Allows clustering of incomplete observations by addressing missing values using multiple imputation. For achieving this goal, the methodology consists in three steps, following Audigier and Niang 2022 <doi:10.1007/s11634-022-00519-1>. I) Missing data imputation using dedicated models. Four multiple imputation methods are proposed, two are based on joint modelling and two are fully sequential methods, as discussed in Audigier et al. (2021) <doi:10.48550/arXiv.2106.04424>. II) cluster analysis of imputed data sets. Six clustering methods are available (distances-based or model-based), but custom methods can also be easily used. III) Partition pooling. The set of partitions is aggregated using Non-negative Matrix Factorization based method. An associated instability measure is computed by bootstrap (see Fang, Y. and Wang, J., 2012 <doi:10.1016/j.csda.2011.09.003>). Among applications, this instability measure can be used to choose a number of clusters with missing values. The package also proposes several diagnostic tools to tune the number of imputed data sets, to tune the number of iterations in fully sequential imputation, to check the fit of imputation models, etc.

It aims to find significant pathways through network topology information. It has several advantages compared with current pathway enrichment tools. First, pathway node instead of single gene is taken as the basic unit when analysing networks to meet the fact that genes must be constructed into complexes to hold normal functions. Second, multiple network centrality measures are applied simultaneously to measure importance of nodes from different aspects to make a full view on the biological system. CePa extends standard pathway enrichment methods, which include both over-representation analysis procedure and gene-set analysis procedure. <doi:10.1093/bioinformatics/btt008>.

Implementations of canonical associative learning models, with tools to run experiment simulations, estimate model parameters, and compare model representations. Experiments and results are represented using S4 classes and methods.

This package provides a consistent interface for connecting R to various data sources including file systems and databases. Designed for clinical research, connector streamlines access to ADAM', SDTM for example. It helps to deal with multiple data formats through a standardized API and centralized configuration.

This package implements the framework introduced in Di Francesco and Mellace (2025) <doi:10.48550/arXiv.2502.11691>, shifting the focus to well-defined and interpretable estimands that quantify how treatment affects the probability distribution over outcome categories. It supports selection-on-observables, instrumental variables, regression discontinuity, and difference-in-differences designs.

Cox model inference for relative hazard and covariate-specific pure risk estimated from stratified and unstratified case-cohort data as described in Etievant, L., Gail, M.H. (Lifetime Data Analysis, 2024) <doi:10.1007/s10985-024-09621-2>.

This package provides a covariate-augmented overdispersed Poisson factor model is proposed to jointly perform a high-dimensional Poisson factor analysis and estimate a large coefficient matrix for overdispersed count data. More details can be referred to Liu et al. (2024) <doi:10.1093/biomtc/ujae031>.

Calculates centrality indices additional to the igraph package centrality functions.

Predicts anticancer peptides using random forests trained on the n-gram encoded peptides. The implemented algorithm can be accessed from both the command line and shiny-based GUI. The CancerGram model is too large for CRAN and it has to be downloaded separately from the repository: <https://github.com/BioGenies/CancerGramModel>. For more information see: Burdukiewicz et al. (2020) <doi:10.3390/pharmaceutics12111045>.

This package provides essential Cleaning Validation functions for complying with pharmaceutical cleaning process regulatory standards. The package includes non-parametric methods to analyze drug active-ingredient residue (DAR), cleaning agent residue (CAR), and microbial colonies (Mic) for non-Poisson distributions. Additionally, Poisson methods are provided for Mic analysis when Mic data follow a Poisson distribution.

This package provides a tiny package to generate CRediT author statements (<https://credit.niso.org/>). It provides three functions: create a template, read it back and generate the CRediT author statement in a text file.

Various statistical methods and models which are typically used for the estimation of outstanding claims reserves in general insurance, including those to estimate the claims development result as required under Solvency II.

Estimation and statistical process control are performed under copula-based time-series models. Available are statistical methods in Long and Emura (2014 JCSA), Emura et al. (2017 Commun Stat-Simul) <DOI:10.1080/03610918.2015.1073303>, Huang and Emura (2021 Commun Stat-Simul) <DOI:10.1080/03610918.2019.1602647>, Lin et al. (2021 Comm Stat-Simul) <DOI:10.1080/03610918.2019.1652318>, Sun et al. (2020 JSS Series in Statistics)<DOI:10.1007/978-981-15-4998-4>, and Huang and Emura (2021, in revision).

Imports and cleans opencovid19-fr <https://github.com/opencovid19-fr/data> data on COVID-19 in France.

CIFTI files contain brain imaging data in "grayordinates," which represent the gray matter as cortical surface vertices (left and right) and subcortical voxels (cerebellum, basal ganglia, and other deep gray matter). ciftiTools provides a unified environment for reading, writing, visualizing and manipulating CIFTI-format data. It supports the "dscalar," "dlabel," and "dtseries" intents. Grayordinate data is read in as a "xifti" object, which is structured for convenient access to the data and metadata, and includes support for surface geometry files to enable spatially-dependent functionality such as static or interactive visualizations and smoothing.

Get programmatic access to the open data provided by the Czech Statistical Office (CZSO, <https://csu.gov.cz>).

This package provides a comprehensive high-level package, for composite indicator construction and analysis. It is a "development environment" for composite indicators and scoreboards, which includes utilities for construction (indicator selection, denomination, imputation, data treatment, normalisation, weighting and aggregation) and analysis (multivariate analysis, correlation plotting, short cuts for principal component analysis, global sensitivity analysis, and more). A composite indicator is completely encapsulated inside a single hierarchical list called a "coin". This allows a fast and efficient work flow, as well as making quick copies, testing methodological variations and making comparisons. It also includes many plotting options, both statistical (scatter plots, distribution plots) as well as for presenting results.

This package implements the estimation and inference methods for counterfactual analysis described in Chernozhukov, Fernandez-Val and Melly (2013) <DOI:10.3982/ECTA10582> "Inference on Counterfactual Distributions," Econometrica, 81(6). The counterfactual distributions considered are the result of changing either the marginal distribution of covariates related to the outcome variable of interest, or the conditional distribution of the outcome given the covariates. They can be applied to estimate quantile treatment effects and wage decompositions.

This package provides a statistical framework and computational procedure for identifying the sub-populations within a tumor, determining the mutation profiles of each subpopulation, and inferring the tumor's phylogenetic history. The input are variant allele frequencies (VAFs) of somatic single nucleotide alterations (SNAs) along with allele-specific coverage ratios between the tumor and matched normal sample for somatic copy number alterations (CNAs). These quantities can be directly taken from the output of existing software. Canopy provides a general mathematical framework for pooling data across samples and sites to infer the underlying parameters. For SNAs that fall within CNA regions, Canopy infers their temporal ordering and resolves their phase. When there are multiple evolutionary configurations consistent with the data, Canopy outputs all configurations along with their confidence assessment.

Bayesian and ML Emax model fitting, graphics and simulation for clinical dose response. The summary data from the dose response meta-analyses in Thomas, Sweeney, and Somayaji (2014) <doi:10.1080/19466315.2014.924876> and Thomas and Roy (2016) <doi:10.1080/19466315.2016.1256229> Wu, Banerjee, Jin, Menon, Martin, and Heatherington(2017) <doi:10.1177/0962280216684528> are included in the package. The prior distributions for the Bayesian analyses default to the posterior predictive distributions derived from these references.

Easy access to data from Brazil's population censuses. The package provides a simple and efficient way to download and read the data sets and the documentation of all the population censuses taken in and after 1960 in the country. The package is built on top of the Arrow platform <https://arrow.apache.org/docs/r/>, which allows users to work with larger-than-memory census data using dplyr familiar functions. <https://arrow.apache.org/docs/r/articles/arrow.html#analyzing-arrow-data-with-dplyr>.

This package contains the Multi-Species Acute Toxicity Database (CAS & SMILES columns only) [United States (US) Department of Health and Human Services (DHHS) National Institutes of Health (NIH) National Cancer Institute (NCI), "Multi-Species Acute Toxicity Database", <https://cactus.nci.nih.gov/download/acute-toxicity-db/>] combined with the Toxic Substances Control Act (TSCA) Inventory [United States Environmental Protection Agency (US EPA), "Toxic Substances Control Act (TSCA) Chemical Substance Inventory", <https://www.epa.gov/tsca-inventory/how-access-tsca-inventory

Stacking rings are tools used to stack pottery in a Kiln. A relatively large group of stacking rings was found in the area of the sanctuary of Dionysos in Miletus in the 1970s. Measurements and additional info is gathered in this package and made available for use by other researchers. The data along with its archaeological context and analysis has been published in "Archäologischer Anzeiger" (2020/1, <doi:10.34780/aa.v0i1.1014>).

Integrative context-dependent clustering for heterogeneous biomedical datasets. Identifies local clustering structures in related datasets, and a global clusters that exist across the datasets.