This package provides a powerful tool for automating the early detection of disease outbreaks in time series data. aeddo employs advanced statistical methods, including hierarchical models, in an innovative manner to effectively characterize outbreak signals. It is particularly useful for epidemiologists, public health professionals, and researchers seeking to identify and respond to disease outbreaks in a timely fashion. For a detailed reference on hierarchical models, consult Henrik Madsen and Poul Thyregod's book (2011), ISBN: 9781420091557.

Flagger to detect acute kidney injury (AKI) in a patient dataset.

R codes for the (adaptive) Sum of Powered Score ('SPU and aSPU') tests, inverse variance weighted Sum of Powered score ('SPUw and aSPUw') tests and gene-based and some pathway based association tests (Pathway based Sum of Powered Score tests ('SPUpath'), adaptive SPUpath ('aSPUpath') test, GEEaSPU test for multiple traits - single SNP (single nucleotide polymorphism) association in generalized estimation equations, MTaSPUs test for multiple traits - single SNP association with Genome Wide Association Studies ('GWAS') summary statistics, Gene-based Association Test that uses an extended Simes procedure ('GATES'), Hybrid Set-based Test ('HYST') and extended version of GATES test for pathway-based association testing ('GATES-Simes'). ). The tests can be used with genetic and other data sets with covariates. The response variable is binary or quantitative. Summary; (1) Single trait-'SNP set association with individual-level data ('aSPU', aSPUw', aSPUr'), (2) Single trait-'SNP set association with summary statistics ('aSPUs'), (3) Single trait-pathway association with individual-level data ('aSPUpath'), (4) Single trait-pathway association with summary statistics ('aSPUsPath'), (5) Multiple traits-single SNP association with individual-level data ('GEEaSPU'), (6) Multiple traits- single SNP association with summary statistics ('MTaSPUs'), (7) Multiple traits-'SNP set association with summary statistics('MTaSPUsSet'), (8) Multiple traits-pathway association with summary statistics('MTaSPUsSetPath').

This package provides a collection of tools for the estimation of animals home range.

This package implements the differential equations associated to different versions of Allometric Trophic Models (ATN) to estimate the temporal dynamics of species biomasses in food webs. It offers several features to generate synthetic food webs and to parametrise models as well as a wrapper to the ODE solver deSolve.

Converts legacy microscopy video formats (H.264/H.265, AVI/MJPEG, TIFF stacks) to the modern AV1 codec with minimal quality loss. Typical use cases include compressing large TIFF stacks from confocal microscopy and time-lapse experiments from hundreds of gigabytes to manageable sizes, re-encoding MP4 files exported from CellProfiler', ImageJ'/'Fiji', and microscope software with approximately 2x better compression at the same visual quality, and converting legacy AVI (MJPEG) and H.265 recordings to a single patent-free format suited for long-term archival. Automatically selects the best available backend: GPU hardware acceleration via Vulkan VK_KHR_VIDEO_ENCODE_AV1 or VAAPI (tested on AMD RDNA4; bundled headers, builds with any Vulkan SDK >= 1.3.275), with automatic fallback to CPU encoding through FFmpeg and SVT-AV1'. User controls quality via a single CRF parameter; each backend adapts automatically (CPU and Vulkan use CRF directly, VAAPI targets 55 percent of input bitrate). TIFF stacks use near-lossless CRF 5 by default, with optional proportional scaling via tiff_scale (multiplier or bounding box, aspect ratio always preserved). Small frames are automatically scaled up to meet hardware encoder minimums. Audio tracks are preserved automatically. Provides a simple R API for batch conversion of entire experiment folders.

This package provides simple and intuitive functions for basic statistical analyses. Methods include the t-test (Student 1908 <doi:10.1093/biomet/6.1.1>), the Mann-Whitney U test (Mann and Whitney 1947 <doi:10.1214/aoms/1177730491>), Pearson's correlation (Pearson 1895 <doi:10.1098/rspl.1895.0041>), and analysis of variance (Fisher 1925, <doi:10.1007/978-1-4612-4380-9_5>). Functions are compatible with ggplot2 and dplyr'.

This package provides Azure Active Directory (AAD) authentication functionality for R users of Microsoft's Azure cloud <https://azure.microsoft.com/en-us>. Use this package to obtain OAuth 2.0 tokens for services including Azure Resource Manager, Azure Storage and others. It supports both AAD v1.0 and v2.0, as well as multiple authentication methods, including device code and resource owner grant. Tokens are cached in a user-specific directory obtained using the rappdirs package. The interface is based on the OAuth framework in the httr package, but customised and streamlined for Azure. Part of the AzureR family of packages.

This package implements Collective And Point Anomaly (CAPA) Fisch, Eckley, and Fearnhead (2022) <doi:10.1002/sam.11586>, Multi-Variate Collective And Point Anomaly (MVCAPA) Fisch, Eckley, and Fearnhead (2021) <doi:10.1080/10618600.2021.1987257>, Proportion Adaptive Segment Selection (PASS) Jeng, Cai, and Li (2012) <doi:10.1093/biomet/ass059>, and Bayesian Abnormal Region Detector (BARD) Bardwell and Fearnhead (2015) <doi:10.1214/16-BA998>. These methods are for the detection of anomalies in time series data. Further information regarding the use of this package along with detailed examples can be found in Fisch, Grose, Eckley, Fearnhead, and Bardwell (2024) <doi:10.18637/jss.v110.i01>.

This package provides a minimalist ggplot2 theme, colour scales, and pkgdown template built around a curated colour palette system inspired by Josef Albers colour theory (Albers (1963, ISBN:978-0-300-17935-4) "Interaction of Color"). Includes helpers to apply consistent theming to ggplot2 plots, gt tables, and bslib Bootstrap 5 sites, along with one-command setup functions for adopting the style across an R package.

Evaluates acute lymphoblastic leukemia maintenance therapy practice at patient and cohort level.

Many complex plots are actually composite plots, such as oncoplot', funkyheatmap', upsetplot', etc. We can produce subplots using ggplot2 and combine them to create composite plots using aplot'. In this way, it is easy to customize these complex plots, by adding, deleting or modifying subplots in the final plot. This package provides a set of utilities to help users to create subplots and complex plots.

Adversarial random forests (ARFs) recursively partition data into fully factorized leaves, where features are jointly independent. The procedure is iterative, with alternating rounds of generation and discrimination. Data becomes increasingly realistic at each round, until original and synthetic samples can no longer be reliably distinguished. This is useful for several unsupervised learning tasks, such as density estimation and data synthesis. Methods for both are implemented in this package. ARFs naturally handle unstructured data with mixed continuous and categorical covariates. They inherit many of the benefits of random forests, including speed, flexibility, and solid performance with default parameters. For details, see Watson et al. (2023) <https://proceedings.mlr.press/v206/watson23a.html>.

Automated data quality auditing using unsupervised machine learning. Provides AI-driven anomaly detection for data quality assessment, primarily designed for Electronic Health Records (EHR) data, with benchmarking capabilities for validation and publication. Methods based on: Liu et al. (2008) <doi:10.1109/ICDM.2008.17>, Breunig et al. (2000) <doi:10.1145/342009.335388>.

Automatically calculates cognostic groups for plot objects and list column plot objects. Results are returned in a nested data frame.

This package provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required.

This package implements wavelet-based approaches for describing population admixture. Principal Components Analysis (PCA) is used to define the population structure and produce a localized admixture signal for each individual. Wavelet summaries of the PCA output describe variation present in the data and can be related to population-level demographic processes. For more details, see J Sanderson, H Sudoyo, TM Karafet, MF Hammer and MP Cox. 2015. Reconstructing past admixture processes from local genomic ancestry using wavelet transformation. Genetics 200:469-481 <doi:10.1534/genetics.115.176842>.

This package provides functions to simulate data sets from hierarchical ecological models, including all the simulations described in the two volume publication Applied Hierarchical Modeling in Ecology: Analysis of distribution, abundance and species richness in R and BUGS by Marc Kéry and Andy Royle: volume 1 (2016, ISBN: 978-0-12-801378-6) and volume 2 (2021, ISBN: 978-0-12-809585-0), <https://www.mbr-pwrc.usgs.gov/pubanalysis/keryroylebook/>. It also has all the utility functions and data sets needed to replicate the analyses shown in the books.

The real-life time series data are hardly pure linear or nonlinear. Merging a linear time series model like the autoregressive moving average (ARMA) model with a nonlinear neural network model such as the Long Short-Term Memory (LSTM) model can be used as a hybrid model for more accurate modeling purposes. Both the autoregressive integrated moving average (ARIMA) and autoregressive fractionally integrated moving average (ARFIMA) models can be implemented. Details can be found in Box et al. (2015, ISBN: 978-1-118-67502-1) and Hochreiter and Schmidhuber (1997) <doi:10.1162/neco.1997.9.8.1735>.

Analyses of Proportions can be performed on the Anscombe (arcsine-related) transformed data. The ANOPA package can analyze proportions obtained from up to four factors. The factors can be within-subject or between-subject or a mix of within- and between-subject. The main, omnibus analysis can be followed by additive decompositions into interaction effects, main effects, simple effects, contrast effects, etc., mimicking precisely the logic of ANOVA. For that reason, we call this set of tools ANOPA (Analysis of Proportion using Anscombe transform) to highlight its similarities with ANOVA. The ANOPA framework also allows plots of proportions easy to obtain along with confidence intervals. Finally, effect sizes and planning statistical power are easily done under this framework. Only particularity, the ANOPA computes F statistics which have an infinite degree of freedom on the denominator. See Laurencelle and Cousineau (2023) <doi:10.3389/fpsyg.2022.1045436>.

This package provides helpers for querying the EPA Walkability Index <https://www.epa.gov/smartgrowth/national-walkability-index-user-guide-and-methodology> and working with Census GEOID/FIPS identifiers <https://www.census.gov/programs-surveys/geography/guidance/geo-identifiers.html>.

An interface to the AutoDesk Platform Services ('APS') API including the Authentication API for obtaining OAuth2 tokens with expiry tracking, Data Management API for managing buckets and objects across the platform's cloud services, Design Automation API for running automated tasks on design files in the cloud, Model Derivative API for translating design files into SVF', SVF2', OBJ', and STL formats and extracting model data, Reality Capture API for generating 3D models from photogrammetry image sets, and Viewer for rendering 2D and 3D models in Shiny applications.

This package provides tools for designing and analyzing Acceptance Sampling plans. Supports both Attributes Sampling (Binomial and Poisson distributions) and Variables Sampling (Normal and Beta distributions), enabling quality control for fractional and compositional data. Uses nonlinear programming for sampling plan optimization, minimizing sample size while controlling producer's and consumer's risks. Operating Characteristic curves are available for plan visualization.

This package provides tools for geometric morphometric analysis. The package includes tools of virtual anthropology to align two not articulated parts belonging to the same specimen, to build virtual cavities as endocast (Profico et al, 2021 <doi:10.1002/ajpa.24340>).