Distributional instrumental variable (DIV) model for estimation of the interventional distribution of the outcome Y under a do intervention on the treatment X. Instruments, predictors and targets can be univariate or multivariate. Functionality includes estimation of the (conditional) interventional mean and quantiles, as well as sampling from the fitted (conditional) interventional distribution.

Compare functional enrichment between two experimentally-derived groups of genes or proteins (Peterson, DR., et al.(2018)) <doi: 10.1371/journal.pone.0198139>. Given a list of gene symbols, diffEnrich will perform differential enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) REST API. This package provides a number of functions that are intended to be used in a pipeline. Briefly, the user provides a KEGG formatted species id for either human, mouse or rat, and the package will download and clean species specific ENTREZ gene IDs and map them to their respective KEGG pathways by accessing KEGG's REST API. KEGG's API is used to guarantee the most up-to-date pathway data from KEGG. Next, the user will identify significantly enriched pathways from two gene sets, and finally, the user will identify pathways that are differentially enriched between the two gene sets. In addition to the analysis pipeline, this package also provides a plotting function.

Implement dynamic linear models outlined in Shumway and Stoffer (2025) <doi:10.1007/978-3-031-70584-7>. Two model structures for data smoothing and forecasting are considered. The specific models proposed will be added once the manuscript is published.

We provide three distance metrics for measuring the separation between two clusters in high-dimensional spaces. The first metric is the centroid distance, which calculates the Euclidean distance between the centers of the two groups. The second is a ridge Mahalanobis distance, which incorporates a ridge correction constant, alpha, to ensure that the covariance matrix is invertible. The third metric is the maximal data piling distance, which computes the orthogonal distance between the affine spaces spanned by each class. These three distances are asymptotically interconnected and are applicable in tasks such as discrimination, clustering, and outlier detection in high-dimensional settings.

This package provides a graphical user interface for the dqcheckr package. Provides a point-and-click shiny application for configuring dataset quality checks, running them against recurring file deliveries, and browsing historical check results â without writing any R code.

Adopts the general least squares-based data-driven normalization strategy developed by Heckmann et al. (2011) <doi:10.1186/1471-2105-12-250> to correct for technical variance in gene expression data generated via digital polymerase chain reaction (dPCR). Performs normalization of raw copy numbers and also calculates relative variability metrics that can be used to assess the impact of normalization on variance.

Dynamic slicing is a method designed for dependency detection between a categorical variable and a continuous variable. It could be applied for non-parametric hypothesis testing and gene set enrichment analysis.

Enhancing cross-language compatibility within the RStudio environment and supporting seamless language understanding, the deepRstudio package leverages the power of the DeepL API (see <https://www.deepl.com/docs-api>) to enable seamless, fast, accurate, and affordable translation of code comments, documents, and text. This package offers the ability to translate selected text into English (EN), as well as from English into various languages, namely Japanese (JA), Chinese (ZH), Spanish (ES), French (FR), Russian (RU), Portuguese (PT), and Indonesian (ID). With much of the text being written in English, the emphasis is on compatibility from English. It is also designed for developers working on multilingual projects and data analysts collaborating with international teams, simplifying the translation process and making code more accessible and comprehensible to people with diverse language backgrounds. This package uses the rstudioapi package and DeepL API, and is simply implemented, executed from addins or via shortcuts on RStudio'. With just a few steps, content can be translated between supported languages, promoting better collaboration and expanding the global reach of work. The functionality of this package works only on RStudio using rstudioapi'.

Distances on dual-weighted directed graphs using priority-queue shortest paths (Padgham (2019) <doi:10.32866/6945>). Weighted directed graphs have weights from A to B which may differ from those from B to A. Dual-weighted directed graphs have two sets of such weights. A canonical example is a street network to be used for routing in which routes are calculated by weighting distances according to the type of way and mode of transport, yet lengths of routes must be calculated from direct distances.

Extremely fast and memory efficient computation of the DER (or PaF) income polarization index as proposed by Duclos J. Y., Esteban, J. and Ray D. (2004). "Polarization: concepts, measurement, estimation". Econometrica, 72(6): 1737--1772. <doi:10.1111/j.1468-0262.2004.00552.x>. The index may be computed for a single or for a range of values of the alpha-parameter and bootstrapping is also available.

Calculates Distinctiveness Centrality in social networks. For formulas and descriptions, see Fronzetti Colladon and Naldi (2020) <doi:10.1371/journal.pone.0233276>.

Estimates a variety of Dynamic Conditional Correlation (DCC) models. More in detail, the dccmidas package allows the estimation of the corrected DCC (cDCC) of Aielli (2013) <doi:10.1080/07350015.2013.771027>, the DCC-MIDAS of Colacito et al. (2011) <doi:10.1016/j.jeconom.2011.02.013>, the Asymmetric DCC of Cappiello et al. <doi:10.1093/jjfinec/nbl005>, and the Dynamic Equicorrelation (DECO) of Engle and Kelly (2012) <doi:10.1080/07350015.2011.652048>. dccmidas offers the possibility of including standard GARCH <doi:10.1016/0304-4076(86)90063-1>, GARCH-MIDAS <doi:10.1162/REST_a_00300> and Double Asymmetric GARCH-MIDAS <doi:10.1016/j.econmod.2018.07.025> models in the univariate estimation. Moreover, also the scalar and diagonal BEKK <doi:10.1017/S0266466600009063> models can be estimated. Finally, the package calculates also the var-cov matrix under two non-parametric models: the Moving Covariance and the RiskMetrics specifications.

Implementation of new discrete statistical distributions. Each distribution includes the traditional functions as well as an additional function called the family function, which can be used to estimate parameters within the gamlss framework.

This package provides select, insert, update, upsert, and delete database operations. Supports PostgreSQL', MySQL', SQLite', and more, and plays nicely with the DBI package.

This package provides tools to apply Ensemble Empirical Mode Decomposition (EEMD) for cyclostratigraphy purposes. Mainly: a new algorithm, extricate, that performs EEMD in seconds, a linear interpolation algorithm using the greatest rational common divisor of depth or time, different algorithms to compute instantaneous amplitude, frequency and ratios of frequencies, and functions to verify and visualise the outputs. The functions were developed during the CRASH project (Checking the Reproducibility of Astrochronology in the Hauterivian). When using for publication please cite Wouters, S., Crucifix, M., Sinnesael, M., Da Silva, A.C., Zeeden, C., Zivanovic, M., Boulvain, F., Devleeschouwer, X., 2022, "A decomposition approach to cyclostratigraphic signal processing". Earth-Science Reviews 225 (103894). <doi:10.1016/j.earscirev.2021.103894>.

Work with data on Venetian doges and dogaresse and the noble families of the Republic of Venice, and use it for social network analysis, as used in Merelo (2022) <doi:10.48550/arXiv.2209.07334>.

Fits Gaussian Mixtures by applying evolution. As fitness function a mixture of the chi square test for distributions and a novel measure for approximating the common area under curves between multiple Gaussians is used. The package presents an alternative to the commonly used Likelihood Maximization as is used in Expectation Maximization. The algorithm and applications of this package are published under: Lerch, F., Ultsch, A., Lotsch, J. (2020) <doi:10.1038/s41598-020-57432-w>. The evolution is based on the GA package: Scrucca, L. (2013) <doi:10.18637/jss.v053.i04> while the Gaussian Mixture Logic stems from AdaptGauss': Ultsch, A, et al. (2015) <doi:10.3390/ijms161025897>.

Dynamic Reservoir Simulation Model (DYRESM) and Computational Aquatic Ecosystem Dynamics Model (CAEDYM) model development, including assisting with calibrating selected model parameters and visualising model output through time series plot, profile plot, contour plot, and scatter plot. For more details, see Yu et al. (2023) <https://journal.r-project.org/articles/RJ-2023-008/>.

The state-of-the-art algorithms for distance metric learning, including global and local methods such as Relevant Component Analysis, Discriminative Component Analysis, Local Fisher Discriminant Analysis, etc. These distance metric learning methods are widely applied in feature extraction, dimensionality reduction, clustering, classification, information retrieval, and computer vision problems.

In the context of data quality assessment, this package provides a number of functions for evaluating data quality across various dimensions, including completeness, plausibility, concordance, conformance, currency, timeliness, and correctness. It has been developed based on two well-known frameworksâ Michael G. Kahn (2016) <doi:10.13063/2327-9214.1244> and Nicole G. Weiskopf (2017) <doi:10.5334/egems.218>â for data quality assessment. Using this package, users can evaluate the quality of their datasets, provided that corresponding metadata are available.

This package performs sensitivity analysis for the sharp null, attributable effects, and weak nulls in matched studies with continuous exposures and binary or continuous outcomes as described in Zhang, Small, Heng (2024) <doi:10.48550/arXiv.2401.06909> and Zhang, Heng (2024) <doi:10.48550/arXiv.2409.12848>. Two of the functions require installation of the Gurobi optimizer. Please see <https://docs.gurobi.com/current/#refman/ins_the_r_package.html> for guidance.

This package provides methods for fitting nonstationary Gaussian process models by spatial deformation, as introduced by Sampson and Guttorp (1992) <doi:10.1080/01621459.1992.10475181>, and by dimension expansion, as introduced by Bornn et al. (2012) <doi:10.1080/01621459.2011.646919>. Low-rank thin-plate regression splines, as developed in Wood, S.N. (2003) <doi:10.1111/1467-9868.00374>, are used to either transform co-ordinates or create new latent dimensions.

Gaussian mixture modeling of one- and two-dimensional data, provided in original or binned form, with an option to estimate the number of model components. The method uses Gaussian Mixture Models (GMM) with initial parameters determined by a dynamic programming algorithm, leading to stable and reproducible model fitting. For more details see Zyla, J., Szumala, K., Polanski, A., Polanska, J., & Marczyk, M. (2026) <doi:10.1016/j.jocs.2026.102811>.

This package provides a deep neural network model with a monotonic increasing single index function tailored for periodontal disease studies. The residuals are assumed to follow a skewed T distribution, a skewed normal distribution, or a normal distribution. More details can be found at Liu, Huang, and Bai (2024) <doi:10.1016/j.csda.2024.108012>.