Amiga Disk Files (ADF) are virtual representations of 3.5 inch floppy disks for the Commodore Amiga. Most disk drives from other systems (including modern drives) are not able to read these disks. The adfExplorer package enables you to establish R connections to files on such virtual DOS-formatted disks, which can be use to read from and write to those files.

This package creates all leave-one-out models and produces predictions for test samples.

We developed a lightweight machine learning tool for RNA profiling of acute lymphoblastic leukemia (ALL), however, it can be used for any problem where multiple classes need to be identified from multi-dimensional data. The methodology is described in Makinen V-P, Rehn J, Breen J, Yeung D, White DL (2022) Multi-cohort transcriptomic subtyping of B-cell acute lymphoblastic leukemia, International Journal of Molecular Sciences 23:4574, <doi:10.3390/ijms23094574>. The classifier contains optimized mean profiles of the classes (centroids) as observed in the training data, and new samples are matched to these centroids using the shortest Euclidean distance. Centroids derived from a dataset of 1,598 ALL patients are included, but users can train the models with their own data as well. The output includes both numerical and visual presentations of the classification results. Samples with mixed features from multiple classes or atypical values are also identified.

This package provides a dependency-free collection of simple functions for cleaning rectangular data. This package allows to detect, count and replace values or discard rows/columns using a predicate function. In addition, it provides tools to check conditions and return informative error messages.

Nonparametric data-driven approach to discovering heterogeneous subgroups in a selection-on-observables framework. aggTrees allows researchers to assess whether there exists relevant heterogeneity in treatment effects by generating a sequence of optimal groupings, one for each level of granularity. For each grouping, we obtain point estimation and inference about the group average treatment effects. Please reference the use as Di Francesco (2022) <doi:10.2139/ssrn.4304256>.

Programming neuroscience specific Clinical Data Standards Interchange Consortium (CDISC) compliant Analysis Data Model (ADaM) datasets in R'. ADaM datasets are a mandatory part of any New Drug or Biologics License Application submitted to the United States Food and Drug Administration (FDA). Analysis derivations are implemented in accordance with the "Analysis Data Model Implementation Guide" (CDISC Analysis Data Model Team, 2021, <https://www.cdisc.org/standards/foundational/adam>). This package extends the admiral package.

Extraction of subsequences into FASTA files from GenBank annotations where gene names may vary among accessions. Borstein & O'Meara (2018) <doi:10.7717/peerj.5179>.

This package provides functions to conduct title and abstract screening in systematic reviews using large language models, such as the Generative Pre-trained Transformer (GPT) models from OpenAI <https://platform.openai.com/>. These functions can enhance the quality of title and abstract screenings while reducing the total screening time significantly. In addition, the package includes tools for quality assessment of title and abstract screenings, as described in Vembye, Christensen, Mølgaard, and Schytt (2025) <DOI:10.1037/met0000769>.

Automatically generate a changelog file (NEWS.md / CHANGELOG.md) from the git history using conventional commit messages (<https://www.conventionalcommits.org/en/v1.0.0/>).

Analysis of moderation (ANOMO) method conceptualizes the difference and equivalence tests as a moderation problem to test the difference and equivalence of two estimates (e.g., two means or two effects).

Presents a series of molecular and genetic routines in the R environment with the aim of assisting in analytical pipelines before and after the use of asreml or another library to perform analyses such as Genomic Selection or Genome-Wide Association Analyses. Methods and examples are described in Gezan, Oliveira, Galli, and Murray (2022) <https://asreml.kb.vsni.co.uk/wp-content/uploads/sites/3/ASRgenomics_Manual.pdf>.

Runs projections of groups of matrix projection models (MPMs), allowing density dependence mechanisms to work across MPMs. This package was developed to run both adaptive dynamics simulations such as pairwise and multiple invasibility analyses, and community projections in which species are represented by MPMs. All forms of MPMs are allowed, including integral projection models (IPMs).

This package implements a parsimonious evolutionary model to analyze and predict gene-functional annotations in phylogenetic trees as described in Vega Yon et al. (2021) <doi:10.1371/journal.pcbi.1007948>. Focusing on computational efficiency, aphylo makes it possible to estimate pooled phylogenetic models, including thousands (hundreds) of annotations (trees) in the same run. The package also provides the tools for visualization of annotated phylogenies, calculation of posterior probabilities (prediction) and goodness-of-fit assessment featured in Vega Yon et al. (2021).

An R Shiny application for visual and statistical exploration and web communication of archaeological spatial data, either remains or sites. It offers interactive 3D and 2D visualisations (cross sections and maps of remains, timeline of the work made in a site) which can be exported in SVG and HTML formats. It performs simple spatial statistics (convex hull, regression surfaces, 2D kernel density estimation) and allows exporting data to other online applications for more complex methods. archeoViz can be used offline locally or deployed on a server, either with interactive input of data or with a static data set. Example is provided at <https://analytics.huma-num.fr/archeoviz/en>.

Extremely efficient toolkit for solving the best subset selection problem <https://www.jmlr.org/papers/v23/21-1060.html>. This package is its R interface. The package implements and generalizes algorithms designed in <doi:10.1073/pnas.2014241117> that exploits a novel sequencing-and-splicing technique to guarantee exact support recovery and globally optimal solution in polynomial times for linear model. It also supports best subset selection for logistic regression, Poisson regression, Cox proportional hazard model, Gamma regression, multiple-response regression, multinomial logistic regression, ordinal regression, Ising model reconstruction <doi:10.1080/01621459.2025.2571245>, (sequential) principal component analysis, and robust principal component analysis. The other valuable features such as the best subset of group selection <doi:10.1287/ijoc.2022.1241> and sure independence screening <doi:10.1111/j.1467-9868.2008.00674.x> are also provided.

This package provides functions to estimate and interpret the alpha-NOMINATE ideal point model developed in Carroll et al. (2013, <doi:10.1111/ajps.12029>). alpha-NOMINATE extends traditional spatial voting frameworks by allowing for a mixture of Gaussian and quadratic utility functions, providing flexibility in modeling political actors preferences. The package uses Markov Chain Monte Carlo (MCMC) methods for parameter estimation, supporting robust inference about individuals ideological positions and the shape of their utility functions. It also contains functions to simulate data from the model and to calculate the probability of a vote passing given the ideal points of the legislators/voters and the estimated location of the choice alternatives.

Browse through a continuously updated list of existing RStudio addins and install/uninstall their corresponding packages.

An interactive shiny application for performing non-compartmental analysis (NCA) on pre-clinical and clinical pharmacokinetic data. The package builds on PKNCA for core estimators and provides interactive visualizations, CDISC outputs ('ADNCA', PP', ADPP') and configurable TLGs (tables, listings, and graphs). Typical use cases include exploratory analysis, validation, reporting or teaching/demonstration of NCA methods. Methods and core estimators are described in Denney, Duvvuri, and Buckeridge (2015) "Simple, Automatic Noncompartmental Analysis: The PKNCA R Package" <doi:10.1007/s10928-015-9432-2>.

Designed for the development and application of hidden Markov models and profile HMMs for biological sequence analysis. Contains functions for multiple and pairwise sequence alignment, model construction and parameter optimization, file import/export, implementation of the forward, backward and Viterbi algorithms for conditional sequence probabilities, tree-based sequence weighting, and sequence simulation. Features a wide variety of potential applications including database searching, gene-finding and annotation, phylogenetic analysis and sequence classification. Based on the models and algorithms described in Durbin et al (1998, ISBN: 9780521629713).

Implementation in R of the alpha-shape of a finite set of points in the three-dimensional space. The alpha-shape generalizes the convex hull and allows to recover the shape of non-convex and even non-connected sets in 3D, given a random sample of points taken into it. Besides the computation of the alpha-shape, this package provides users with functions to compute the volume of the alpha-shape, identify the connected components and facilitate the three-dimensional graphical visualization of the estimated set.

Original idea was presented in the thesis "A statistical analysis tool for agricultural research" to obtain the degree of Master on science, National Engineering University (UNI), Lima-Peru. Some experimental data for the examples come from the CIP and others research. Agricolae offers extensive functionality on experimental design especially for agricultural and plant breeding experiments, which can also be useful for other purposes. It supports planning of lattice, Alpha, Cyclic, Complete Block, Latin Square, Graeco-Latin Squares, augmented block, factorial, split and strip plot designs. There are also various analysis facilities for experimental data, e.g. treatment comparison procedures and several non-parametric tests comparison, biodiversity indexes and consensus cluster.

Facilitates writing computationally reproducible student theses in PDF format that conform to the American Psychological Association (APA) manuscript guidelines (6th Edition). The package currently provides two R Markdown templates for homework and theses at the Psychology Department of the University of Cologne. The package builds on the package papaja but is tailored to the requirements of student theses and omits features for simplicity.

Fast tool to calculate the Adjusted Market Inefficiency Measure following Tran & Leirvik (2019) <doi:10.1016/j.frl.2019.03.004>. This tool provides rolling window estimates of the Adjusted Market Inefficiency Measure for multiple instruments simultaneously.

Computes the Area Under the Kendall (AUK) estimator for multivariate independence. The AUK estimator is based on the survival copula and quantifies the deviation from the null hypothesis of independence. The methodology implemented in this package is based on the work of Afendras', Markatou', and Papantonis (2025) <doi:10.1016/j.jmva.2025.105589>.