This package provides tools for converting and imputing date values to the ISO 8601 standard format and for reconciling differences between two versions of a data set. The package automatically detects date patterns within data frame columns and converts them to consistent ISO-formatted dates, with optional imputation of missing day or month components based on user-defined rules. It also includes functionality to identify inserted, deleted, and updated records, as well as column- and value-level changes, when comparing old and new versions of a data frame. Only one date format may be applied within a single column.

Solves quadratic programming problems using Richard L. Dykstra's cyclic projection algorithm. Routine allows for a combination of equality and inequality constraints. See Dykstra (1983) <doi:10.1080/01621459.1983.10477029> for details.

This package creates discretised versions of continuous distribution functions by mapping continuous values to an underlying discrete grid, based on a (uniform) frequency of discretisation, a valid discretisation point, and an integration range. For a review of discretisation methods, see Chakraborty (2015) <doi:10.1186/s40488-015-0028-6>.

Convert a directory structure into a JSON format. This package lets you recursively traverse a directory and convert its contents into a JSON object, making it easier to import code base from file systems into large language models.

This package provides a GUI to solve dynamic biplots and classical biplot. Try matrices of 2-way and 3-way. The GUI can be run in multiple languages.

R package to build and simulate deterministic compartmental models that can be non-Markovian. Length of stay in each compartment can be defined to follow a parametric distribution (d_exponential(), d_gamma(), d_weibull(), d_lognormal()) or a non-parametric distribution (nonparametric()). Other supported types of transition from one compartment to another includes fixed transition (constant()), multinomial (multinomial()), fixed transition probability (transprob()).

Datasets and functions to accompany the book Analisis de datos con el programa estadistico R: una introduccion aplicada by Salas-Eljatib (2021, ISBN: 9789566086109). The package helps carry out data management, exploratory analyses, and model fitting.

Functionality for analyzing dose-volume histograms (DVH) in radiation oncology: Read DVH text files, calculate DVH metrics as well as generalized equivalent uniform dose (gEUD), biologically effective dose (BED), equivalent dose in 2 Gy fractions (EQD2), normal tissue complication probability (NTCP), and tumor control probability (TCP). Show DVH diagrams, check and visualize quality assurance constraints for the DVH. Includes web-based graphical user interface.

Detect abrupt changes in time series with local fluctuations as a random walk process and autocorrelated noise as an AR(1) process. See Romano, G., Rigaill, G., Runge, V., Fearnhead, P. (2021) <doi:10.1080/01621459.2021.1909598>.

In tumor tissue, underlying genomic instability can lead to DNA copy number alterations, e.g., copy number gains or losses. Sporadic copy number alterations occur randomly throughout the genome, whereas recurrent alterations are observed in the same genomic region across multiple independent samples, perhaps because they provide a selective growth advantage. Here we use cyclic shift permutations to identify recurrent copy number alterations in a single cohort or recurrent copy number differences in two cohorts based on a common set of genomic markers. Additional functionality is provided to perform downstream analyses, including the creation of summary files and graphics. DiNAMIC.Duo builds upon the original DiNAMIC package of Walter et al. (2011) <doi:10.1093/bioinformatics/btq717> and leverages the theory developed in Walter et al. (2015) <doi:10.1093/biomet/asv046>. An article describing DiNAMIC.Duo by Walter et al. (2022) can be found at <doi: 10.1093/bioinformatics/btac542>.

Create and customize interactive collapsible D3 trees using the D3 JavaScript library and the htmlwidgets package. These trees can be used directly from the R console, from RStudio', in Shiny apps and R Markdown documents. When in Shiny the tree layout is observed by the server and can be used as a reactive filter of structured data.

Fit and explore Drift Diffusion Models (DDMs), a common tool in psychology for describing decision processes in simple tasks. It can handle both time-independent and time-dependent DDMs. You either choose prebuilt models or create your own, and the package takes care of model predictions and parameter estimation. Model predictions are derived via the numerical solutions provided by Richter, Ulrich, and Janczyk (2023, <doi:10.1016/j.jmp.2023.102756>).

DAGs With Omitted Objects Displayed (DAGWOOD) is a framework to help reveal key hidden assumptions in a causal DAG. This package provides an implementation of the DAGWOOD algorithm. Further description can be found in Haber et al (2022) <DOI:10.1016/j.annepidem.2022.01.001>.

This package implements the algorithm described in Jun Li and Alicia T. Lamere, "DiPhiSeq: Robust comparison of expression levels on RNA-Seq data with large sample sizes" (Unpublished). Detects not only genes that show different average expressions ("differential expression", DE), but also genes that show different diversities of expressions in different groups ("differentially dispersed", DD). DD genes can be important clinical markers. DiPhiSeq uses a redescending penalty on the quasi-likelihood function, and thus has superior robustness against outliers and other noise. Updates from version 0.1.0: (1) Added the option of using adaptive initial value for phi. (2) Added a function for estimating the proportion of outliers in the data. (3) Modified the input parameter names for clarity, and modified the output format for the main function.

This package provides a set of tools to generate dynamic spectrogram visualizations in video format.

This package provides an extensive and curated collection of datasets related to the digestive system, stomach, intestines, liver, pancreas, and associated diseases. This package includes clinical trials, observational studies, experimental datasets, cohort data, and case series involving gastrointestinal disorders such as gastritis, ulcers, pancreatitis, liver cirrhosis, colon cancer, colorectal conditions, Helicobacter pylori infection, irritable bowel syndrome, intestinal infections, and post-surgical outcomes. The datasets support educational, clinical, and research applications in gastroenterology, public health, epidemiology, and biomedical sciences. Designed for researchers, clinicians, data scientists, students, and educators interested in digestive diseases, the package facilitates reproducible analysis, modeling, and hypothesis testing using real-world and historical data.

This package provides a collection of functions which aim to assist common computational workflow for analysis of matabolomic data..

This is the companion package to the Data Visualization Geometries Encyclopedia, providing seamless access to the associated data.

This package provides a systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. DrugSim2DR first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.

Streamlines analysis of qualitative data exported from Dedoose <https://www.dedoose.com>. Supports monitoring thematic saturation, calculating code frequencies, organizing excerpts, generating dynamic codebooks, and producing code network maps within R'.

The framework provides functions to generate ODEs of reaction networks, parameter transformations, observation functions, residual functions, etc. The framework follows the paradigm that derivative information should be used for optimization whenever possible. Therefore, all major functions produce and can handle expressions for symbolic derivatives. The methods used in dMod were published in Kaschek et al, 2019, <doi:10.18637/jss.v088.i10>.

Provide tools for drought monitoring based on univariate and multivariate drought indicators.Statistical drought prediction based on Ensemble Streamflow Prediction (ESP), drought risk assessments, and drought propagation are also provided. Please see Hao Zengchao et al. (2017) <doi:10.1016/j.envsoft.2017.02.008>.

In tumor tissue, underlying genomic instability can lead to DNA copy number alterations, e.g., copy number gains or losses. Sporadic copy number alterations occur randomly throughout the genome, whereas recurrent alterations are observed in the same genomic region across multiple independent samples, perhaps because they provide a selective growth advantage. This package implements the DiNAMIC procedure for assessing the statistical significance of recurrent DNA copy number aberrations (Bioinformatics (2011) 27(5) 678 - 685).

Dose Titration Algorithm Tuning (DTAT) is a methodologic framework allowing dose individualization to be conceived as a continuous learning process that begins in early-phase clinical trials and continues throughout drug development, on into clinical practice. This package includes code that researchers may use to reproduce or extend key results of the DTAT research programme, plus tools for trialists to design and simulate a 3+3/PC dose-finding study. Please see Norris (2017a) <doi:10.12688/f1000research.10624.3> and Norris (2017c) <doi:10.1101/240846>.