Network meta-analysis and meta-regression (allows including up to three covariates) for individual participant data, aggregate data, and mixtures of both formats using the three-level hierarchical model. Each format can come from randomized controlled trials or non-randomized studies or mixtures of both. Estimates are generated in a Bayesian framework using JAGS. The implemented models are described by Hamza et al. 2023 <DOI:10.1002/jrsm.1619>.

Encrypts and decrypts using basic ciphers. None of these should be used in place of real encryption using state of the art tools. The ciphers included use methods described in the ciphers's Wikipedia and cryptography hobby websites.

Evaluation for density and distribution function of convolution of gamma distributions in R. Two related exact methods and one approximate method are implemented with efficient algorithm and C++ code. A quick guide for choosing correct method and usage of this package is given in package vignette. For the detail of methods used in this package, we refer the user to Mathai(1982)<doi:10.1007/BF02481056>, Moschopoulos(1984)<doi:10.1007/BF02481123>, Barnabani(2017)<doi:10.1080/03610918.2014.963612>, Hu et al.(2020)<doi:10.1007/s00180-019-00924-9>.

This package provides access to the Calcite Design System javascript components via integration with the htmltools and shiny packages. Pre-built and interactive components can be used to generate either static html or interactive web applications. Learn more about the Calcite Design System at <https://developers.arcgis.com/calcite-design-system/>.

This package provides tools for extracting occurrences, assessing potential driving factors, predicting occurrences, and quantifying impacts of compound events in hydrology and climatology. Please see Hao Zengchao et al. (2022) <doi:10.1016/j.earscirev.2022.104241>.

Implementation of the categorical instrumental variable (CIV) estimator proposed by Wiemann (2023) <arXiv:2311.17021>. CIV allows for optimal instrumental variable estimation in settings with relatively few observations per category. To obtain valid inference in these challenging settings, CIV leverages a regularization assumption that implies existence of a latent categorical variable with fixed finite support achieving the same first stage fit as the observed instrument.

Generate random numbers from the Cryptographically Secure Pseudorandom Number Generator (CSPRNG) provided by the underlying operating system. System CSPRNGs are seeded internally by the OS with entropy it gathers from the system hardware. The following system functions are used: arc4random_buf() on macOS and BSD; BCryptgenRandom() on Windows; Sys_getrandom() on Linux.

Convert text into synthesized speech and get a list of supported voices for a region. Microsoft's Cognitive Services Text to Speech REST API <https://learn.microsoft.com/en-us/azure/cognitive-services/speech-service/rest-text-to-speech?tabs=streaming> supports neural text to speech voices, which support specific languages and dialects that are identified by locale.

This function conducts the Cochran-Armitage trend test to a 2 by k contingency table. It will report the test statistic (Z) and p-value.A linear trend in the frequencies will be calculated, because the weights (0,1,2) will be used by default.

The cmgnd implements the constrained mixture of generalized normal distributions model, a flexible statistical framework for modelling univariate data exhibiting non-normal features such as skewness, multi-modality, and heavy tails. By imposing constraints on model parameters, the cmgnd reduces estimation complexity while maintaining high descriptive power, offering an efficient solution in the presence of distributional irregularities. For more details see Duttilo and Gattone (2025) <doi:10.1007/s00180-025-01638-x> and Duttilo et al (2025) <doi:10.48550/arXiv.2506.03285>.

This package provides functions for visualizing, animating, solving and analyzing the Rubik's cube. Includes data structures for solvable and unsolvable cubes, random moves and random state scrambles and cubes, 3D displays and animations using OpenGL', patterned cube generation, and lightweight solvers. See Rokicki, T. (2008) <arXiv:0803.3435> for the Kociemba solver.

This package performs classical age-depth modelling of dated sediment deposits - prior to applying more sophisticated techniques such as Bayesian age-depth modelling. Any radiocarbon dated depths are calibrated. Age-depth models are constructed by sampling repeatedly from the dated levels, each time drawing age-depth curves. Model types include linear interpolation, linear or polynomial regression, and a range of splines. See Blaauw (2010) <doi:10.1016/j.quageo.2010.01.002>.

Estimation of population size of migratory caribou herds based on large scale aggregations monitored by radio telemetry. It implements the methodology found in the article by Rivest et al. (1998) about caribou abundance estimation. It also includes a function based on the Lincoln-Petersen Index as applied to radio telemetry data by White and Garrott (1990).

It fits linear regression models for censored spatial data. It provides different estimation methods as the SAEM (Stochastic Approximation of Expectation Maximization) algorithm and seminaive that uses Kriging prediction to estimate the response at censored locations and predict new values at unknown locations. It also offers graphical tools for assessing the fitted model. More details can be found in Ordonez et al. (2018) <doi:10.1016/j.spasta.2017.12.001>.

Determining the value of Stirling numbers of 1st kind and 2nd kind,references: Bóna,Miklós(2017,ISBN 9789813148840).

We present corto (Correlation Tool), a simple package to infer gene regulatory networks and visualize master regulators from gene expression data using DPI (Data Processing Inequality) and bootstrapping to recover edges. An initial step is performed to calculate all significant edges between a list of source nodes (centroids) and target genes. Then all triplets containing two centroids and one target are tested in a DPI step which removes edges. A bootstrapping process then calculates the robustness of the network, eventually re-adding edges previously removed by DPI. The algorithm has been optimized to run outside a computing cluster, using a fast correlation implementation. The package finally provides functions to calculate network enrichment analysis from RNA-Seq and ATAC-Seq signatures as described in the article by Giorgi lab (2020) <doi:10.1093/bioinformatics/btaa223>.

Continuous glucose monitoring (CGM) systems provide real-time, dynamic glucose information by tracking interstitial glucose values throughout the day. Glycemic variability, also known as glucose variability, is an established risk factor for hypoglycemia (Kovatchev) and has been shown to be a risk factor in diabetes complications. Over 20 metrics of glycemic variability have been identified. Here, we provide functions to calculate glucose summary metrics, glucose variability metrics (as defined in clinical publications), and visualizations to visualize trends in CGM data. Cho P, Bent B, Wittmann A, et al. (2020) <https://diabetes.diabetesjournals.org/content/69/Supplement_1/73-LB.abstract> American Diabetes Association (2020) <https://professional.diabetes.org/diapro/glucose_calc> Kovatchev B (2019) <doi:10.1177/1932296819826111> Kovdeatchev BP (2017) <doi:10.1038/nrendo.2017.3> Tamborlane W V., Beck RW, Bode BW, et al. (2008) <doi:10.1056/NEJMoa0805017> Umpierrez GE, P. Kovatchev B (2018) <doi:10.1016/j.amjms.2018.09.010>.

This package provides a tool for transforming coordinates in a color space to common color names using data from the Royal Horticultural Society and the International Union for the Protection of New Varieties of Plants.

This package provides methods and data for color science - color conversions by observer, illuminant, and gamma. Color matching functions and chromaticity diagrams. Color indices, color differences, and spectral data conversion/analysis. This package is deprecated and will someday be removed; for reasons and details please see the README file.

This package provides a collection of utilities for the statistical analysis of multivariate circular data using distributions based on Multivariate Nonnegative Trigonometric Sums (MNNTS). The package includes functions for calculation of densities and distributions, for the estimation of parameters, and more.

This package provides functions for fitting GEV and POT (via point process fitting) models for extremes in climate data, providing return values, return probabilities, and return periods for stationary and nonstationary models. Also provides differences in return values and differences in log return probabilities for contrasts of covariate values. Functions for estimating risk ratios for event attribution analyses, including uncertainty. Under the hood, many of the functions use functions from extRemes', including for fitting the statistical models. Details are given in Paciorek, Stone, and Wehner (2018) <doi:10.1016/j.wace.2018.01.002>.

R interface for RAPIDS cuML (<https://github.com/rapidsai/cuml>), a suite of GPU-accelerated machine learning libraries powered by CUDA (<https://en.wikipedia.org/wiki/CUDA>).

Includes several classifications such as International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD10), Anatomical Therapeutic Chemical (ATC) Classification, The International Classification of Diseases for Oncology (ICD-O-3), and International Classification of Primary Care (ICPC). Includes function that adds descriptive label to code value. Depending on classification following languages are available: English, Finnish, Swedish, and Latin.

This package provides a framework that facilitates spatio-temporal analysis of climate dynamics through exploring and measuring different dimensions of climate change in space and time.