Fast C++ agglomerative hierarchical clustering algorithm packaged into easily callable R functions, designed to help cluster biological terms based on how similar of genes are expressed in their activation.

This package provides a simple user-friendly library based on the python module reservoirpy'. It provides a flexible interface to implement efficient Reservoir Computing (RC) architectures with a particular focus on Echo State Networks (ESN). Some of its features are: offline and online training, parallel implementation, sparse matrix computation, fast spectral initialization, advanced learning rules (e.g. Intrinsic Plasticity) etc. It also makes possible to easily create complex architectures with multiple reservoirs (e.g. deep reservoirs), readouts, and complex feedback loops. Moreover, graphical tools are included to easily explore hyperparameters. Finally, it includes several tutorials exploring time series forecasting, classification and hyperparameter tuning. For more information about reservoirpy', please see Trouvain et al. (2020) <doi:10.1007/978-3-030-61616-8_40>. This package was developed in the framework of the University of Bordeauxâ s IdEx "Investments for the Future" program / RRI PHDS.

Analysis of corneal data obtained from a Placido disk corneal topographer with calculation of irregularity indices. This package performs analyses of corneal data obtained from a Placido disk corneal topographer, with the calculation of the Placido irregularity indices and the posterior analysis. The package is intended to be easy to use by a practitioner, providing a simple interface and yielding easily interpretable results. A corneal topographer is an ophthalmic clinical device that obtains measurements in the cornea (the anterior part of the eye). A Placido disk corneal topographer makes use of the Placido disk [Rowsey et al. (1981)]<doi:10.1001/archopht.1981.03930011093022>, which produce a circular pattern of measurement nodes. The raw information measured by such a topographer is used by practitioners to analyze curvatures, to study optical aberrations, or to diagnose specific conditions of the eye (e.g. keratoconus, an important corneal disease). The rPACI package allows the calculation of the corneal irregularity indices described in [Castro-Luna et al. (2020)]<doi:10.1016%2Fj.clae.2019.12.006>, [Ramos-Lopez et al. (2013)]<doi:10.1097%2FOPX.0b013e3182843f2a>, and [Ramos-Lopez et al. (2011)]<doi:10.1097/opx.0b013e3182279ff8>. It provides a simple interface to read corneal topography data files as exported by a typical Placido disk topographer, to compute the irregularity indices mentioned before, and to display summary plots that are easy to interpret for a clinician.

The ability to plot raster graphics in PDF files can be useful when one needs multi-page documents, but the plots contain so many individual elements that (the usual) use of vector graphics results in inconveniently large file sizes. Internally, the package plots each individual page as a PNG, and then combines them in one PDF file.

Use trend filtering, a type of regularized nonparametric regression, to estimate the instantaneous reproduction number, also called Rt. This value roughly says how many new infections will result from each new infection today. Values larger than 1 indicate that an epidemic is growing while those less than 1 indicate decline. For more details about this methodology, see Liu, Cai, Gustafson, and McDonald (2024) <doi:10.1371/journal.pcbi.1012324>.

We visualize the standard deviation of a data set as the radius of a cylinder whose volume equals the total volume of several cylinders made by revolving the empirical cumulative distribution function about the vertical line through the mean. For more details see Sarkar and Rashid (2016) <doi:10.1080/00031305.2016.1165734>.

Integrates the Groovy scripting language with the R Project for Statistical Computing.

The Regional Vulnerability Index (RVI), a statistical measure of brain structural abnormality, quantifies an individual's similarity to the expected pattern (effect size) of deficits in schizophrenia (Kochunov P, Fan F, Ryan MC, et al. (2020) <doi:10.1002/hbm.25045>).

We provide a number of algorithms to estimate fundamental statistics including Fréchet mean and geometric median for manifold-valued data. Also, C++ header files are contained that implement elementary operations on manifolds such as Sphere, Grassmann, and others. See Bhattacharya and Bhattacharya (2012) <doi:10.1017/CBO9781139094764> if you are interested in statistics on manifolds, and Absil et al (2007, ISBN:9780691132983) on computational aspects of optimization on matrix manifolds.

This package provides functions to access, search and download spacetime earth observation data via SpatioTemporal Asset Catalog (STAC). This package supports the version 1.0.0 (and older) of the STAC specification (<https://github.com/radiantearth/stac-spec>). For further details see Simoes et al. (2021) <doi:10.1109/IGARSS47720.2021.9553518>.

The ropenblas package (<https://prdm0.github.io/ropenblas/>) is useful for users of any GNU/Linux distribution. It will be possible to download, compile and link the OpenBLAS library (<https://www.openblas.net/>) with the R language, always by the same procedure, regardless of the GNU/Linux distribution used. With the ropenblas package it is possible to download, compile and link the latest version of the OpenBLAS library even the repositories of the GNU/Linux distribution used do not include the latest versions of OpenBLAS'. If of interest, older versions of the OpenBLAS library may be considered. Linking R with an optimized version of BLAS (<https://netlib.org/blas/>) may improve the computational performance of R code. The OpenBLAS library is an optimized implementation of BLAS that can be easily linked to R with the ropenblas package.

This is a collection of tools to allow the medical professional to calculate appropriate reference ranges (intervals) with confidence intervals around the limits for diagnostic purposes.

Image data used as examples in the loon R package.

Honest and nearly-optimal confidence intervals in fuzzy and sharp regression discontinuity designs and for inference at a point based on local linear regression. The implementation is based on Armstrong and Kolesár (2018) <doi:10.3982/ECTA14434>, and Kolesár and Rothe (2018) <doi:10.1257/aer.20160945>. Supports covariates, clustering, and weighting.

The algorithm provided in this package generates perfect sample for unimodal or multimodal posteriors. Read Once Coupling From The Past, with Metropolis-Multishift is used to generate a perfect sample for a given posterior density based on the two extreme starting paths, minimum and maximum of the most interest range of the posterior. It uses the monotone random operation of multishift coupler which allows to sandwich all of the state space in one point. It means both Markov Chains starting from the maximum and minimum will be coalesced. The generated sample is independent from the starting points. It is useful for mixture distributions too. The output of this function is a real value as an exact draw from the posterior distribution.

This package provides tools to read various file types into one list of data structures, usually, but not limited to, data frames. Excel files are read sheet-wise, i.e., all or a selection of sheets can be read. Field delimiters and decimal separators are determined automatically.

Simulation of phenotype / genotype data under assortative mating. Includes functions for generating Bahadur order-2 multivariate Bernoulli variables with general and diagonal-plus-low-rank correlation structures. Further details are provided in: Border and Malik (2022) <doi:10.1101/2022.10.13.512132>.

This package provides a robust and powerful approach is developed for replicability analysis of two Genome-wide association studies (GWASs) accounting for the linkage disequilibrium (LD) among genetic variants. The LD structure in two GWASs is captured by a four-state hidden Markov model (HMM). The unknowns involved in the HMM are estimated by an efficient expectation-maximization (EM) algorithm in combination with a non-parametric estimation of functions. By incorporating information from adjacent locations via the HMM, this approach identifies the entire clusters of genotype-phenotype associated signals, improving the power of replicability analysis while effectively controlling the false discovery rate.

This is a library to access the current API of the web speed test service GTmetrix'. It provides a convenient wrapper to start tests, get reports, and access all kinds of meta data. For more information about using the API please visit <https://gtmetrix.com/api/docs/2.0/>.

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2025) <doi:10.1007/978-3-031-89669-9>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Designed to be compatible with the R package DBI (Database Interface) when connecting to Amazon Web Service ('AWS') Athena <https://aws.amazon.com/athena/>. To do this Python Boto3 Software Development Kit ('SDK') <https://boto3.amazonaws.com/v1/documentation/api/latest/index.html> is used as a driver.

Computes the power resulting from completely randomized and rerandomized experiments with two groups. Furthermore, computes the sample size necessary to obtain a desired level of power for completely randomized and rerandomized experiments.

Compute yield-stability index based on Bayesian methodology, which is useful for analyze multi-environment trials in plant breeding programs. References: Cotes Torres JM, Gonzalez Jaimes EP, and Cotes Torres A (2016) <https://revistas.unimilitar.edu.co/index.php/rfcb/article/view/2037> Seleccion de Genotipos con Alta Respuesta y Estabilidad Fenotipica en Pruebas Regionales: Recuperando el Concepto Biologico.

Computes 26 financial risk measures for any continuous distribution. The 26 financial risk measures include value at risk, expected shortfall due to Artzner et al. (1999) <DOI:10.1007/s10957-011-9968-2>, tail conditional median due to Kou et al. (2013) <DOI:10.1287/moor.1120.0577>, expectiles due to Newey and Powell (1987) <DOI:10.2307/1911031>, beyond value at risk due to Longin (2001) <DOI:10.3905/jod.2001.319161>, expected proportional shortfall due to Belzunce et al. (2012) <DOI:10.1016/j.insmatheco.2012.05.003>, elementary risk measure due to Ahmadi-Javid (2012) <DOI:10.1007/s10957-011-9968-2>, omega due to Shadwick and Keating (2002), sortino ratio due to Rollinger and Hoffman (2013), kappa due to Kaplan and Knowles (2004), Wang (1998)'s <DOI:10.1080/10920277.1998.10595708> risk measures, Stone (1973)'s <DOI:10.2307/2978638> risk measures, Luce (1980)'s <DOI:10.1007/BF00135033> risk measures, Sarin (1987)'s <DOI:10.1007/BF00126387> risk measures, Bronshtein and Kurelenkova (2009)'s risk measures.