Uses non-linear regression to statistically compare two circadian rhythms. Groups are only compared if both are rhythmic (amplitude is non-zero). Performs analyses regarding mesor, phase, and amplitude, reporting on estimates and statistical differences, for each, between groups. Details can be found in Parsons et al (2020) <doi:10.1093/bioinformatics/btz730>.

This package provides several functions to identify and analyse miRNA sponge, including popular methods for identifying miRNA sponge interactions, two types of global ceRNA regulation prediction methods and four types of context-specific prediction methods( Li Y et al.(2017) <doi:10.1093/bib/bbx137>), which are based on miRNA-messenger RNA regulation alone, or by integrating heterogeneous data, respectively. In addition, For predictive ceRNA relationship pairs, this package provides several downstream analysis algorithms, including regulatory network analysis and functional annotation analysis, as well as survival prognosis analysis based on expression of ceRNA ternary pair.

Use optimal equal-HR method to determine two optimal cutpoints of a continuous predictor that has a U-shaped relationship with survival outcomes based on Cox regression model. The optimal equal-HR method estimates two optimal cut-points that have approximately the same log hazard value based on Cox regression model and divides individuals into different groups according to their HR values.

Fit and apply ComBat, linear mixed-effects models (LMM), or prescaling to harmonize magnetic resonance imaging (MRI) data from different sites. Briefly, these methods remove differences between sites due to using different scanning devices, and LMM additionally tests linear hypotheses. As detailed in the manual, the original ComBat function was first modified for the harmonization of MRI data (Fortin et al. (2017) <doi:10.1016/j.neuroimage.2017.11.024>) and then modified again to create separate functions for fitting and applying the harmonization and allow missing values and constant rows for its use within the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium (Radua et al. (2020) <doi:10.1016/j.neuroimage.2020.116956>); this package includes the latter version. LMM calls "lme" massively considering specific brain imaging details. Finally, prescaling is a good option for fMRI, where different devices can have varying units of measurement.

Allows to plot a number of information related to the interpretation of Correspondence Analysis results. It provides the facility to plot the contribution of rows and columns categories to the principal dimensions, the quality of points display on selected dimensions, the correlation of row and column categories to selected dimensions, etc. It also allows to assess which dimension(s) is important for the data structure interpretation by means of different statistics and tests. The package also offers the facility to plot the permuted distribution of the table total inertia as well as of the inertia accounted for by pairs of selected dimensions. Different facilities are also provided that aim to produce interpretation-oriented scatterplots. Reference: Alberti 2015 <doi:10.1016/j.softx.2015.07.001>.

In many studies across different disciplines, detailed measures of the variables of interest are available. If assumptions can be made regarding the direction of effects between the assessed variables, this has to be considered in the analysis. The functions in this package implement the novel approach CIEE (causal inference using estimating equations; Konigorski et al., 2018, <DOI:10.1002/gepi.22107>) for estimating and testing the direct effect of an exposure variable on a primary outcome, while adjusting for indirect effects of the exposure on the primary outcome through a secondary intermediate outcome and potential factors influencing the secondary outcome. The underlying directed acyclic graph (DAG) of this considered model is described in the vignette. CIEE can be applied to studies in many different fields, and it is implemented here for the analysis of a continuous primary outcome and a time-to-event primary outcome subject to censoring. CIEE uses estimating equations to obtain estimates of the direct effect and robust sandwich standard error estimates. Then, a large-sample Wald-type test statistic is computed for testing the absence of the direct effect. Additionally, standard multiple regression, regression of residuals, and the structural equation modeling approach are implemented for comparison.

This package provides a collection of coding functions as alternatives to the standard functions in the stats package, which have names starting with contr.'. Their main advantage is that they provide a consistent method for defining marginal effects in factorial models. In a simple one-way ANOVA model the intercept term is always the simple average of the class means.

This package implements a kernel-based association test for copy number variation (CNV) aggregate analysis in a certain genomic region (e.g., gene set, chromosome, or genome) that is robust to the within-locus and across-locus etiological heterogeneity, and bypass the need to define a "locus" unit for CNVs. Brucker, A., et al. (2020) <doi:10.1101/666875>.

This package provides tools for visualization of, and inference on, the calibration of prediction models on the cumulative domain. This provides a method for evaluating calibration of risk prediction models without having to group the data or use tuning parameters (e.g., loess bandwidth). This package implements the methodology described in Sadatsafavi and Patkau (2024) <doi:10.1002/sim.10138>. The core of the package is cumulcalib(), which takes in vectors of binary responses and predicted risks. The plot() and summary() methods are implemented for the results returned by cumulcalib().

Cleaning and standardizing tabular data package, tailored specifically for curating epidemiological data. It streamlines various data cleaning tasks that are typically expected when working with datasets in epidemiology. It returns the processed data in the same format, and generates a comprehensive report detailing the outcomes of each cleaning task.

In computer experiments space-filling designs are having great impact. Most popularly used space-filling designs are Uniform designs (UDs), Latin hypercube designs (LHDs) etc. For further references one can see Mckay (1979) <DOI:10.1080/00401706.1979.10489755> and Fang (1980) <https://cir.nii.ac.jp/crid/1570291225616774784>. In this package, we have provided algorithms for generate efficient LHDs and UDs. Here, generated LHDs are efficient as they possess lower value of Maxpro measure, Phi_p value and Maximum Absolute Correlation (MAC) value based on the weightage given to each criterion. On the other hand, the produced UDs are having good space-filling property as they always attain the lower bound of Discrete Discrepancy measure. Further, some useful functions added in this package for adding more value to this package.

This package provides tools for assessing data quality, performing exploratory analysis, and semi-automatic preprocessing of messy data with change tracking for integral dataset cleaning.

An interactive document on the topic of classification tree analysis using rmarkdown and shiny packages. Runtime examples are provided in the package function as well as at <https://kartikeyab.shinyapps.io/CTShiny/>.

This package provides an extension to the purrr family of mapping functions to apply a function to each combination of elements in a list of inputs. Also includes functions for automatically detecting output type in mapping functions, finding every combination of elements of lists or rows of data frames, and applying multiple models to multiple subsets of a dataset.

This package provides methods for learning causal relationships among a set of foreground variables X based on signals from a (potentially much larger) set of background variables Z, which are known non-descendants of X. The confounder blanket learner (CBL) uses sparse regression techniques to simultaneously perform many conditional independence tests, with complementary pairs stability selection to guarantee finite sample error control. CBL is sound and complete with respect to a so-called "lazy oracle", and works with both linear and nonlinear systems. For details, see Watson & Silva (2022) <arXiv:2205.05715>.

This package provides functions for nonlinear regression parameters estimation by algorithms based on Controlled Random Search algorithm. Both functions (crs4hc(), crs4hce()) adapt current search strategy by four heuristics competition. In addition, crs4hce() improves adaptability by adaptive stopping condition.

Computation of a cubic B-spline basis for arbitrary knots. It also provides the 1st and 2nd derivatives, as well as the integral of the basis elements. It is used by the author to fit penalized B-spline models, see e.g. Jullion, A. and Lambert, P. (2006) <doi:10.1016/j.csda.2006.09.027>, Lambert, P. and Eilers, P.H.C. (2009) <doi:10.1016/j.csda.2008.11.022> and, more recently, Lambert, P. (2021) <doi:10.1016/j.csda.2021.107250>. It is inspired by the algorithm developed by de Boor, C. (1977) <doi:10.1137/0714026>.

Enable the use of Shepherd.js to create tours in Shiny applications.

This package provides a collection of ergonomic large language model assistants designed to help you complete repetitive, hard-to-automate tasks quickly. After selecting some code, press the keyboard shortcut you've chosen to trigger the package app, select an assistant, and watch your chore be carried out. While the package ships with a number of chore helpers for R package development, users can create custom helpers just by writing some instructions in a markdown file.

Perform evaluation of automatic subject indexing methods. The main focus of the package is to enable efficient computation of set retrieval and ranked retrieval metrics across multiple dimensions of a dataset, e.g. document strata or subsets of the label set. The package also provides the possibility of computing bootstrap confidence intervals for all major metrics, with seamless integration of parallel computation and propensity scored variants of standard metrics.

This package provides a lightweight data validation and testing toolkit for R. Its guiding philosophy is that adding code-based data checks to users existing workflow should be both quick and intuitive. The suite of functions included therefore mirror the common data checks many users already perform by hand or by eye. Additionally, the checkthat package is optimized to work within tidyverse data manipulation pipelines.

Implementation of Librino, Levorato, and Zorzi (2014) <doi:10.1002/wcm.2305> algorithm for computation of the intersection areas of an arbitrary number of circles.

This package provides access to consolidated information from the Brazilian Federal Government Payment Card. Includes functions to retrieve, clean, and organize data directly from the Transparency Portal <https://portaldatransparencia.gov.br/download-de-dados/cpgf/> and a curated dataset hosted on the Open Science Framework <https://osf.io/z2mxc/>. Useful for public spending analysis, transparency research, and reproducible workflows in auditing or investigative journalism.

This package implements computationally-efficient construction of confidence intervals from permutation or randomization tests for simple differences in means, based on Nguyen (2009) <doi:10.15760/etd.7798>.