Covariance measure tests for conditional independence testing against conditional covariance and nonlinear conditional mean alternatives. The package implements versions of the generalised covariance measure test (Shah and Peters, 2020, <doi:10.1214/19-aos1857>) and projected covariance measure test (Lundborg et al., 2023, <doi:10.1214/24-AOS2447>). The tram-GCM test, for censored responses, is implemented including the Cox model and survival forests (Kook et al., 2024, <doi:10.1080/01621459.2024.2395588>). Application examples to variable significance testing and modality selection can be found in Kook and Lundborg (2024, <doi:10.1093/bib/bbae475>).

Client for the Open Citations Corpus (<http://opencitations.net/>). Includes a set of functions for getting one identifier type from another, as well as getting references and citations for a given identifier.

Designs guide sequences for CRISPR/Cas9 genome editing and provides information on sequence features pertinent to guide efficiency. Sequence features include annotated off-target predictions in a user-selected genome and a predicted efficiency score based on the model described in Doench et al. (2016) <doi:10.1038/nbt.3437>. Users are able to import additional genomes and genome annotation files to use when searching and annotating off-target hits. All guide sequences and off-target data can be generated through the R console with sgRNA_Design() or through crispRdesignR's user interface with crispRdesignRUI(). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and the associated protein Cas9 refer to a technique used in genome editing.

This package provides a comprehensive framework for time series omics analysis, integrating changepoint detection, smooth and shape-constrained trends, and uncertainty quantification. It supports gene- and transcript-level inferences, p-value aggregation for improved power, and both case-only and case-control designs. It includes an interactive shiny interface. The methods are described in Yates et al. (2024) <doi:10.1101/2024.12.22.630003>.

Encode and decode c-squares, from and to simple feature (sf) or spatiotemporal arrays (stars) objects. Use c-squares codes to quickly join or query spatial data.

This package provides a general cross-fitting engine for semiparametric estimation (e.g., double/debiased machine learning). Supports user-defined target functionals and directed acyclic graphs of nuisance learners with per-node training fold widths, target-specific evaluation windows, and fold-allocation modes ("overlap", "disjoint", "independence"). Returns either numeric estimates (mode = "estimate") or cross-fitted prediction functions (mode = "predict"), with configurable aggregation over panels and repetitions, reuse-aware caching, and failure isolation, making it well-suited for simulation studies and large benchmarks.

This package provides a reliable and efficient tool for cleaning univariate time series data. It implements reliable and efficient procedures for automating the process of cleaning univariate time series data. The package provides integration with already developed and deployed tools for missing value imputation and outlier detection. It also provides a way of visualizing large time-series data in different resolutions.

Parameter estimation, one-step ahead forecast and new location prediction methods for spatio-temporal data.

Use frequentist and Bayesian methods to estimate parameters from a binary outcome misclassification model. These methods correct for the problem of "label switching" by assuming that the sum of outcome sensitivity and specificity is at least 1. A description of the analysis methods is available in Hochstedler and Wells (2023) <doi:10.48550/arXiv.2303.10215>.

Fits constrained groupwise additive index models and provides functions for inference and interpretation of these models. The method is described in Masselot, Chebana, Campagna, Lavigne, Ouarda, Gosselin (2022) "Constrained groupwise additive index models" <doi:10.1093/biostatistics/kxac023>.

For ordinal rating data, estimate and test models within the family of CUB models and their extensions (where CUB stands for Combination of a discrete Uniform and a shifted Binomial distributions); Simulation routines, plotting facilities and fitting measures are also provided.

This package provides a simple package to grab cheat sheets and save them to your local computer.

This package provides a tool for exploring correlations. It makes it possible to easily perform routine tasks when exploring correlation matrices such as ignoring the diagonal, focusing on the correlations of certain variables against others, or rearranging and visualizing the matrix in terms of the strength of the correlations.

Process command line arguments, as part of a data analysis workflow. command makes it easier to construct a workflow consisting of lots of small, self-contained scripts, all run from a Makefile or shell script. The aim is a workflow that is modular, transparent, and reliable.

Fitting and inference functions for generalized linear models with constrained coefficients.

Test for cluster tendency (clusterability) of a data set. The methods implemented - reducing the data set to a single dimension using principal component analysis or computing pairwise distances, and performing a multimodality test like the Dip Test or Silverman's Critical Bandwidth Test - are described in Adolfsson, Ackerman, and Brownstein (2019) <doi:10.1016/j.patcog.2018.10.026>. Such methods can inform whether clustering algorithms are appropriate for a data set.

Perceptually uniform palettes for commonly used variables in oceanography as functions taking an integer and producing character vectors of colours. See Thyng, K.M., Greene, C.A., Hetland, R.D., Zimmerle, H.M. and S.F. DiMarco (2016) <doi:10.5670/oceanog.2016.66> for the guidelines adhered to when creating the palettes.

To optimize clinical trial designs and data analysis methods consistently through trial simulation, we need to simulate multivariate mixed-type virtual patient data independent of designs and analysis methods under evaluation. To make the outcome of optimization more realistic, relevant empirical patient level data should be utilized when itâ s available. However, a few problems arise in simulating trials based on small empirical data, where the underlying marginal distributions and their dependence structure cannot be understood or verified thoroughly due to the limited sample size. To resolve this issue, we use the copula invariance property, which can generate the joint distribution without making a strong parametric assumption. The function copula.sim can generate virtual patient data with optional data validation methods that are based on energy distance and ball divergence measurement. The function compare.copula.sim can conduct comparison of marginal mean and covariance of simulated data. To simulate patient-level data from a hypothetical treatment arm that would perform differently from the observed data, the function new.arm.copula.sim can be used to generate new multivariate data with the same dependence structure of the original data but with a shifted mean vector.

This package provides an interface to the ClinicalOmicsDB API, allowing for easy data downloading and importing. ClinicalOmicsDB is a database of clinical and omics data from cancer patients. The database is accessible at <http://trials.linkedomics.org>.

This package provides a new robust principal component analysis algorithm is implemented that relies upon the Cauchy Distribution. The algorithm is suitable for high dimensional data even if the sample size is less than the number of variables. The methodology is described in this paper: Fayomi A., Pantazis Y., Tsagris M. and Wood A.T.A. (2024). "Cauchy robust principal component analysis with applications to high-dimensional data sets". Statistics and Computing, 34: 26. <doi:10.1007/s11222-023-10328-x>.

Parameters of a user-specified probability distribution are modelled by a multi-layer perceptron artificial neural network. This framework can be used to implement probabilistic nonlinear models including mixture density networks, heteroscedastic regression models, zero-inflated models, etc. following Cannon (2012) <doi:10.1016/j.cageo.2011.08.023>.

After using this, a publication-ready correlation table with p-values indicated will be created. The input can be a full data frame; any string and Boolean terms will be dropped as part of functionality. Correlations and p-values are calculated using the Hmisc framework. Output of the correlation_matrix() function is a table of strings; this gets saved out to a .csv2 with the save_correlation_matrix() function for easy insertion into a paper. For more details about the process, consult <https://paulvanderlaken.com/2020/07/28/publication-ready-correlation-matrix-significance-r/>.

An API wrapper for Cryptowatch to get prices and other information (e.g., volume, trades, order books, bid and ask prices, live quotes, and more) about cryptocurrencies and crypto exchanges. See <https://docs.cryptowat.ch/rest-api> for a detailed documentation.

This package provides an extension to the purrr family of mapping functions to apply a function to each combination of elements in a list of inputs. Also includes functions for automatically detecting output type in mapping functions, finding every combination of elements of lists or rows of data frames, and applying multiple models to multiple subsets of a dataset.