation can be found on Matta, T.H., Rutkowski, L., Rutkowski, D. et al. (2018) <doi:10.1186/s40536-018-0068-8>.

"Learning with Subset Stacking" is a supervised learning algorithm that is based on training many local estimators on subsets of a given dataset, and then passing their predictions to a global estimator. You can find the details about LESS in our manuscript at <arXiv:2112.06251>.

This package provides functions for the implementation of a density goodness-of-fit test, based on piecewise approximation of the L2 distance.

Generate concentration-time profiles from linear pharmacokinetic (PK) systems, possibly with first-order absorption or zero-order infusion, possibly with one or more peripheral compartments, and possibly under steady-state conditions. Single or multiple doses may be specified. Secondary (derived) PK parameters (e.g. Cmax, Ctrough, AUC, Tmax, half-life, etc.) are computed.

This package provides a simple mechanism to specify a symmetric block diagonal matrices (often used for covariance matrices). This is based on the domain specific language implemented in nlmixr2 but expanded to create matrices in R generally instead of specifying parts of matrices to estimate. It has expanded to include some matrix manipulation functions that are generally useful for rxode2 and nlmixr2'.

Estimate and confidence/credible intervals for an unknown regressor x0 given an observed y0.

Processing of Landsat or other multispectral satellite imagery. Includes relative normalization, image-based radiometric correction, and topographic correction options. The original package description was published as Goslee (2011) <doi:10.18637/jss.v043.i04>, and details of the topographic corrections in Goslee (2012) <doi:10.14358/PERS.78.9.973>.

Various plots and functions that make use of the lattice/trellis plotting framework. The plots, which include loaPlot(), loaMapPlot() and trianglePlot(), and use panelPal(), a function that extends lattice and hexbin package methods to automate plot subscript and panel-to-panel and panel-to-key synchronization/management.

Creating efficiently new column(s) in a data frame (including tibble) by applying a function one row at a time.

Lights Out is a puzzle game consisting of a grid of lights that are either on or off. Pressing any light will toggle it and its adjacent lights. The goal of the game is to switch all the lights off. This package provides an interface to play the game on different board sizes, both through the command line or with a visual application. Puzzles can also be solved using the automatic solver included. View a demo online at <https://daattali.com/shiny/lightsout/>.