This package provides a spatially-aware cell clustering algorithm is provided with cluster significance assessment. It comprises four key modules: spatially-aware cell-gene co-embedding, cell clustering, signature gene identification, and cluster significant assessment. More details can be referred to Peng Xie, et al. (2025) <doi:10.1016/j.cell.2025.05.035>.

The network analysis plays an important role in numerous application domains including biomedicine. Estimation of the number of communities is a fundamental and critical issue in network analysis. Most existing studies assume that the number of communities is known a priori, or lack of rigorous theoretical guarantee on the estimation consistency. This method proposes a regularized network embedding model to simultaneously estimate the community structure and the number of communities in a unified formulation. The proposed model equips network embedding with a novel composite regularization term, which pushes the embedding vector towards its center and collapses similar community centers with each other. A rigorous theoretical analysis is conducted, establishing asymptotic consistency in terms of community detection and estimation of the number of communities. Reference: Ren, M., Zhang S. and Wang J. (2022). "Consistent Estimation of the Number of Communities via Regularized Network Embedding". Biometrics, <doi:10.1111/biom.13815>.

Evaluates the stability and significance of clusters on igraph graphs. Supports weighted and unweighted graphs. Implements the cluster evaluation methods defined by Arratia A, Renedo M (2021) <doi:10.7717/peerj-cs.600>. Also includes an implementation of the Reduced Mutual Information introduced by Newman et al. (2020) <doi:10.1103/PhysRevE.101.042304>.

As different antipsychotic medications have different potencies, the doses of different medications cannot be directly compared. Various strategies are used to convert doses into a common reference so that comparison is meaningful. Chlorpromazine (CPZ) has historically been used as a reference medication into which other antipsychotic doses can be converted, as "chlorpromazine-equivalent doses". Using conversion keys generated from widely-cited scientific papers, e.g. Gardner et. al 2010 <doi:10.1176/appi.ajp.2009.09060802> and Leucht et al. 2016 <doi:10.1093/schbul/sbv167>, antipsychotic doses are converted to CPZ (or any specified antipsychotic) equivalents. The use of the package is described in the included vignette. Not for clinical use.

This package implements cross-validation methods for linear and ridge regression models. The package provides grid-based selection of the ridge penalty parameter using Singular Value Decomposition (SVD) and supports K-fold cross-validation, Leave-One-Out Cross-Validation (LOOCV), and Generalized Cross-Validation (GCV). Computations are implemented in C++ via RcppArmadillo with optional parallelization using RcppParallel'. The methods are suitable for high-dimensional settings where the number of predictors exceeds the number of observations.

Set of methods to constrain numerical series and time series within arbitrary boundaries.

Compile inline C code and easily call with automatically generated wrapper functions. By allowing user-defined headers and compilation flags (preprocessor, compiler and linking flags) the user can configure optimization options and linking to third party libraries. Multiple functions may be defined in a single block of code - which may be defined in a string or a path to a source file.

This package provides a set of common functions to be used for displaying messages, checking variables, finding absolute paths, starting applications, etc. More functions will be added later.

Evaluates predictive performance under feature-level missingness in repeated-measures continuous glucose monitoring-like data. The benchmark injects missing values at user-specified rates, imputes incomplete feature matrices using an iterative chained-equations approach inspired by multivariate imputation by chained equations (MICE; Azur et al. (2011) <doi:10.1002/mpr.329>), fits Random Forest regression models (Breiman (2001) <doi:10.1023/A:1010933404324>) and k-nearest-neighbor regression models (Zhang (2016) <doi:10.21037/atm.2016.03.37>), and reports mean absolute percentage error and R-squared across missingness rates.

Design and use of control charts for detecting mean changes based on a delayed updating of the in-control parameter estimates. See Capizzi and Masarotto (2019) <doi:10.1080/00224065.2019.1640096> for the description of the method.

Fits a Causal Effect Random Forest of Interaction Tress (CERFIT) which is a modification of the Random Forest algorithm where each split is chosen to maximize subgroup treatment heterogeneity. Doing this allows it to estimate the individualized treatment effect for each observation in either randomized controlled trial (RCT) or observational data. For more information see L. Li, R. A. Levine, and J. Fan (2022) <doi:10.1002/sta4.457>.

Data sets used for copula modeling in addition to those in the R package copula'. These include a random subsample from the US National Education Longitudinal Study (NELS) of 1988 and nursing home data from Wisconsin.

Make fake data that looks realistic, supporting addresses, person names, dates, times, colors, coordinates, currencies, digital object identifiers ('DOIs'), jobs, phone numbers, DNA sequences, doubles and integers from distributions and within a range.

Maximum likelihood estimation in respondent driven samples.

Computation of decision intervals (H) and average run lengths (ARL) for CUSUM charts. Details of the method are seen in Hawkins and Olwell (2012): Cumulative sum charts and charting for quality improvement, Springer Science & Business Media.

Analyzes and modifies metabolomics raw data (generated using Gas Chromatography-Atmospheric Pressure Chemical Ionization-Mass Spectrometry) to correct overloaded signals, i.e. ion intensities exceeding detector saturation leading to a cut-off peak. Data in xcmsRaw format are accepted as input and mzXML files can be processed alternatively. Overloaded signals are detected automatically and modified using an Gaussian or an Isotopic-Ratio approach. Quality control plots are generated and corrected data are stored within the original xcmsRaw or mzXML respectively to allow further processing.

Helps visualizing what is summarized in Pearson's correlation coefficient. That is, it visualizes its main constituent, namely the distances of the single values to their respective mean. The visualization thereby shows what the etymology of the word correlation contains: In pairwise combination, bringing back (see package Vignette for more details). I hope that the correlatio package may benefit some people in understanding and critically evaluating what Pearson's correlation coefficient summarizes in a single number, i.e., to what degree and why Pearson's correlation coefficient may (or may not) be warranted as a measure of association.

Estimate the severity of a disease and ascertainment of cases, as discussed in Nishiura et al. (2009) <doi:10.1371/journal.pone.0006852>.

Design and evaluate choice-based conjoint survey experiments. Generate a variety of survey designs, including random designs, frequency-based designs, and D-optimal designs, as well as "labeled" designs (also known as "alternative-specific designs"), designs with "no choice" options, and designs with dominant alternatives removed. Conveniently inspect and compare designs using a variety of metrics, including design balance, overlap, and D-error, and simulate choice data for a survey design either randomly or according to a utility model defined by user-provided prior parameters. Conduct a power analysis for a given survey design by estimating the same model on different subsets of the data to simulate different sample sizes. Bayesian D-efficient designs using the cea and modfed methods are obtained using the idefix package by Traets et al (2020) <doi:10.18637/jss.v096.i03>. Choice simulation and model estimation in power analyses are handled using the logitr package by Helveston (2023) <doi:10.18637/jss.v105.i10>.

Numerical integration of cause-specific survival curves to arrive at cause-specific cumulative incidence functions, with three usage modes: 1) Convenient API for parametric survival regression followed by competing-risk analysis, 2) API for CFC, accepting user-specified survival functions in R, and 3) Same as 2, but accepting survival functions in C++. For mathematical details and software tutorial, see Mahani and Sharabiani (2019) <DOI:10.18637/jss.v089.i09>.

This package creates auto-grading check-fields and check-boxes for rmarkdown or quarto HTML. It can be used in class, when teacher share materials and tasks, so students can solve some problems and check their work. In contrast to the learnr package, the checkdown package works serverlessly without shiny'.

Nonparametric two-sample procedure for comparing survival quantiles.

Chemical analysis of proteins based on their amino acid compositions. Amino acid compositions can be read from FASTA files and used to calculate chemical metrics including carbon oxidation state and stoichiometric hydration state, as described in Dick et al. (2020) <doi:10.5194/bg-17-6145-2020>. Other properties that can be calculated include protein length, grand average of hydropathy (GRAVY), isoelectric point (pI), molecular weight (MW), standard molal volume (V0), and metabolic costs (Akashi and Gojobori, 2002 <doi:10.1073/pnas.062526999>; Wagner, 2005 <doi:10.1093/molbev/msi126>; Zhang et al., 2018 <doi:10.1038/s41467-018-06461-1>). A database of amino acid compositions of human proteins derived from UniProt is provided.

Perform state and parameter inference, and forecasting, in stochastic state-space systems using the ctsmTMB class. This class, built with the R6 package, provides a user-friendly interface for defining and handling state-space models. Inference is based on maximum likelihood estimation, with derivatives efficiently computed through automatic differentiation enabled by the TMB'/'RTMB packages (Kristensen et al., 2016) <doi:10.18637/jss.v070.i05>. The available inference methods include Kalman filters, in addition to a Laplace approximation-based smoothing method. For further details of these methods refer to the documentation of the CTSMR package <https://ctsm.info/ctsmr-reference.pdf> and Thygesen (2025) <doi:10.48550/arXiv.2503.21358>. Forecasting capabilities include moment predictions and stochastic path simulations, both implemented in C++ using Rcpp (Eddelbuettel et al., 2018) <doi:10.1080/00031305.2017.1375990> for computational efficiency.