Searches for, accesses, and retrieves Statistics Canada data tables, as well as individual vectors, as tidy data frames. This package enriches the tables with metadata, deals with encoding issues, allows for bilingual English or French language data retrieval, and bundles convenience functions to make it easier to work with retrieved table data. For more efficient data access the package allows for caching data in a local database and database level filtering, data manipulation and summarizing.

Predict the course of clinical trial with a time-to-event endpoint for both two-arm and single-arm design. Each of the four primary study design parameters (the expected number of observed events, the number of subjects enrolled, the observation time, and the censoring parameter) can be derived analytically given the other three parameters. And the simulation datasets can be generated based on the design settings.

This package provides a generic sleepâ wake cycle detection algorithm for analyzing unlabeled actigraphy data. The algorithm has been validated against event markers using data from the Multi-Ethnic Study of Atherosclerosis (MESA) Sleep study, and its methodological details are described in Chen and Sun (2024) <doi:10.1098/rsos.231468>. The package provides functions to estimate sleep metrics (e.g., sleep and wake onset times) and circadian rhythm metrics (e.g., mesor, phasor, interdaily stability, intradaily variability), as well as tools for screening actigraphy quality, fitting cosinor models, and performing parametric change point detection. The workflow can also be used to segment long actigraphy sequences into regularized structures for physical activity research.

There are 6 novel robust tests for equal correlation. They are all based on logistic regressions. The score statistic U is proportion to difference of two correlations based on different types of correlation in 6 methods. The ST1() is based on Pearson correlation. ST2() improved ST1() by using median absolute deviation. ST3() utilized type M correlation and ST4() used Spearman correlation. ST5() and ST6() used two different ways to combine ST3() and ST4(). We highly recommend ST5() according to the article titled New Statistical Methods for Constructing Robust Differential Correlation Networks to characterize the interactions among microRNAs published in Scientific Reports. Please see the reference: Yu et al. (2019) <doi:10.1038/s41598-019-40167-8>.

Construct directed graphs of S4 class hierarchies and visualize them. In general, these graphs typically are DAGs (directed acyclic graphs), often simple trees in practice.

This package performs forward and backward stepwise regression for the proportional subdistribution hazards model in competing risks (Fine & Gray 1999). Procedure uses AIC, BIC and BICcr as selection criteria. BICcr has a penalty of k = log(n*), where n* is the number of primary events. This version includes improved handling of factors, interactions, and polynomial terms.

This package provides a compilation of tests for hypotheses regarding covariance and correlation matrices for one or more groups. The hypothesis can be specified through a corresponding hypothesis matrix and a vector or by choosing one of the basic hypotheses, while for the structure test, only the latter works. Thereby Monte-Carlo and Bootstrap-techniques are used, and the respective method must be chosen, and the functions provide p-values and mostly also estimators of calculated covariance matrices of test statistics. For more details on the methodology, see Sattler et al. (2022) <doi:10.1016/j.jspi.2021.12.001>, Sattler and Pauly (2024) <doi:10.1007/s11749-023-00906-6>, and Sattler and Dobler (2025) <doi:10.48550/arXiv.2310.11799>.

This package provides tools to process CBASS-derived PAM data efficiently. Minimal requirements are PAM-based photosynthetic efficiency data (or data from any other continuous variable that changes with temperature, e.g. relative bleaching scores) from 4 coral samples (nubbins) subjected to 4 temperature profiles of at least 2 colonies from 1 coral species from 1 site. Please refer to the following CBASS (Coral Bleaching Automated Stress System) papers for in-depth information regarding CBASS acute thermal stress assays, experimental design considerations, and ED5/ED50/ED95 thermal parameters: Nicolas R. Evensen et al. (2023) <doi:10.1002/lom3.10555> Christian R. Voolstra et al. (2020) <doi:10.1111/gcb.15148> Christian R. Voolstra et al. (2025) <doi:10.1146/annurev-marine-032223-024511>.

Manipulate and view coronavirus data and other societally relevant data at a basic level.

Implementations of the family of map() functions with frequent saving of the intermediate results. The contained functions let you start the evaluation of the iterations where you stopped (reading the already evaluated ones from cache), and work with the currently evaluated iterations while remaining ones are running in a background job. Parallel computing is also easier with the workers parameter.

This model fitting tool incorporates cyclic coordinate descent and majorization-minimization approaches to fit a variety of regression models found in large-scale observational healthcare data. Implementations focus on computational optimization and fine-scale parallelization to yield efficient inference in massive datasets. Please see: Suchard, Simpson, Zorych, Ryan and Madigan (2013) <doi:10.1145/2414416.2414791>.

Computes the coverage correlation coefficient introduced in <doi:10.48550/arXiv.2508.06402> , a statistical measure that quantifies dependence between two random vectors by computing the union volume of data-centered hypercubes in a uniform space.

Automated assessment and selection of weighting factors for accurate quantification using linear calibration curve. In addition, a shiny App is provided, allowing users to analyze their data using an interactive graphical user interface, without any programming requirements.

Tool to assessing whether the results of a study could be influenced by collinearity. Simulations under a given hypothesized truth regarding effects of an exposure on the outcome are used and the resulting curves of lagged effects are visualized. A user's manual is provided, which includes detailed examples (e.g. a cohort study looking for windows of vulnerability to air pollution, a time series study examining the linear association of air pollution with hospital admissions, and a time series study examining the non-linear association between temperature and mortality). The methods are described in Basagana and Barrera-Gomez (2021) <doi:10.1093/ije/dyab179>.

This package provides various tools of for clustering multivariate angular data on the torus. The package provides angular adaptations of usual clustering methods such as the k-means clustering, pairwise angular distances, which can be used as an input for distance-based clustering algorithms, and implements clustering based on the conformal prediction framework. Options for the conformal scores include scores based on a kernel density estimate, multivariate von Mises mixtures, and naive k-means clusters. Moreover, the package provides some basic data handling tools for angular data.

This package provides functions for cobin and micobin regression models, a new family of generalized linear models for continuous proportional data (Y in the closed unit interval [0, 1]). It also includes an exact, efficient sampler for the Kolmogorov-Gamma random variable. For details, see Lee et al. (2025+) <doi:10.48550/arXiv.2504.15269>.

Automated method for doublet detection in flow or mass cytometry data, based on simulating doublets and finding events whose protein expression patterns are similar to the simulated doublets.

Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002.

One degree of freedom contrasts for lm', glm', gls', and geese objects.

This package provides conversion functionality between a broad range of scientific, historical, and industrial unit types.

Check for namespace collisions between a string input (your function or package name) and half a million packages and functions on CRAN.

This package implements the count splitting methodology from Neufeld et al. (2022) <doi:10.1093/biostatistics/kxac047> and Neufeld et al. (2023) <arXiv:2307.12985>. Intended for turning a matrix of single-cell RNA sequencing counts, or similar count datasets, into independent folds that can be used for training/testing or cross validation. Assumes that the entries in the matrix are from a Poisson or a negative binomial distribution.

This package contains a time series classification method that obtains a set of filters that maximize the between-class and minimize the within-class distances.

Create self-contained SVG information cards with embedded Google Fonts', shields-style badges, and custom logos. Cards are fully portable SVG files ideal for dashboards, reports, and web applications. Includes functions to export cards to PNG format and display them in R Markdown and Quarto documents.