This package provides tools to estimate and manage empirical distributions, which should work with survey data. One of the main features is the possibility to create data cubes of estimated statistics, that include all the combinations of the variables of interest (see for example functions dcc5() and dcc6()).

This package provides a convenient API interface to access immunological data within the CAVD DataSpace'(<https://dataspace.cavd.org>), a data sharing and discovery tool that facilitates exploration of HIV immunological data from pre-clinical and clinical HIV vaccine studies.

Shiny modules to import data into an application or addin from various sources, and to manipulate them after that.

This package implements the DAAREM method for accelerating the convergence of slow, monotone sequences from smooth, fixed-point iterations such as the EM algorithm. For further details about the DAAREM method, see Henderson, N.C. and Varadhan, R. (2019) <doi:10.1080/10618600.2019.1594835>.

Semi-Binary and Semi-Ternary Matrix Decomposition are performed based on Non-negative Matrix Factorization (NMF) and Singular Value Decomposition (SVD). For the details of the methods, see the reference section of GitHub README.md <https://github.com/rikenbit/dcTensor>.

Dose Titration Algorithm Tuning (DTAT) is a methodologic framework allowing dose individualization to be conceived as a continuous learning process that begins in early-phase clinical trials and continues throughout drug development, on into clinical practice. This package includes code that researchers may use to reproduce or extend key results of the DTAT research programme, plus tools for trialists to design and simulate a 3+3/PC dose-finding study. Please see Norris (2017a) <doi:10.12688/f1000research.10624.3> and Norris (2017c) <doi:10.1101/240846>.

Gives you the ability to use arbitrary Docker images (including custom ones) to process Rmarkdown code chunks.

Use numerical optimization to fit ordinary differential equations (ODEs) to time series data to examine the dynamic relationships between variables or the characteristics of a dynamical system. It can now be used to estimate the parameters of ODEs up to second order, and can also apply to multilevel systems. See <https://github.com/yueqinhu/defit> for details.

Joint dimension reduction and spatial clustering is conducted for Single-cell RNA sequencing and spatial transcriptomics data, and more details can be referred to Wei Liu, Xu Liao, Yi Yang, Huazhen Lin, Joe Yeong, Xiang Zhou, Xingjie Shi and Jin Liu. (2022) <doi:10.1093/nar/gkac219>. It is not only computationally efficient and scalable to the sample size increment, but also is capable of choosing the smoothness parameter and the number of clusters as well.

This package provides a tool to sample data with the desired properties.Samples can be drawn by purposive sampling with determining distributional conditions, such as deviation from normality (skewness and kurtosis), and sample size in quantitative research studies. For purposive sampling, a researcher has something in mind and participants that fit the purpose of the study are included (Etikan,Musa, & Alkassim, 2015) <doi:10.11648/j.ajtas.20160501.11>.Purposive sampling can be useful for answering many research questions (Klar & Leeper, 2019) <doi:10.1002/9781119083771.ch21>.

This package provides a suite of tools to help modelers and decision-makers effectively interpret and communicate decision risk when evaluating multiple policy options. It uses model outputs from uncertainty analysis for baseline scenarios and policy alternatives to generate visual representations of uncertainty and quantitative measures for assessing associated risks. For more details see Wiggins and colleagues (2025) <doi:10.1371/journal.pone.0332522> and <https://dut.ihe.ca/>.

Computes the first stage GMM estimate of a dynamic linear model with p lags of the dependent variables.

This package provides statistical tools for analyzing net and relative survival, with a key feature of relaxing the assumption of independent censoring and incorporating the effect of dependent competing risks. It employs a copula-based methodology, specifically the Archimedean copula, to simulate data, conduct survival analysis, and offer comparisons with other methods. This approach is detailed in the work of Adatorwovor et al. (2022) <doi:10.1515/ijb-2021-0016>.

This package provides documentation in form of a common vignette to packages distr', distrEx', distrMod', distrSim', distrTEst', distrTeach', and distrEllipse'.

Differential exon usage test for RNA-Seq data via an empirical Bayes shrinkage method for the dispersion parameter the utilizes inclusion-exclusion data to analyze the propensity to skip an exon across groups. The input data consists of two matrices where each row represents an exon and the columns represent the biological samples. The first matrix is the count of the number of reads expressing the exon for each sample. The second matrix is the count of the number of reads that either express the exon or explicitly skip the exon across the samples, a.k.a. the total count matrix. Dividing the two matrices yields proportions representing the propensity to express the exon versus skipping the exon for each sample.

Different sample size calculations with different study designs. These techniques are explained by Chow (2007) <doi:10.1201/9781584889830>.

Tools, methods and processes for the management of analysis workflows. These lightweight solutions facilitate structuring R&D activities. These solutions were developed to comply with Good Documentation Practice (GDP), with ALCOA+ principles as proposed by the U.S. FDA, and with FAIR principles as discussed by Jacobsen et al. (2017) <doi:10.1162/dint_r_00024>.

Function to create forest plots. Functions to use posterior samples from Bayesian bivariate meta-analysis model, Bayesian hierarchical summary receiver operating characteristic (HSROC) meta-analysis model or Bayesian latent class (LC) meta-analysis model to create Summary Receiver Operating Characteristic (SROC) plots using methods described by Harbord et al (2007)<doi:10.1093/biostatistics/kxl004>.

While autoregressive distributed lag (ARDL) models allow for extremely flexible dynamics, interpreting substantive significance of complex lag structures remains difficult. This package is designed to assist users in dynamically simulating and plotting the results of various ARDL models. It also contains post-estimation diagnostics, including a test for cointegration when estimating the error-correction variant of the autoregressive distributed lag model (Pesaran, Shin, and Smith 2001 <doi:10.1002/jae.616>).

Estimates the Dyad Ratios Algorithm for pooling and smoothing poll estimates. The Dyad Ratios Algorithm smooths both forward and backward in time over polling results allowing differences in both question type and polling house. The result is an estimate of a single latent variable that describes the systematic trend over time in the (noisy) polling results. See James A. Stimson (2018) <doi:10.1177/0759106318761614> and the package's vignette for more details.

This package creates discretised versions of continuous distribution functions by mapping continuous values to an underlying discrete grid, based on a (uniform) frequency of discretisation, a valid discretisation point, and an integration range. For a review of discretisation methods, see Chakraborty (2015) <doi:10.1186/s40488-015-0028-6>.

Implement some deep learning architectures and neural network algorithms, including BP,RBM,DBN,Deep autoencoder and so on.

Estimation of heterogeneity-robust difference-in-differences estimators, with a binary, discrete, or continuous treatment, in designs where past treatments may affect the current outcome.

Generate motivational quotes and Shakespearean word combinations (bardâ bits) that a user can consider for their personal projects. Each of the package functions takes two arguments, cat which default to any, and a a numeric or character seed to ensure reproducible results.