This package provides a deep neural network model with a monotonic increasing single index function tailored for periodontal disease studies. The residuals are assumed to follow a skewed T distribution, a skewed normal distribution, or a normal distribution. More details can be found at Liu, Huang, and Bai (2024) <doi:10.1016/j.csda.2024.108012>.

Deconvolving cell types from high-throughput gene profiling data. For more information on dtangle see Hunt et al. (2019) <doi:10.1093/bioinformatics/bty926>.

Compute degree days from daily min and max temperatures for modeling plant and insect development.

This package contains a robust set of tools designed for constructing deep neural networks, which are highly adaptable with user-defined loss function and probability models. It includes several practical applications, such as the (deepAFT) model, which utilizes a deep neural network approach to enhance the accelerated failure time (AFT) model for survival data. Another example is the (deepGLM) model that applies deep neural network to the generalized linear model (glm), accommodating data types with continuous, categorical and Poisson distributions.

Detrend fluorescence microscopy image series for fluorescence fluctuation and correlation spectroscopy ('FCS and FFS') analysis. This package contains functionality published in a 2016 paper <doi:10.1093/bioinformatics/btx434> but it has been extended since then with the Robin Hood algorithm and thus contains unpublished work.

This package performs sensitivity analysis for the sharp null, attributable effects, and weak nulls in matched studies with continuous exposures and binary or continuous outcomes as described in Zhang, Small, Heng (2024) <doi:10.48550/arXiv.2401.06909> and Zhang, Heng (2024) <doi:10.48550/arXiv.2409.12848>. Two of the functions require installation of the Gurobi optimizer. Please see <https://docs.gurobi.com/current/#refman/ins_the_r_package.html> for guidance.

Preferred methods for common analytical tasks that are undertaken across the Department, including number formatting, project templates and curated reference data.

Implementing algorithms and fitting models when sites (possibly remote) share computation summaries rather than actual data over HTTP with a master R process (using opencpu', for example). A stratified Cox model and a singular value decomposition are provided. The former makes direct use of code from the R survival package. (That is, the underlying Cox model code is derived from that in the R survival package.) Sites may provide data via several means: CSV files, Redcap API, etc. An extensible design allows for new methods to be added in the future and includes facilities for local prototyping and testing. Web applications are provided (via shiny') for the implemented methods to help in designing and deploying the computations.

Apache licensed alternative to Highcharter which provides functions for both fast and beautiful interactive visualization for Markdown and Shiny'.

Probability generating function, formulae for the probabilities (discrete density) and random generation for discrete stable random variables.

Displays a terrible joke, the kind only dads crack.

This package provides functions for estimating Gaussian dispersion regression models (Aitkin, 1987 <doi:10.2307/2347792>), overdispersed binomial logit models (Williams, 1987 <doi:10.2307/2347977>), and overdispersed Poisson log-linear models (Breslow, 1984 <doi:10.2307/2347661>), using a quasi-likelihood approach.

Datasets and functions to accompany the book Analisis de datos con el programa estadistico R: una introduccion aplicada by Salas-Eljatib (2021, ISBN: 9789566086109). The package helps carry out data management, exploratory analyses, and model fitting.

This package provides a shiny application that enables the user to create a prototype UI, being able to drag and drop UI components before being able to save or download the equivalent R code.

This package provides methods for valuation of life insurance premiums and reserves (including variable-benefit and fractional coverage) based on "Actuarial Mathematics" by Bowers, H.U. Gerber, J.C. Hickman, D.A. Jones and C.J. Nesbitt (1997, ISBN: 978-0938959465), "Actuarial Mathematics for Life Contingent Risks" by Dickson, David C. M., Hardy, Mary R. and Waters, Howard R (2009) <doi:10.1017/CBO9780511800146> and "Life Contingencies" by Jordan, C. W (1952) <doi:10.1017/S002026810005410X>. It also contains functions for equivalent interest and discount rate calculation, present and future values of annuities, and loan amortization schedule.

Flexible and efficient cleaning of data with interactivity. datacleanr facilitates best practices in data analyses and reproducibility with built-in features and by translating interactive/manual operations to code. The package is designed for interoperability, and so seamlessly fits into reproducible analyses pipelines in R'.

Decorrelates a set of summary statistics (i.e., Z-scores or P-values per SNP) via Decorrelation by Orthogonal Transformation (DOT) approach and performs gene-set analyses by combining transformed statistic values; operations are performed with algorithms that rely only on the association summary results and the linkage disequilibrium (LD). For more details on DOT and its power, see Olga (2020) <doi:10.1371/journal.pcbi.1007819>.

Implementations of the multiple testing procedures for discrete tests described in the paper Döhler, Durand and Roquain (2018) "New FDR bounds for discrete and heterogeneous tests" <doi:10.1214/18-EJS1441>. The main procedures of the paper (HSU and HSD), their adaptive counterparts (AHSU and AHSD), and the HBR variant are available and are coded to take as input the results of a test procedure from package DiscreteTests', or a set of observed p-values and their discrete support under their nulls. A shortcut function to obtain such p-values and supports is also provided, along with a wrapper allowing to apply discrete procedures directly to data.

An interface to DifferentialEquations.jl <https://diffeq.sciml.ai/dev/> from the R programming language. It has unique high performance methods for solving ordinary differential equations (ODE), stochastic differential equations (SDE), delay differential equations (DDE), differential-algebraic equations (DAE), and more. Much of the functionality, including features like adaptive time stepping in SDEs, are unique and allow for multiple orders of magnitude speedup over more common methods. Supports GPUs, with support for CUDA (NVIDIA), AMD GPUs, Intel oneAPI GPUs, and Apple's Metal (M-series chip GPUs). diffeqr attaches an R interface onto the package, allowing seamless use of this tooling by R users. For more information, see Rackauckas and Nie (2017) <doi:10.5334/jors.151>.

This package provides a collection of functions that perform jump regression and image analysis such as denoising, deblurring and jump detection. The implemented methods are based on the following research: Qiu, P. (1998) <doi:10.1214/aos/1024691468>, Qiu, P. and Yandell, B. (1997) <doi: 10.1080/10618600.1997.10474746>, Qiu, P. (2009) <doi: 10.1007/s10463-007-0166-9>, Kang, Y. and Qiu, P. (2014) <doi: 10.1080/00401706.2013.844732>, Qiu, P. and Kang, Y. (2015) <doi: 10.5705/ss.2014.054>, Kang, Y., Mukherjee, P.S. and Qiu, P. (2018) <doi: 10.1080/00401706.2017.1415975>, Kang, Y. (2020) <doi: 10.1080/10618600.2019.1665536>.

R codes for distance based cell lineage reconstruction. Our methods won both sub-challenges 2 and 3 of the Allen Institute Cell Lineage Reconstruction DREAM Challenge in 2020. References: Gong et al. (2021) <doi:10.1016/j.cels.2021.05.008>, Gong et al. (2022) <doi:10.1186/s12859-022-04633-x>.

Provide a Dens-based method for estimating functional connection in large scale brain networks using partial correlation.

Assesses data quality in Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) databases. Executes data quality checks and provides an R `shiny` application to view the results.

This package provides a systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. DrugSim2DR first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.