The image of the amino acid transform on the protein level is drawn, and the automatic routing of the functional elements such as the domain and the mutation site is completed.

Grafts the extinct bird species from the Avotrex database (Sayol et al., in review) on to the BirdTree phylogenies <https://birdtree.org>, using a set of different commands.

This package provides a powerful tool for automating the early detection of disease outbreaks in time series data. aeddo employs advanced statistical methods, including hierarchical models, in an innovative manner to effectively characterize outbreak signals. It is particularly useful for epidemiologists, public health professionals, and researchers seeking to identify and respond to disease outbreaks in a timely fashion. For a detailed reference on hierarchical models, consult Henrik Madsen and Poul Thyregod's book (2011), ISBN: 9781420091557.

Causal discovery in linear structural equation models (Schultheiss, and Bühlmann (2023) <doi:10.1093/biomet/asad008>) and vector autoregressive models (Schultheiss, Ulmer, and Bühlmann (2025) <doi:10.1515/jci-2024-0011>) with explicit error control for false discovery, at least asymptotically.

Data sets are referred to in the text "Applied Survival Analysis Using R" by Dirk F. Moore, Springer, 2016, ISBN: 978-3-319-31243-9, <DOI:10.1007/978-3-319-31245-3>.

Imports Azure Application Insights for web pages into Shiny apps via Microsoft's JavaScript snippet. Allows app developers to submit page tracking and submit events.

This package implements the allan variance and allan variance linear regression estimator for latent time series models. More details about the method can be found, for example, in Guerrier, S., Molinari, R., & Stebler, Y. (2016) <doi:10.1109/LSP.2016.2541867>.

This package provides a thin wrapper around the ajv JSON validation package for JavaScript. See <http://epoberezkin.github.io/ajv/> for details.

An iterative implementation of a recursive binary partitioning algorithm to measure pairwise dependence with a modular design that allows user specification of the splitting logic and stop criteria. Helper functions provide suggested versions of both and support visualization and the computation of summary statistics on final binnings. For a thorough discussion and demonstration of the algorithm, see Salahub and Oldford (2025) <doi:10.1002/sam.70042>.

Visualization of Design of Experiments from the agricolae package with ggplot2 framework The user provides an experiment design from the agricolae package, calls the corresponding function and will receive a visualization with ggplot2 based functions that are specific for each design. As there are many different designs, each design is tested on its type. The output can be modified with standard ggplot2 commands or with other packages with ggplot2 function extensions.

Processes noble gas mass spectrometer data to determine the isotopic composition of argon (comprised of Ar36, Ar37, Ar38, Ar39 and Ar40) released from neutron-irradiated potassium-bearing minerals. Then uses these compositions to calculate precise and accurate geochronological ages for multiple samples as well as the covariances between them. Error propagation is done in matrix form, which jointly treats all samples and all isotopes simultaneously at every step of the data reduction process. Includes methods for regression of the time-resolved mass spectrometer signals to t=0 ('time zero') for both single- and multi-collector instruments, blank correction, mass fractionation correction, detector intercalibration, decay corrections, interference corrections, interpolation of the irradiation parameter between neutron fluence monitors, and (weighted mean) age calculation. All operations are performed on the logs of the ratios between the different argon isotopes so as to properly treat them as compositional data', sensu Aitchison [1986, The Statistics of Compositional Data, Chapman and Hall].

Developed for use by those tasked with the routine detection, characterisation and quantification of discrete changes in air quality time-series, such as identifying the impacts of air quality policy interventions. The main functions use signal isolation then break-point/segment (BP/S) methods based on strucchange and segmented methods to detect and quantify change events (Ropkins & Tate, 2021, <doi:10.1016/j.scitotenv.2020.142374>; Ropkins et al., 2026, <doi:10.21105/joss.08839>).

This package implements a framework for creating boxplots where the whisker lengths are determined by formal multiple testing procedures, making them adaptive to sample size and data characteristics. The function bh_boxplot() generates boxplots that control the False Discovery Rate (FDR) via the Benjamini-Hochberg procedure, and the function holm_boxplot() generates boxplots that control the Family-Wise Error Rate (FWER) via the Holm procedure. The methods are based on the framework in Gang, Lin, and Tong (2025) <doi:10.48550/arXiv.2510.20259>.

It can sometimes be difficult to ascertain when some events (such as property crime) occur because the victim is not present when the crime happens. As a result, police databases often record a start (or from') date and time, and an end (or to') date and time. The time span between these date/times can be minutes, hours, or sometimes days, hence the term Aoristic'. Aoristic is one of the past tenses in Greek and represents an uncertain occurrence in time. For events with a location describes with either a latitude/longitude, or X,Y coordinate pair, and a start and end date/time, this package generates an aoristic data frame with aoristic weighted probability values for each hour of the week, for each observation. The coordinates are not necessary for the program to calculate aoristic weights; however, they are part of this package because a spatial component has been integral to aoristic analysis from the start. Dummy coordinates can be introduced if the user only has temporal data. Outputs include an aoristic data frame, as well as summary graphs and displays. For more information see: Ratcliffe, JH (2002) Aoristic signatures and the temporal analysis of high volume crime patterns, Journal of Quantitative Criminology. 18 (1): 23-43. Note: This package replaces an original aoristic package (version 0.6) by George Kikuchi that has been discontinued with his permission.

This package provides functions to estimate and interpret the alpha-NOMINATE ideal point model developed in Carroll et al. (2013, <doi:10.1111/ajps.12029>). alpha-NOMINATE extends traditional spatial voting frameworks by allowing for a mixture of Gaussian and quadratic utility functions, providing flexibility in modeling political actors preferences. The package uses Markov Chain Monte Carlo (MCMC) methods for parameter estimation, supporting robust inference about individuals ideological positions and the shape of their utility functions. It also contains functions to simulate data from the model and to calculate the probability of a vote passing given the ideal points of the legislators/voters and the estimated location of the choice alternatives.

Fit, interpret, and compute predictions with oblique random forests. Includes support for partial dependence, variable importance, passing customized functions for variable importance and identification of linear combinations of features. Methods for the oblique random survival forest are described in Jaeger et al., (2023) <DOI:10.1080/10618600.2023.2231048>.

Analysis of data from unreplicated orthogonal experiments such as 2-level factorial and fractional factorial designs and Plackett-Burman designs using the all possible comparisons (APC) methodology developed by Miller (2005) <doi:10.1198/004017004000000608>.

Estimate ideal efficiencies of aerosol sampling through sample lines. Functions were developed consistent with the approach described in Hogue, Mark; Thompson, Martha; Farfan, Eduardo; Hadlock, Dennis, (2014), "Hand Calculations for Transport of Radioactive Aerosols through Sampling Systems" Health Phys 106, 5, S78-S87, <doi:10.1097/HP.0000000000000092>.

This package provides a collection of tools for the analysis of habitat selection.

It performs Canonical Correlation Analysis and provides inferential guaranties on the correlation components. The p-values are computed following the resampling method developed in Winkler, A. M., Renaud, O., Smith, S. M., & Nichols, T. E. (2020). Permutation inference for canonical correlation analysis. NeuroImage, <doi:10.1016/j.neuroimage.2020.117065>. Furthermore, it provides plotting tools to visualize the results.

This package contains various functions for optimal scaling. One function performs optimal scaling by maximizing an aspect (i.e. a target function such as the sum of eigenvalues, sum of squared correlations, squared multiple correlations, etc.) of the corresponding correlation matrix. Another function performs implements the LINEALS approach for optimal scaling by minimization of an aspect based on pairwise correlations and correlation ratios. The resulting correlation matrix and category scores can be used for further multivariate methods such as structural equation models.

Efficient algorithms <https://jmlr.org/papers/v24/21-0751.html> for computing Area Under Minimum, directional derivatives, and line search optimization of a linear model, with objective defined as either max Area Under the Curve or min Area Under Minimum.

Package ACV (short for Affine Cross-Validation) offers an improved time-series cross-validation loss estimator which utilizes both in-sample and out-of-sample forecasting performance via a carefully constructed affine weighting scheme. Under the assumption of stationarity, the estimator is the best linear unbiased estimator of the out-of-sample loss. Besides that, the package also offers improved versions of Diebold-Mariano and Ibragimov-Muller tests of equal predictive ability which deliver more power relative to their conventional counterparts. For more information, see the accompanying article Stanek (2021) <doi:10.2139/ssrn.3996166>.

The irregularly-spaced data are interpolated onto regular latitude-longitude grids by weighting each station according to its distance and angle from the center of a search radius. In addition to this, we also provide a simple way (Jones and Hulme, 1996) to grid the irregularly-spaced data points onto regular latitude-longitude grids by averaging all stations in grid-boxes. This study was supported by the National Natural Science Foundation of China (NSFC, Grant No. 42205177).