An abstract DList class helps storing large list-type objects in a distributed manner. Corresponding high-level functions and methods for handling distributed storage (DStorage) and lists allows for processing such DLists on distributed systems efficiently. In doing so it uses a well defined storage backend implemented based on the DStorage class.

Statistical models fit to compositional data are often difficult to interpret due to the sum to 1 constraint on data variables. DImodelsVis provides novel visualisations tools to aid with the interpretation of models fit to compositional data. All visualisations in the package are created using the ggplot2 plotting framework and can be extended like every other ggplot object.

This package provides density, distribution function, quantile function and random generation for the split normal and split-t distributions, and computes their mean, variance, skewness and kurtosis for the two distributions (Li, F, Villani, M. and Kohn, R. (2010) <doi:10.1016/j.jspi.2010.04.031>).

Deep compositional spatial models are standard spatial covariance models coupled with an injective warping function of the spatial domain. The warping function is constructed through a composition of multiple elemental injective functions in a deep-learning framework. The package implements two cases for the univariate setting; first, when these warping functions are known up to some weights that need to be estimated, and, second, when the weights in each layer are random. In the multivariate setting only the former case is available. Estimation and inference is done using `tensorflow`, which makes use of graphics processing units. For more details see Zammit-Mangion et al. (2022) <doi:10.1080/01621459.2021.1887741>, Vu et al. (2022) <doi:10.5705/ss.202020.0156>, Vu et al. (2023) <doi:10.1016/j.spasta.2023.100742>, and Shao et al. (2025) <doi:10.48550/arXiv.2505.12548>.

Prediction methods where explanatory information is coded as a matrix of distances between individuals. Distances can either be directly input as a distances matrix, a squared distances matrix, an inner-products matrix or computed from observed predictors.

This package provides methods for evaluating the probability mass function, cumulative distribution function, and generating random samples from discrete tempered stable distributions. For more details see Grabchak (2021) <doi:10.1007/s11009-021-09904-3>.

Secant acceleration applied to derivative-free Spectral Residual Methods for solving large-scale nonlinear systems of equations. The main reference follows: E. G. Birgin and J. M. Martinez (2022) <doi:10.1137/20M1388024>.

This package provides a robust identification of differential binding sites method for analyzing ChIP-seq (Chromatin Immunoprecipitation Sequencing) comparing two samples that considers an ensemble of finite mixture models combined with a local false discovery rate (fdr) allowing for flexible modeling of data. Methods for Differential Identification using Mixture Ensemble (DIME) is described in: Taslim et al., (2011) <doi:10.1093/bioinformatics/btr165>.

Based on random forest principle, DynForest is able to include multiple longitudinal predictors to provide individual predictions. Longitudinal predictors are modeled through the random forest. The methodology is fully described for a survival outcome in: Devaux, Helmer, Genuer & Proust-Lima (2023) <doi: 10.1177/09622802231206477>.

This package provides a shiny application that enables the user to create a prototype UI, being able to drag and drop UI components before being able to save or download the equivalent R code.

Tissue-specific enrichment analysis to assess lists of candidate genes or RNA-Seq expression profiles. Pei G., Dai Y., Zhao Z. Jia P. (2019) deTS: Tissue-Specific Enrichment Analysis to decode tissue specificity. Bioinformatics, In submission.

Various diffusion models to forecast new product growth. Currently the package contains Bass, Gompertz, Gamma/Shifted Gompertz and Weibull curves. See Meade and Islam (2006) <doi:10.1016/j.ijforecast.2006.01.005>.

Includes functions for the construction of matched samples that are balanced and representative by design. Among others, these functions can be used for matching in observational studies with treated and control units, with cases and controls, in related settings with instrumental variables, and in discontinuity designs. Also, they can be used for the design of randomized experiments, for example, for matching before randomization. By default, designmatch uses the highs optimization solver, but its performance is greatly enhanced by the Gurobi optimization solver and its associated R interface. For their installation, please follow the instructions at <https://www.gurobi.com/getting-started/> and <https://docs.gurobi.com/projects/optimizer/en/current/reference/r/setup.html>. We have also included directions in the gurobi_installation file in the inst folder.

Read, construct and write CDISC (Clinical Data Interchange Standards Consortium) Dataset JSON (JavaScript Object Notation) files, while validating per the Dataset JSON schema file, as described in CDISC (2023) <https://www.cdisc.org/standards/data-exchange/dataset-json>.

This package provides a small package containing helper utilities for creating functions for computing statistics.

The debar sequence processing pipeline is designed for denoising high throughput sequencing data for the animal DNA barcode marker cytochrome c oxidase I (COI). The package is designed to detect and correct insertion and deletion errors within sequencer outputs. This is accomplished through comparison of input sequences against a profile hidden Markov model (PHMM) using the Viterbi algorithm (for algorithm details see Durbin et al. 1998, ISBN: 9780521629713). Inserted base pairs are removed and deleted base pairs are accounted for through the introduction of a placeholder character. Since the PHMM is a probabilistic representation of the COI barcode, corrections are not always perfect. For this reason debar censors base pairs adjacent to reported indel sites, turning them into placeholder characters (default is 7 base pairs in either direction, this feature can be disabled). Testing has shown that this censorship results in the correct sequence length being restored, and erroneous base pairs being masked the vast majority of the time (>95%).

This package provides a wrapper on top of the Domino Command-Line Client'. It lets you run Domino commands (e.g., "run", "upload", "download") directly from your R environment. Under the hood, it uses R's system function to run the Domino executable, which must be installed as a prerequisite. Domino is a service that makes it easy to run your code on scalable hardware, with integrated version control and collaboration features designed for analytical workflows (see <http://www.dominodatalab.com> for more information).

This package provides an extensive and curated collection of datasets related to the digestive system, stomach, intestines, liver, pancreas, and associated diseases. This package includes clinical trials, observational studies, experimental datasets, cohort data, and case series involving gastrointestinal disorders such as gastritis, ulcers, pancreatitis, liver cirrhosis, colon cancer, colorectal conditions, Helicobacter pylori infection, irritable bowel syndrome, intestinal infections, and post-surgical outcomes. The datasets support educational, clinical, and research applications in gastroenterology, public health, epidemiology, and biomedical sciences. Designed for researchers, clinicians, data scientists, students, and educators interested in digestive diseases, the package facilitates reproducible analysis, modeling, and hypothesis testing using real-world and historical data.

We provide a comprehensive software to estimate general K-stage DTRs from SMARTs with Q-learning and a variety of outcome-weighted learning methods. Penalizations are allowed for variable selection and model regularization. With the outcome-weighted learning scheme, different loss functions - SVM hinge loss, SVM ramp loss, binomial deviance loss, and L2 loss - are adopted to solve the weighted classification problem at each stage; augmentation in the outcomes is allowed to improve efficiency. The estimated DTR can be easily applied to a new sample for individualized treatment recommendations or DTR evaluation.

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).

In-line functions for multivariate optimization via desirability functions (Derringer and Suich, 1980, <doi:10.1080/00224065.1980.11980968>) with easy use within dplyr pipelines.

The Data Driven I-V Feature Extraction is used to extract Current-Voltage (I-V) features from I-V curves. I-V curves indicate the relationship between current and voltage for a solar cell or Photovoltaic (PV) modules. The I-V features such as maximum power point (Pmp), shunt resistance (Rsh), series resistance (Rs),short circuit current (Isc), open circuit voltage (Voc), fill factor (FF), current at maximum power (Imp) and voltage at maximum power(Vmp) contain important information of the performance for PV modules. The traditional method uses the single diode model to model I-V curves and extract I-V features. This package does not use the diode model, but uses data-driven a method which select different linear parts of the I-V curves to extract I-V features. This method also uses a sampling method to calculate uncertainties when extracting I-V features. Also, because of the partially shaded array, "steps" occurs in I-V curves. The "Segmented Regression" method is used to identify steps in I-V curves. This material is based upon work supported by the U.S. Department of Energyâ s Office of Energy Efficiency and Renewable Energy (EERE) under Solar Energy Technologies Office (SETO) Agreement Number DE-EE0007140. Further information can be found in the following paper. [1] Ma, X. et al, 2019. <doi:10.1109/JPHOTOV.2019.2928477>.

Edit and validate taxonomic data in compliance with Darwin Core standards (Darwin Core Taxon class <https://dwc.tdwg.org/terms/#taxon>).

This package provides a systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. DrugSim2DR first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.