Differential analyses and Enrichment pipeline for bulk ATAC-seq data analyses. This package combines different packages to have an ultimate package for both data analyses and visualization of ATAC-seq data. Methods are described in Karakaslar et al. (2021) <doi:10.1101/2021.03.05.434143>.

This package provides a clustered random forest algorithm for fitting random forests for data of independent clusters, that exhibit within cluster dependence. Details of the method can be found in Young and Buehlmann (2025) <doi:10.48550/arXiv.2503.12634>.

Load and analyze updated time series worldwide data of reported cases for the Novel Coronavirus Disease (COVID-19) from different sources, including the Johns Hopkins University Center for Systems Science and Engineering (JHU CSSE) data repository <https://github.com/CSSEGISandData/COVID-19>, "Our World in Data" <https://github.com/owid/> among several others. The datasets reporting the COVID-19 cases are available in two main modalities, as a time series sequences and aggregated data for the last day with greater spatial resolution. Several analysis, visualization and modelling functions are available in the package that will allow the user to compute and visualize total number of cases, total number of changes and growth rate globally or for an specific geographical location, while at the same time generating models using these trends; generate interactive visualizations and generate Susceptible-Infected-Recovered (SIR) model for the disease spread.

Constructs a shiny app function with interactive displays for conditional visualization of models, data and density functions. An extended version of package condvis'. Catherine B. Hurley, Mark O'Connell,Katarina Domijan (2021) <doi:10.1080/10618600.2021.1983439>.

Exploring fitted models by interactively taking 2-D and 3-D sections in data space.

An interactive application for working with contingency Tables. The application has a template for solving contingency table problems like chisquare test of independence,association plot between two categorical variables. Runtime examples are provided in the package function as well as at <https://jarvisatharva.shinyapps.io/CategoricalDataAnalysis/>.

Linear or nonlinear cross-lagged panel model can be built from input data. Users can choose the appropriate method from three methods for constructing nonlinear cross lagged models. These three methods include polynomial regression, generalized additive model and generalized linear mixed model.In addition, a function for determining linear relationships is provided. Relevant knowledge of cross lagged models can be learned through the paper by Fredrik Falkenström (2024) <doi:10.1016/j.cpr.2024.102435> and the paper by A Gasparrini (2010) <doi:10.1002/sim.3940>.

Generates a visualization of binary classifier performance as a grid of diagnostic plots with just one function call. Includes ROC curves, prediction density, accuracy, precision, recall and calibration plots, all using ggplot2 for easy modification. Debug your binary classifiers faster and easier!

Generate cofeature (feature by sample) matrices. The package utilizes ggplot2::geom_tile() to generate the matrix allowing for easy additions from the base matrix.

An investigative tool designed to help users visualize correlations between variables in their datasets. This package aims to provide an easy and effective way to explore and visualize these correlations, making it easier to interpret and communicate results.

This is a function for validating microarray clusters via reproducibility, based on the paper referenced below.

In phase I clinical trials, the primary objective is to ascertain the maximum tolerated dose (MTD) corresponding to a specified target toxicity rate. The subsequent phase II trials are designed to examine the potential efficacy of the drug based on the MTD obtained from the phase I trials, with the aim of identifying the optimal biological dose (OBD). The CFO package facilitates the implementation of dose-finding trials by utilizing calibration-free odds type (CFO-type) designs. Specifically, it encompasses the calibration-free odds (CFO) (Jin and Yin (2022) <doi:10.1177/09622802221079353>), randomized CFO (rCFO), precision CFO (pCFO), two-dimensional CFO (2dCFO) (Wang et al. (2023) <doi:10.3389/fonc.2023.1294258>), time-to-event CFO (TITE-CFO) (Jin and Yin (2023) <doi:10.1002/pst.2304>), fractional CFO (fCFO), accumulative CFO (aCFO), TITE-aCFO, and f-aCFO (Fang and Yin (2024) <doi: 10.1002/sim.10127>). It supports phase I/II trials for the CFO design and only phase I trials for the other CFO-type designs. The â CFO package accommodates diverse CFO-type designs, allowing users to tailor the approach based on factors such as dose information inclusion, handling of late-onset toxicity, and the nature of the target drug (single-drug or drug-combination). The functionalities embedded in CFO package include the determination of the dose level for the next cohort, the selection of the MTD for a real trial, and the execution of single or multiple simulations to obtain operating characteristics. Moreover, these functions are equipped with early stopping and dose elimination rules to address safety considerations. Users have the flexibility to choose different distributions, thresholds, and cohort sizes among others for their specific needs. The output of the CFO package can be summary statistics as well as various plots for better visualization. An interactive web application for CFO is available at the provided URL.

Comprehensive data analysis software, and the name "cg" stands for "compare groups." Its genesis and evolution are driven by common needs to compare administrations, conditions, etc. in medicine research and development. The current version provides comparisons of unpaired samples, i.e. a linear model with one factor of at least two levels. It also provides comparisons of two paired samples. Good data graphs, modern statistical methods, and useful displays of results are emphasized.

Useful tools for fitting, validating, and forecasting of practical convolution-closed time series models for low counts are provided. Marginal distributions of the data can be modelled via Poisson and Generalized Poisson innovations. Regression effects can be incorporated through time varying innovation rates. The models are described in Jung and Tremayne (2011) <doi:10.1111/j.1467-9892.2010.00697.x> and the model assessment tools are presented in Czado et al. (2009) <doi:10.1111/j.1541-0420.2009.01191.x> and, Tsay (1992) <doi:10.2307/2347612>.

Deriving skill structures from skill assignment data for courses (sets of learning objects).

Predicts anticancer peptides using random forests trained on the n-gram encoded peptides. The implemented algorithm can be accessed from both the command line and shiny-based GUI. The CancerGram model is too large for CRAN and it has to be downloaded separately from the repository: <https://github.com/BioGenies/CancerGramModel>. For more information see: Burdukiewicz et al. (2020) <doi:10.3390/pharmaceutics12111045>.

Analyzes spatial transcriptomic data using cells-by-genes and cell location matrices to find gene pairs that coordinate their expression between spatially adjacent cells. It enables quantitative analysis and graphical assessment of these cross-expression patterns. See Sarwar et al. (2025) <doi:10.1101/2024.09.17.613579> and <https://github.com/gillislab/CrossExpression/> for more details.

This package provides a simple way to assess the stability of candidate housekeeping genes is implemented in this package.

Mapas terrestres con topologias simplificadas. Estos mapas no tienen precision geodesica, por lo que aplica el DFL-83 de 1979 de la Republica de Chile y se consideran referenciales sin validez legal. No se incluyen los territorios antarticos y bajo ningun evento estos mapas significan que exista una cesion u ocupacion de territorios soberanos en contra del Derecho Internacional por parte de Chile. Esta paquete esta documentado intencionalmente en castellano asciificado para que funcione sin problema en diferentes plataformas. (Terrestrial maps with simplified toplogies. These maps lack geodesic precision, therefore DFL-83 1979 of the Republic of Chile applies and are considered to have no legal validity. Antartic territories are excluded and under no event these maps mean there is a cession or occupation of sovereign territories against International Laws from Chile. This package was intentionally documented in asciified spanish to make it work without problem on different platforms.).

Interface to easily access Cropland Data Layer (CDL) data for any area of interest via the CropScape <https://nassgeodata.gmu.edu/CropScape/> web service.

We aim to deal with the average treatment effect (ATE), where the data are subject to high-dimensionality and measurement error. This package primarily contains two functions, which are used to generate artificial data and estimate ATE with high-dimensional and error-prone data accommodated.

This package provides a simulation model and accompanying functions that support assessing silvicultural concepts on the forest estate level with a focus on the CO2 uptake by wood growth and CO2 emissions by forest operations. For achieving this, a virtual forest estate area is split into the areas covered by typical phases of the silvicultural concept of interest. Given initial area shares of these phases, the dynamics of these areas is simulated. The typical carbon stocks and flows which are known for all phases are attributed post-hoc to the areas and upscaled to the estate level. CO2 emissions by forest operations are estimated based on the amounts and dimensions of the harvested timber. Probabilities of damage events are taken into account.

Allows Brownian motion, fractional Brownian motion, and integrated Ornstein-Uhlenbeck process components to be added to linear and non-linear mixed effects models using the structures and methods of the nlme package.

This package performs the Cram method, a general and efficient approach to simultaneous learning and evaluation using a generic machine learning algorithm. In a single pass of batched data, the proposed method repeatedly trains a machine learning algorithm and tests its empirical performance. Because it utilizes the entire sample for both learning and evaluation, cramming is significantly more data-efficient than sample-splitting. Unlike cross-validation, Cram evaluates the final learned model directly, providing sharper inference aligned with real-world deployment. The method naturally applies to both policy learning and contextual bandits, where decisions are based on individual features to maximize outcomes. The package includes cram_policy() for learning and evaluating individualized binary treatment rules, cram_ml() to train and assess the population-level performance of machine learning models, and cram_bandit() for on-policy evaluation of contextual bandit algorithms. For all three functions, the package provides estimates of the average outcome that would result if the model were deployed, along with standard errors and confidence intervals for these estimates. Details of the method are described in Jia, Imai, and Li (2024) <https://www.hbs.edu/ris/Publication%20Files/2403.07031v1_a83462e0-145b-4675-99d5-9754aa65d786.pdf> and Jia et al. (2025) <doi:10.48550/arXiv.2403.07031>.