Many modern C/C++ development tools in the clang toolchain, such as clang-tidy or clangd', rely on the presence of a compilation database in JSON format <https://clang.llvm.org/docs/JSONCompilationDatabase.html>. This package temporarily injects additional build flags into the R build process to generate such a compilation database.

Includes several classifications such as International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD10), Anatomical Therapeutic Chemical (ATC) Classification, The International Classification of Diseases for Oncology (ICD-O-3), and International Classification of Primary Care (ICPC). Includes function that adds descriptive label to code value. Depending on classification following languages are available: English, Finnish, Swedish, and Latin.

This package provides a Bayesian meta-analysis method for studying cross-phenotype genetic associations. It uses summary-level data across multiple phenotypes to simultaneously measure the evidence of aggregate-level pleiotropic association and estimate an optimal subset of traits associated with the risk locus. CPBayes is based on a spike and slab prior. The methodology is available from: A Majumdar, T Haldar, S Bhattacharya, JS Witte (2018) <doi:10.1371/journal.pgen.1007139>.

Encrypts and decrypts using basic ciphers. None of these should be used in place of real encryption using state of the art tools. The ciphers included use methods described in the ciphers's Wikipedia and cryptography hobby websites.

Light-weight functions for computing descriptive statistics in different circular spaces (e.g., 2pi, 180, or 360 degrees), to handle angle-dependent biases, pad circular data, and more. Specifically aimed for psychologists and neuroscientists analyzing circular data. Basic methods are based on Jammalamadaka and SenGupta (2001) <doi:10.1142/4031>, removal of cardinal biases is based on the approach introduced in van Bergen, Ma, Pratte, & Jehee (2015) <doi:10.1038/nn.4150> and Chetverikov and Jehee (2023) <doi:10.1038/s41467-023-43251-w>.

This package provides a collection of functions for top-down exploratory data analysis of spectral data including nuclear magnetic resonance (NMR), infrared (IR), Raman, X-ray fluorescence (XRF) and other similar types of spectroscopy. Includes functions for plotting and inspecting spectra, peak alignment, hierarchical cluster analysis (HCA), principal components analysis (PCA) and model-based clustering. Robust methods appropriate for this type of high-dimensional data are available. ChemoSpec is designed for structured experiments, such as metabolomics investigations, where the samples fall into treatment and control groups. Graphical output is formatted consistently for publication quality plots. ChemoSpec is intended to be very user friendly and to help you get usable results quickly. A vignette covering typical operations is available.

This package provides a set of functions to manage CRAN'-like repositories efficiently.

These experimental expression data (5 leukemic CLL B-lymphocyte of aggressive form from GSE39411', <doi:10.1073/pnas.1211130110>), after B-cell receptor stimulation, are used as examples by packages such as the Cascade one, a modeling tool allowing gene selection, reverse engineering, and prediction in cascade networks. Jung, N., Bertrand, F., Bahram, S., Vallat, L., and Maumy-Bertrand, M. (2014) <doi:10.1093/bioinformatics/btt705>.

In phase I clinical trials, the primary objective is to ascertain the maximum tolerated dose (MTD) corresponding to a specified target toxicity rate. The subsequent phase II trials are designed to examine the potential efficacy of the drug based on the MTD obtained from the phase I trials, with the aim of identifying the optimal biological dose (OBD). The CFO package facilitates the implementation of dose-finding trials by utilizing calibration-free odds type (CFO-type) designs. Specifically, it encompasses the calibration-free odds (CFO) (Jin and Yin (2022) <doi:10.1177/09622802221079353>), randomized CFO (rCFO), precision CFO (pCFO), two-dimensional CFO (2dCFO) (Wang et al. (2023) <doi:10.3389/fonc.2023.1294258>), time-to-event CFO (TITE-CFO) (Jin and Yin (2023) <doi:10.1002/pst.2304>), fractional CFO (fCFO), accumulative CFO (aCFO), TITE-aCFO, and f-aCFO (Fang and Yin (2024) <doi: 10.1002/sim.10127>). It supports phase I/II trials for the CFO design and only phase I trials for the other CFO-type designs. The â CFO package accommodates diverse CFO-type designs, allowing users to tailor the approach based on factors such as dose information inclusion, handling of late-onset toxicity, and the nature of the target drug (single-drug or drug-combination). The functionalities embedded in CFO package include the determination of the dose level for the next cohort, the selection of the MTD for a real trial, and the execution of single or multiple simulations to obtain operating characteristics. Moreover, these functions are equipped with early stopping and dose elimination rules to address safety considerations. Users have the flexibility to choose different distributions, thresholds, and cohort sizes among others for their specific needs. The output of the CFO package can be summary statistics as well as various plots for better visualization. An interactive web application for CFO is available at the provided URL.

Interact with Condor from R via SSH connection. Files are first uploaded from user machine to submitter machine, and the job is then submitted from the submitter machine to Condor'. Functions are provided to submit, list, and download Condor jobs from R. Condor is an open source high-throughput computing software framework for distributed parallelization of computationally intensive tasks.

Estimate sample sizes needed to capture target levels of genetic diversity from a population (multivariate allele frequencies) for applications like germplasm conservation and breeding efforts. Compares bootstrap samples to a full population using linear regression, employing the R-squared value to represent the proportion of diversity captured. Iteratively increases sample size until a user-defined target R-squared is met. Offers a parallelized R implementation of a previously developed python method. All ploidy levels are supported. For more details, see Sandercock et al. (2024) <doi:10.1073/pnas.2403505121>.

Model-free selection of covariates under unconfoundedness for situations where the parameter of interest is an average causal effect. This package is based on model-free backward elimination algorithms proposed in de Luna, Waernbaum and Richardson (2011). Marginal co-ordinate hypothesis testing is used in situations where all covariates are continuous while kernel-based smoothing appropriate for mixed data is used otherwise.

Model building, surrogate model based optimization and Efficient Global Optimization in combinatorial or mixed search spaces.

Exploring fitted models by interactively taking 2-D and 3-D sections in data space.

This package provides an object class for dealing with many multivariate probability distributions at once, useful for simulation.

This package provides tools for estimation and clustering of spherical data, seamlessly integrated with the flexmix package. Includes the necessary M-step implementations for both Poisson Kernel-Based Distribution (PKBD) and spherical Cauchy distribution. Additionally, the package provides random number generators for PKBD and spherical Cauchy distribution. Methods are based on Golzy M., Markatou M. (2020) <doi:10.1080/10618600.2020.1740713>, Kato S., McCullagh P. (2020) <doi:10.3150/20-bej1222> and Sablica L., Hornik K., Leydold J. (2023) <doi:10.1214/23-ejs2149>.

This package provides functions for hit gene identification and quantification of sgRNA (single-guided RNA) abundances for CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) pooled screen data analysis. Details are in Jeong et al. (2019) <doi:10.1101/gr.245571.118> and Baggerly et al. (2003) <doi:10.1093/bioinformatics/btg173>.

Check digits are used like file hashes to verify that a number has been transcribed accurately. The functions provided by this package help to calculate and verify check digits according to various algorithms.

This package provides an interactive shiny web application for constructing, analyzing, and visualizing composite indices from multidimensional datasets. Users can upload or select indicator data, group variables into logical categories, apply normalization and weighting methods (such as equal or custom schemes), and compute aggregate composite indices. The shiny interface includes tools for exploring results through tables, plots, and data exports, making it useful for researchers, policymakers, and analysts interested in index-based evaluations.

This package provides a tool for transforming coordinates in a color space to common color names using data from the Royal Horticultural Society and the International Union for the Protection of New Varieties of Plants.

This package provides igraph objects representing engineering plans of study across multiple disciplines and institutions. The data are intended for use with the CurricularComplexity package (Reeping, 2026) <https://CRAN.R-project.org/package=CurricularComplexity> to support analyses of curricular structure. The package leverages network analysis approaches implemented in igraph (Csárdi et al., 2025) <doi:10.5281/zenodo.7682609>.

Uses monotonically constrained Cubic Bezier Splines (CBS) to approximate latent utility functions in intertemporal choice and risky choice data. For more information, see Lee, Glaze, Bradlow, and Kable <doi:10.1007/s11336-020-09723-4>.

This package provides a wrapper for circlize'. All components are based on classes and objects. Users can use the addition symbol (+) to combine components for a circular visualization with ggplot2 style.The package is described in Zhang Z, Cao T, Huang Y and Xia Y (2025) <doi:10.3389/fgene.2025.1535368>.

This package provides functions for making contour plots. The contour plot can be created from grid data, a function, or a data set. If non-grid data is given, then a Gaussian process is fit to the data and used to create the contour plot.