Comparison of the accuracy of two binary diagnostic tests in a "paired" study design, i.e. when each test is applied to each subject in the study.

This package provides a HTML widget that shows differences between files (text, images, and data frames).

Function to test spatial segregation and association based in contingency table analysis of nearest neighbour counts following Dixon (2002) <doi:10.1080/11956860.2002.11682700>. Some Fortran code has been included to the original dixon2002() function of the ecespa package to improve speed.

Discrete event simulation (DES) involves modeling of systems having discrete, i.e. abrupt, state changes. For instance, when a job arrives to a queue, the queue length abruptly increases by 1. This package is an R implementation of the event-oriented approach to DES; see the tutorial in Matloff (2008) <http://heather.cs.ucdavis.edu/~matloff/156/PLN/DESimIntro.pdf>.

This package implements the Oaxaca-Blinder decomposition method and generalizations of it that decompose differences in distributional statistics beyond the mean. The function ob_decompose() decomposes differences in the mean outcome between two groups into one part explained by different covariates (composition effect) and into another part due to differences in the way covariates are linked to the outcome variable (structure effect). The function further divides the two effects into the contribution of each covariate and allows for weighted doubly robust decompositions. For distributional statistics beyond the mean, the function performs the recentered influence function (RIF) decomposition proposed by Firpo, Fortin, and Lemieux (2018). The function dfl_decompose() divides differences in distributional statistics into an composition effect and a structure effect using inverse probability weighting as introduced by DiNardo, Fortin, and Lemieux (1996). The function also allows to sequentially decompose the composition effect into the contribution of single covariates. References: Firpo, Sergio, Nicole M. Fortin, and Thomas Lemieux. (2018) <doi:10.3390/econometrics6020028>. "Decomposing Wage Distributions Using Recentered Influence Function Regressions." Fortin, Nicole M., Thomas Lemieux, and Sergio Firpo. (2011) <doi:10.3386/w16045>. "Decomposition Methods in Economics." DiNardo, John, Nicole M. Fortin, and Thomas Lemieux. (1996) <doi:10.2307/2171954>. "Labor Market Institutions and the Distribution of Wages, 1973-1992: A Semiparametric Approach." Oaxaca, Ronald. (1973) <doi:10.2307/2525981>. "Male-Female Wage Differentials in Urban Labor Markets." Blinder, Alan S. (1973) <doi:10.2307/144855>. "Wage Discrimination: Reduced Form and Structural Estimates.".

This package provides a Shiny Input for date-ranges, which pops up two calendars for selecting dates, times, or predefined ranges like "Last 30 Days". It wraps the JavaScript library daterangepicker which is available at <https://www.daterangepicker.com>.

Identifies code blocks that have a high level of similarity within a set of R files.

Computations of Fisher's z-tests concerning different kinds of correlation differences. The diffpwr family entails approaches to estimating statistical power via Monte Carlo simulations. Important to note, the Pearson correlation coefficient is sensitive to linear association, but also to a host of statistical issues such as univariate and bivariate outliers, range restrictions, and heteroscedasticity (e.g., Duncan & Layard, 1973 <doi:10.1093/BIOMET/60.3.551>; Wilcox, 2013 <doi:10.1016/C2010-0-67044-1>). Thus, every power analysis requires that specific statistical prerequisites are fulfilled and can be invalid if the prerequisites do not hold. To this end, the bootcor family provides bootstrapping confidence intervals for the incorporated correlation difference tests.

Exploratory analysis of a data base. Using the functions of this package is possible to filter the data set detecting atypical values (outliers) and to perform exploratory analysis through visual inspection or dispersion measures. With this package you can explore the structure of your data using several parameters at the same time joining statistical parameters with different graphics. Finally, this package aid to confirm or reject the hypothesis that your data structure presents a normal distribution. Therefore this package is useful to get a previous insight of your data before to carry out statistical analysis.

Statistical methods for retrospectively detecting changes in location and/or dispersion of univariate and multivariate variables. Data values are assumed to be independent, can be individual (one observation at each instant of time) or subgrouped (more than one observation at each instant of time). Control limits are computed, often using a permutation approach, so that a prescribed false alarm probability is guaranteed without making any parametric assumptions on the stable (in-control) distribution. See G. Capizzi and G. Masarotto (2018) <doi:10.1007/978-3-319-75295-2_1> for an introduction to the package.

This package contains a single function dclust() for divisive hierarchical clustering based on recursive k-means partitioning (k = 2). Useful for clustering large datasets where computation of a n x n distance matrix is not feasible (e.g. n > 10,000 records). For further information see Steinbach, Karypis and Kumar (2000) <http://glaros.dtc.umn.edu/gkhome/fetch/papers/docclusterKDDTMW00.pdf>.

This package provides time series regression models with one predictor using finite distributed lag models, polynomial (Almon) distributed lag models, geometric distributed lag models with Koyck transformation, and autoregressive distributed lag models. It also consists of functions for computation of h-step ahead forecasts from these models. See Demirhan (2020)(<doi:10.1371/journal.pone.0228812>) and Baltagi (2011)(<doi:10.1007/978-3-642-20059-5>) for more information.

Ingredient specific diagnostics for drug exposure records in the Observational Medical Outcomes Partnership (OMOP) common data model.

Mapping, spatial analysis, and statistical modeling of microdata from sources such as the Demographic and Health Surveys <https://www.dhsprogram.com/> and Integrated Public Use Microdata Series <https://www.ipums.org/>. It can also be extended to other datasets. The package supports spatial correlation index construction and visualization, along with empirical Bayes approximation of regression coefficients in a multistage setup. The main functionality is repeated regression â for example, if we have to run regression for n groups, the group ID should be vertically composed into the variable for the parameter `location_var`. It can perform various kinds of regression, such as Generalized Regression Models, logit, probit, and more. Additionally, it can incorporate interaction effects. The key benefit of the package is its ability to store the regression results performed repeatedly on a dataset by the group ID, along with respective p-values and map those estimates.

Several functions are provided for dose-response (or concentration-response) characterization from omics data. DRomics is especially dedicated to omics data obtained using a typical dose-response design, favoring a great number of tested doses (or concentrations) rather than a great number of replicates (no need of replicates). DRomics provides functions 1) to check, normalize and or transform data, 2) to select monotonic or biphasic significantly responding items (e.g. probes, metabolites), 3) to choose the best-fit model among a predefined family of monotonic and biphasic models to describe each selected item, 4) to derive a benchmark dose or concentration and a typology of response from each fitted curve. In the available version data are supposed to be single-channel microarray data in log2, RNAseq data in raw counts, or already pretreated continuous omics data (such as metabolomic data) in log scale. In order to link responses across biological levels based on a common method, DRomics also handles apical data as long as they are continuous and follow a normal distribution for each dose or concentration, with a common standard error. For further details see Delignette-Muller et al (2023) <DOI:10.24072/pcjournal.325> and Larras et al (2018) <DOI:10.1021/acs.est.8b04752>.

Consider ambiguity in probabilistic descriptions by replacing a parametric probabilistic description of uncertainty by a non-parametric set of probability distributions in the form of a Density Ratio Class. This is of particular interest in Bayesian inference. The Density Ratio Class is particularly suited for this purpose as it is invariant under Bayesian inference, marginalization, and propagation through a deterministic model. Here, invariant means that the result of the operation applied to a Density Ratio Class is again a Density Ratio Class. In particular the invariance under Bayesian inference thus enables iterative learning within the same framework of Density Ratio Classes. The use of imprecise probabilities in general, and Density Ratio Classes in particular, lead to intervals of characteristics of probability distributions, such as cumulative distribution functions, quantiles, and means. The package is based on a sample of the distribution proportional to the upper bound of the class. Typically this will be a sample from the posterior in Bayesian inference. Based on such a sample, the package provides functions to calculate lower and upper class boundaries and lower and upper bounds of cumulative distribution functions, and quantiles. Rinderknecht, S.L., Albert, C., Borsuk, M.E., Schuwirth, N., Kuensch, H.R. and Reichert, P. (2014) "The effect of ambiguous prior knowledge on Bayesian model parameter inference and prediction." Environmental Modelling & Software. 62, 300-315, 2014. <doi:10.1016/j.envsoft.2014.08.020>. Sriwastava, A. and Reichert, P. "Robust Bayesian Estimation of Value Function Parameters using Imprecise Priors." Submitted. <https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4973574>.

Allows users to quickly and easily detect data containing Personally Identifiable Information (PII) through convenience functions.

Data sets and functions, for the display of gene expression array (microarray) data, and for demonstrations with such data.

This package provides a robust identification of differential binding sites method for analyzing ChIP-seq (Chromatin Immunoprecipitation Sequencing) comparing two samples that considers an ensemble of finite mixture models combined with a local false discovery rate (fdr) allowing for flexible modeling of data. Methods for Differential Identification using Mixture Ensemble (DIME) is described in: Taslim et al., (2011) <doi:10.1093/bioinformatics/btr165>.

Supports propensity score-based methodsâ including matching, stratification, and weightingâ for estimating causal treatment effects. It also implements calibration using negative control outcomes to enhance robustness. debiasedTrialEmulation facilitates effect estimation for both binary and time-to-event outcomes, supporting risk ratio (RR), odds ratio (OR), and hazard ratio (HR) as effect measures. It integrates statistical modeling and visualization tools to assess covariate balance, equipoise, and bias calibration. Additional methodsâ including approaches to address immortal time bias, information bias, selection bias, and informative censoringâ are under development. Users interested in these extended features are encouraged to contact the package authors.

Reaction rate dynamics can be retrieved from metabolite concentration time courses. User has to provide corresponding stoichiometric matrix but not a regulation model (Michaelis-Menten or similar). Instead of solving an ordinary differential equation (ODE) system describing the evolution of concentrations, we use B-splines to catch the concentration and rate dynamics then solve a least square problem on their coefficients with non-negativity (and optionally monotonicity) constraints. Constraints can be also set on initial values of concentration. The package dynafluxr can be used as a library but also as an application with command line interface dynafluxr::cli("-h") or graphical user interface dynafluxr::gui().

This package provides functions for deep learning estimation of Conditional Average Treatment Effects (CATEs) from meta-learner models and Population Average Treatment Effects on the Treated (PATT) in settings with treatment noncompliance using reticulate, TensorFlow and Keras3. Functions in the package also implements the conformal prediction framework that enables computation and illustration of conformal prediction (CP) intervals for estimated individual treatment effects (ITEs) from meta-learner models. Additional functions in the package permit users to estimate the meta-learner CATEs and the PATT in settings with treatment noncompliance using weighted ensemble learning via the super learner approach and R neural networks.

This package provides a common interface for applying dimensionality reduction methods, such as Principal Component Analysis ('PCA'), Independent Component Analysis ('ICA'), diffusion maps, Locally-Linear Embedding ('LLE'), t-distributed Stochastic Neighbor Embedding ('t-SNE'), and Uniform Manifold Approximation and Projection ('UMAP'). Has built-in support for sparse matrices.

This package provides statistical tests and support functions for detecting irregular digit patterns in numerical data. The package includes tools for extracting digits at various locations in a number, tests for repeated values, and (Bayesian) tests of digit distributions.