This package provides a `.` object which can be used for unpacking assignments. For example, `.[rows, columns] <- dim(cars)` could be used to pull the number of rows and number of columns from `dim(cars)` into individual variables `rows` and `columns` in a single step.

Models the relationship between dose levels and responses in a pharmacological experiment using the 4 Parameter Logistic model. Traditional packages on dose-response modelling such as drc and nplr often draw errors due to convergence failure especially when data have outliers or non-logistic shapes. This package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical principle. These methods are used as remedies to convergence failure problems. Gadagkar, S. R. and Call, G. B. (2015) <doi:10.1016/j.vascn.2014.08.006> Ritz, C. and Baty, F. and Streibig, J. C. and Gerhard, D. (2015) <doi:10.1371/journal.pone.0146021>.

This package provides functions for fitting Cox proportional hazards models for grouped time-to-event data, where the shared group-specific frailties have a discrete nonparametric distribution. The methods proposed in the package is described by Gasperoni, F., Ieva, F., Paganoni, A. M., Jackson, C. H., Sharples, L. (2018) <doi:10.1093/biostatistics/kxy071>. There are also functions for simulating from these models, with a nonparametric or a parametric baseline hazard function.

This package provides a flexible container to manage and annotate Differential Gene Expression (DGE) analysis results (Smythe et. al (2015) <doi:10.1093/nar/gkv007>). The DGEobj has data slots for row (gene), col (samples), assays (matrix n-rows by m-samples dimensions) and metadata (not keyed to row, col, or assays). A set of accessory functions to deposit, query and retrieve subsets of a data workflow has been provided. Attributes are used to capture metadata such as species and gene model, including reproducibility information such that a 3rd party can access a DGEobj history to see how each data object was created or modified. Since the DGEobj is customizable and extensible it is not limited to RNA-seq analysis types of workflows -- it can accommodate nearly any data analysis workflow that starts from a matrix of assays (rows) by samples (columns).

Dynamic CUR (dCUR) boosts the CUR decomposition (Mahoney MW., Drineas P. (2009) <doi:10.1073/pnas.0803205106>) varying the k, the number of columns and rows used, and its final purposes to help find the stage, which minimizes the relative error to reduce matrix dimension. The goal of CUR Decomposition is to give a better interpretation of the matrix decomposition employing proper variable selection in the data matrix, in a way that yields a simplified structure. Its origins come from analysis in genetics. The goal of this package is to show an alternative to variable selection (columns) or individuals (rows). The idea proposed consists of adjusting the probability distributions to the leverage scores and selecting the best columns and rows that minimize the reconstruction error of the matrix approximation ||A-CUR||. It also includes a method that recalibrates the relative importance of the leverage scores according to an external variable of the user's interest.

The new (dQTG.seq1 and dQTG.seq2) and existing (SmoothLOD, G', deltaSNP and ED) bulked segregant analysis methods are used to identify various types of quantitative trait loci for complex traits via extreme phenotype individuals in bi-parental segregation populations (F2, backcross, doubled haploid and recombinant inbred line). The numbers of marker alleles in extreme low and high pools are used in existing methods to identify trait-related genes, while the numbers of marker alleles and genotypes in extreme low and high pools are used in the new methods to construct a new statistic Gw for identifying trait-related genes. dQTG-seq2 is feasible to identify extremely over-dominant and small-effect genes in F2. Li P, Li G, Zhang YW, Zuo JF, Liu JY, Zhang YM (2022, <doi: 10.1016/j.xplc.2022.100319>).

This package provides a collection of functions that perform jump regression and image analysis such as denoising, deblurring and jump detection. The implemented methods are based on the following research: Qiu, P. (1998) <doi:10.1214/aos/1024691468>, Qiu, P. and Yandell, B. (1997) <doi: 10.1080/10618600.1997.10474746>, Qiu, P. (2009) <doi: 10.1007/s10463-007-0166-9>, Kang, Y. and Qiu, P. (2014) <doi: 10.1080/00401706.2013.844732>, Qiu, P. and Kang, Y. (2015) <doi: 10.5705/ss.2014.054>, Kang, Y., Mukherjee, P.S. and Qiu, P. (2018) <doi: 10.1080/00401706.2017.1415975>, Kang, Y. (2020) <doi: 10.1080/10618600.2019.1665536>.

The models of probability density functions are Gaussian or exponential distributions with polynomial correction terms. Using a maximum likelihood method, dsdp computes parameters of Gaussian or exponential distributions together with degrees of polynomials by a grid search, and coefficient of polynomials by a variant of semidefinite programming. It adopts Akaike Information Criterion for model selection. See a vignette for a tutorial and more on our Github repository <https://github.com/tsuchiya-lab/dsdp/>.

Distributed Online Covariance Matrix Tests Docovt is a powerful tool designed to efficiently process and analyze distributed datasets. It enables users to perform covariance matrix tests in an online, distributed manner, making it highly suitable for large-scale data analysis. By leveraging advanced computational techniques, Docovt ensures robust and scalable solutions for statistical analysis, particularly in scenarios where data is dispersed across multiple nodes or sources. This package is ideal for researchers and practitioners working with high-dimensional data, providing a flexible and efficient framework for covariance matrix estimation and hypothesis testing. The philosophy of Docovt is described in Guo G.(2025) <doi:10.1016/j.physa.2024.130308>.

Helper functions for descriptive tasks such as making print-friendly bivariate tables, sample size flow counts, and visualizing sample distributions. Also contains R approximations of some common SAS and Stata functions such as PROC MEANS from SAS and ladder', gladder', and pwcorr from Stata'.

Calculates the T-Statistic for the drift burst hypothesis from the working paper Christensen, Oomen and Reno (2018) <DOI:10.2139/ssrn.2842535>. The authors MATLAB code is available upon request, see: <https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2842535>.

This package provides a metric called Density-Based Clustering Validation index (DBCV) index to evaluate clustering results, following the <https://github.com/pajaskowiak/clusterConfusion/blob/main/R/dbcv.R> R implementation by Pablo Andretta Jaskowiak. Original DBCV index article: Moulavi, D., Jaskowiak, P. A., Campello, R. J., Zimek, A., and Sander, J. (April 2014), "Density-based clustering validation", Proceedings of SDM 2014 -- the 2014 SIAM International Conference on Data Mining (pp. 839-847), <doi:10.1137/1.9781611973440.96>. A more recent article on the DBCV index: Chicco, D., Sabino, G.; Oneto, L.; Jurman, G. (August 2025), "The DBCV index is more informative than DCSI, CDbw, and VIASCKDE indices for unsupervised clustering internal assessment of concave-shaped and density-based clusters", PeerJ Computer Science 11:e3095 (pp. 1-), <doi:10.7717/peerj-cs.3095>.

The distributed online expectation maximization algorithms are used to solve parameters of Poisson mixture models. The philosophy of the package is described in Guo, G. (2022) <doi:10.1080/02664763.2022.2053949>.

Flexibly convert data between long and wide format using just two functions: reshape_toLong() and reshape_toWide().

This package provides tools to help the design and analysis of resilient non-inferiority trials. These include functions for sample size calculations and analyses of trials, with either a risk difference, risk ratio or arc-sine difference margin, and a function to run simulations to design a trial with the methods described in Quartagno et al. (2019) <arXiv:1905.00241>.

Simulation models (apps) of various within-host immune response scenarios. The purpose of the package is to help individuals learn about within-host infection and immune response modeling from a dynamical systems perspective. All apps include explanations of the underlying models and instructions on what to do with the models.

Supports the process of applying a cut to Standard Data Tabulation Model (SDTM), as part of the analysis of specific points in time of the data, normally as part of investigation into clinical trials. The functions support different approaches of cutting to the different domains of SDTM normally observed.

Allows users to quickly and easily describe data using common descriptive statistics.

This package provides information on drug names (brand, generic and street) for drugs tracked by the DEA. There are functions that will search synonyms and return the drug names and types. The vignettes have extensive information on the work done to create the data for the package.

This package provides efficient Markov chain Monte Carlo (MCMC) algorithms for dynamic shrinkage processes, which extend global-local shrinkage priors to the time series setting by allowing shrinkage to depend on its own past. These priors yield locally adaptive estimates, useful for time series and regression functions with irregular features. The package includes full MCMC implementations for trend filtering using dynamic shrinkage on signal differences, producing locally constant or linear fits with adaptive credible bands. Also included are models with static shrinkage and normal-inverse-Gamma priors for comparison. Additional tools cover dynamic regression with time-varying coefficients and B-spline models with shrinkage on basis differences, allowing for flexible curve-fitting with unequally spaced data. Some support for heteroscedastic errors, outlier detection, and change point estimation. Methods in this package are described in Kowal et al. (2019) <doi:10.1111/rssb.12325>, Wu et al. (2024) <doi:10.1080/07350015.2024.2362269>, Schafer and Matteson (2024) <doi:10.1080/00401706.2024.2407316>, and Cho and Matteson (2024) <doi:10.48550/arXiv.2408.11315>.

Makes it easy to engage with the Application Program Interface (API) of the TCdata360 and Govdata360 platforms at <https://tcdata360.worldbank.org/> and <https://govdata360.worldbank.org/>, respectively. These application program interfaces provide access to over 5000 trade, competitiveness, and governance indicator data, metadata, and related information from sources both inside and outside the World Bank Group. Package functions include easier download of data sets, metadata, and related information, as well as searching based on user-inputted query.

Estimation of functional linear mixed models for densely sampled data based on functional principal component analysis.

Function to test spatial segregation and association based in contingency table analysis of nearest neighbour counts following Dixon (2002) <doi:10.1080/11956860.2002.11682700>. Some Fortran code has been included to the original dixon2002() function of the ecespa package to improve speed.

This package provides a way to apply Distance-Based Common Spatial Patterns (DB-CSP) techniques in different fields, both classical Common Spatial Patterns (CSP) as well as DB-CSP. The method is composed of two phases: applying the DB-CSP algorithm and performing a classification. The main idea behind the CSP is to use a linear transform to project data into low-dimensional subspace with a projection matrix, in such a way that each row consists of weights for signals. This transformation maximizes the variance of two-class signal matrices.The dbcsp object is created to compute the projection vectors. For exploratory and descriptive purpose, plot and boxplot functions can be used. Functions train, predict and selectQ are implemented for the classification step.