This package is an R package designed for QC, analysis, and exploration of single cell RNA-seq data. It easily enables widely-used analytical techniques, including the identification of highly variable genes, dimensionality reduction; PCA, ICA, t-SNE, standard unsupervised clustering algorithms; density clustering, hierarchical clustering, k-means, and the discovery of differentially expressed genes and markers.

This package provides a simple and light-weight API for memory profiling of R expressions. The profiling is built on top of R's built-in memory profiler utils::Rprofmem(), which records every memory allocation done by R (also native code).

This package aims to streamline and accelerate the process of saving and loading R objects, improving speed and compression compared to other methods. The package provides two compression formats: the qs2 format, which uses R serialization via the C API while optimizing compression and disk I/O, and the qdata format, featuring custom serialization for slightly faster performance and better compression. Additionally, the qs2 format can be directly converted to the standard RDS format, ensuring long-term compatibility with future versions of R.

This package provides .C64(), an enhanced version of .C() and .Fortran() from the R foreign function interface. .C64() supports long vectors, arguments of type 64-bit integer, and provides a mechanism to avoid unnecessary copies of read-only and write-only arguments. This makes it a convenient and fast interface to C/C++ and Fortran code.

As a successor of the packages BatchJobs and BatchExperiments, this package provides a parallel implementation of the Map function for high performance computing systems managed by various schedulers. A multicore and socket mode allow the parallelization on a local machines, and multiple machines can be hooked up via SSH to create a makeshift cluster. Moreover, the package provides an abstraction mechanism to define large-scale computer experiments in a well-organized and reproducible way.

This package computes the Kendall rank correlation and Mann-Kendall trend test.

This package provides tools to compute and represent gene set enrichment or depletion from your data based on pre-saved maps from the Atlas of Cancer Signalling Networks (ACSN) or user imported maps. The gene set enrichment can be run with hypergeometric test or Fisher exact test, and can use multiple corrections. Visualization of data can be done either by barplots or heatmaps.

This is a package to compare sequence fragment lengths or molecular weights from pairs of lanes. The number of matching bands in the Restriction Fragment Length Polymorphism (RFLP) data is calculated using the align-and-count method.

The biglm package lets you create a linear model object that uses only codep^2 memory for p variables. It can be updated with more data using update. This allows linear regression on data sets larger than memory.

This package provides functions to make zebra-striped tables (tables with alternating row colors) in LaTeX and HTML formats easily from data.frame, matrix, lm, aov, anova, glm, coxph, nls, fitdistr, mytable and cbind.mytable objects.

This package completes R's functional programming tools with missing features present in other programming languages.

Circle Manhattan Plot is an R package that can lay out genome-wide association study P-value results in both traditional rectangular patterns, QQ-plot and novel circular ones. United in only one bull's eye style plot, association results from multiple traits can be compared interactively, thereby to reveal both similarities and differences between signals. Additional functions include: highlight signals, a group of SNPs, chromosome visualization and candidate genes around SNPs.

This package provides analytic derivatives and information matrices for fitted linear mixed effects (lme) models and generalized least squares (gls) models estimated using lme() (from package nlme) and gls() (from package nlme), respectively. The package includes functions for estimating the sampling variance-covariance of variance component parameters using the inverse Fisher information. The variance components include the parameters of the random effects structure (for lme models), the variance structure, and the correlation structure. The expected and average forms of the Fisher information matrix are used in the calculations, and models estimated by full maximum likelihood or restricted maximum likelihood are supported. The package also includes a function for estimating standardized mean difference effect sizes based on fitted lme or gls models.

This package provides qualitative methods for the validation of dynamic models. It contains

1. an orthogonal set of deviance measures for absolute, relative and ordinal scale and

2. approaches accounting for time shifts.

The first approach transforms time to take time delays and speed differences into account. The second divides the time series into interval units according to their main features and finds the longest common subsequence (LCS) using a dynamic programming algorithm.

This package provides a number of user-level functions to work with grid graphics, notably to arrange multiple grid-based plots on a page, and draw tables.

This package provides a collection of miscellaneous basic statistic functions and convenience wrappers for efficiently describing data. The author's intention was to create a toolbox, which facilitates the (notoriously time consuming) first descriptive tasks in data analysis, consisting of calculating descriptive statistics, drawing graphical summaries and reporting the results. The package contains furthermore functions to produce documents using MS Word (or PowerPoint) and functions to import data from Excel. Many of the included functions can be found scattered in other packages and other sources written partly by Titans of R. The reason for collecting them here, was primarily to have them consolidated in ONE instead of dozens of packages (which themselves might depend on other packages which are not needed at all), and to provide a common and consistent interface as far as function and arguments naming, NA handling, recycling rules etc. are concerned. Google style guides were used as naming rules (in absence of convincing alternatives). The BigCamelCase style was consequently applied to functions borrowed from contributed R packages as well.

This package provides a flexible approach to Bayesian optimization / model based optimization building on the bbotk package. The mlr3mbo is a toolbox providing both ready-to-use optimization algorithms as well as their fundamental building blocks allowing for straightforward implementation of custom algorithms. Single- and multi-objective optimization is supported as well as mixed continuous, categorical and conditional search spaces. Moreover, using mlr3mbo for hyperparameter optimization of machine learning models within the mlr3 ecosystem is straightforward via mlr3tuning.

This package provides simple utility functions to read from and write to the system clipboards.

This is a data only package providing the algorithmic complexity of short strings, computed using the coding theorem method. For a given set of symbols in a string, all possible or a large number of random samples of Turing machines with a given number of states (e.g., 5) and number of symbols corresponding to the number of symbols in the strings were simulated until they reached a halting state or failed to end. This package contains data on 4.5 million strings from length 1 to 12 simulated on Turing machines with 2, 4, 5, 6, and 9 symbols. The complexity of the string corresponds to the distribution of the halting states.

Designed to enable simultaneous substitution in strings in a safe fashion. Safe means it does not rely on placeholders (which can cause errors in same length matches).

Low-rank matrix decompositions are fundamental tools and widely used for data analysis, dimension reduction, and data compression. Classically, highly accurate deterministic matrix algorithms are used for this task. However, the emergence of large-scale data has severely challenged our computational ability to analyze big data. The concept of randomness has been demonstrated as an effective strategy to quickly produce approximate answers to familiar problems such as the singular value decomposition (SVD). This package provides several randomized matrix algorithms such as the randomized singular value decomposition (rsvd), randomized principal component analysis (rpca), randomized robust principal component analysis (rrpca), randomized interpolative decomposition (rid), and the randomized CUR decomposition (rcur). In addition several plot functions are provided.

This package provides various methods for MRI tissue classification.

This package estimates the parameters in Dirichlet-Multinomial and computes log-likelihoods.

This package provides an R interface to V8: Google's JavaScript and WebAssembly engine.