An algorithm for identifying candidate driver combinations in cancer. CRSO is based on a theoretical model of cancer in which a cancer rule is defined to be a collection of two or more events (i.e., alterations) that are minimally sufficient to cause cancer. A cancer rule set is a set of cancer rules that collectively are assumed to account for all of ways to cause cancer in the population. In CRSO every event is designated explicitly as a passenger or driver within each patient. Each event is associated with a patient-specific, event-specific passenger penalty, reflecting how unlikely the event would have happened by chance, i.e., as a passenger. CRSO evaluates each rule set by assigning all samples to a rule in the rule set, or to the null rule, and then calculating the total statistical penalty from all unassigned event. CRSO uses a three phase procedure find the best rule set of fixed size K for a range of Ks. A core rule set is then identified from among the best rule sets of size K as the rule set that best balances rule set size and statistical penalty. Users should consult the crso vignette for an example walk through of a full CRSO run. The full description, of the CRSO algorithm is presented in: Klein MI, Cannataro V, Townsend J, Stern DF and Zhao H. "Identifying combinations of cancer driver in individual patients." BioRxiv 674234 [Preprint]. June 19, 2019. <doi:10.1101/674234>. Please cite this article if you use crso'.

This comprehensive framework for periodic time series modeling is designated as "CLIC" (The LIC for Distributed Cosine Regression Analysis) analysis. It is predicated on the assumption that the underlying data exhibits complex periodic structures beyond simple harmonic components. The philosophy of the method is articulated in Guo G. (2020) <doi:10.1080/02664763.2022.2053949>.

Colocalisation analysis tests whether two traits share a causal genetic variant in a specified genomic region. Proportional testing for colocalisation has been previously proposed [Wallace (2013) <doi:10.1002/gepi.21765>], but is reimplemented here to overcome barriers to its adoption. Its use is complementary to the fine- mapping based colocalisation method in the coloc package, and may be used in particular to identify false "H3" conclusions in coloc'.

Estimates hidden Markov models from the family of Cholesky-decomposed Gaussian hidden Markov models (CDGHMM) under various missingness schemes. This family improves upon estimation of traditional Gaussian HMMs by introducing parsimony, as well as, controlling for dropped out observations and non-random missingness. See Neal, Sochaniwsky and McNicholas (2024) <DOI:10.1007/s11222-024-10462-0>.

This package provides ability to control how many times in function calls conditions are thrown (shown to the user). Includes control of warnings and messages.

For those wishing to interact with the Charles Schwab Individual Trader API (<https://developer.schwab.com/products/trader-api--individual>) with R in a simplified manner, this package offers wrapper functions around authentication and the available API calls to streamline the process.

The theory of cooperative games with transferable utility offers useful insights into the way parties can share gains from cooperation and secure sustainable agreements, see e.g. one of the books by Chakravarty, Mitra and Sarkar (2015, ISBN:978-1107058798) or by Driessen (1988, ISBN:978-9027727299) for more details. A comprehensive set of tools for cooperative game theory with transferable utility is provided. Users can create special families of cooperative games, like e.g. bankruptcy games, cost sharing games and weighted voting games. There are functions to check various game properties and to compute five different set-valued solution concepts for cooperative games. A large number of point-valued solution concepts is available reflecting the diverse application areas of cooperative game theory. Some of these point-valued solution concepts can be used to analyze weighted voting games and measure the influence of individual voters within a voting body. There are routines for visualizing both set-valued and point-valued solutions in the case of three or four players.

This package provides a constrained generalized additive model is fitted by the cgam routine. Given a set of predictors, each of which may have a shape or order restrictions, the maximum likelihood estimator for the constrained generalized additive model is found using an iteratively re-weighted cone projection algorithm. The ShapeSelect routine chooses a subset of predictor variables and describes the component relationships with the response. For each predictor, the user needs only specify a set of possible shape or order restrictions. A model selection method chooses the shapes and orderings of the relationships as well as the variables. The cone information criterion (CIC) is used to select the best combination of variables and shapes. A genetic algorithm may be used when the set of possible models is large. In addition, the cgam routine implements a two-dimensional isotonic regression using warped-plane splines without additivity assumptions. It can also fit a convex or concave regression surface with triangle splines without additivity assumptions. See Liao X, Meyer MC (2019)<doi:10.18637/jss.v089.i05> for more details.

Calculates the co-ranking matrix to assess the quality of a dimensionality reduction.

This package provides functions calculating Conley (1999) <doi:10.1016/S0304-4076(98)00084-0> standard errors. The package started by merging and extending multiple packages and other published scripts on this econometric technique. It strongly emphasizes computational optimization. Details are available in the function documentation and in the vignette.

Implementation of the categorical instrumental variable (CIV) estimator proposed by Wiemann (2023) <arXiv:2311.17021>. CIV allows for optimal instrumental variable estimation in settings with relatively few observations per category. To obtain valid inference in these challenging settings, CIV leverages a regularization assumption that implies existence of a latent categorical variable with fixed finite support achieving the same first stage fit as the observed instrument.

This package implements a basis function or functional data analysis framework for several techniques of multivariate analysis in continuous-time setting. Specifically, we introduced continuous-time analogues of several classical techniques of multivariate analysis, such as principal component analysis, canonical correlation analysis, Fisher linear discriminant analysis, K-means clustering, and so on. Details are in Biplab Paul, Philip T. Reiss, Erjia Cui and Noemi Foa (2025) "Continuous-time multivariate analysis" <doi: 10.1080/10618600.2024.2374570>.

Access the Cumulocity API and retrieve data on devices, measurements, and events. Documentation for the API can be found at <https://www.cumulocity.com/guides/reference/rest-implementation/>.

Execute Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. Specify engine parameters and select from different run options, including simple estimation, stepwise covariate search, bootstrapping, simulation, visual predictive check, and more. Models are executed using the Certara.RsNLME package.

Sample and cell filtering as well as visualisation of output metrics from Cell Ranger by Grace X.Y. Zheng et al. (2017) <doi:10.1038/ncomms14049>. CRMetrics allows for easy plotting of output metrics across multiple samples as well as comparative plots including statistical assessments of these. CRMetrics allows for easy removal of ambient RNA using SoupX by Matthew D Young and Sam Behjati (2020) <doi:10.1093/gigascience/giaa151> or CellBender by Stephen J Fleming et al. (2022) <doi:10.1101/791699>. Furthermore, it is possible to preprocess data using Pagoda2 by Nikolas Barkas et al. (2021) <https://github.com/kharchenkolab/pagoda2> or Seurat by Yuhan Hao et al. (2021) <doi:10.1016/j.cell.2021.04.048> followed by embedding of cells using Conos by Nikolas Barkas et al. (2019) <doi:10.1038/s41592-019-0466-z>. Finally, doublets can be detected using scrublet by Samuel L. Wolock et al. (2019) <doi:10.1016/j.cels.2018.11.005> or DoubletDetection by Gayoso et al. (2020) <doi:10.5281/zenodo.2678041>. In the end, cells are filtered based on user input for use in downstream applications.

This package provides igraph objects representing engineering plans of study across multiple disciplines and institutions. The data are intended for use with the CurricularComplexity package (Reeping, 2026) <https://CRAN.R-project.org/package=CurricularComplexity> to support analyses of curricular structure. The package leverages network analysis approaches implemented in igraph (Csárdi et al., 2025) <doi:10.5281/zenodo.7682609>.

This package provides tools for fitting, assessing, and comparing logistic and conditional logistic regression models. Includes residual diagnostics and goodness of fit measures for model development and evaluation in matched case control studies.

Data on international and other major cricket matches from ESPNCricinfo <https://www.espncricinfo.com> and Cricsheet <https://cricsheet.org>. This package provides some functions to download the data into tibbles ready for analysis.

This package provides a time series usually does not have a uniform growth rate. Compound Annual Growth Rate measures the average annual growth over a given period. More details can be found in Bardhan et al. (2022) <DOI:10.18805/ag.D-5418>.

Exploits dynamical seasonal forecasts in order to provide information relevant to stakeholders at the seasonal timescale. The package contains process-based methods for forecast calibration, bias correction, statistical and stochastic downscaling, optimal forecast combination and multivariate verification, as well as basic and advanced tools to obtain tailored products. This package was developed in the context of the ERA4CS project MEDSCOPE and the H2020 S2S4E project and includes contributions from ArticXchange project founded by EU-PolarNet 2. Implements methods described in Pérez-Zanón et al. (2022) <doi:10.5194/gmd-15-6115-2022>, Doblas-Reyes et al. (2005) <doi:10.1111/j.1600-0870.2005.00104.x>, Mishra et al. (2018) <doi:10.1007/s00382-018-4404-z>, Sanchez-Garcia et al. (2019) <doi:10.5194/asr-16-165-2019>, Straus et al. (2007) <doi:10.1175/JCLI4070.1>, Terzago et al. (2018) <doi:10.5194/nhess-18-2825-2018>, Torralba et al. (2017) <doi:10.1175/JAMC-D-16-0204.1>, D'Onofrio et al. (2014) <doi:10.1175/JHM-D-13-096.1>, Verfaillie et al. (2017) <doi:10.5194/gmd-10-4257-2017>, Van Schaeybroeck et al. (2019) <doi:10.1016/B978-0-12-812372-0.00010-8>, Yiou et al. (2013) <doi:10.1007/s00382-012-1626-3>.

Various estimators of causal effects based on inverse probability weighting, doubly robust estimation, and double machine learning. Specifically, the package includes methods for estimating average treatment effects, direct and indirect effects in causal mediation analysis, and dynamic treatment effects. The models refer to studies of Froelich (2007) <doi:10.1016/j.jeconom.2006.06.004>, Huber (2012) <doi:10.3102/1076998611411917>, Huber (2014) <doi:10.1080/07474938.2013.806197>, Huber (2014) <doi:10.1002/jae.2341>, Froelich and Huber (2017) <doi:10.1111/rssb.12232>, Hsu, Huber, Lee, and Lettry (2020) <doi:10.1002/jae.2765>, and others.

Interactive shiny application for running classical test theory (item analysis).

This package provides methods and plotting functions for displaying categorical data on an interactive heatmap using plotly'. Provides functionality for strictly categorical heatmaps, heatmaps illustrating categorized continuous data and annotated heatmaps. Also, there are various options to interact with the x-axis to prevent overlapping axis labels, e.g. via simple sliders or range sliders. Besides the viewer pane, resulting plots can be saved as a standalone HTML file, embedded in R Markdown documents or in a Shiny app.

This package provides various tools of for clustering multivariate angular data on the torus. The package provides angular adaptations of usual clustering methods such as the k-means clustering, pairwise angular distances, which can be used as an input for distance-based clustering algorithms, and implements clustering based on the conformal prediction framework. Options for the conformal scores include scores based on a kernel density estimate, multivariate von Mises mixtures, and naive k-means clusters. Moreover, the package provides some basic data handling tools for angular data.