Fit and apply ComBat, linear mixed-effects models (LMM), or prescaling to harmonize magnetic resonance imaging (MRI) data from different sites. Briefly, these methods remove differences between sites due to using different scanning devices, and LMM additionally tests linear hypotheses. As detailed in the manual, the original ComBat function was first modified for the harmonization of MRI data (Fortin et al. (2017) <doi:10.1016/j.neuroimage.2017.11.024>) and then modified again to create separate functions for fitting and applying the harmonization and allow missing values and constant rows for its use within the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium (Radua et al. (2020) <doi:10.1016/j.neuroimage.2020.116956>); this package includes the latter version. LMM calls "lme" massively considering specific brain imaging details. Finally, prescaling is a good option for fMRI, where different devices can have varying units of measurement.

This package provides a wrapper for circlize'. All components are based on classes and objects. Users can use the addition symbol (+) to combine components for a circular visualization with ggplot2 style.The package is described in Zhang Z, Cao T, Huang Y and Xia Y (2025) <doi:10.3389/fgene.2025.1535368>.

Maps of Comoro Islands. Layers include the country coastline, each island coastline and administrative regions boundaries.

This package provides methods for color vision deficiencies (CVD), to help understanding and mitigating issues with CVDs and to generate tests for diagnosis and interpretation.

An algorithm for identifying candidate driver combinations in cancer. CRSO is based on a theoretical model of cancer in which a cancer rule is defined to be a collection of two or more events (i.e., alterations) that are minimally sufficient to cause cancer. A cancer rule set is a set of cancer rules that collectively are assumed to account for all of ways to cause cancer in the population. In CRSO every event is designated explicitly as a passenger or driver within each patient. Each event is associated with a patient-specific, event-specific passenger penalty, reflecting how unlikely the event would have happened by chance, i.e., as a passenger. CRSO evaluates each rule set by assigning all samples to a rule in the rule set, or to the null rule, and then calculating the total statistical penalty from all unassigned event. CRSO uses a three phase procedure find the best rule set of fixed size K for a range of Ks. A core rule set is then identified from among the best rule sets of size K as the rule set that best balances rule set size and statistical penalty. Users should consult the crso vignette for an example walk through of a full CRSO run. The full description, of the CRSO algorithm is presented in: Klein MI, Cannataro V, Townsend J, Stern DF and Zhao H. "Identifying combinations of cancer driver in individual patients." BioRxiv 674234 [Preprint]. June 19, 2019. <doi:10.1101/674234>. Please cite this article if you use crso'.

Method for identifying the instar of Curculionid larvae from the observed distribution of the headcapsule size of mature larvae.

Browser cookies are name-value pairs that are saved in a user's browser by a website. Cookies allow websites to persist information about the user and their use of the website. Here we provide tools for working with cookies in shiny apps, in part by wrapping the js-cookie JavaScript library <https://github.com/js-cookie/js-cookie>.

These experimental expression data (5 leukemic CLL B-lymphocyte of aggressive form from GSE39411', <doi:10.1073/pnas.1211130110>), after B-cell receptor stimulation, are used as examples by packages such as the Cascade one, a modeling tool allowing gene selection, reverse engineering, and prediction in cascade networks. Jung, N., Bertrand, F., Bahram, S., Vallat, L., and Maumy-Bertrand, M. (2014) <doi:10.1093/bioinformatics/btt705>.

This package provides an interactive shiny web application for constructing, analyzing, and visualizing composite indices from multidimensional datasets. Users can upload or select indicator data, group variables into logical categories, apply normalization and weighting methods (such as equal or custom schemes), and compute aggregate composite indices. The shiny interface includes tools for exploring results through tables, plots, and data exports, making it useful for researchers, policymakers, and analysts interested in index-based evaluations.

Estimating mutation and selection coefficients on synonymous codon bias usage based on models of ribosome overhead cost (ROC). Multinomial logistic regression and Markov Chain Monte Carlo are used to estimate and predict protein production rates with/without the presence of expressions and measurement errors. Work flows with examples for simulation, estimation and prediction processes are also provided with parallelization speedup. The whole framework is tested with yeast genome and gene expression data of Yassour, et al. (2009) <doi:10.1073/pnas.0812841106>.

Randomization-Based Inference for customized experiments. Computes Fisher-Exact P-Values alongside null randomization distributions. Retrieves counternull sets and generates counternull distributions. Computes Fisher Intervals and Fisher-Adjusted P-Values. Package includes visualization of randomization distributions and Fisher Intervals. Users can input custom test statistics and their own methods for randomization. Rosenthal and Rubin (1994) <doi:10.1111/j.1467-9280.1994.tb00281.x>.

In the context of paid research studies and clinical trials, budget considerations and patient sampling from available populations are subject to inherent constraints. We introduce the CDsampling package, which integrates optimal design theories within the framework of constrained sampling. This package offers the possibility to find both D-optimal approximate and exact allocations for samplings with or without constraints. Additionally, it provides functions to find constrained uniform sampling as a robust sampling strategy with limited model information. Our package offers functions for the computation of the Fisher information matrix under generalized linear models (including regular linear regression model) and multinomial logistic models.To demonstrate the applications, we also provide a simulated dataset and a real dataset embedded in the package. Yifei Huang, Liping Tong, and Jie Yang (2025)<doi:10.5705/ss.202022.0414>.

Test for cluster tendency (clusterability) of a data set. The methods implemented - reducing the data set to a single dimension using principal component analysis or computing pairwise distances, and performing a multimodality test like the Dip Test or Silverman's Critical Bandwidth Test - are described in Adolfsson, Ackerman, and Brownstein (2019) <doi:10.1016/j.patcog.2018.10.026>. Such methods can inform whether clustering algorithms are appropriate for a data set.

We aim to deal with the average treatment effect (ATE), where the data are subject to high-dimensionality and measurement error. This package primarily contains two functions, which are used to generate artificial data and estimate ATE with high-dimensional and error-prone data accommodated.

This package provides an implementation of â Curricular Analyticsâ , a framework for analyzing and quantifying the complexity of academic curricula. Curricula are modelled as directed acyclic graphs and analytics are provided based on path lengths and edge density. This work directly comes from Heileman et al. (2018) <doi:10.48550/arXiv.1811.09676>.

Implementation of the Control Polygon Reduction and Control Net Reduction methods for finding parsimonious B-spline regression models.

General functions for convolutions of data. Moving average, running median, and other filters are available. Bibliography regarding the functions can be found in the following text. Richard G. Brereton (2003) <ISBN:9780471489771>.

Design and use of control charts for detecting mean changes based on a delayed updating of the in-control parameter estimates. See Capizzi and Masarotto (2019) <doi:10.1080/00224065.2019.1640096> for the description of the method.

This package performs cryptographic randomness tests on a sequence of random integers or bits. Included tests are greatest common divisor, birthday spacings, book stack, adaptive chi-square, topological binary, and three random walk tests (Ryabko and Monarev, 2005) <doi:10.1016/j.jspi.2004.02.010>. Tests except greatest common divisor and birthday spacings are not covered by standard test suites. In addition to the chi-square goodness-of-fit test, results of Anderson-Darling, Kolmogorov-Smirnov, and Jarque-Bera tests are also generated by some of the cryptographic randomness tests.

Calculating silhouette information for clusters on circular or linear data using fast algorithms. These algorithms run in linear time on sorted data, in contrast to quadratic time by the definition of silhouette. When used together with the fast and optimal circular clustering method FOCC (Debnath & Song 2021) <doi:10.1109/TCBB.2021.3077573> implemented in R package OptCirClust', circular silhouette can be maximized to find the optimal number of circular clusters; it can also be used to estimate the period of noisy periodical data.

There are several non-functional-form-based interaction tests for testing interaction in unreplicated two-way layouts. However, no single test can detect all patterns of possible interaction and the tests are sensitive to a particular pattern of interaction. This package combines six non-functional-form-based interaction tests for testing additivity. These six tests were proposed by Boik (1993) <doi:10.1080/02664769300000004>, Piepho (1994), Kharrati-Kopaei and Sadooghi-Alvandi (2007) <doi:10.1080/03610920701386851>, Franck et al. (2013) <doi:10.1016/j.csda.2013.05.002>, Malik et al. (2016) <doi:10.1080/03610918.2013.870196> and Kharrati-Kopaei and Miller (2016) <doi:10.1080/00949655.2015.1057821>. The p-values of these six tests are combined by Bonferroni, Sidak, Jacobi polynomial expansion, and the Gaussian copula methods to provide researchers with a testing approach which leverages many existing methods to detect disparate forms of non-additivity. This package is based on the following published paper: Shenavari and Kharrati-Kopaei (2018) "A Method for Testing Additivity in Unreplicated Two-Way Layouts Based on Combining Multiple Interaction Tests". In addition, several sentences in help files or descriptions were copied from that paper.

Balancing and rounding matrices subject to restrictions. Adjustment of matrices so that columns and rows add up to given vectors, rounding of a matrix while keeping the column and/or row totals, performing these by blocks...

The theory of cooperative games with transferable utility offers useful insights into the way parties can share gains from cooperation and secure sustainable agreements, see e.g. one of the books by Chakravarty, Mitra and Sarkar (2015, ISBN:978-1107058798) or by Driessen (1988, ISBN:978-9027727299) for more details. A comprehensive set of tools for cooperative game theory with transferable utility is provided. Users can create special families of cooperative games, like e.g. bankruptcy games, cost sharing games and weighted voting games. There are functions to check various game properties and to compute five different set-valued solution concepts for cooperative games. A large number of point-valued solution concepts is available reflecting the diverse application areas of cooperative game theory. Some of these point-valued solution concepts can be used to analyze weighted voting games and measure the influence of individual voters within a voting body. There are routines for visualizing both set-valued and point-valued solutions in the case of three or four players.

Calculate various cardiovascular disease risk scores from the Framingham Heart Study (FHS), the American College of Cardiology (ACC), and the American Heart Association (AHA) as described in Dâ agostino, et al (2008) <doi:10.1161/circulationaha.107.699579>, Goff, et al (2013) <doi:10.1161/01.cir.0000437741.48606.98>, and Mclelland, et al (2015) <doi:10.1016/j.jacc.2015.08.035>.