DataSHIELD is an infrastructure and series of R packages that enables the remote and non-disclosive analysis of sensitive research data. This package is the DataSHIELD interface implementation for Opal', which is the data integration application for biobanks by OBiBa'. Participant data, once collected from any data source, must be integrated and stored in a central data repository under a uniform model. Opal is such a central repository. It can import, process, validate, query, analyze, report, and export data. Opal is the reference implementation of the DataSHIELD infrastructure.

This package provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi: 10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The dtpcrm package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.

This package provides a graphical user interface (GUI) to the functions implemented in the R package DQAstats'. Publication: Mang et al. (2021) <doi:10.1186/s12911-022-01961-z>.

This package provides methods for fitting nonstationary Gaussian process models by spatial deformation, as introduced by Sampson and Guttorp (1992) <doi:10.1080/01621459.1992.10475181>, and by dimension expansion, as introduced by Bornn et al. (2012) <doi:10.1080/01621459.2011.646919>. Low-rank thin-plate regression splines, as developed in Wood, S.N. (2003) <doi:10.1111/1467-9868.00374>, are used to either transform co-ordinates or create new latent dimensions.

Fits Gaussian Mixtures by applying evolution. As fitness function a mixture of the chi square test for distributions and a novel measure for approximating the common area under curves between multiple Gaussians is used. The package presents an alternative to the commonly used Likelihood Maximization as is used in Expectation Maximization. The algorithm and applications of this package are published under: Lerch, F., Ultsch, A., Lotsch, J. (2020) <doi:10.1038/s41598-020-57432-w>. The evolution is based on the GA package: Scrucca, L. (2013) <doi:10.18637/jss.v053.i04> while the Gaussian Mixture Logic stems from AdaptGauss': Ultsch, A, et al. (2015) <doi:10.3390/ijms161025897>.

Designed for genomic and proteomic data analysis, enabling unbiased PubMed searching, protein interaction network visualization, and comprehensive data summarization. This package aims to help users identify novel targets within their data sets based on protein network interactions and publication precedence of target's association with research context based on literature precedence. Methods in this package are described in detail in: Douglas (Year) <to-be-added DOI or link to the preprint>. Key functionalities of this package also leverage methodologies from previous works, such as: - Szklarczyk et al. (2023) <doi:10.1093/nar/gkac1000> - Winter (2017) <doi:10.32614/RJ-2017-066>.

This package provides a framework for creating production outputs. Users can frame a table, listing, or figure with headers and footers and save to an output file. Stores an intermediate docorator object for reproducibility and rendering to multiple output types.

Feature selection from high dimensional data using a diploid genetic algorithm with Incomplete Dominance for genotype to phenotype mapping and Random Assortment of chromosomes approach to recombination.

This package provides a decorator is a function that receives a function, extends its behaviour, and returned the altered function. Any caller that uses the decorated function uses the same interface as it were the original, undecorated function. Decorators serve two primary uses: (1) Enhancing the response of a function as it sends data to a second component; (2) Supporting multiple optional behaviours. An example of the first use is a timer decorator that runs a function, outputs its execution time on the console, and returns the original function's result. An example of the second use is input type validation decorator that during running time tests whether the caller has passed input arguments of a particular class. Decorators can reduce execution time, say by memoization, or reduce bugs by adding defensive programming routines.

Simultaneously detect the number and locations of change points in piecewise linear models under stationary Gaussian noise allowing autocorrelated random noise. The core idea is to transform the problem of detecting change points into the detection of local extrema (local maxima and local minima)through kernel smoothing and differentiation of the data sequence, see Cheng et al. (2020) <doi:10.1214/20-EJS1751>. A low-computational and fast algorithm call dSTEM is introduced to detect change points based on the STEM algorithm in D. Cheng and A. Schwartzman (2017) <doi:10.1214/16-AOS1458>.

This package performs analysis of popular experimental designs used in the field of biological research. The designs covered are completely randomized design, randomized complete block design, factorial completely randomized design, factorial randomized complete block design, split plot design, strip plot design and latin square design. The analysis include analysis of variance, coefficient of determination, normality test of residuals, standard error of mean, standard error of difference and multiple comparison test of means. The package has functions for transformation of data and yield data conversion. Some datasets are also added in order to facilitate examples.

This package provides a `.` object which can be used for unpacking assignments. For example, `.[rows, columns] <- dim(cars)` could be used to pull the number of rows and number of columns from `dim(cars)` into individual variables `rows` and `columns` in a single step.

This package provides tools for fitting Bayesian Distributed Lag Models (DLMs) to longitudinal response data that is a count or binary. Count data is fit using negative binomial regression and binary is fit using quantile regression. The contribution of the lags are fit via b-splines. In addition, infers the predictor inclusion uncertainty. Multimomial models are not supported. Based on Dempsey and Wyse (2025) <doi:10.48550/arXiv.2403.03646>.

This package provides a Graphical User Interface (GUI) to import, save, detrend and perform standard tree-ring analyses. The interactive detrending allows the user to check how well the detrending curve fits each time-series and change it when needed.

Programmatic interface to the Daymet web services (<http://daymet.ornl.gov>). Allows for easy downloads of Daymet climate data directly to your R workspace or your computer. Routines for both single pixel data downloads and gridded (netCDF) data are provided.

The models of probability density functions are Gaussian or exponential distributions with polynomial correction terms. Using a maximum likelihood method, dsdp computes parameters of Gaussian or exponential distributions together with degrees of polynomials by a grid search, and coefficient of polynomials by a variant of semidefinite programming. It adopts Akaike Information Criterion for model selection. See a vignette for a tutorial and more on our Github repository <https://github.com/tsuchiya-lab/dsdp/>.

This is an R implementation of Fast and Scalable Learning of Sparse Changes in High-Dimensional Gaussian Graphical Model Structure (DIFFEE). The DIFFEE algorithm can be used to fast estimate the differential network between two related datasets. For instance, it can identify differential gene network from datasets of case and control. By performing data-driven network inference from two high-dimensional data sets, this tool can help users effectively translate two aggregated data blocks into knowledge of the changes among entities between two Gaussian Graphical Model. Please run demo(diffeeDemo) to learn the basic functions provided by this package. For further details, please read the original paper: Beilun Wang, Arshdeep Sekhon, Yanjun Qi (2018) <arXiv:1710.11223>.

Given a set of predictive quantiles from a distribution, estimate the distribution and create `d`, `p`, `q`, and `r` functions to evaluate its density function, distribution function, and quantile function, and generate random samples. On the interior of the provided quantiles, an interpolation method such as a monotonic cubic spline is used; the tails are approximated by a location-scale family.

This package provides a collection of functions for directional data (including massive data, with millions of observations) analysis. Hypothesis testing, discriminant and regression analysis, MLE of distributions and more are included. The standard textbook for such data is the "Directional Statistics" by Mardia, K. V. and Jupp, P. E. (2000). Other references include: a) Paine J.P., Preston S.P., Tsagris M. and Wood A.T.A. (2018). "An elliptically symmetric angular Gaussian distribution". Statistics and Computing 28(3): 689-697. <doi:10.1007/s11222-017-9756-4>. b) Tsagris M. and Alenazi A. (2019). "Comparison of discriminant analysis methods on the sphere". Communications in Statistics: Case Studies, Data Analysis and Applications 5(4):467--491. <doi:10.1080/23737484.2019.1684854>. c) Paine J.P., Preston S.P., Tsagris M. and Wood A.T.A. (2020). "Spherical regression models with general covariates and anisotropic errors". Statistics and Computing 30(1): 153--165. <doi:10.1007/s11222-019-09872-2>. d) Tsagris M. and Alenazi A. (2024). "An investigation of hypothesis testing procedures for circular and spherical mean vectors". Communications in Statistics-Simulation and Computation, 53(3): 1387--1408. <doi:10.1080/03610918.2022.2045499>. e) Yu Z. and Huang X. (2024). A new parameterization for elliptically symmetric angular Gaussian distributions of arbitrary dimension. Electronic Journal of Statistics, 18(1): 301--334. <doi:10.1214/23-EJS2210>. f) Tsagris M. and Alzeley O. (2025). "Circular and spherical projected Cauchy distributions: A Novel Framework for Circular and Directional Data Modeling". Australian & New Zealand Journal of Statistics, 67(1): 77--103. <doi:10.1111/anzs.12434>. g) Tsagris M., Papastamoulis P. and Kato S. (2025). "Directional data analysis: spherical Cauchy or Poisson kernel-based distribution". Statistics and Computing, 35:51. <doi:10.1007/s11222-025-10583-0>.

An open, multi-algorithmic pipeline for easy, fast and efficient analysis of cellular sub-populations and the molecular signatures that characterize them. The pipeline consists of four successive steps: data pre-processing, cellular clustering with pseudo-temporal ordering, defining differential expressed genes and biomarker identification. More details on Ghannoum et. al. (2021) <doi:10.3390/ijms22031399>. This package implements extensions of the work published by Ghannoum et. al. (2019) <doi:10.1101/700989>.

This package provides mean squared error (MSE) and plot the kernel densities related to extreme value distributions with their estimated values. By using Gumbel and Weibull Kernel. See Salha et al. (2014) <doi:10.4236/ojs.2014.48061> and Khan and Akbar (2021) <doi:10.4236/ojs.2021.112018 >.

This package performs emulation of dynamic simulators using Gaussian process via one-step ahead approach. The package implements a flexible framework for approximating time-dependent outputs from computationally expensive dynamic systems. It is specifically designed for nonlinear dynamic systems where full simulations may be costly. The underlying Gaussian process model accounts for temporal dependency through the one-step-ahead formulation, allowing for accurate emulation of complex dynamics. Hyperparameters are estimated via maximum likelihood. For methodological details, see Heo (2025, <doi:10.48550/arXiv.2503.20250>) for exact method, and Mohammadi, Challenor, and Goodfellow (2019, <doi:10.1016/j.csda.2019.05.006>) for Monte Carlo method.

Easy-to-use and efficient interface for Bayesian inference of complex panel (time series) data using dynamic multivariate panel models by Helske and Tikka (2024) <doi:10.1016/j.alcr.2024.100617>. The package supports joint modeling of multiple measurements per individual, time-varying and time-invariant effects, and a wide range of discrete and continuous distributions. Estimation of these dynamic multivariate panel models is carried out via Stan'. For an in-depth tutorial of the package, see (Tikka and Helske, 2025) <doi:10.18637/jss.v115.i05>.

This package provides a foreach parallel adapter for parabar backends. This package offers a minimal implementation of the %dopar% operator, enabling users to run foreach loops in parallel, leveraging the parallel and progress-tracking capabilities of the parabar package. Learn more about parabar and doParabar at <https://parabar.mihaiconstantin.com>.